Oxethazaine (BioDeep_00000002737)

 

Secondary id: BioDeep_00001871369

human metabolite blood metabolite


代谢物信息卡片


2-[(2-hydroxyethyl)({[methyl(2-methyl-1-phenylpropan-2-yl)carbamoyl]methyl})amino]-N-methyl-N-(2-methyl-1-phenylpropan-2-yl)acetamide

化学式: C28H41N3O3 (467.3147756000001)
中文名称: 奥昔卡因
谱图信息: 最多检出来源 Homo sapiens(blood) 10.11%

分子结构信息

SMILES: CC(C)(CC1=CC=CC=C1)N(C)C(=O)CN(CCO)CC(=O)N(C)C(C)(C)CC2=CC=CC=C2
InChI: InChI=1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3

描述信息

C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AD - Local anesthetics
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
Same as: D01152

同义名列表

15 个代谢物同义名

2-[(2-hydroxyethyl)({[methyl(2-methyl-1-phenylpropan-2-yl)carbamoyl]methyl})amino]-N-methyl-N-(2-methyl-1-phenylpropan-2-yl)acetamide; 2,2-((2-Hydroxyethyl)imino)bis(N-alpha,alpha-dimethylphenethyl)-N-methylacetamide; Oxethazaine monohydrochloride; Oxethazaine hydrochloride; Oxethazaine; Robercain R; Oxethazine; Oxetacaine; Oxetacain; Strocain; Muthesa; Mucaine; Tepilta; Oxaine; Oxethazaine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • M Ahsan Shaker, Naveed Akhtar, Muhammad Usman Minhas, Kifayat Ullah Khan, Muhammad Imad-Ud-Din Zangi, Abubakar Munir. Effect of an Al/Mg Hydroxide Antacid and Food on the Pharmacokinetics of Dexibuprofen. Drug research. 2020 Apr; 70(4):158-164. doi: 10.1055/a-1114-5745. [PMID: 32110819]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Hokuto Namba, Yuki Nishimura, Norimitsu Kurata, Mariko Iwase, Takahito Hirai, Yuji Kiuchi. Inhibitory Effect of Oxethazaine on Midazolam Metabolism in Rats. Biological & pharmaceutical bulletin. 2017; 40(9):1361-1365. doi: 10.1248/bpb.b16-01016. [PMID: 28867721]
  • Soo-Yeun Lee, In-Jee You, Min-Jung Kim, Seung-Hwan Kwon, Sa-Ik Hong, Ji-Hyun Kim, Moon-Hee Jang, Seung-Min Oh, Kyu-Hyuck Chung, Seok-Yong Lee, Choon-Gon Jang. The abuse potential of oxethazaine: effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal models. Pharmacology, biochemistry, and behavior. 2013 Apr; 105(?):98-104. doi: 10.1016/j.pbb.2013.01.022. [PMID: 23402942]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Wei-Hsun Huang, Chin-Hung Liu, Ray H Liu, Ying Lung Tseng. Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis. Journal of analytical toxicology. 2010 Mar; 34(2):73-7. doi: 10.1093/jat/34.2.73. [PMID: 20223098]
  • Mei-Chich Hsu, Su-Fan Lin, Cheng-Ping Kuan, Wei-Lan Chu, Kuei-Hui Chan, Guo-Ping Chang-Chien. Oxethazaine as the source of mephentermine and phentermine in athlete's urine. Forensic science international. 2009 Mar; 185(1-3):e1-5. doi: 10.1016/j.forsciint.2008.12.009. [PMID: 19157735]
  • R Yasuno, T Oguma, Y Masuda. Ca2+ enhancement of hemolysis induced by the topical anesthetic oxethazaine in vitro. Biological & pharmaceutical bulletin. 1998 Dec; 21(12):1294-9. doi: 10.1248/bpb.21.1294. [PMID: 9881642]
  • F Penouil, D Morel, M C Saux, A Brachet-Liermain, L Potaux, M Aparicio. [Resorption of cyclosporin administered by oral route to renal transplant patients. Influence of breakfast and an antacid drug]. Therapie. 1988 Jan; 43(1):15-9. doi: NULL. [PMID: 3282341]
  • Y Yamazaki. Inhibitory mechanism of oxethazaine on release of endogenous secretin and pancreatic response in dogs. Digestive diseases and sciences. 1982 Sep; 27(9):821-7. doi: 10.1007/bf01391376. [PMID: 6896683]
  • Y Yamazaki, T Hayakawa, A Noda, T Kondo. Influence of topical anesthetic, anticholinergic and ganglionic blocking agents on endogenous secretin release and pancreatic secretion in dogs. Gastroenterologia Japonica. 1982; 17(1):10-4. doi: 10.1007/bf02774754. [PMID: 6122624]