Mepivacaine (BioDeep_00000002034)
Secondary id: BioDeep_00000405893
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide
化学式: C15H22N2O (246.1732042)
中文名称: N-(2,6-二甲基苯基)-1-甲基哌啶-2-甲酰胺, 甲哌卡因
谱图信息:
最多检出来源 Homo sapiens(blood) 8.85%
分子结构信息
SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C
InChI: InChI=1S/C15H22N2O/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18)
描述信息
A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BB - Amides
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3126
同义名列表
47 个代谢物同义名
N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide; N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide; AstraZeneca brand OF mepivacaine hydrochloride; Dentsply brand OF mepivacaine hydrochloride; Curasan brand OF mepivacaine hydrochloride; Aventis brand OF mepivacaine hydrochloride; Clarben brand OF mepivacaine hydrochloride; Novocol brand OF mepivacaine hydrochloride; Abbott brand OF mepivacaine hydrochloride; Inibsa brand OF mepivacaine hydrochloride; Pascoe brand OF mepivacaine hydrochloride; Sanofi brand OF mepivacaine hydrochloride; Braun brand OF mepivicaine hydrochloride; Astra brand OF mepivacaine hydrochloride; Hexal brand OF mepivacaine hydrochloride; 3m Brand OF mepivacaine hydrochloride; (+-)-1-Methyl-2,6-pipecoloxylidide; Monohydrochloride, mepivacaine; 1-Methyl-2,6-pipecoloxylidide; Mepivacaine monohydrochloride; Hydrochloride, mepivacaine; Mepivacaine hydrochloride; S-Ropivacaine mesylate; Mepivacain-injektopas; Mepivacain injektopas; Braun, mepivacaina; Mepivacaina braun; Carboplyin dental; Mepivacaine HCL; DL-Mepivacaine; Mepivastesin; Mepivacainum; Mepivacaina; mepivacaine; Scandinibsa; Mepivicaine; Scandicaine; Carbocaïne; Scandonest; Scandicain; Carbocaine; Polocaine; Mepihexal; Isocaine; Meaverin; Isogaine; Mecain
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:6759
- KEGG: C07528
- KEGGdrug: D08181
- PubChem: 4062
- HMDB: HMDB0015096
- Metlin: METLIN43244
- DrugBank: DB00961
- ChEMBL: CHEMBL1087
- Wikipedia: Mepivacaine
- MeSH: Mepivacaine
- chemspider: 3922
- CAS: 22801-44-1
- CAS: 96-88-8
- MoNA: EQ312606
- MoNA: EQ312603
- MoNA: EQ312601
- MoNA: EQ312605
- MoNA: EQ312602
- MoNA: EQ312604
- PMhub: MS000001713
- PubChem: 9731
- NIKKAJI: J4.726K
- RefMet: Mepivacaine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Leanda Livesey, Fred DeGraves, Courtney Allred, Lindsey Boone, John Schumacher. The efficacy of injecting a distillate of the pitcher plant (Sarraceniaceae) adjacent to the palmar digital nerves of horses to ameliorate lameness caused by digital pain.
Journal of equine veterinary science.
2024 Feb; 133(?):104974. doi:
10.1016/j.jevs.2023.104974. [PMID: 38145776] - Seong-Ho Ok, Dawon Kang, Soo Hee Lee, Hyun-Jin Kim, Seung Hyun Ahn, Ju-Tae Sohn. Lipid emulsions attenuate the inhibition of carnitine acylcarnitine translocase induced by toxic doses of local anesthetics in rat cardiomyoblasts.
Human & experimental toxicology.
2022 Jan; 41(?):9603271211065978. doi:
10.1177/09603271211065978. [PMID: 35135371] - Catina Frydendal, Katrine B Nielsen, Lise C Berg, Gaby van Galen, Ditte M T Adler, Stine M Andreassen, Stine Jacobsen. Influence of clinical and experimental intra-articular inflammation on neutrophil gelatinase-associated lipocalin concentrations in horses.
Veterinary surgery : VS.
2021 Apr; 50(3):641-649. doi:
10.1111/vsu.13582. [PMID: 33522003] - Elizabeth Jabbour, Carsten Fütterer, Sebastian Zach, Anna-Isabelle Kälsch, Michael Keese, Nuh N Rahbari, Bernhard K Krämer, Kay G Schwenke. Implantation of a peritoneal dialysis catheter in patients with ESRD using local anesthesia and Remifentanil.
PloS one.
2021; 16(11):e0259351. doi:
10.1371/journal.pone.0259351. [PMID: 34735524] - Jose L Mendez-Angulo, Maria M Granados, Rolf Modesto, Juan M Serrano-Rodriguez, Francisco J Funes, Setefilla Quiros, Rafael J Gomez-Villamandos, Sara Zaldívar, Troy N Trumble. Systemic and local effects of lidocaine or mepivacaine when used for intravenous regional anaesthesia of the distal limb in standing sedated horses.
Equine veterinary journal.
2020 Sep; 52(5):743-751. doi:
10.1111/evj.13236. [PMID: 31972065] - Eric M Yung, Faraj W Abdallah, Carla Todaro, Emily Spence, Andrew Grant, Richard Brull. Optimal local anesthetic regimen for saddle block in ambulatory anorectal surgery: an evidence-based systematic review.
Regional anesthesia and pain medicine.
2020 09; 45(9):733-739. doi:
10.1136/rapm-2020-101603. [PMID: 32699103] - Drew W Koch, Jeremiah T Easley, Jennifer N Hatzel, Brad B Nelson, Dean A Hendrickson, Jason Bruemmer, Eileen S Hackett. Prospective randomized investigation of topical anesthesia during unilateral laparoscopic ovariectomy in horses.
Veterinary surgery : VS.
2020 Jun; 49 Suppl 1(?):O54-O59. doi:
10.1111/vsu.13264. [PMID: 31225655] - M Abass, S Picek, J F G Garzón, C Kühnle, A Zaghlou, R Bettschart-Wolfensberger. Local mepivacaine before castration of horses under medetomidine isoflurane balanced anaesthesia is effective to reduce perioperative nociception and cytokine release.
Equine veterinary journal.
2018 Nov; 50(6):733-738. doi:
10.1111/evj.12947. [PMID: 29660154] - J-C-A Ferreira, I-S Catunda, B-C-E Vasconcelos, K-A-A da Silva, E-F-C Nogueira, E-E Vidal. Evaluation of the plasmatic level of mepivacaine in different anatomical regions.
Medicina oral, patologia oral y cirugia bucal.
2018 Jul; 23(4):e493-e497. doi:
10.4317/medoral.22374. [PMID: 29924762] - Victor Figueiredo Leite, João Eduardo Daud Amadera, Anna Maria Buehler. Viscosupplementation for Hip Osteoarthritis: A Systematic Review and Meta-Analysis of the Efficacy on Pain and Disability, and the Occurrence of Adverse Events.
Archives of physical medicine and rehabilitation.
2018 03; 99(3):574-583.e1. doi:
10.1016/j.apmr.2017.07.010. [PMID: 28803906] - Ruo-Wang Duan, Jiong Song, Yu-Ping Li, Chun-Gen Xing. A novel LC-MS/MS method for mepivacaine determination and pharmacokinetic study in a single-dose two-period crossover in healthy subjects.
Artificial cells, nanomedicine, and biotechnology.
2017 Dec; 45(8):1605-1611. doi:
10.1080/21691401.2016.1267013. [PMID: 27976931] - Daniel J Corwin, Alexis Topjian, Brenda L Banwell, Kevin Osterhoudt. Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity.
Clinical toxicology (Philadelphia, Pa.).
2017 Jul; 55(6):603-607. doi:
10.1080/15563650.2017.1294693. [PMID: 28489457] - V Mojica, D Nieuwveld, A E Herrera, G Mestres, A M López, X Sala-Blanch. Axillary brachial plexus block duration with mepivacaine in patients with chronic renal failure. Case-control study.
Revista espanola de anestesiologia y reanimacion.
2017 Apr; 64(4):192-197. doi:
10.1016/j.redar.2016.09.011. [PMID: 28017345] - H C Scarparo, R N Maia, Ea Dos Santos Filho, Ecs Soares, Fwg Costa, Csr Fonteles, T P Bezerra, T R Ribeiro, N R Romero. Plasma mepivacaine concentrations in patients undergoing third molar surgery.
Australian dental journal.
2016 12; 61(4):446-454. doi:
10.1111/adj.12410. [PMID: 26780408] - Ali Mokhtari. Chemiluminescence Determination of Local Anaesthetic Mepivacaine in Human Plasma and Pharmaceuticals.
Acta chimica Slovenica.
2016 12; 63(4):920-928. doi:
10.17344/acsi.2015.2161. [PMID: 28004094] - C Aumeier, B Kasdorf, M Gruber, H Busse, C H Wiese, W Zink, B M Graf, Y A Zausig. Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model.
British journal of anaesthesia.
2014 Apr; 112(4):735-41. doi:
10.1093/bja/aet353. [PMID: 24169820] - M Harvey, G Cave. Lipid rescue: does the sink hold water? And other controversies.
British journal of anaesthesia.
2014 Apr; 112(4):622-5. doi:
10.1093/bja/aeu010. [PMID: 24535605] - Seyed Mosayeb Daryanavard, Amin Jeppsson-Dadoun, Lars I Andersson, Mahdi Hashemi, Anders Colmsjö, Mohamed Abdel-Rehim. Molecularly imprinted polymer in microextraction by packed sorbent for the simultaneous determination of local anesthetics: lidocaine, ropivacaine, mepivacaine and bupivacaine in plasma and urine samples.
Biomedical chromatography : BMC.
2013 Nov; 27(11):1481-8. doi:
10.1002/bmc.2946. [PMID: 23832864] - Soo Hee Lee, Hui-Jin Sung, Seong-Ho Ok, Jongsun Yu, Mun-Jeoung Choi, Jin Soo Lim, Ju-Tae Sohn. Lipid emulsions enhance the norepinephrine-mediated reversal of local anesthetic-induced vasodilation at toxic doses.
Yonsei medical journal.
2013 Nov; 54(6):1524-32. doi:
10.3349/ymj.2013.54.6.1524. [PMID: 24142661] - D Soto Mesa, M A Bermejo Álvarez, M J García Menéndez, M Fayad Fayad. [Axillary brachial plexus block in a patient with Bardet-Biedl syndrome].
Revista espanola de anestesiologia y reanimacion.
2012 Nov; 59(9):518-9. doi:
10.1016/j.redar.2012.05.017. [PMID: 22749304] - Guy Weinberg, Lisa Warren. Lipid resuscitation: listening to our patients and learning from our models.
Anesthesia and analgesia.
2012 Apr; 114(4):710-2. doi:
10.1213/ane.0b013e31824b7eed. [PMID: 22434892] - Erik S Litonius, Tomohisa Niiya, Pertti J Neuvonen, Per H Rosenberg. Intravenous lipid emulsion only minimally influences bupivacaine and mepivacaine distribution in plasma and does not enhance recovery from intoxication in pigs.
Anesthesia and analgesia.
2012 Apr; 114(4):901-6. doi:
10.1213/ane.0b013e3182367a37. [PMID: 22025489] - Giovana Radomille Tofoli, Cíntia M S Cereda, Daniele Ribeiro Araújo, Michelle Franz-Montan, Francisco Carlos Groppo, Daiane Quaglio, Jose Pedrazzoli Junior, Silvana Aparecida Calafatti, Fabio Alessandro Proença Barros, Eneida de Paula. Pharmacokinetic study of liposome-encapsulated and plain mepivacaine formulations injected intra-orally in volunteers.
The Journal of pharmacy and pharmacology.
2012 Mar; 64(3):397-403. doi:
10.1111/j.2042-7158.2011.01425.x. [PMID: 22309271] - Weiming Ruan, Deborah French, Alicia Wong, Kenneth Drasner, Alan H B Wu. A mixed (long- and medium-chain) triglyceride lipid emulsion extracts local anesthetic from human serum in vitro more effectively than a long-chain emulsion.
Anesthesiology.
2012 Feb; 116(2):334-9. doi:
10.1097/aln.0b013e318242a5f1. [PMID: 22273855] - Michael Froehle, Nikolaus A Haas, Guenther Kirchner, Deniz Kececioglu, Eugen Sandica. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application.
Case reports in pediatrics.
2012; 2012(?):491692. doi:
10.1155/2012/491692. [PMID: 22966472] - Hui-Jin Sung, Seong-Ho Ok, Jin-Young Sohn, Yong Hyeok Son, Jun Kyu Kim, Soo Hee Lee, Jeong Yeol Han, Dong Hoon Lim, Il-Woo Shin, Heon-Keun Lee, Young-Kyun Chung, Mun-Jeoung Choi, Ju-Tae Sohn. Vasoconstriction potency induced by aminoamide local anesthetics correlates with lipid solubility.
Journal of biomedicine & biotechnology.
2012; 2012(?):170958. doi:
10.1155/2012/170958. [PMID: 22778542] - Sarah Ciechanowicz, Vinod Patil. Lipid emulsion for local anesthetic systemic toxicity.
Anesthesiology research and practice.
2012; 2012(?):131784. doi:
10.1155/2012/131784. [PMID: 21969824] - Andreas Leffler, Anja Lattrell, Sergej Kronewald, Florian Niedermirtl, Carla Nau. Activation of TRPA1 by membrane permeable local anesthetics.
Molecular pain.
2011 Aug; 7(?):62. doi:
10.1186/1744-8069-7-62. [PMID: 21861907] - Grant Cave, Martyn Harvey, Andis Graudins. Intravenous lipid emulsion as antidote: a summary of published human experience.
Emergency medicine Australasia : EMA.
2011 Apr; 23(2):123-41. doi:
10.1111/j.1742-6723.2011.01398.x. [PMID: 21489160] - Gaurav Kuthiala, Geeta Chaudhary. Ropivacaine: A review of its pharmacology and clinical use.
Indian journal of anaesthesia.
2011 Mar; 55(2):104-10. doi:
10.4103/0019-5049.79875. [PMID: 21712863] - Seong-Ho Ok, Ju-Tae Sohn, Ji-Seok Baik, Jae-Gak Kim, Sang-Seung Park, Hui-Jin Sung, Mi-Kyung Shin, Yong-Hyun Kwon, Chang-Shin Park, Il-Woo Shin, Heon-Keun Lee, Young-Kyun Chung. Lipid emulsion reverses Levobupivacaine-induced responses in isolated rat aortic vessels.
Anesthesiology.
2011 Feb; 114(2):293-301. doi:
10.1097/aln.0b013e3182054d22. [PMID: 21239969] - Pere Domingo, Javier Torres-Torronteras, Virginia Pomar, Marta Giralt, Joan Carles Domingo, Maria Del Mar Gutierrez, José M Gallego-Escuredo, Maria Gracia Mateo, Pedro Cano-Soldado, Irene Fernandez, Marçal Pastor-Anglada, Francesc Vidal, Francesc Villarroya, Antoni Andreu, Ramon Marti. Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome.
PloS one.
2010 Nov; 5(11):e13896. doi:
10.1371/journal.pone.0013896. [PMID: 21085568] - Ruriko Konishi, Izumi Kawagoe, Masanori Kanai, Sonoko Kimura, Hiromasa Mitsuhata. [Anaphylactic reaction to epidural block in an outpatient].
Masui. The Japanese journal of anesthesiology.
2010 Oct; 59(10):1287-90. doi:
. [PMID: 20960905] - Paul A Moore, Elliot V Hersh. Local anesthetics: pharmacology and toxicity.
Dental clinics of North America.
2010 Oct; 54(4):587-99. doi:
10.1016/j.cden.2010.06.015. [PMID: 20831923] - Cynthia A Wong. Advances in labor analgesia.
International journal of women's health.
2010 Aug; 1(?):139-54. doi:
10.2147/ijwh.s4553. [PMID: 21072284] - Giovana Radomille Tofoli, Cíntia Maria Saia Cereda, Daniele Ribeiro de Araujo, Eneida de Paula, Rui Barbosa Brito, José Pedrazzoli, Eduardo Meurer, Fábio Alessandro Proença Barros, Francisco Carlos Groppo, Maria Cristina Volpato, José Ranali. Pharmacokinetic and local toxicity studies of liposome-encapsulated and plain mepivacaine solutions in rats.
Drug delivery.
2010 Feb; 17(2):68-76. doi:
10.3109/10717540903508995. [PMID: 20070242] - James P Scarth, Holly A Spencer, Sarah E Timbers, Simon C Hudson, Lynn L Hillyer. The use of in vitro technologies coupled with high resolution accurate mass LC-MS for studying drug metabolism in equine drug surveillance.
Drug testing and analysis.
2010 Jan; 2(1):1-10. doi:
10.1002/dta.88. [PMID: 20878880] - Joo-Hee Kim, Gil-Soon Choi, Young-Min Ye, Dong-Ho Nahm, Hae-Sim Park. Acute urticaria caused by the injection of goat-derived hyaluronidase.
Allergy, asthma & immunology research.
2009 Oct; 1(1):48-50. doi:
10.4168/aair.2009.1.1.48. [PMID: 20224671] - York A Zausig, Wolfgang Zink, Meike Keil, Barbara Sinner, Juergen Barwing, Christoph H R Wiese, Bernhard M Graf. Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest.
Anesthesia and analgesia.
2009 Oct; 109(4):1323-6. doi:
10.1213/ane.0b013e3181af7fb3. [PMID: 19762764] - Gianpaolo Carrafiello, Domenico Laganà, Andrea Ianniello, Federico Fontana, Monica Mangini, Lucia Mocciardini, Emanuela Spanò, Filippo Piacentino, Salvatore Cuffari, Carlo Fugazzola. Plasma-mediated radiofrequency ablation followed by percutaneous cementoplasty under fluoro-CT guidance: a case report.
Cases journal.
2009 Aug; 2(?):8548. doi:
10.4076/1757-1626-2-8548. [PMID: 19918385] - Hélène Charbonneau, Thi Aurore Pham Marcou, Jean-Xavier Mazoit, Paul J Zetlaoui, Dan Benhamou. Early use of lipid emulsion to treat incipient mepivacaine intoxication.
Regional anesthesia and pain medicine.
2009 May; 34(3):277-8. doi:
10.1097/aap.0b013e31819340be. [PMID: 19436188] - I Jimena, I Tasset, R López-Martos, A J Rubio, E Luque, P Montilla, J Peña, I Túnez. Effects of magnetic stimulation on oxidative stress and skeletal muscle regeneration induced by mepivacaine in rat.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2009 Jan; 5(1):44-9. doi:
10.2174/157340609787049217. [PMID: 19149649] - Emile Calenda, Stelian A Dinescu. Failure of lipid emulsion to reverse neurotoxicity after an ultrasound-guided axillary block with ropivacaine and mepivacaine.
Journal of anesthesia.
2009; 23(3):472-3. doi:
10.1007/s00540-009-0755-2. [PMID: 19685142] - Shigekiyo Matsumoto, Chihiro Shingu, Seigo Hidaka, Koji Goto, Satoshi Hagiwara, Hideo Iwasaka, Takayuki Noguchi. Anesthetic management of a patient with hyperthyroidism due to hydatidiform mole.
Journal of anesthesia.
2009; 23(4):594-6. doi:
10.1007/s00540-009-0809-5. [PMID: 19921374] - Alastair T Kay, David M Bolt, Akikazu Ishihara, Paivi J Rajala-Schultz, Alicia L Bertone. Anti-inflammatory and analgesic effects of intra-articular injection of triamcinolone acetonide, mepivacaine hydrochloride, or both on lipopolysaccharide-induced lameness in horses.
American journal of veterinary research.
2008 Dec; 69(12):1646-54. doi:
10.2460/ajvr.69.12.1646. [PMID: 19046013] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Issam Tanoubi, Philippe Cuvillon, Emmanuel Nouvellon, Louis Philippe Fortier, Pierre Drolet, Jacques Ripart. [Case report: bilateral femoral and sciatic regional anesthesia in a polytraumatized patient].
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2008 Jun; 55(6):371-5. doi:
10.1007/bf03021493. [PMID: 18566201] - Rainer J Litz, Thomas Roessel, Axel R Heller, Sebastian N Stehr. Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection.
Anesthesia and analgesia.
2008 May; 106(5):1575-7, table of contents. doi:
10.1213/ane.0b013e3181683dd7. [PMID: 18420880] - Lauren G Kleine, Mauricio Solano, Mary Rusckowski, Kathleen E Hunt, Karen L Johnson, Carl A Kirker-Head. Evaluation of technetium Tc 99m-labeled biotin for scintigraphic detection of soft tissue inflammation in horses.
American journal of veterinary research.
2008 May; 69(5):639-46. doi:
10.2460/ajvr.69.5.639. [PMID: 18447795] - Julio A Warren, R Brian Thoma, Alexandru Georgescu, Saurin J Shah. Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block.
Anesthesia and analgesia.
2008 May; 106(5):1578-80, table of contents. doi:
10.1213/01.ane.0000281434.80883.88. [PMID: 18420881] - Sanda Mihaela Popescu, Mihai Nechifor, Mihaela Baniceru, Octavian Croitoru, Florica Popescu. Effect of propranolol on mepivacaine serum concentrations in dental practice.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.
2008 Apr; 105(4):e19-23. doi:
10.1016/j.tripleo.2007.12.010. [PMID: 18329563] - Stina Garvin, Charlotta Dabrosin. In vivo measurement of tumor estradiol and vascular endothelial growth factor in breast cancer patients.
BMC cancer.
2008 Mar; 8(?):73. doi:
10.1186/1471-2407-8-73. [PMID: 18366667] - Takahiro Ueno, Hironori Tsuchiya, Maki Mizogami, Ko Takakura. Local anesthetic failure associated with inflammation: verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite.
Journal of inflammation research.
2008; 1(?):41-8. doi:
10.2147/jir.s3982. [PMID: 22096346] - Antoine Amado, Apra Sood, James S Taylor. Contact allergy to lidocaine: a report of sixteen cases.
Dermatitis : contact, atopic, occupational, drug.
2007 Dec; 18(4):215-20. doi:
10.2310/6620.2007.06059. [PMID: 18021602] - Shelby L Corman, Susan J Skledar. Use of lipid emulsion to reverse local anesthetic-induced toxicity.
The Annals of pharmacotherapy.
2007 Nov; 41(11):1873-7. doi:
10.1345/aph.1k244. [PMID: 17895327] - Hannes M Bergmann, Ingo Nolte, Sabine Kramer. Comparison of analgesic efficacy of preoperative or postoperative carprofen with or without preincisional mepivacaine epidural anesthesia in canine pelvic or femoral fracture repair.
Veterinary surgery : VS.
2007 Oct; 36(7):623-32. doi:
10.1111/j.1532-950x.2007.00314.x. [PMID: 17894588] - Domenico Lapenna, Giuliano Ciofani, Sante Donato Pierdomenico, Matteo Neri, Maria Adele Giamberardino, Franco Cuccurullo. Amiodarone inhibits tocopherol-mediated human lipoprotein peroxidation.
Biochemical pharmacology.
2007 Jul; 74(2):265-72. doi:
10.1016/j.bcp.2007.04.022. [PMID: 17531203] - Ju Mizuno, Tobias Gauss, Masahiro Suzuki, Masakazu Hayashida, Hideko Arita, Kazuo Hanaoka. Encephalopathy and rhabdomyolysis induced by iotrolan during epiduroscopy.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2007 Jan; 54(1):49-53. doi:
10.1007/bf03021899. [PMID: 17197468] - R Fuzier, O Fourcade, V Fuzier, H Gonzalez, N Albert, D Riviere, X Capdevila. [Characteristics of mepivacaine axillary brachial plexus block performed at 2800 m of altitude].
Annales francaises d'anesthesie et de reanimation.
2007 Jan; 26(1):17-22. doi:
10.1016/j.annfar.2006.06.026. [PMID: 17141465] - A Spasiano, I Flore, A Pesamosca, G Della Rocca. Comparison between spinal anaesthesia and sciatic-femoral block for arthroscopic knee surgery.
Minerva anestesiologica.
2007 Jan; 73(1-2):13-21. doi:
NULL. [PMID: 17159764] - Christoph J Konrad, Guido K Schuepfer, Michael Neuburger, Marcus Schley, Martin Schmelz, Joachim Schmeck. Reduction of pulmonary edema by short-acting local anesthetics.
Regional anesthesia and pain medicine.
2006 May; 31(3):254-9. doi:
10.1016/j.rapm.2006.01.003. [PMID: 16701192] - Einosuke Tanaka, Takako Nakamura, Shinichi Inomata, Katsuya Honda. Simultaneous determination of three local anesthetic drugs from the pipecoloxylidide group in human serum by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Apr; 834(1-2):213-6. doi:
10.1016/j.jchromb.2006.02.034. [PMID: 16530026] - Johan Knutsson, Anders Tibbelin, Magnus Von Unge. Adjuvant local anaesthetics in the epipharyngeal space in day-case adenoidectomy: a prospective, randomized, double-blind, placebo-controlled trial.
Acta oto-laryngologica.
2006 Jan; 126(1):51-5. doi:
10.1080/00016480510043459. [PMID: 16308255] - I Tanoubi, N Vialles, P Cuvillon, J Ripart. [Systemic toxicity with mepivacaine following axillary block in a patient with terminal kidney failure].
Annales francaises d'anesthesie et de reanimation.
2006 Jan; 25(1):33-5. doi:
10.1016/j.annfar.2005.07.076. [PMID: 16253473] - Adriana M Viana, Antonio Carlos de Campos, Mayra T Morlin, Verónica K L Chin. Plasma catecholamine concentrations and hemodynamic responses to vasoconstrictor during conventional or Gow-Gates mandibular anesthesia.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.
2005 Oct; 100(4):415-9. doi:
10.1016/j.tripleo.2005.01.005. [PMID: 16182162] - A Koehler, R Oertel, W Kirch. Simultaneous determination of bupivacaine, mepivacain, prilocaine and ropivacain in human serum by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2005 Sep; 1088(1-2):126-30. doi:
10.1016/j.chroma.2005.03.071. [PMID: 16130740] - J F Lundberg, J Martner, C Raner, O Winsö, B Biber. Dopamine or norepinephrine infusion during thoracic epidural anesthesia? Differences in hemodynamic effects and plasma catecholamine levels.
Acta anaesthesiologica Scandinavica.
2005 Aug; 49(7):962-8. doi:
10.1111/j.1399-6576.2005.00732.x. [PMID: 16045657] - Leonardo Fernandes Fraceto, Alberto Spisni, Shirley Schreier, Eneida de Paula. Differential effects of uncharged aminoamide local anesthetics on phospholipid bilayers, as monitored by 1H-NMR measurements.
Biophysical chemistry.
2005 May; 115(1):11-8. doi:
10.1016/j.bpc.2004.12.003. [PMID: 15848279] - Y U Adachi, M Satomoto, H Higuchi, K Watanabe. Rapid fluid infusion therapy decreases the plasma concentration of continuously infused propofol.
Acta anaesthesiologica Scandinavica.
2005 Mar; 49(3):331-6. doi:
10.1111/j.1399-6576.2005.00564.x. [PMID: 15752398] - Eiji Masaki, Hirokazu Saito, Kazuhiro Shoji, Masato Matsushima. Postoperative analgesic effect of epidural neostigmine and plasma cortisol and IL-6 responses.
Journal of clinical anesthesia.
2004 Nov; 16(7):488-92. doi:
10.1016/j.jclinane.2003.12.009. [PMID: 15590250] - Jorge Heller, John Barr. Poly(ortho esters)--from concept to reality.
Biomacromolecules.
2004 Sep; 5(5):1625-32. doi:
10.1021/bm040049n. [PMID: 15360265] - Sachiko Imamura, Kyung-ho Chang, Yuuichiro Saitoh, Erika Sano, Tooru Akune, Kazuo Hanaoka. [The successful anesthetic management of a patient with pheochromocytoma using prostaglandin E1 and a novel, short-acting beta-adrenergic blocker: landiolol hydrochloride].
Masui. The Japanese journal of anesthesiology.
2004 Jul; 53(7):806-9. doi:
. [PMID: 15298253] - Daniele R de Araujo, Cíntia M S Cereda, Giovana B Brunetto, Luciana M A Pinto, Maria Helena A Santana, Eneida de Paula. Encapsulation of mepivacaine prolongs the analgesia provided by sciatic nerve blockade in mice.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2004 Jun; 51(6):566-72. doi:
10.1007/bf03018399. [PMID: 15197119] - M Baniceru, O Croitoru, S M Popescu. Determination of some local anesthetics in human serum by gas chromatography with solid-phase extraction.
Journal of pharmaceutical and biomedical analysis.
2004 May; 35(3):593-8. doi:
10.1016/j.jpba.2004.02.012. [PMID: 15137984] - Takahiro Fujimoto, Tomoki Nishiyama, Kazuo Hanaoka. [A case of ectopic pheochromocytoma of pulmonary origin].
Masui. The Japanese journal of anesthesiology.
2004 May; 53(5):537-9. doi:
. [PMID: 15198238] - L Moltó, R Pallarés, J Castillo, L L Gallart, F Escolano. [Severe anaphylactic reaction to metamizol during subarachnoid anesthesia].
Revista espanola de anestesiologia y reanimacion.
2004 Mar; 51(3):151-4. doi:
. [PMID: 15200187] - D H Bremerich, R L Schlösser, N L'Allemand, R P Brandes, A Ahr, D Piorko, M Kaufmann, P Kessler. Mepivacaine for spinal anesthesia in parturients undergoing elective cesarean delivery: maternal and neonatal plasma concentrations and neonatal outcome.
Zentralblatt fur Gynakologie.
2003 Dec; 125(12):518-21. doi:
10.1055/s-2003-44817. [PMID: 14755363] - Katherine L Chin, John A Yagiela, Christine L Quinn, Kent R Henderson, Donald F Duperon. Serum mepivacaine concentrations after intraoral injection in young children.
Journal of the California Dental Association.
2003 Oct; 31(10):757-64. doi:
NULL. [PMID: 14626871] - Tetsuo Yamada, Tetsuo Murayama, Masahiko Andoh. Adjuvant hydrodistension under epidural anesthesia for interstitial cystitis.
International journal of urology : official journal of the Japanese Urological Association.
2003 Sep; 10(9):463-8; discussion 469. doi:
10.1046/j.1442-2042.2003.00664.x. [PMID: 12941123] - A I Espina, A V Castellanos, J L Fereira. Age-related changes in blood capillary endothelium of human dental pulp: an ultrastructural study.
International endodontic journal.
2003 Jun; 36(6):395-403. doi:
10.1046/j.1365-2591.2003.00659.x. [PMID: 12801286] - Curry G Keoughan, Dwayne H Rodgerson, Murray P Brown. Hand-assisted laparoscopic left nephrectomy in standing horses.
Veterinary surgery : VS.
2003 May; 32(3):206-12. doi:
10.1053/jvet.2003.50028. [PMID: 12784196] - Saeed Taheri, Lawrence P Cogswell, Alison Gent, Gary R Strichartz. Hydrophobic and ionic factors in the binding of local anesthetics to the major variant of human alpha1-acid glycoprotein.
The Journal of pharmacology and experimental therapeutics.
2003 Jan; 304(1):71-80. doi:
10.1124/jpet.102.042028. [PMID: 12490577] - Yachiyo Tabuchi, Yoshihiro Takamitsu. [Perioperative management for nephrectomy using combined spinal-epidural anesthesia with sedation in a patient with cerebral palsy under maintenance hemodialysis].
Masui. The Japanese journal of anesthesiology.
2002 Nov; 51(11):1268-71. doi:
NULL. [PMID: 12481458] - Maki Mizogami, Hironori Tsuchiya, Jun Harada. Membrane effects of ropivacaine compared with those of bupivacaine and mepivacaine.
Fundamental & clinical pharmacology.
2002 Aug; 16(4):325-30. doi:
10.1046/j.1472-8206.2002.00090.x. [PMID: 12570022] - P Prieto-Alvarez, A Calas-Guerra, J Fuentes-Bellido, E Martínez-Verdera, A Benet-Català, J P Lorenzo-Foz. Comparison of mepivacaine and lidocaine for intravenous regional anaesthesia: pharmacokinetic study and clinical correlation.
British journal of anaesthesia.
2002 Apr; 88(4):516-9. doi:
10.1093/bja/88.4.516. [PMID: 12066727] - T Grobosch, U Lemm-Ahlers. Immunoassay screening of lysergic acid diethylamide (LSD) and its confirmation by HPLC and fluorescence detection following LSD ImmunElute extraction.
Journal of analytical toxicology.
2002 Apr; 26(3):181-6. doi:
10.1093/jat/26.3.181. [PMID: 11991536] - A Casati, G Cappelleri, M Berti, G Fanelli, P Di Benedetto, G Torri. Randomized comparison of remifentanil-propofol with a sciatic-femoral nerve block for out-patient knee arthroscopy.
European journal of anaesthesiology.
2002 Feb; 19(2):109-14. doi:
10.1017/s0265021502000194. [PMID: 11999592] - M R Gough, G Mayhew, G A Munroe. Diffusion of mepivacaine between adjacent synovial structures in the horse. Part 1: forelimb foot and carpus.
Equine veterinary journal.
2002 Jan; 34(1):80-4. doi:
10.2746/042516402776181097. [PMID: 11817556] - Joel B Gunter. Benefit and risks of local anesthetics in infants and children.
Paediatric drugs.
2002; 4(10):649-72. doi:
10.2165/00128072-200204100-00003. [PMID: 12269841] - Tetsuya Horai, Tomoki Nishiyama, Hirotoshi Yamamoto, Kazuo Hanaoka. [High dose L-dopa infusion during general anesthesia for gastrectomy in a patient with parkinsonism].
Masui. The Japanese journal of anesthesiology.
2002 Jan; 51(1):42-5. doi:
NULL. [PMID: 11840662] - M R Gough, G A Munroe, G Mayhew. Diffusion of mepivacaine between adjacent synovial structures in the horse. Part 2: tarsus and stifle.
Equine veterinary journal.
2002 Jan; 34(1):85-90. doi:
10.2746/042516402776181088. [PMID: 11817557] - R Murtaza, H L Jackman, B Alexander, A Lleshi-Tali, A P Winnie, R Igic. Simultaneous determination of mepivacaine, tetracaine, and p-butylaminobenzoic acid by high-performance liquid chromatography.
Journal of pharmacological and toxicological methods.
2001 Nov; 46(3):131-6. doi:
10.1016/s1056-8719(02)00171-5. [PMID: 12183188] - H Iskandar, E Guillaume, F Dixmérias, B Binje, S Rakotondriamihary, R Thiebaut, P Maurette. The enhancement of sensory blockade by clonidine selectively added to mepivacaine after midhumeral block.
Anesthesia and analgesia.
2001 Sep; 93(3):771-5. doi:
10.1097/00000539-200109000-00043. [PMID: 11524354] - V Tagariello, A Caporuscio, O De Tommaso. Mepivacaine: update on an evergreen local anaesthetic.
Minerva anestesiologica.
2001 Sep; 67(9 Suppl 1):5-8. doi:
NULL. [PMID: 11778086] - T Hiraki, K Oishi, T Kano. [Anesthetic management of a patient with a history of acute intermittent porphyria and an elevation of urinary porphobilinogen].
Masui. The Japanese journal of anesthesiology.
2001 Aug; 50(8):882-5. doi:
NULL. [PMID: 11554022] - J Rodríguez, V Rodríguez, A Naveira, O Quintela, M Bárcena, E Gallardo, F Gude, J Alvarez. Epidural washout with high volumes of saline to accelerate recovery from epidural anaesthesia.
Acta anaesthesiologica Scandinavica.
2001 Aug; 45(7):893-8. doi:
10.1034/j.1399-6576.2001.045007893.x. [PMID: 11472293] - Y Mizukoshi, K Shibata, M Yoshida. Left ventricular contractility is reduced by hypercapnic acidosis and thoracolumbar epidural anesthesia in rabbits.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2001 Jun; 48(6):557-62. doi:
10.1007/bf03016832. [PMID: 11444450] - H Kutchai, L M Geddis. Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics.
Pharmacological research.
2001 Apr; 43(4):399-403. doi:
10.1006/phrs.2001.0803. [PMID: 11352545] - J Rodríguez, O Quintela, M López-Rivadulla, M Bárcena, C Diz, J Alvarez. High doses of mepivacaine for brachial plexus block in patients with end-stage chronic renal failure. A pilot study.
European journal of anaesthesiology.
2001 Mar; 18(3):171-6. doi:
10.1046/j.0265-0215.2000.00806.x. [PMID: 11298176]