Zalcitabine (BioDeep_00000001914)

 

Secondary id: BioDeep_00001867699

human metabolite blood metabolite


代谢物信息卡片


4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one

化学式: C9H13N3O3 (211.0957)
中文名称: 2,3-二脱氧胞苷
谱图信息: 最多检出来源 Homo sapiens(viridiplantae) 7.2%

分子结构信息

SMILES: C1CC(OC1CO)N2C=CC(=NC2=O)N
InChI: InChI=1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1

描述信息

A dideoxynucleoside compound in which the 3-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5 to 3 phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy. [PubChem]
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AF - Nucleoside and nucleotide reverse transcriptase inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D018894 - Reverse Transcriptase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent
D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
KEIO_ID Z001
Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection.

同义名列表

16 个代谢物同义名

4-Amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one; 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one; 2,3-Dideoxycytidine;ddC;Dideoxycytidine; Hoffman-la roche brand OF zalcitabine; Roche brand OF zalcitabine; 2,3 Dideoxycytidine; 2,3-Dideoxycytidine; Dideoxycytidine; DDC (Antiviral); Zalcitabine; HIVID roche; DDCYD; Hivid; DDC; 2',3'-Dideoxycytidine; Zalcitabine



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AXIN2, CASP3, CDKN2A, CDKN2B, CXCR4, DCK, MAPK14, POLB, TK2
Peripheral membrane protein 2 CYP1B1, ERVW-1
Endoplasmic reticulum membrane 2 CD4, CYP1B1
Nucleus 9 AXIN2, CASP3, CDKN2A, CDKN2B, DCK, MAPK14, POLB, TFAM, TK1
cytosol 9 AXIN2, CASP3, CDKN2A, CDKN2B, DCK, MAPK14, PRKCQ, TFAM, TK1
centrosome 1 AXIN2
nucleoplasm 5 CASP3, CDKN2A, DCK, MAPK14, POLB
Cell membrane 4 CD4, CD8A, CXCR4, TNF
Multi-pass membrane protein 2 CXCR4, SLC22A6
cell junction 1 CXCR4
cell surface 2 CXCR4, TNF
glutamatergic synapse 2 CASP3, MAPK14
neuronal cell body 2 CASP3, TNF
Lysosome 1 CXCR4
plasma membrane 9 AXIN2, CD4, CD8A, CXCR4, ERVW-1, IFNLR1, PRKCQ, SLC22A6, TNF
Membrane 4 CXCR4, CYP1B1, IFNLR1, SLC22A6
basolateral plasma membrane 1 SLC22A6
caveola 1 SLC22A6
extracellular exosome 2 CXCR4, SLC22A6
extracellular space 1 TNF
mitochondrion 6 CDKN2A, CYP1B1, DCK, MAPK14, TFAM, TK2
protein-containing complex 5 CDKN2A, CXCR4, POLB, SLC22A6, TFAM
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 1 CYP1B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 4 CD4, CD8A, ERVW-1, IFNLR1
extracellular region 3 CD8A, MAPK14, TNF
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 3 CDKN2A, TFAM, TK2
anchoring junction 1 CXCR4
centriolar satellite 1 PRKCQ
external side of plasma membrane 4 CD4, CD8A, CXCR4, TNF
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 CXCR4
nucleolus 1 CDKN2A
Early endosome 2 CD4, CXCR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 CD4, TNF
microtubule 1 POLB
mitochondrial nucleoid 1 TFAM
nuclear speck 1 MAPK14
Late endosome 1 CXCR4
receptor complex 1 CD8A
cell leading edge 1 CXCR4
phagocytic cup 1 TNF
Nucleus, nucleolus 1 CDKN2A
spindle pole 1 MAPK14
Basolateral cell membrane 1 SLC22A6
Nucleus, nucleoplasm 1 CDKN2A
basal plasma membrane 1 SLC22A6
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 1 CD4
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 CD4
Basal cell membrane 1 SLC22A6
spindle microtubule 1 POLB
death-inducing signaling complex 1 CASP3
[Transmembrane protein]: Cell membrane 1 ERVW-1
[Surface protein]: Cell membrane 1 ERVW-1
[Isoform 1]: Cell membrane 1 CD8A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
senescence-associated heterochromatin focus 1 CDKN2A
Mitochondrion matrix, mitochondrion nucleoid 1 TFAM
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform smARF]: Mitochondrion 1 CDKN2A
[Syncytin-1]: Virion 1 ERVW-1


文献列表

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