Estrone 3-sulfate (BioDeep_00000001705)

 

Secondary id: BioDeep_00000637488

human metabolite Endogenous blood metabolite


代谢物信息卡片


[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate

化学式: C18H22O5S (350.1187882)
中文名称: 共轭雌激素
谱图信息: 最多检出来源 Homo sapiens(blood) 0.29%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Estrone 3-sulfate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/estrone_3-sulfate (retrieved 2024-11-08) (BioDeep RN: BioDeep_00000001705). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O
InChI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)

描述信息

Estrone sulfate is a sulfated estrone derivative. Estrone sulfate acts as a long-lived reservoir that can be converted as needed to the more active estradiol (from estrone via 17 beta-hydroxysteroid dehydrogenase). Estrone Sulfate (E1S) is the most abundant circulating estrogen in non-pregnant women as well as normal men. Estrone is primarily synthesized from estrone sulfate. Estrone is an estrogenic hormone secreted by the ovaries and adipose tissues. Estrone is one of the three estrogens found in humans. The other two are estriol and estradiol. Estrone is the least prevalent of the three. Estradiol plays a critical role on reproductive and sexual functioning in women and it also affects other organs including the bones. Estriol is an estrogen that is prevalent primarily during pregnancy. [HMDB]
Estrone sulfate is a sulfated estrone derivative. Estrone sulfate acts as a long-lived reservoir that can be converted as needed to the more active estradiol (from estrone via 17 beta-hydroxysteroid dehydrogenase). Estrone Sulfate (E1S) is the most abundant circulating estrogen in non-pregnant women as well as normal men. Estrone is primarily synthesized from estrone sulfate. Estrone is an estrogenic hormone secreted by the ovaries and adipose tissues. Estrone is one of the three estrogens found in humans. The other two are estriol and estradiol. Estrone is the least prevalent of the three. Estradiol plays a critical role on reproductive and sexual functioning in women and it also affects other organs including the bones. Estriol is an estrogen that is prevalent primarily during pregnancy.
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

42 个代谢物同义名

[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate; [(1S,10R,11S,15S)-15-methyl-14-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-trien-5-yl]oxidanesulfonic acid; 3-Hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulphuric acid; 3-Hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulfuric acid; 3-Hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulphate; 3-hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulfate; 17-oxoestra-1,3,5(10)-trien-3-yl hydrogen sulfate; Estrone sulfate, 16-(14)C-labeled; Estrone hydrogen sulphuric acid; Estrone sulfate, potassium salt; Estrone sulfate, ammonium salt; Estrone hydrogen sulfuric acid; Sodium estrone 3-monosulphate; Estrone sulfate, 14C-labeled; Estrone sulfate, sodium salt; Sodium estrone 3-monosulfate; Estrone hydrogen sulphate; Estrone hydrogen sulphate; Estrone hydrogen sulfate; Potassium estrone sulfate; Sodium estrone 3-sulphate; estrone hydrogen sulfate; Sodium estrone 3-sulfate; Estrone sulphate sodium; Sodium estrone sulfate; Estrone sulphuric acid; Estrone sulfate sodium; Estrone sulfuric acid; Estrogenic substances; Estrone-3-sulphate; Estrone 3-sulphate; estrone 3-sulfate; Estrone-3-sulfate; Oestrone sulphate; Estrone sulphate; estrone sulfate; [6,7-3H] E1S; Conestoral; Premarin; Estrone; Ogen; Evex



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

74 个相关的代谢反应过程信息。

Reactome(44)

BioCyc(0)

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(27)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shengwei Zhang, Jing Li, Yanxia Li, Linshu Jiang, Yan Zhao, Xiaoman Jiang, Xuelian Zhang, Wenzhuo Shi. Assimilation behaviors and metabolite formations of estrone sulfate sodium (E1-3S) and 17β-estradiol-3-O-sulfate sodium (E2-3S) in the wheat. Journal of environmental management. 2023 Jul; 345(?):118666. doi: 10.1016/j.jenvman.2023.118666. [PMID: 37506444]
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  • Patrice Dufour, Justine Courtois, Ysaline Seynaeve, Stéphanie Peeters, Caroline Le Goff, Etienne Cavalier, Jérôme Ponthier. Development and validation of a liquid chromatography coupled to mass spectrometer (LC-MS) method for the simultaneous quantification of estrone-3-sulfate, progesterone, estrone and estradiol in serum of mares and American bisons. Research in veterinary science. 2021 May; 136(?):343-350. doi: 10.1016/j.rvsc.2021.03.014. [PMID: 33770524]
  • Julian Peter Müller, Lena Keufgens, Dirk Gründemann. Hyperosmolarity stimulates transporter-mediated insertion of estrone sulfate into the plasma membrane, but inhibits the uptake by SLC10A1 (NTCP). Biochemical pharmacology. 2021 04; 186(?):114484. doi: 10.1016/j.bcp.2021.114484. [PMID: 33617845]
  • Jinghui Zhang, Guofeng You. Peptide Hormone Insulin Regulates Function, Expression, and SUMOylation of Organic Anion Transporter 3. The AAPS journal. 2021 03; 23(2):41. doi: 10.1208/s12248-021-00575-z. [PMID: 33709304]
  • Carina Ankarberg-Lindgren, Mats X Andersson, Jovanna Dahlgren. Determination of estrone sulfate, testosterone, androstenedione, DHEAS, cortisol, cortisone, and 17α-hydroxyprogesterone by LC-MS/MS in children and adolescents. Scandinavian journal of clinical and laboratory investigation. 2020 Dec; 80(8):672-680. doi: 10.1080/00365513.2020.1829699. [PMID: 33258387]
  • Yusuke Masuo, Ken-Ichi Fujita, Kenji Mishiro, Natsumi Seba, Tatsuya Kogi, Hidenori Okumura, Natsumi Matsumoto, Munetaka Kunishima, Yukio Kato. 6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients. Drug metabolism and pharmacokinetics. 2020 Dec; 35(6):555-562. doi: 10.1016/j.dmpk.2020.09.001. [PMID: 33191090]
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  • Wataru Iwasaki, Chiwa Kataoka, Kazuyuki Sawadaishi, Keitaro Suyama, Nobutomo Morita, Masaya Miyazaki. A Simple, Low Cost, Sensitive, and Portable Electrochemical Immunochromatography Sensing Device to Measure Estrone-3-Sulfate. Sensors (Basel, Switzerland). 2020 Aug; 20(17):. doi: 10.3390/s20174781. [PMID: 32847124]
  • X Liu, T Schwarz, M Murawski, C Tayade, R Kridli, A M Prieto Granados, C Sharma, P M Bartlewski. Measurements of circulating progesterone and estrone sulfate concentrations as a diagnostic and prognostic tool in porcine pregnancy revisited. Domestic animal endocrinology. 2020 04; 71(?):106402. doi: 10.1016/j.domaniend.2019.106402. [PMID: 31972516]
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  • K Satué, M Marcilla, P Medica, A Ferlazzo, E Fazio. Sequential concentrations of placental growth factor and haptoglobin, and their relation to oestrone sulphate and progesterone in pregnant Spanish Purebred mare. Theriogenology. 2018 Jul; 115(?):77-83. doi: 10.1016/j.theriogenology.2018.04.033. [PMID: 29730538]
  • Henriette E Meyer Zu Schwabedissen, Celio Ferreira, Anima M Schaefer, Mouhssin Oufir, Isabell Seibert, Matthias Hamburger, Rommel G Tirona. Thyroid Hormones Are Transport Substrates and Transcriptional Regulators of Organic Anion Transporting Polypeptide 2B1. Molecular pharmacology. 2018 07; 94(1):700-712. doi: 10.1124/mol.117.111161. [PMID: 29735582]
  • Rie Iijima, Tomoki Watanabe, Kan'ichiro Ishiuchi, Takashi Matsumoto, Junko Watanabe, Toshiaki Makino. Interactions between crude drug extracts used in Japanese traditional Kampo medicines and organic anion-transporting polypeptide 2B1. Journal of ethnopharmacology. 2018 Mar; 214(?):153-159. doi: 10.1016/j.jep.2017.12.016. [PMID: 29248449]
  • S Caceres, B Monsalve, L Peña, P J de Andres, A Alonso-Diez, M J Illera, W A Woodward, J M Reuben, G Silvan, J C Illera. In vitro and in vivo effect of flutamide on steroid hormone secretion in canine and human inflammatory breast cancer cell lines. Veterinary and comparative oncology. 2018 Mar; 16(1):148-158. doi: 10.1111/vco.12324. [PMID: 28589573]
  • Jinghui Zhang, Chenchang Liu, Guofeng You. AG490, a JAK2-specific inhibitor, downregulates the expression and activity of organic anion transporter-3. Journal of pharmacological sciences. 2018 Mar; 136(3):142-148. doi: 10.1016/j.jphs.2018.01.006. [PMID: 29487013]
  • Yuyong Ke, Alain Bélanger, Jean-Nicolas Simard, Renaud Gonthier, Céline Martel, Mario Vaillancourt, Fernand Labrie. Concentration range of serum sex steroids in normal postmenopausal women and those with diagnosis of vulvovaginal atrophy. Menopause (New York, N.Y.). 2018 03; 25(3):293-300. doi: 10.1097/gme.0000000000000993. [PMID: 29206779]
  • Haoxun Wang, Chenchang Liu, Guofeng You. The activity of organic anion transporter-3: Role of dexamethasone. Journal of pharmacological sciences. 2018 Feb; 136(2):79-85. doi: 10.1016/j.jphs.2017.12.011. [PMID: 29422382]
  • Emre Karakus, Daniel Zahner, Gary Grosser, Regina Leidolf, Cemal Gundogdu, Alberto Sánchez-Guijo, Stefan A Wudy, Joachim Geyer. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Frontiers in pharmacology. 2018; 9(?):941. doi: 10.3389/fphar.2018.00941. [PMID: 30186172]
  • Yugo Hamada, Kenji Ikemura, Takuya Iwamoto, Masahiro Okuda. Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers. Pharmacology. 2018; 101(3-4):176-183. doi: 10.1159/000485920. [PMID: 29353278]
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  • Birgitta C Burckhardt, Maja Henjakovic, Yohannes Hagos, Gerhard Burckhardt. Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3. The Journal of pharmacology and experimental therapeutics. 2017 09; 362(3):450-458. doi: 10.1124/jpet.117.241406. [PMID: 28630284]
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