estrone sulfate (BioDeep_00000637488)
Main id: BioDeep_00000001705
代谢物信息卡片
3-hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulfate
化学式: C18H22O5S (350.11878820000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(=O)[C@@]2(C)CC[C@]3([H])C4C=CC(OS(O)(=O)=O)=CC=4CC[C@@]3([H])[C@@]21[H]
InChI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,18+/m1/s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:17474
- KEGG: C02538
- PubChem: 3001028
- DrugBank: DB04574
- ChEMBL: CHEMBL494753
- LipidMAPS: LMST02010043
- CAS: 481-97-0
- PubChem: 5545
- 3DMET: B04855
- NIKKAJI: J5.782G
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shengwei Zhang, Jing Li, Yanxia Li, Linshu Jiang, Yan Zhao, Xiaoman Jiang, Xuelian Zhang, Wenzhuo Shi. Assimilation behaviors and metabolite formations of estrone sulfate sodium (E1-3S) and 17β-estradiol-3-O-sulfate sodium (E2-3S) in the wheat.
Journal of environmental management.
2023 Jul; 345(?):118666. doi:
10.1016/j.jenvman.2023.118666. [PMID: 37506444] - Jieru Chen, Yuanping Xue, Xiaoyu Shuai, Chunxu Ni, Zihui Fang, Ling Ye, Mei Hong. Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1.
Toxicology and applied pharmacology.
2022 01; 435(?):115848. doi:
10.1016/j.taap.2021.115848. [PMID: 34958783] - Patrice Dufour, Justine Courtois, Ysaline Seynaeve, Stéphanie Peeters, Caroline Le Goff, Etienne Cavalier, Jérôme Ponthier. Development and validation of a liquid chromatography coupled to mass spectrometer (LC-MS) method for the simultaneous quantification of estrone-3-sulfate, progesterone, estrone and estradiol in serum of mares and American bisons.
Research in veterinary science.
2021 May; 136(?):343-350. doi:
10.1016/j.rvsc.2021.03.014. [PMID: 33770524] - Julian Peter Müller, Lena Keufgens, Dirk Gründemann. Hyperosmolarity stimulates transporter-mediated insertion of estrone sulfate into the plasma membrane, but inhibits the uptake by SLC10A1 (NTCP).
Biochemical pharmacology.
2021 04; 186(?):114484. doi:
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The AAPS journal.
2021 03; 23(2):41. doi:
10.1208/s12248-021-00575-z. [PMID: 33709304] - Carina Ankarberg-Lindgren, Mats X Andersson, Jovanna Dahlgren. Determination of estrone sulfate, testosterone, androstenedione, DHEAS, cortisol, cortisone, and 17α-hydroxyprogesterone by LC-MS/MS in children and adolescents.
Scandinavian journal of clinical and laboratory investigation.
2020 Dec; 80(8):672-680. doi:
10.1080/00365513.2020.1829699. [PMID: 33258387] - Yusuke Masuo, Ken-Ichi Fujita, Kenji Mishiro, Natsumi Seba, Tatsuya Kogi, Hidenori Okumura, Natsumi Matsumoto, Munetaka Kunishima, Yukio Kato. 6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients.
Drug metabolism and pharmacokinetics.
2020 Dec; 35(6):555-562. doi:
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Molecular pharmaceutics.
2020 10; 17(10):3748-3758. doi:
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Liver international : official journal of the International Association for the Study of the Liver.
2019 12; 39(12):2350-2359. doi:
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Animal science journal = Nihon chikusan Gakkaiho.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
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Animal reproduction science.
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Chemico-biological interactions.
2019 May; 305(?):12-20. doi:
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The journal of physiological sciences : JPS.
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Molecular pharmaceutics.
2018 12; 15(12):5501-5513. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Jul; 120(?):181-190. doi:
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Molecular pharmacology.
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Menopause (New York, N.Y.).
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Frontiers in pharmacology.
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Steroids.
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Pharmaceutical biology.
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Journal of pharmaceutical sciences.
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Reproduction in domestic animals = Zuchthygiene.
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Nephron.
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Die Pharmazie.
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PloS one.
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Theriogenology.
2014 Oct; 82(7):972-81. doi:
10.1016/j.theriogenology.2014.07.015. [PMID: 25139753] - N J Dias, K W Selcer. Steroid sulfatase mediated growth Sof human MG-63 pre-osteoblastic cells.
Steroids.
2014 Oct; 88(?):77-82. doi:
10.1016/j.steroids.2014.07.001. [PMID: 25042472] - Shelley S Tworoger, Xuehong Zhang, A Heather Eliassen, Jing Qian, Graham A Colditz, Walter C Willett, Bernard A Rosner, Peter Kraft, Susan E Hankinson. Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2014 Oct; 32(28):3111-7. doi:
10.1200/jco.2014.56.1068. [PMID: 25135988] - Hartmut Glaeser, Krystyna Bujok, Ingrid Schmidt, Martin F Fromm, Kathrin Mandery. Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin.
Naunyn-Schmiedeberg's archives of pharmacology.
2014 Sep; 387(9):883-91. doi:
10.1007/s00210-014-1000-6. [PMID: 24947867] - Per Eystein Lønning, Benjamin P Haynes, Mitch Dowsett. Relationship of body mass index with aromatisation and plasma and tissue oestrogen levels in postmenopausal breast cancer patients treated with aromatase inhibitors.
European journal of cancer (Oxford, England : 1990).
2014 Apr; 50(6):1055-64. doi:
10.1016/j.ejca.2014.01.007. [PMID: 24507547] - V Sini, G Lunardi, M Cirillo, M Turazza, C Bighin, S Giraudi, A Levaggi, P Piccioli, G Bisagni, R Gnoni, G Stridi, M Porpiglia, E Picardo, R Ponzone, D Marenco, M Mansutti, F Puglisi, L Del Mastro. Body mass index and circulating oestrone sulphate in women treated with adjuvant letrozole.
British journal of cancer.
2014 Mar; 110(5):1133-8. doi:
10.1038/bjc.2014.2. [PMID: 24448359] - Arjinajarn Phatchawan, Srimaroeng Chutima, Chatsudthipong Varanuj, Lungkaphin Anusorn. Decreased renal organic anion transporter 3 expression in type 1 diabetic rats.
The American journal of the medical sciences.
2014 Mar; 347(3):221-7. doi:
10.1097/maj.0b013e3182831740. [PMID: 23470271] - Zhen Li, Florence Shin Gee Cheung, Jian Zheng, Ting Chan, Ling Zhu, Fanfan Zhou. Interaction of the bioactive flavonol, icariin, with the essential human solute carrier transporters.
Journal of biochemical and molecular toxicology.
2014 Feb; 28(2):91-7. doi:
10.1002/jbt.21540. [PMID: 24265111] - Angelica Crisci, Alessandra Rota, Duccio Panzani, Micaela Sgorbini, Jennifer C Ousey, Francesco Camillo. Clinical, ultrasonographic, and endocrinological studies on donkey pregnancy.
Theriogenology.
2014 Jan; 81(2):275-83. doi:
10.1016/j.theriogenology.2013.09.026. [PMID: 24157228] - Naoki Isobe, Chihiro Iwamoto, Hirokazu Kubota, Yukinori Yoshimura. Relationship between the somatic cell count in milk and reproductive function in peripartum dairy cows.
The Journal of reproduction and development.
2014; 60(6):433-7. doi:
10.1262/jrd.2014-065. [PMID: 25196356] - B Williamson, A C Soars, A Owen, P White, R J Riley, M G Soars. Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA.
Xenobiotica; the fate of foreign compounds in biological systems.
2013 Oct; 43(10):920-31. doi:
10.3109/00498254.2013.776194. [PMID: 23461378] - Yoshihisa Shitara, Kumiko Takeuchi, Toshiharu Horie. Long-lasting inhibitory effects of saquinavir and ritonavir on OATP1B1-mediated uptake.
Journal of pharmaceutical sciences.
2013 Sep; 102(9):3427-35. doi:
10.1002/jps.23477. [PMID: 23440887] - L Torres-Santiago, V Mericq, M Taboada, N Unanue, K O Klein, R Singh, J Hossain, R J Santen, J L Ross, N Mauras. Metabolic effects of oral versus transdermal 17β-estradiol (E₂): a randomized clinical trial in girls with Turner syndrome.
The Journal of clinical endocrinology and metabolism.
2013 Jul; 98(7):2716-24. doi:
10.1210/jc.2012-4243. [PMID: 23678038] - Avijit Haldar, Saumen K Pal, Sandip Chakraborty, Mausumi Hazorika, Subhransu Pan, Debasis Majumdar, Chanchal K Biswas, Aditi Patra, Rouhollah Mirmahmoudi, Bukkaaraya S Prakash. Endocrine markers for identifying prolificacy potential and predicting fetal number in goats.
Animal reproduction science.
2013 Jul; 140(1-2):54-61. doi:
10.1016/j.anireprosci.2013.05.005. [PMID: 23787106] - Aijie Zhang, Changyuan Wang, Qi Liu, Qiang Meng, Jinyong Peng, Huijun Sun, Xiaochi Ma, Xiaokui Huo, Kexin Liu. Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.
Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):994-1003. doi:
10.1124/dmd.112.049452. [PMID: 23396419] - Ling Li, Amr Nouraldeen, Alan G E Wilson. Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect.
Xenobiotica; the fate of foreign compounds in biological systems.
2013 Mar; 43(3):253-62. doi:
10.3109/00498254.2012.713146. [PMID: 22928802] - Xiaoxiao Liu, Jiujiu Huang, Yongxue Sun, Kai Zhan, Zheren Zhang, Mei Hong. Identification of multiple binding sites for substrate transport in bovine organic anion transporting polypeptide 1a2.
Drug metabolism and disposition: the biological fate of chemicals.
2013 Mar; 41(3):602-7. doi:
10.1124/dmd.112.047910. [PMID: 23255551] - Yohannes Hagos, Gerhard Burckhardt, Birgitta C Burckhardt. Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives.
American journal of physiology. Renal physiology.
2013 Feb; 304(4):F403-9. doi:
10.1152/ajprenal.00412.2012. [PMID: 23255614] - G Lunardi, P Piccioli, P Bruzzi, R Notaro, S Lastraioli, M Serra, P Marroni, C Bighin, M Mansutti, F Puglisi, M Porpiglia, R Ponzone, G Bisagni, O Garrone, G Cavazzini, M Clavarezza, L Del Mastro. Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole.
Breast cancer research and treatment.
2013 Jan; 137(1):167-74. doi:
10.1007/s10549-012-2306-z. [PMID: 23129173] - Chutima Srimaroeng, Jennifer Perry Cecile, Ramsey Walden, John B Pritchard. Regulation of renal organic anion transporter 3 (SLC22A8) expression and function by the integrity of lipid raft domains and their associated cytoskeleton.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2013; 31(4-5):565-78. doi:
10.1159/000350077. [PMID: 23615001] - Kristine R Monroe, Frank Z Stanczyk, Kathleen H Besinque, Malcolm C Pike. The effect of grapefruit intake on endogenous serum estrogen levels in postmenopausal women.
Nutrition and cancer.
2013; 65(5):644-52. doi:
10.1080/01635581.2013.795982. [PMID: 23859031] - Atcharaporn Ontawong, Naruwan Saowakon, Pornpun Vivithanaporn, Anchalee Pongchaidecha, Narissara Lailerd, Doungporn Amornlerdpison, Anusorn Lungkaphin, Chutima Srimaroeng. Antioxidant and renoprotective effects of Spirogyra neglecta (Hassall) Kützing extract in experimental type 2 diabetic rats.
BioMed research international.
2013; 2013(?):820786. doi:
10.1155/2013/820786. [PMID: 23862157] - Catherine L Carpenter, Karen Duvall, Patricia Jardack, Luyi Li, Susanne M Henning, Zhaoping Li, David Heber. Weight loss reduces breast ductal fluid estrogens in obese postmenopausal women: a single arm intervention pilot study.
Nutrition journal.
2012 Dec; 11(?):102. doi:
10.1186/1475-2891-11-102. [PMID: 23217221] - Hartmut Blode, Susan Zeun, Susanne Parke, Torsten Zimmermann, Beate Rohde, Uwe Mellinger, Michael Kunz. Evaluation of the effects of rifampicin, ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing estradiol valerate and dienogest in healthy postmenopausal women.
Contraception.
2012 Oct; 86(4):337-44. doi:
10.1016/j.contraception.2012.01.010. [PMID: 22445438] - Anne Mette Lund Würtz, Anne Tjønneland, Jane Christensen, Lars Ove Dragsted, Julie Aarestrup, Cecilie Kyrø, Kim Overvad, Anja Olsen. Serum estrogen and SHBG levels and breast cancer incidence among users and never users of hormone replacement therapy.
Cancer causes & control : CCC.
2012 Oct; 23(10):1711-20. doi:
10.1007/s10552-012-0050-7. [PMID: 22926300] - Yohannes Hagos, Gunnar Schley, Johannes Schödel, Wolfgang Krick, Gerhard Burckhardt, Carsten Willam, Birgitta C Burckhardt. α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).
Pflugers Archiv : European journal of physiology.
2012 Oct; 464(4):367-74. doi:
10.1007/s00424-012-1140-9. [PMID: 22875277] - Anett Engel, Stefan Oswald, Werner Siegmund, Markus Keiser. Pharmaceutical excipients influence the function of human uptake transporting proteins.
Molecular pharmaceutics.
2012 Sep; 9(9):2577-81. doi:
10.1021/mp3001815. [PMID: 22808947] - J Volkery, J Gottschalk, A Sobiraj, T Wittek, A Einspanier. Progesterone, pregnanediol-3-glucuronide, relaxin and oestrone sulphate concentrations in saliva, milk and urine of female alpacas (Vicugna pacos) and their application in pregnancy diagnosis.
The Veterinary record.
2012 Aug; 171(8):195. doi:
10.1136/vr.100393. [PMID: 22859412] - Elizabeth J Folkerd, J Michael Dixon, Lorna Renshaw, Roger P A'Hern, Mitch Dowsett. Suppression of plasma estrogen levels by letrozole and anastrozole is related to body mass index in patients with breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2012 Aug; 30(24):2977-80. doi:
10.1200/jco.2012.42.0273. [PMID: 22802308] - Anita C A Dankers, Fred C G J Sweep, Jeanne C L M Pertijs, Vivienne Verweij, Jeroen J M W van den Heuvel, Jan B Koenderink, Frans G M Russel, Rosalinde Masereeuw. Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones.
Cell and tissue research.
2012 Aug; 349(2):551-63. doi:
10.1007/s00441-012-1417-5. [PMID: 22581381] - Lei Qin, Shui-Pang Tam, Roger G Deeley. Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jul; 40(7):1403-13. doi:
10.1124/dmd.112.044867. [PMID: 22511347] - M M Al-Bataineh, D Van Der Merwe, B D Schultz, R Gehring. Molecular and functional identification of organic anion transporter isoforms in cultured bovine mammary epithelial cells (BME-UV).
Journal of veterinary pharmacology and therapeutics.
2012 Jun; 35(3):209-15. doi:
10.1111/j.1365-2885.2011.01309.x. [PMID: 21623837] - Heidi Kidron, Gloria Wissel, Nenad Manevski, Marika Häkli, Raimo A Ketola, Moshe Finel, Marjo Yliperttula, Henri Xhaard, Arto Urtti. Impact of probe compound in MRP2 vesicular transport assays.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 May; 46(1-2):100-5. doi:
10.1016/j.ejps.2012.02.016. [PMID: 22406294] - L Del Pup, D Postruznik, G Corona. Effect of one-month treatment with vaginal promestriene on serum estrone sulfate levels in cancer patients: a pilot study.
Maturitas.
2012 May; 72(1):93-4. doi:
10.1016/j.maturitas.2012.01.017. [PMID: 22349253] - Amy M Goss, Betty E Darnell, Marian A Brown, Robert A Oster, Barbara A Gower. Longitudinal associations of the endocrine environment on fat partitioning in postmenopausal women.
Obesity (Silver Spring, Md.).
2012 May; 20(5):939-44. doi:
10.1038/oby.2011.362. [PMID: 22173571] - Lan-Xiang Wu, Cheng-Xian Guo, Wang-Qing Chen, Jing Yu, Qiang Qu, Yao Chen, Zhi-Rong Tan, Guo Wang, Lan Fan, Qing Li, Wei Zhang, Hong-Hao Zhou. Inhibition of the organic anion-transporting polypeptide 1B1 by quercetin: an in vitro and in vivo assessment.
British journal of clinical pharmacology.
2012 May; 73(5):750-7. doi:
10.1111/j.1365-2125.2011.04150.x. [PMID: 22114872] - Lan-Xiang Wu, Cheng-Xian Guo, Qiang Qu, Jing Yu, Wang-Qing Chen, Guo Wang, Lan Fan, Qing Li, Wei Zhang, Hong-Hao Zhou. Effects of natural products on the function of human organic anion transporting polypeptide 1B1.
Xenobiotica; the fate of foreign compounds in biological systems.
2012 Apr; 42(4):339-48. doi:
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