Mycophenolic acid (BioDeep_00000001551)

 

Secondary id: BioDeep_00000397767

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid

化学式: C17H20O6 (320.126)
中文名称: 霉酚酸
谱图信息: 最多检出来源 Homo sapiens(plant) 25.97%

分子结构信息

SMILES: C/C(=C\Cc1c(c2c(COC2=O)c(C)c1OC)O)/CCC(=O)O
InChI: InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

描述信息

Mycophenolic acid is an an immunosuppresant drug and potent anti-proliferative, and can be used in place of the older anti-proliferative azathioprine. It is usually used as part of triple therapy including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. It is also useful in research for the selection of animal cells that express the E. coli gene coding for XGPRT (xanthine guanine phosphoribosyltransferase).
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants > L04AA - Selective immunosuppressants
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
C471 - Enzyme Inhibitor > C2087 - Inosine Monophosphate Dehydrogenase Inhibitor
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant
CONFIDENCE standard compound; INTERNAL_ID 8577
CONFIDENCE standard compound; INTERNAL_ID 2698
CONFIDENCE standard compound; INTERNAL_ID 4128
COVID info from COVID-19 Disease Map
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects[1][2].

同义名列表

23 个代谢物同义名

(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid; 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methyl-4-hexenoic acid; (e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid; (e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate; Mycophenolic acid morpholinoethyl ester; Mofetil hydrochloride, mycophenolate; Mycophenolate mofetil hydrochloride; Mofetil, mycophenolate; Acidum mycophenolicum; Mycophenolate Mofetil; Mycophenolate, sodium; Acide mycophenolique; Sodium mycophenolate; mycophenolate sodium; Micofenolico acido; Acid, mycophenolic; Acido micofenolico; Mycophenolic acid; Mycophenoic acid; Mycophenolsaeure; Mycophenolate; Myfortic; Cellcept



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

6 个相关的代谢反应过程信息。

Reactome(4)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(1)

PharmGKB(0)

30 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ALB, CYP3A4, EMP2
Endoplasmic reticulum membrane 4 CYP3A4, CYP3A5, UGT1A1, UGT1A7
Nucleus 2 ALB, EMP2
cytosol 2 ALB, GPT
centrosome 1 ALB
Cell membrane 5 CD40LG, CD8A, EMP2, PDCD1, TNF
Multi-pass membrane protein 3 ABCC2, ATP4A, EMP2
Golgi apparatus membrane 1 EMP2
cell surface 4 ABCC2, CD40LG, EMP2, TNF
Golgi apparatus 3 ALB, CD40LG, EMP2
Golgi membrane 2 EMP2, INS
neuronal cell body 1 TNF
plasma membrane 10 ABCC2, ATP4A, CD40LG, CD8A, EMP2, IFNLR1, IL2RA, PDCD1, TNF, UGT1A1
Membrane 11 ABCC2, ATP4A, CD40LG, CYP3A4, CYP3A5, EMP2, IFNLR1, IL2RA, PDCD1, UGT1A1, UGT1A7
apical plasma membrane 3 ABCC2, ATP4A, EMP2
extracellular exosome 2 ALB, GPT
endoplasmic reticulum 3 ALB, UGT1A1, UGT1A7
extracellular space 9 ALB, ATP4A, CD40LG, IL10, IL2, IL4, IL6, INS, TNF
perinuclear region of cytoplasm 2 EMP2, UGT1A1
intercellular canaliculus 1 ABCC2
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 2 CYP3A4, CYP3A5
Microsome membrane 2 CYP3A4, CYP3A5
Single-pass type I membrane protein 3 CD8A, IFNLR1, IL2RA
Secreted 7 ALB, CD40LG, IL10, IL2, IL4, IL6, INS
extracellular region 8 ALB, CD8A, IL10, IL2, IL4, IL6, INS, TNF
Single-pass membrane protein 2 UGT1A1, UGT1A7
[Isoform 2]: Secreted 1 CD8A
anchoring junction 1 ALB
external side of plasma membrane 5 CD40LG, CD8A, IL2RA, PDCD1, TNF
cytoplasmic vesicle 1 EMP2
apical part of cell 1 EMP2
recycling endosome 1 TNF
Single-pass type II membrane protein 2 CD40LG, TNF
Apical cell membrane 3 ABCC2, ATP4A, EMP2
Cytoplasm, perinuclear region 2 EMP2, UGT1A1
Membrane raft 2 EMP2, TNF
receptor complex 1 CD8A
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
plasma membrane raft 1 CD8A
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, IL6, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 1]: Cell membrane 1 CD8A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-2 receptor complex 1 IL2RA
T cell receptor complex 1 CD8A
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 UGT1A1
potassium:proton exchanging ATPase complex 1 ATP4A
cytochrome complex 1 UGT1A1
[CD40 ligand, soluble form]: Secreted 1 CD40LG
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Mei Liu, Yangjuan Bai, Yunan He, Yanqu Zhou, Zhonglin Liu, Hong Chen, Xiuxiu Liu, Chunmei Fu. High-throughput detection of mycophenolic acid in human plasma based on sensitive and rapid fluorescence nitrogen-doped carbon dots sensing platform. Journal of pharmaceutical and biomedical analysis. 2023 Sep; 234(?):115545. doi: 10.1016/j.jpba.2023.115545. [PMID: 37364453]
  • Neri Azar, Orna Liarzi, Maor Zavitan, Mohamed Samara, Ahmed Nasser, David Ezra. Endophytic Penicillium species secretes mycophenolic acid that inhibits the growth of phytopathogenic fungi. Microbial biotechnology. 2023 08; 16(8):1629-1638. doi: 10.1111/1751-7915.14203. [PMID: 36700385]
  • Sifei Han, Tim Quach, Luojuan Hu, Shea Fern Lim, Dan Zheng, Nathania J Leong, Garima Sharma, Daniel Bonner, Jamie S Simpson, Natalie L Trevaskis, Christopher J H Porter. Increasing Linker Chain Length and Intestinal Stability Enhances Lymphatic Transport and Lymph Node Exposure of Triglyceride Mimetic Prodrugs of a Model Immunomodulator Mycophenolic Acid. Molecular pharmaceutics. 2023 05; 20(5):2675-2685. doi: 10.1021/acs.molpharmaceut.3c00099. [PMID: 36996486]
  • El-Sayed R El-Sayed, Amira G Zaki. Unlocking the biosynthetic potential of Penicillium roqueforti for hyperproduction of the immunosuppressant mycophenolic acid: Gamma radiation mutagenesis and response surface optimization of fermentation medium. Biotechnology and applied biochemistry. 2023 Feb; 70(1):306-317. doi: 10.1002/bab.2353. [PMID: 35481612]
  • Yongqiang Dong, Jinmin Shi, Shanshan Wang, Yanhong Liu, Shirong Yu, Lijun Zhao. The efficacy of immunosuppressive drugs induction therapy for lupus nephritis: a systematic review and network meta-analysis. Renal failure. 2023; 45(2):2290365. doi: 10.1080/0886022x.2023.2290365. [PMID: 38087473]
  • Z A Chalyy, M G Kiseleva, I B Sedova, V A Tutelyan. [Mycotoxins in spices consumed in Russia]. Voprosy pitaniia. 2023; 92(2):26-34. doi: 10.33029/0042-8833-2023-92-2-26-34. [PMID: 37346017]
  • Qian Li, Xinxin Kong, Minle Tian, Jing Wang, Zhenle Yang, Lichun Yu, Suwen Liu, Cong Wang, Xiaoyuan Wang, Shuzhen Sun. Clinical features of children with anti-CFH autoantibody-associated hemolytic uremic syndrome: a report of 8 cases. Renal failure. 2022 Dec; 44(1):1061-1069. doi: 10.1080/0886022x.2022.2089167. [PMID: 35730179]
  • Ying Jiang, Yongjing Cheng, Shiliang Ma, Tong Li, Zhe Chen, Xiaoxia Zuo, Xuan Zhang. Systemic lupus erythematosus-complicating immune thrombocytopenia: From pathogenesis to treatment. Journal of autoimmunity. 2022 10; 132(?):102887. doi: 10.1016/j.jaut.2022.102887. [PMID: 36030136]
  • Jieren Luo, Jiesen Yu, Zichao Sui, Ying Zhong, Qingshan Zheng, Lujin Li. Comparison on the effect of seven drugs to prevent relapses of neuromyelitis optica spectrum disorders: A modeling analysis of literature aggregate data. International immunopharmacology. 2022 Sep; 110(?):109004. doi: 10.1016/j.intimp.2022.109004. [PMID: 35785726]
  • Lin Cheng, Pu Yao, Bangbi Weng, Ming Yang, Qian Wang. Meta-analysis of the associations of IMPDH and UGT1A9 polymorphisms with rejection in kidney transplant recipients taking mycophenolic acid. European journal of clinical pharmacology. 2022 Aug; 78(8):1227-1238. doi: 10.1007/s00228-022-03311-4. [PMID: 35524809]
  • Kai Wang, Yangbing Li, Bing Chen, Hao Chen, David E Smith, Duxin Sun, Meihua R Feng, Gordon L Amidon. In Vitro Predictive Dissolution Test Should Be Developed and Recommended as a Bioequivalence Standard for the Immediate-Release Solid Oral Dosage Forms of the Highly Variable Mycophenolate Mofetil. Molecular pharmaceutics. 2022 07; 19(7):2048-2060. doi: 10.1021/acs.molpharmaceut.1c00792. [PMID: 35603895]
  • Pierluigi Toniutto, Edmondo Falleti, Sara Cmet, Annarosa Cussigh, Laura Veneto, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Carlo Fabris, Assunta Sartor, Roberto Peressutti, Francesco Curcio, Laura Regattin, Lucrezia Grillone. Past COVID-19 and immunosuppressive regimens affect the long-term response to anti-SARS-CoV-2 vaccination in liver transplant recipients. Journal of hepatology. 2022 Jul; 77(1):152-162. doi: 10.1016/j.jhep.2022.02.015. [PMID: 35283215]
  • Howard J Huang, Kenneth Schechtman, Medhat Askar, Cory Bernadt, Brigitte Mittler, Peter Dore, Chad Witt, Derek Byers, Rodrigo Vazquez-Guillamet, Laura Halverson, Ruben Nava, Varun Puri, Andrew Gelman, Daniel Kreisel, Ramsey R Hachem. A pilot randomized controlled trial of de novo belatacept-based immunosuppression following anti-thymocyte globulin induction in lung transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2022 07; 22(7):1884-1892. doi: 10.1111/ajt.17028. [PMID: 35286760]
  • Stephanie Witek, Gregory Malat, Deirdre Sawinski, Chelsea Sammons, Christopher LaFratte, Abigail Forte, Rahul Samudralwar, Sandra Lyle, Jamal Rashid, Jennifer Trofe-Clark. Tolerability of mycophenolate mofetil in elderly kidney transplant recipients: A retrospective cohort study. Clinical transplantation. 2022 07; 36(7):e14671. doi: 10.1111/ctr.14671. [PMID: 35416337]
  • Dengyan Wu, Rui Ma, Xingmin Wang, Yonghong Yang. Efficacy and Safety of Tacrolimus in the Treatment of Pediatric Henoch-Schönlein Purpura Nephritis. Paediatric drugs. 2022 Jul; 24(4):389-401. doi: 10.1007/s40272-022-00506-1. [PMID: 35508891]
  • Pajaree Chariyavilaskul, Weeraya Phaisal, Wonngarm Kittanamongkolchai, Chutima Rukrung, Sirirat Anutrakulchai, Yingyos Avihingsanon. Pharmacokinetics and pharmacodynamics profiles of enteric-coated mycophenolate sodium in female patients with difficult-to-treat lupus nephritis. Clinical and translational science. 2022 Jul; 15(7):1776-1786. doi: 10.1111/cts.13295. [PMID: 35570339]
  • Yan Liu, Huanxi Zhang, Jun Li, Longshan Liu, Chenglin Wu, Qian Fu, Min Huang, Xiao Chen, Changxi Wang, Pan Chen. Pharmacokinetics of free and total mycophenolic acid in paediatric and adult renal transplant recipients: Exploratory analysis of the effects of clinical factors and gene variants. Basic & clinical pharmacology & toxicology. 2022 Jul; 131(1):60-73. doi: 10.1111/bcpt.13743. [PMID: 35567285]
  • Stella Kilduff, Jonathan Butler, Hiroshi Sogawa, Sonia Solomon. Practice patterns and outcomes for pediatric ANCA vasculitis transplant recipients in a national cohort. Pediatric nephrology (Berlin, Germany). 2022 Jul; 37(7):1667-1673. doi: 10.1007/s00467-021-05341-z. [PMID: 34796388]
  • Gebre-Mariam Tsegay Hailu, Shemsu Umer Hussen, Seifemichael Getachew, Alemseged Beyene Berha. Management practice and treatment outcomes of adult patients with Lupus Nephritis at the Renal Clinic of St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. BMC nephrology. 2022 06; 23(1):214. doi: 10.1186/s12882-022-02846-z. [PMID: 35715762]
  • Jay Erdman, Josephine Wolfram, David Nimke, Richard Croy, Xuegong Wang, Tim Weaver, David Schladt, William E Fitzsimmons. Lung Transplant Outcomes in Adults in the United States: Retrospective Cohort Study Using Real-world Evidence from the SRTR. Transplantation. 2022 06; 106(6):1233-1242. doi: 10.1097/tp.0000000000004011. [PMID: 34974456]
  • Quentin Beaulieu, Daolun Zhang, Isabelle Melki, Véronique Baudouin, Lauriane Goldwirst, Jean-Baptiste Woillard, Evelyne Jacqz-Aigrain. Pharmacokinetics of mycophenolic acid and external evaluation of two limited sampling strategies of drug exposure in patients with juvenile systematic lupus erythematosus. European journal of clinical pharmacology. 2022 Jun; 78(6):1003-1010. doi: 10.1007/s00228-022-03295-1. [PMID: 35294622]
  • Yuji Hidaka, Norihiko Goto, Shigeyoshi Yamanaga, Kohei Kinoshita, Kosuke Tanaka, Chiaki Kawabata, Mariko Toyoda, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Makoto Tsujita, Takahisa Hiramitsu, Hiroshi Yokomizo, Akira Miyata, Shunji Narumi, Takaaki Kobayashi, Yoshihiko Watarai. Two-year outcomes of low-exposure extended-release tacrolimus and mycophenolate mofetil regimen in de novo kidney transplantation: A multi-center randomized controlled trial. Clinical transplantation. 2022 06; 36(6):e14655. doi: 10.1111/ctr.14655. [PMID: 35343620]
  • Paolo De Simone, Jessica Bronzoni, Caterina Martinelli. Everolimus versus mycophenolate mofetil in liver transplantation: every improvement in renal function matters. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 2022 06; 114(6):312-313. doi: 10.17235/reed.2022.8902/2022. [PMID: 35545915]
  • Aleixandra Mendoza Rojas, Dennis A Hesselink, Nicole M van Besouw, Marjolein Dieterich, Ronella de Kuiper, Carla C Baan, Teun van Gelder. High Tacrolimus Intrapatient Variability and Subtherapeutic Immunosuppression are Associated With Adverse Kidney Transplant Outcomes. Therapeutic drug monitoring. 2022 06; 44(3):369-376. doi: 10.1097/ftd.0000000000000955. [PMID: 35394988]
  • Mianhui Chen, Yaling Shen, Lin Lin, Wei Wei, Dongzhi Wei. Mn2+ modulates the production of mycophenolic acid in Penicillium brevicompactum NRRL864 via reactive oxygen species signaling and the investigation of pb-pho. Fungal biology. 2022 Jun; 126(6-7):461-470. doi: 10.1016/j.funbio.2022.04.006. [PMID: 35667833]
  • Miguel Gómez-Bravo, Martín Prieto Castillo, Miquel Navasa, Gloria Sánchez-Antolín, Laura Lladó, Alejandra Otero, Trinidad Serrano, Carlos Jiménez Romero, Miguel García González, Andrés Valdivieso, María Luisa González-Diéguez, Manuel de la Mata, José A Pons, Magdalena Salcedo, Juan M Rodrigo, Valentín Cuervas-Mons, Antonio González Rodríguez, Mireia Caralt, Fernando Pardo, Evaristo Varo Pérez, Gonzalo Crespo, Ángel Rubin, Magda Guilera, Anna Aldea, Julio Santoyo. Effects of everolimus plus minimized tacrolimus on kidney function in liver transplantation: REDUCE, a prospective, randomized controlled study. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva. 2022 06; 114(6):335-342. doi: 10.17235/reed.2022.8549/2021. [PMID: 35469409]
  • Durga Prasanna Misra, Vikas Agarwal. Management of refractory lupus nephritis: rationale to consider tacrolimus. Kidney international. 2022 06; 101(6):1293. doi: 10.1016/j.kint.2022.03.004. [PMID: 35597593]
  • Rona M Smith, Daniel J Cooper, Rainer Doffinger, Hannah Stacey, Abdulrahman Al-Mohammad, Ian Goodfellow, Stephen Baker, Sara Lear, Myra Hosmilo, Nicholas Pritchard, Nicholas Torpey, David Jayne, Vivien Yiu, Anil Chalisey, Jacinta Lee, Enric Vilnar, Chee Kay Cheung, Rachel B Jones. SARS-COV-2 vaccine responses in renal patient populations. BMC nephrology. 2022 05; 23(1):199. doi: 10.1186/s12882-022-02792-w. [PMID: 35641961]
  • Selcan Demir, Bora Gülhan, Seza Özen, Kübra Çeleğen, Ezgi Deniz Batu, Nesrin Taş, Diclehan Orhan, Yelda Bilginer, Ali Düzova, Fatih Ozaltin, Rezan Topaloğlu. Long-term renal survival of paediatric patients with lupus nephritis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2022 05; 37(6):1069-1077. doi: 10.1093/ndt/gfab152. [PMID: 33826705]
  • Sumona Bhattacharya, Gianna Stoleru, Preet Patel, Ameer Abutaleb, Kristen Stashek, Raymond K Cross. Characterization of Mycophenolate Mofetil Gastrointestinal Toxicity and Risk Factors for Severe Disease and Poor Prognosis. Inflammatory bowel diseases. 2022 05; 28(5):811-814. doi: 10.1093/ibd/izab254. [PMID: 34792581]
  • R Biesen, M Frese-Schaper, P Enghard, Q Cheng, F Hiepe, S Frese. Refractory mixed proliferative and membranous lupus nephritis treated with the topoisomerase I inhibitor irinotecan as add-on therapy. Scandinavian journal of rheumatology. 2022 05; 51(3):237-240. doi: 10.1080/03009742.2021.1980979. [PMID: 34726116]
  • Hannah Kaminski, Nassim Kamar, Olivier Thaunat, Nicolas Bouvier, Sophie Caillard, Isabelle Garrigue, Dany Anglicheau, Jean-Philippe Rérolle, Yannick Le Meur, Antoine Durrbach, Thomas Bachelet, Hélène Savel, Roxane Coueron, Jonathan Visentin, Arnaud Del Bello, Isabelle Pellegrin, Julie Déchanet-Merville, Pierre Merville, Rodolphe Thiébaut, Lionel Couzi. Incidence of cytomegalovirus infection in seropositive kidney transplant recipients treated with everolimus: A randomized, open-label, multicenter phase 4 trial. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2022 05; 22(5):1430-1441. doi: 10.1111/ajt.16946. [PMID: 34990047]
  • Jonathan Mitchell, Teresa P-Y Chiang, Jennifer L Alejo, Amy Chang, Aura T Abedon, Robin K Avery, Aaron A R Tobian, Allan B Massie, Macey L Levan, Daniel S Warren, Jacqueline M Garonzik-Wang, Dorry L Segev, William A Werbel. Effect of Mycophenolate Mofetil Dosing on Antibody Response to SARS-CoV-2 Vaccination in Heart and Lung Transplant Recipients. Transplantation. 2022 05; 106(5):e269-e270. doi: 10.1097/tp.0000000000004090. [PMID: 35250006]
  • Magdalena Hurkacz, Hanna Augustyniak-Bartosik, Joanna Pondel, Krystyna Głowacka, Magdalena Krajewska. Are in clinical practice measurements of concentrations and the calculation of mycophenolate mofetil pharmacokinetic parameters needed for optimizing therapy in patients with renal diseases or kidney transplantation?. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2022 May; 31(5):519-527. doi: 10.17219/acem/146122. [PMID: 35195961]
  • Evra Çelikkaya, Tülin Güngör, Deniz Karakaya, Evrim Kargın Çakıcı, Fatma Yazılıtaş, Fatih Özaltın, Mehmet Bülbül. Clinically Different Presentations of Family Members With the Same Homozygote Diacylglycerol Kinase Epsilon Mutation: Case Report. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2022 05; 20(Suppl 3):45-48. doi: 10.6002/ect.pediatricsymp2022.o13. [PMID: 35570599]
  • Takahiro Shinzato, Toshihiro Shimizu, Daiki Iwami, Noriyoshi Fukushima, Kenichi Tabata. Recurrent lupus nephritis in renal allograft triggered by pregnancy. CEN case reports. 2022 05; 11(2):237-241. doi: 10.1007/s13730-021-00659-x. [PMID: 34762263]
  • Sabaa Asif, Joanne Bargman, Bourne Auguste. A review of the AURORA and BLISS trials: will it revolutionize the treatment of lupus nephritis?. Current opinion in nephrology and hypertension. 2022 05; 31(3):278-282. doi: 10.1097/mnh.0000000000000792. [PMID: 35249969]
  • Teun van Gelder, Robert B Huizinga, Laura Lisk, Neil Solomons. Voclosporin: a novel calcineurin inhibitor with no impact on mycophenolic acid levels in patients with SLE. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2022 04; 37(5):917-922. doi: 10.1093/ndt/gfab022. [PMID: 33527141]
  • Aviya Lanis, Rita Volochayev, David E Kleiner, Anusha Vittal, Theo Heller, Lisa G Rider, Susan Shenoi. Nodular Regenerative Hyperplasia of the liver in Juvenile Dermatomyositis. Pediatric rheumatology online journal. 2022 Apr; 20(1):30. doi: 10.1186/s12969-022-00690-x. [PMID: 35443665]
  • Tomoko Hamaya, Shingo Hatakeyama, Tohru Yoneyama, Yuki Tobisawa, Hirotake Kodama, Takeshi Fujita, Reiichi Murakami, Naoki Fujita, Teppei Okamoto, Hayato Yamamoto, Takahiro Yoneyama, Yasuhiro Hashimoto, Hisao Saitoh, Shunji Narumi, Hirofumi Tomita, Chikara Ohyama. Seroprevalence of SARS-CoV-2 spike IgG antibodies after the second BNT162b2 mRNA vaccine in Japanese kidney transplant recipients. Scientific reports. 2022 04; 12(1):5876. doi: 10.1038/s41598-022-09897-0. [PMID: 35393481]
  • Tetsuji Morishita, Akiyoshi Sakai, Hidetoshi Matsunami. Seroconversions After Withdrawal From Mycophenolate Mofetil in Solid Organ Transplant Recipients Without a Third Dose of BNT162b2 mRNA Coronavirus Disease 2019 Vaccine: A Case Series. Transplantation. 2022 04; 106(4):e238-e239. doi: 10.1097/tp.0000000000004043. [PMID: 35030156]
  • Shili Ge, Maggie Chu, Jacqueline Tang, Joseph Kahwaji, Artur Karasyov, Darly Lovato, Ashley Vo, Jua Choi, Stanley C Jordan, Ruan Zhang, Mieko Toyoda. Viral-specific cytotoxic T-cell responses in HLA-sensitized kidney transplant patients maintained on everolimus and low-dose tacrolimus. Transplant infectious disease : an official journal of the Transplantation Society. 2022 Apr; 24(2):e13805. doi: 10.1111/tid.13805. [PMID: 35213773]
  • Fabian Echterdiek, Bernd Döhler, Joerg Latus, Vedat Schwenger, Caner Süsal. Influence of Calcineurin Inhibitor Choice on Outcomes in Kidney Transplant Recipients Aged ≥60 Y: A Collaborative Transplant Study Report. Transplantation. 2022 04; 106(4):e212-e218. doi: 10.1097/tp.0000000000004060. [PMID: 35066544]
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  • Caoilfhionn M Connolly, Teresa Po-Yu Chiang, Brian J Boyarsky, Jake A Ruddy, Mayan Teles, Jennifer L Alejo, Allan Massie, William A Werbel, Ami A Shah, Lisa Christopher-Stine, Jacqueline Garonzik-Wang, Dorry L Segev, Julie J Paik. Temporary hold of mycophenolate augments humoral response to SARS-CoV-2 vaccination in patients with rheumatic and musculoskeletal diseases: a case series. Annals of the rheumatic diseases. 2022 02; 81(2):293-295. doi: 10.1136/annrheumdis-2021-221252. [PMID: 34556484]
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  • Marta Kantauskaite, Lisa Müller, Thilo Kolb, Svenja Fischer, Jonas Hillebrandt, Katrin Ivens, Marcel Andree, Tom Luedde, Hans M Orth, Ortwin Adams, Heiner Schaal, Claudia Schmidt, Eva Königshausen, Lars C Rump, Jörg Timm, Johannes Stegbauer. Intensity of mycophenolate mofetil treatment is associated with an impaired immune response to SARS-CoV-2 vaccination in kidney transplant recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2022 02; 22(2):634-639. doi: 10.1111/ajt.16851. [PMID: 34551181]
  • Klaus Nunes Ficher, Yasmin Dreige, Paulo Ricardo Gessolo Lins, Alexandra Nicolau Ferreira, Juliana Toniato de Rezende Freschi, Kamilla Linhares, Suelen Stopa Martins, Luciana Custodio, Marina Cristelli, Laila Viana, Daniel Wagner Santos, Renato de Marco, Maria Gerbase-DeLima, Henrique Proença, Wilson Aguiar, Monica Nakamura, Claudia Rosso Felipe, Jose Medina Pestana, Helio Tedesco Silva. Long-term Efficacy and Safety of Everolimus Versus Mycophenolate in Kidney Transplant Recipients Receiving Tacrolimus. Transplantation. 2022 02; 106(2):381-390. doi: 10.1097/tp.0000000000003714. [PMID: 33988338]
  • Chunxai Tang, Wei Wang, Yuxi Xue, Junwei Yang. Effect of MMF Immunosuppression Based on CNI Reduction on CNI-Related Renal Damage after Lung Transplantation. Journal of healthcare engineering. 2022; 2022(?):8099684. doi: 10.1155/2022/8099684. [PMID: 35126949]
  • Yanjia Che, Yuanyang Chen, Zhiwei Wang, Sihao Zheng, Kai Xing, Shun Yuan, Xiaohan Zhong. The Combination of Rhodosin and MMF Prolongs Cardiac Allograft Survival by Inhibiting DC Maturation by Promoting Mitochondrial Fusion. Oxidative medicine and cellular longevity. 2022; 2022(?):7260305. doi: 10.1155/2022/7260305. [PMID: 35855862]
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  • Hannah Kaminski, Gabriel Marseres, Nathalie Yared, Marie-Julie Nokin, Vincent Pitard, Atika Zouine, Isabelle Garrigue, Séverine Loizon, Myriam Capone, Xavier Gauthereau, Maria Mamani-Matsuda, Roxane Coueron, Raúl V Durán, Benoît Pinson, Isabelle Pellegrin, Rodolphe Thiébaut, Lionel Couzi, Pierre Merville, Julie Déchanet-Merville. mTOR Inhibitors Prevent CMV Infection through the Restoration of Functional αβ and γδ T cells in Kidney Transplantation. Journal of the American Society of Nephrology : JASN. 2022 01; 33(1):121-137. doi: 10.1681/asn.2020121753. [PMID: 34725108]
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  • Paweł K Kunicki, Aleksandra Wróbel. Validated Simple HPLC-UV Method for Mycophenolic Acid (MPA) Monitoring in Human Plasma. Internal Standardization: Is It Necessary?. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237252. [PMID: 34885834]
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  • Jeffrey X Yang, Katrina A Williamson, Alí Duarte-García. 75-Year-Old Man With Fever and Malaise. Mayo Clinic proceedings. 2021 11; 96(11):2905-2910. doi: 10.1016/j.mayocp.2021.02.034. [PMID: 34736613]
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  • Sanjay R V Gadi, Patricia A R Brunker, Hanny Al-Samkari, David B Sykes, Rebecca R Saff, Janet Lo, Pavan Bendapudi, David E Leaf, Rebecca Karp Leaf. Severe autoimmune hemolytic anemia following receipt of SARS-CoV-2 mRNA vaccine. Transfusion. 2021 11; 61(11):3267-3271. doi: 10.1111/trf.16672. [PMID: 34549821]
  • Leticia García Gago, Daniela Astudillo Jarrín, Catuxa Rodríguez Magariños, María Calvo Rodríguez, Tamara Ferreiro Hermida, Andrés López Muñiz, Constantino Fernández Rivera, Ángel Alonso Hernández. Edema Associated With Everolimus de Novo. Transplantation proceedings. 2021 Nov; 53(9):2681-2684. doi: 10.1016/j.transproceed.2021.07.053. [PMID: 34620498]
  • Jung Yoon Choi, Hyery Kim, Hee Jo Baek, Hoon Kook, Jae Min Lee, Bo Kyung Kim, Hong Yul An, Kyung Taek Hong, Hee Young Shin, Hyoung Jin Kang. Open-Label, Multicenter Phase II Study of Combination Therapy of Imatinib Mesylate and Mycophenolate Mofetil in Pediatric Patients with Steroid-Refractory Sclerotic/Fibrotic Type Chronic Graft-versus-Host Disease. Transplantation and cellular therapy. 2021 11; 27(11):925.e1-925.e7. doi: 10.1016/j.jtct.2021.07.019. [PMID: 34314892]
  • Walter J F M van der Velden, Goda Choi, Moniek A de Witte, Arnold van der Meer, Anton F J de Haan, Nicole M A Blijlevens, Gerwin Huls, Jürgen Kuball, Suzanne van Dorp. Anti-thymocyte globulin with CsA and MMF as GVHD prophylaxis in nonmyeloablative HLA-mismatched allogeneic HCT. Bone marrow transplantation. 2021 11; 56(11):2651-2655. doi: 10.1038/s41409-021-01369-9. [PMID: 34148060]
  • Manon Jardou, Quentin Provost, Clarisse Brossier, Émilie Pinault, François-Ludovic Sauvage, Roland Lawson. Alteration of the gut microbiome in mycophenolate-induced enteropathy: impacts on the profile of short-chain fatty acids in a mouse model. BMC pharmacology & toxicology. 2021 10; 22(1):66. doi: 10.1186/s40360-021-00536-4. [PMID: 34711288]
  • Olivier Aubert, Gillian Divard, Julio Pascual, Federico Oppenheimer, Claudia Sommerer, Franco Citterio, Helio Tedesco, Steve Chadban, Mitchell Henry, Flavio Vincenti, Titte Srinivas, Yoshihiko Watarai, Christophe Legendre, Peter Bernhardt, Alexandre Loupy. Application of the iBox prognostication system as a surrogate endpoint in the TRANSFORM randomised controlled trial: proof-of-concept study. BMJ open. 2021 10; 11(10):e052138. doi: 10.1136/bmjopen-2021-052138. [PMID: 34620664]
  • Ping Li, Dongrui Cheng, Jiqiu Wen, Xuefeng Ni, Kenan Xie, Xue Li, Jinsong Chen. Conversion from mycophenolate mofetil to mizoribine in the early stages of BK polyomavirus infection could improve kidney allograft prognosis: a single-center study from China. BMC nephrology. 2021 10; 22(1):328. doi: 10.1186/s12882-021-02527-3. [PMID: 34600511]
  • Qiaofeng Ye, Guangfei Wang, Jinmiao Lu, Yidie Huang, Junqi Zhang, Lin Zhu, Yiqing Zhu, Jianger Lan, Ziwei Li, Yubing Liu, Hong Xu, Zhiping Li. Exposure levels of mycophenolic acid are associated with comorbidities in children with systemic lupus erythematosus. Lupus. 2021 Oct; 30(11):1808-1818. doi: 10.1177/09612033211034555. [PMID: 34304630]