3-ureidopropionate (BioDeep_00000001244)

 

Secondary id: BioDeep_00000399974, BioDeep_00000415778

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


3-[(Aminocarbonyl)amino]propanoic acid

化学式: C4H8N2O3 (132.0535)
中文名称: 3-酰脲丙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 19.61%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

3-ureidopropionate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/3-ureidopropionate (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001244). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CNC(=O)N)C(=O)O
InChI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)

描述信息

Ureidopropionic acid, also known as 3-ureidopropanoate or N-carbamoyl-beta-alanine, belongs to the class of organic compounds known as ureas. Ureas are compounds containing two amine groups joined by a carbonyl (C=O) functional group. Ureidopropionic acid is an intermediate in the metabolism of uracil. More specifically, it is a breakdown product of dihydrouracil and is produced by the enzyme dihydropyrimidase. It is further decomposed into beta-alanine via the enzyme beta-ureidopropionase. Ureidopropionic acid is essentially a urea derivative of beta-alanine. High levels of ureidopropionic acid are found in individuals with beta-ureidopropionase (UP) deficiency (PMID: 11675655). Enzyme deficiencies in pyrimidine metabolism are associated with a risk for severe toxicity against the antineoplastic agent 5-fluorouracil. Ureidopropionic acid has been detected, but not quantified in, several different foods, such as gram beans, broccoli, climbing beans, oriental wheat, and mandarin orange (clementine, tangerine). This could make ureidopropionic acid a potential biomarker for the consumption of these foods.

N-Carbamoyl-β-alanine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=462-88-4 (retrieved 2024-07-01) (CAS RN: 462-88-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Ureidopropionic acid (3-Ureidopropionic acid) is an intermediate in the metabolism of uracil.

同义名列表

42 个代谢物同义名

3-[(Aminocarbonyl)amino]propanoic acid; Ion(-1) OF N-carbamoyl-beta-alanine; 3-[(Aminocarbonyl)amino]propanoate; 3-(carbamoylamino)Propanoic acid; N-(AMINOCARBONYL)-BETA-alanine; 3-(carbamoylamino)Propanoate; N-(AMINOCARBONYL)-b-alanine; N-(AMINOCARBONYL)-β-alanine; N-(Aminocarbonyl)-b-alanine; N-Carbamoyl-β-alanine; beta-Ureidopropanoic acid; beta-Ureidopropionic acid; Carbamoyl-β-alanine; N-Carbamoyl-beta-alanine; N-Carbamyl-beta-alanine; Β-ureidopropionic acid; b-Ureidopropionic acid; 3-Ureidopropionic acid; Carbamoyl-beta-alanine; β-Ureidopropanoic acid; 3-Ureidopropanoic acid; beta-Ureidopropionate; Carbamyl beta-alanine; N-Carbamoyl-β-alanine; Carbamoyl-beta-ala-OH; N-Carbamoyl-b-alanine; Ureidopropanoic acid; Ureidopropionic acid; N-Carbamyl-b-alanine; 3-ureido-Propionate; Carbamoyl-β-alanine; Carbamoyl-b-ala-OH; b-Ureidopropionate; 3-Ureidopropanoate; Β-ureidopropionate; 3-Ureidopropionate; Carbamyl β-alanine; Ureidopropanoate; Ureidopropionate; Ureidopropionic acid; 3-Ureidopropionic acid; 3-Ureidopropionate



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

347 个相关的代谢反应过程信息。

Reactome(13)

BioCyc(0)

WikiPathways(0)

Plant Reactome(300)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(32)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ASL, ASS1, CYP2D6, DPYD
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 9 CYP1B1, CYP2D6, UGT1A1, UGT1A3, UGT1A6, UGT1A9, UGT2B15, UGT2B17, UGT2B7
Nucleus 1 MPO
cytosol 5 ASL, ASS1, DPYD, DPYS, UPB1
dendrite 1 MAOB
nucleoplasm 2 ASS1, MPO
Cell membrane 2 DPP4, GRID1
Cytoplasmic side 1 MAOB
lamellipodium 1 DPP4
Multi-pass membrane protein 1 GRID1
cell junction 1 DPP4
cell surface 1 DPP4
glutamatergic synapse 1 GRID1
Golgi membrane 1 INS
lysosomal membrane 1 DPP4
mitochondrial inner membrane 1 OTC
neuronal cell body 1 MAOB
Cytoplasm, cytosol 1 ASS1
Lysosome 1 MPO
plasma membrane 3 DPP4, GRID1, UGT1A1
Membrane 10 CYP1B1, CYP2D6, DPP4, UGT1A1, UGT1A3, UGT1A6, UGT1A9, UGT2B15, UGT2B17, UGT2B7
apical plasma membrane 1 DPP4
extracellular exosome 7 ASL, ASS1, DPP4, DPYS, GRID1, MPO, UPB1
endoplasmic reticulum 5 CYP2D6, UGT1A1, UGT1A3, UGT1A6, UGT1A9
extracellular space 2 INS, MPO
perinuclear region of cytoplasm 1 UGT1A1
intercellular canaliculus 1 DPP4
mitochondrion 4 CYP1B1, CYP2D6, MAOB, OTC
intracellular membrane-bounded organelle 4 CYP1B1, CYP2D6, MPO, UGT1A6
Microsome membrane 2 CYP1B1, CYP2D6
Secreted 2 DPP4, INS
extracellular region 3 DPP4, INS, MPO
Mitochondrion outer membrane 1 MAOB
Single-pass membrane protein 9 CYP2D6, DPP4, UGT1A1, UGT1A3, UGT1A6, UGT1A9, UGT2B15, UGT2B17, UGT2B7
mitochondrial outer membrane 2 ASS1, MAOB
Mitochondrion matrix 1 OTC
mitochondrial matrix 1 OTC
anchoring junction 1 DPP4
perikaryon 1 ASS1
Single-pass type II membrane protein 1 DPP4
postsynaptic membrane 1 GRID1
Apical cell membrane 1 DPP4
Cytoplasm, perinuclear region 1 UGT1A1
Membrane raft 1 DPP4
focal adhesion 1 DPP4
GABA-ergic synapse 1 GRID1
secretory granule 1 MPO
Postsynaptic cell membrane 1 GRID1
Endomembrane system 1 DPP4
endosome lumen 1 INS
cell body fiber 1 ASS1
azurophil granule 1 MPO
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
endocytic vesicle 1 DPP4
transport vesicle 1 INS
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
mitochondrial envelope 1 MAOB
postsynaptic density membrane 1 GRID1
Single-pass type IV membrane protein 1 MAOB
phagocytic vesicle lumen 1 MPO
lamellipodium membrane 1 DPP4
Cell projection, lamellipodium membrane 1 DPP4
Cell projection, invadopodium membrane 1 DPP4
endoplasmic reticulum chaperone complex 1 UGT1A1
cytochrome complex 1 UGT1A1
[Dipeptidyl peptidase 4 soluble form]: Secreted 1 DPP4


文献列表

  • Helena Pelantová, Martina Bugáňová, Martina Holubová, Blanka Šedivá, Jana Zemenová, David Sýkora, Petra Kaválková, Martin Haluzík, Blanka Železná, Lenka Maletínská, Jaroslav Kuneš, Marek Kuzma. Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination. Molecular and cellular endocrinology. 2016 08; 431(?):88-100. doi: 10.1016/j.mce.2016.05.003. [PMID: 27164444]
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  • Hongde Li, Hong Wei, Yong Wang, Huiru Tang, Yulan Wang. Enhanced green fluorescent protein transgenic expression in vivo is not biologically inert. Journal of proteome research. 2013 Aug; 12(8):3801-8. doi: 10.1021/pr400567g. [PMID: 23827011]
  • Jia V Li, Jasmina Saric, Yulan Wang, Jennifer Keiser, Jürg Utzinger, Elaine Holmes. Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni. Parasites & vectors. 2011 Sep; 4(?):179. doi: 10.1186/1756-3305-4-179. [PMID: 21929782]
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  • Angika Basant, Mayuri Rege, Shobhona Sharma, Haripalsingh M Sonawat. Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression. Malaria journal. 2010 Apr; 9(?):110. doi: 10.1186/1475-2875-9-110. [PMID: 20412601]
  • Bhowmik Salil Kumar, Young-Joo Lee, Hong Jae Yi, Bong Chul Chung, Byung Hwa Jung. Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach. Analytica chimica acta. 2010 Feb; 661(1):47-59. doi: 10.1016/j.aca.2009.11.063. [PMID: 20113715]
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  • Rolf W Sparidans, T M Bosch, M Jörger, Jan H M Schellens, Jos H Beijnen. Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jul; 839(1-2):45-53. doi: 10.1016/j.jchromb.2006.02.016. [PMID: 16513432]
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