Diisodecyl phthalate (BioDeep_00000009989)
Secondary id: BioDeep_00001873586
human metabolite blood metabolite Volatile Flavor Compounds natural product
代谢物信息卡片
1,2-bis(8-methylnonyl) benzene-1,2-dicarboxylate
化学式: C28H46O4 (446.3395916)
中文名称: 邻苯二甲酸二异癸酯, 酞酸二异癸酯, 活性黄1
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC(C)C
InChI: InChI=1S/C28H46O4/c1-23(2)17-11-7-5-9-15-21-31-27(29)25-19-13-14-20-26(25)28(30)32-22-16-10-6-8-12-18-24(3)4/h13-14,19-20,23-24H,5-12,15-18,21-22H2,1-4H3
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:34709
- KEGG: C14578
- PubChem: 33599
- HMDB: HMDB0251351
- Metlin: METLIN70173
- ChEMBL: CHEMBL3183266
- Wikipedia: Diisodecyl phthalate
- chemspider: 30996
- CAS: 26761-40-0
- CAS: 68515-49-1
- CAS: 19269-67-1
- CAS: 89-16-7
- PMhub: MS000023818
- PubChem: 17395578
- NIKKAJI: J3.799K
- RefMet: Diisodecyl phthalate
- KNApSAcK: 34709
- LOTUS: LTS0111789
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 2 - Bacteria: LTS0111789
- 9606 - Homo sapiens: -
- 1883 - Streptomyces: LTS0111789
- 146923 - Streptomyces parvulus: 10.1556/030.63.2016.1.2
- 146923 - Streptomyces parvulus: LTS0111789
- 2062 - Streptomycetaceae: LTS0111789
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Md Saidur Rahman, Won-Ki Pang, Shehreen Amjad, Do-Yeal Ryu, Elikanah Olusayo Adegoke, Yoo-Jin Park, Myung-Geol Pang. Hepatic consequences of a mixture of endocrine-disrupting chemicals in male mice.
Journal of hazardous materials.
2022 08; 436(?):129236. doi:
10.1016/j.jhazmat.2022.129236. [PMID: 35739755] - Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee. Toxicokinetics of di-isodecyl phthalate and its major metabolites in rats through the application of a developed and validated UHPLC-ESI-MS/MS method.
Archives of toxicology.
2021 Nov; 95(11):3515-3537. doi:
10.1007/s00204-021-03153-6. [PMID: 34487205] - Song Zhang, Xiuxiu Chen, Xiaoheng Li, Yiyan Wang, Qiqi Zhu, Tongliang Huang, Ren-Shan Ge. Effects of in utero exposure to diisodecyl phthalate on fetal testicular cells in rats.
Toxicology letters.
2020 May; 330(?):23-29. doi:
10.1016/j.toxlet.2020.04.024. [PMID: 32387388] - Cheng-Di Dong, Ming-Huang Wang, Chih-Feng Chen, Yu-Jen Shih, Ken-Lin Chang, Shu-Hui Lee, Yi-Li Lin, Chung-Hsin Wu, Chiu-Wen Chen. Detecting phthalate esters in sludge particulates from wastewater treatment plants.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2020; 55(10):1233-1240. doi:
10.1080/10934529.2020.1780850. [PMID: 32552322] - Yingying Chen, Chongyao Li, Peng Song, Biao Yan, Xu Yang, Yang Wu, Ping Ma. Hepatic and renal tissue damage in Balb/c mice exposed to diisodecyl phthalate: The role of oxidative stress pathways.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 10; 132(?):110600. doi:
10.1016/j.fct.2019.110600. [PMID: 31228599] - Jijun Shang, Jeanne Corriveau, Alexandre Champoux-Jenane, Julie Gagnon, Emmanuel Moss, Pierre Dumas, Eric Gaudreau, Jonathan Chevrier, Lorraine E Chalifour. Recovery From a Myocardial Infarction Is Impaired in Male C57bl/6 N Mice Acutely Exposed to the Bisphenols and Phthalates That Escape From Medical Devices Used in Cardiac Surgery.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 03; 168(1):78-94. doi:
10.1093/toxsci/kfy276. [PMID: 30398665] - Valentina Pomatto, Erika Cottone, Paolo Cocci, Matteo Mozzicafreddo, Gilberto Mosconi, Erik Russel Nelson, Francesco Alessandro Palermo, Patrizia Bovolin. Plasticizers used in food-contact materials affect adipogenesis in 3T3-L1 cells.
The Journal of steroid biochemistry and molecular biology.
2018 04; 178(?):322-332. doi:
10.1016/j.jsbmb.2018.01.014. [PMID: 29410257] - Munawar Hussain Soomro, Nour Baiz, Claire Philippat, Celine Vernet, Valerie Siroux, Cara Nichole Maesano, Shreosi Sanyal, Remy Slama, Carl-Gustaf Bornehag, Isabella Annesi-Maesano. Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study.
Environmental health perspectives.
2018 02; 126(2):027002. doi:
10.1289/ehp1829. [PMID: 29398652] - Lauren E Johns, Glinda S Cooper, Audrey Galizia, John D Meeker. Exposure assessment issues in epidemiology studies of phthalates.
Environment international.
2015 Dec; 85(?):27-39. doi:
10.1016/j.envint.2015.08.005. [PMID: 26313703] - Leonardo Trasande, Teresa M Attina. Association of exposure to di-2-ethylhexylphthalate replacements with increased blood pressure in children and adolescents.
Hypertension (Dallas, Tex. : 1979).
2015 Aug; 66(2):301-8. doi:
10.1161/hypertensionaha.115.05603. [PMID: 26156503] - Teresa M Attina, Leonardo Trasande. Association of Exposure to Di-2-Ethylhexylphthalate Replacements With Increased Insulin Resistance in Adolescents From NHANES 2009-2012.
The Journal of clinical endocrinology and metabolism.
2015 Jul; 100(7):2640-50. doi:
10.1210/jc.2015-1686. [PMID: 25993640] - Paolo Cocci, Gilberto Mosconi, Augustine Arukwe, Matteo Mozzicafreddo, Mauro Angeletti, Graziano Aretusi, Francesco Alessandro Palermo. Effects of Diisodecyl Phthalate on PPAR:RXR-Dependent Gene Expression Pathways in Sea Bream Hepatocytes.
Chemical research in toxicology.
2015 May; 28(5):935-47. doi:
10.1021/tx500529x. [PMID: 25825955] - Kevin M Kransler, Ammie N Bachman, Richard H McKee. Estimates of daily di-isodecyl phthalate (DIDP) intake calculated from urinary biomonitoring data.
Regulatory toxicology and pharmacology : RTP.
2013 Feb; 65(1):29-33. doi:
10.1016/j.yrtph.2012.11.004. [PMID: 23174424] - Holger Martin Koch, Andreas Haller, Tobias Weiss, Heiko-Udo Käfferlein, Joachim Stork, Thomas Brüning. Phthalate exposure during cold plastisol application--a human biomonitoring study.
Toxicology letters.
2012 Aug; 213(1):100-6. doi:
10.1016/j.toxlet.2011.06.010. [PMID: 21704685] - Gurusankar Saravanabhavan, Janine Murray. Human biological monitoring of diisononyl phthalate and diisodecyl phthalate: a review.
Journal of environmental and public health.
2012; 2012(?):810501. doi:
10.1155/2012/810501. [PMID: 22505951] - Jin Zhou, Xiao-Shan Zhu, Zhong-Hua Cai. Influences of DMP on the fertilization process and subsequent embryogenesis of abalone (Haliotis diversicolor supertexta) by gametes exposure.
PloS one.
2011; 6(10):e25951. doi:
10.1371/journal.pone.0025951. [PMID: 22028799] - Antonia M Calafat, Lee-Yang Wong, Manori J Silva, Ella Samandar, James L Preau, Lily T Jia, Larry L Needham. Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey.
Environmental health perspectives.
2011 Jan; 119(1):50-5. doi:
10.1289/ehp.1002316. [PMID: 20870567] - Eiko Koike, Rie Yanagisawa, Kaori Sadakane, Ken-ichiro Inoue, Takamichi Ichinose, Hirohisa Takano. Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro.
Environmental health perspectives.
2010 Apr; 118(4):472-8. doi:
10.1289/ehp.0901255. [PMID: 20064775] - John D Meeker, Howard Hu, David E Cantonwine, Hector Lamadrid-Figueroa, Antonia M Calafat, Adrienne S Ettinger, Mauricio Hernandez-Avila, Rita Loch-Caruso, Martha María Téllez-Rojo. Urinary phthalate metabolites in relation to preterm birth in Mexico city.
Environmental health perspectives.
2009 Oct; 117(10):1587-92. doi:
10.1289/ehp.0800522. [PMID: 20019910] - Sonia Hernández-Díaz, Allen A Mitchell, Katherine E Kelley, Antonia M Calafat, Russ Hauser. Medications as a potential source of exposure to phthalates in the U.S. population.
Environmental health perspectives.
2009 Feb; 117(2):185-9. doi:
10.1289/ehp.11766. [PMID: 19270786] - Ji-An Chen, Huijie Liu, Zhiqun Qiu, Weiqun Shu. Analysis of di-n-butyl phthalate and other organic pollutants in Chongqing women undergoing parturition.
Environmental pollution (Barking, Essex : 1987).
2008 Dec; 156(3):849-53. doi:
10.1016/j.envpol.2008.05.019. [PMID: 18565632] - Johan Högberg, Annika Hanberg, Marika Berglund, Staffan Skerfving, Mikael Remberger, Antonia M Calafat, Agneta Falk Filipsson, Bo Jansson, Niklas Johansson, Malin Appelgren, Helen Håkansson. Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations.
Environmental health perspectives.
2008 Mar; 116(3):334-9. doi:
10.1289/ehp.10788. [PMID: 18335100] - Kayoko Kato, Manori J Silva, Cynthia Wolf, L Earl Gray, Larry L Needham, Antonia M Calafat. Urinary metabolites of diisodecyl phthalate in rats.
Toxicology.
2007 Jul; 236(1-2):114-22. doi:
10.1016/j.tox.2007.04.009. [PMID: 17499416] - Holger M Koch, Johannes Müller, Jürgen Angerer. Determination of secondary, oxidised di-iso-nonylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Mar; 847(2):114-25. doi:
10.1016/j.jchromb.2006.09.044. [PMID: 17055785] - M J Silva, J A Reidy, K Kato, J L Preau, L L Needham, A M Calafat. Assessment of human exposure to di-isodecyl phthalate using oxidative metabolites as biomarkers.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2007 Mar; 12(2):133-44. doi:
10.1080/13547500601066915. [PMID: 17536764] - Manori J Silva, Kayoko Kato, Cynthia Wolf, Ella Samandar, Sathya S Silva, Earl L Gray, Larry L Needham, Antonia M Calafat. Urinary biomarkers of di-isononyl phthalate in rats.
Toxicology.
2006 Jun; 223(1-2):101-12. doi:
10.1016/j.tox.2006.03.005. [PMID: 16697098] - Matthias Wormuth, Martin Scheringer, Meret Vollenweider, Konrad Hungerbühler. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?.
Risk analysis : an official publication of the Society for Risk Analysis.
2006 Jun; 26(3):803-24. doi:
10.1111/j.1539-6924.2006.00770.x. [PMID: 16834635] - Antonia M Calafat, Manori J Silva, John A Reidy, L Earl Gray, Ella Samandar, James L Preau, Arnetra R Herbert, Larry L Needham. Mono-(3-carboxypropyl) phthalate, a metabolite of di-n-octyl phthalate.
Journal of toxicology and environmental health. Part A.
2006 Feb; 69(3-4):215-27. doi:
10.1080/15287390500227381. [PMID: 16263692] - Cheryl E Mackintosh, Javier Maldonado, Jing Hongwu, Natasha Hoover, Audrey Chong, Michael G Ikonomou, Frank A P C Gobas. Distribution of phthalate esters in a marine aquatic food web: comparison to polychlorinated biphenyls.
Environmental science & technology.
2004 Apr; 38(7):2011-20. doi:
10.1021/es034745r. [PMID: 15112801] - Mark T Albrecht, Wei Wang, Olga Shamova, Robert I Lehrer, Neal L Schiller. Binding of protegrin-1 to Pseudomonas aeruginosa and Burkholderia cepacia.
Respiratory research.
2002; 3(?):18. doi:
10.1186/rr167. [PMID: 11980587] - L J Hushka, S J Waterman, L H Keller, G W Trimmer, J J Freeman, J L Ambroso, M Nicolich, R H McKee. Two-generation reproduction studies in Rats fed di-isodecyl phthalate.
Reproductive toxicology (Elmsford, N.Y.).
2001 Mar; 15(2):153-69. doi:
10.1016/s0890-6238(01)00109-5. [PMID: 11297875] - R H McKee, R T Przygoda, M A Chirdon, G Engelhardt, M Stanley. Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate (DIDP) are not mutagenic.
Journal of applied toxicology : JAT.
2000 Nov; 20(6):491-7. doi:
10.1002/1099-1263(200011/12)20:6<491::aid-jat724>3.0.co;2-h. [PMID: 11180272] - J Nielsen, B Akesson, S Skerfving. Phthalate ester exposure--air levels and health of workers processing polyvinylchloride.
American Industrial Hygiene Association journal.
1985 Nov; 46(11):643-7. doi:
10.1080/15298668591395463. [PMID: 4072908]