Proxigermanium (BioDeep_00000009420)
代谢物信息卡片
Bis (2-Carboxyethylgermanium)sesquioxide
化学式: C6H10Ge2O7 (337.8868)
中文名称: 丙帕锗
谱图信息:
最多检出来源 Mentha canadensis(plant) 100%
分子结构信息
SMILES: C(C[Ge](=O)O[Ge](=O)CCC(=O)O)C(=O)O
InChI: InChI=1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,10)(H,11,12)
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C308 - Immunotherapeutic Agent > C63817 - Chemokine Receptor Antagonist
D007155 - Immunologic Factors > D007369 - Interferon Inducers
D000970 - Antineoplastic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:32060
- KEGGdrug: D01626
- KEGGdrug: D88066
- PubChem: 83030
- CAS: 126595-07-1
- CAS: 12758-40-6
- PMhub: MS000023202
- KEGG: C13086
- PubChem: 585150
- KNApSAcK: 32060
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hao Cui, Shuting Tang, Shiqi Huang, Lidan Lei, Zhenmao Jiang, Lei Li, Shiqiang Wei. Simultaneous mitigation of arsenic and cadmium accumulation in rice grains by foliar inhibitor with ZIF-8@Ge-132.
The Science of the total environment.
2023 Feb; 860(?):160307. doi:
10.1016/j.scitotenv.2022.160307. [PMID: 36403824] - Takaaki Masuda, Miwa Noda, Takahiro Kogawa, Dai Kitagawa, Naoki Hayashi, Takahito Jomori, Yoichi Nakanishi, Keiichi I Nakayama, Shinji Ohno, Koshi Mimori. Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer.
Cancer science.
2020 Mar; 111(3):924-931. doi:
10.1111/cas.14306. [PMID: 31943636] - Yan Liu, Long-Yu Hou, Qing-Mei Li, Ze-Ping Jiang, Wei-Dong Gao, Yan Zhu, Hai-Bo Zhang. Effects of Ge-132 and GeO2 on seed germination and seedling growth of Oenothera biennis L. under NaCl stress.
Environmental technology.
2017 Jan; 38(1):85-93. doi:
10.1080/09593330.2016.1186226. [PMID: 27152861] - Hiroaki Yamaguchi, Yasuhiro Shimada, Tomoya Takeda, Takashi Nakamura, Nariyasu Mano. A novel extraction method based on a reversible chemical conversion for the LC/MS/MS analysis of the stable organic germanium compound Ge-132.
Analytical chemistry.
2015 Feb; 87(4):2042-7. doi:
10.1021/ac504466u. [PMID: 25621844] - Takashi Nakamura, Miki Saito, Yasuhiro Shimada, Haruhiko Fukaya, Yasuo Shida, Yoshihiko Tokuji. Induction of aminolevulinic acid synthase gene expression and enhancement of metabolite, protoporphyrin IX, excretion by organic germanium.
European journal of pharmacology.
2011 Feb; 653(1-3):75-81. doi:
10.1016/j.ejphar.2010.12.002. [PMID: 21167148] - Yukinori Tamura, Masayuki Sugimoto, Toshinori Murayama, Manabu Minami, Yuki Nishikaze, Hiroyuki Ariyasu, Takashi Akamizu, Toru Kita, Masayuki Yokode, Hidenori Arai. C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice.
Journal of atherosclerosis and thrombosis.
2010 Mar; 17(3):219-28. doi:
10.5551/jat.3368. [PMID: 20179360] - Kiyoki Kitagawa, Takashi Wada, Kengo Furuichi, Hiroyuki Hashimoto, Yoshiro Ishiwata, Masahide Asano, Motohiro Takeya, William A Kuziel, Kouji Matsushima, Naofumi Mukaida, Hitoshi Yokoyama. Blockade of CCR2 ameliorates progressive fibrosis in kidney.
The American journal of pathology.
2004 Jul; 165(1):237-46. doi:
10.1016/s0002-9440(10)63292-0. [PMID: 15215179] - Kengo Furuichi, Takashi Wada, Yasunori Iwata, Kiyoki Kitagawa, Ken-Ichi Kobayashi, Hiroyuki Hashimoto, Yoshiro Ishiwata, Masahide Asano, Hui Wang, Kouji Matsushima, Motohiro Takeya, William A Kuziel, Naofumi Mukaida, Hitoshi Yokoyama. CCR2 signaling contributes to ischemia-reperfusion injury in kidney.
Journal of the American Society of Nephrology : JASN.
2003 Oct; 14(10):2503-15. doi:
10.1097/01.asn.0000089563.63641.a8. [PMID: 14514728] - Yasuhiro Eto, Hiroaki Shimokawa, Eriko Tanaka, Kunio Morishige, Masahiro Fuchigami, Yoshiro Ishiwata, Kouji Matsushima, Akira Takeshita. Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits.
Journal of cardiovascular pharmacology.
2003 Feb; 41(2):171-7. doi:
10.1097/00005344-200302000-00004. [PMID: 12548076] - Tomoya Yamashita, Seinosuke Kawashima, Masanori Ozaki, Masayuki Namiki, Nobutaka Inoue, Ken-ichi Hirata, Mitsuhiro Yokoyama. Propagermanium reduces atherosclerosis in apolipoprotein E knockout mice via inhibition of macrophage infiltration.
Arteriosclerosis, thrombosis, and vascular biology.
2002 Jun; 22(6):969-74. doi:
10.1161/01.atv.0000019051.88366.9c. [PMID: 12067906] - Y Wakabayashi. Effect of germanium-132 on low-density lipoprotein oxidation and atherosclerosis in Kurosawa and Kusanagi hypercholesterolemic rabbits.
Bioscience, biotechnology, and biochemistry.
2001 Aug; 65(8):1893-6. doi:
10.1271/bbb.65.1893. [PMID: 11577738] - M K Yang, Y G Kim. Protective role of germanium-132 against paraquat-induced oxidative stress in the livers of senescence-accelerated mice.
Journal of toxicology and environmental health. Part A.
1999 Nov; 58(5):289-97. doi:
10.1080/009841099157250. [PMID: 10598954] - S H Tao, P M Bolger. Hazard assessment of germanium supplements.
Regulatory toxicology and pharmacology : RTP.
1997 Jun; 25(3):211-9. doi:
10.1006/rtph.1997.1098. [PMID: 9237323] - Q C Long, G X Zeng, X L Zhao. Pharmacokinetics of germanium after po beta-carboxyethylgermanium sesquioxide in 24 Chinese volunteers.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1996 Sep; 17(5):415-8. doi:
NULL. [PMID: 9863162] - W Xie, X Chen, K Yang. [Effects of selenium and germanium on lipid peroxidation in rats fed with low-selenium grain].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].
1996 Mar; 30(2):88-90. doi:
NULL. [PMID: 8758855] - K Asano, M Yamano, K Haruyama, E Ikawa, K Nakano, M Kurono, O Wada. Influence of propagermanium (SK-818) on chemically induced renal lesions in rats.
The Journal of toxicological sciences.
1994 Oct; 19 Suppl 2(?):131-43. doi:
10.2131/jts.19.supplementii_131. [PMID: 7830283] - A Fujii, N Kuboyama, J Yamane, S Nakao, Y Furukawa. Effect of organic germanium compound (Ge-132) on experimental osteoporosis in rats.
General pharmacology.
1993 Nov; 24(6):1527-32. doi:
10.1016/0306-3623(93)90447-6. [PMID: 8112531] - W S Song. [Experimental study on prevention of the colorectal cancer by China medical stone and the organgermanium compound].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].
1993 Sep; 27(5):286-9. doi:
NULL. [PMID: 8137660] - L Prónai, S Arimori. Decreased plasma superoxide scavenging activity in immunological disorders--carboxyethylgermanium sesquioxide (Ge-132) as a promoter of prednisolone.
Biotherapy (Dordrecht, Netherlands).
1992; 4(1):1-8. doi:
10.1007/bf02171703. [PMID: 1311942] - Y Q Chen, B Tian, X M Li, Y J Chen, S H Xie. [Effect of carboxyethylgermanium sesquioxide on cultured normal neonatal rat myocardial cells and cells injured by isoproterenol].
Yao xue xue bao = Acta pharmaceutica Sinica.
1992; 27(7):481-5. doi:
. [PMID: 1279937] - T Sanai, S Okuda, K Onoyama, N Oochi, S Takaichi, V Mizuhira, M Fujishima. Chronic tubulointerstitial changes induced by germanium dioxide in comparison with carboxyethylgermanium sesquioxide.
Kidney international.
1991 Nov; 40(5):882-90. doi:
10.1038/ki.1991.289. [PMID: 1762293] - Y Masaki, K Kumano, M Iwamura, T Endo, T Sakai, K Koshiba, K Nakamura, K Yokota, K Sato, H Uchida. Protective effect of an organic germanium compound on warm ischemia and prolonged kidney preservation.
Transplantation proceedings.
1989 Feb; 21(1 Pt 2):1250-1. doi:
NULL. [PMID: 2652411] - R R Brutkiewicz, F Suzuki. Biological activities and antitumor mechanism of an immunopotentiating organogermanium compound, Ge-132 (review).
In vivo (Athens, Greece).
1987 Jul; 1(4):189-203. doi:
NULL. [PMID: 2979786] - F Suzuki. [Ability of sera from mice treated with Ge-132, an organo-germanium compound, to inhibit experimental murine ascites tumors].
Gan to kagaku ryoho. Cancer & chemotherapy.
1985 Dec; 12(12):2314-21. doi:
NULL. [PMID: 3935051] - F Suzuki, R R Brutkiewicz, R B Pollard. Ability of sera from mice treated with Ge-132, an organic germanium compound, to inhibit experimental murine ascites tumours.
British journal of cancer.
1985 Nov; 52(5):757-63. doi:
10.1038/bjc.1985.254. [PMID: 3933536] - I Takahashi, M Fukumoto, N Inagaki, I Ueda, M Nishimura, S Aoyama, Y Oda, E Ohmoto, K Takaoka, M Lai. [Effects of interferon and its inducers on neutrophil chemiluminescence].
Gan to kagaku ryoho. Cancer & chemotherapy.
1984 Jul; 11(7):1439-43. doi:
NULL. [PMID: 6588923]
