Cefroxadine (BioDeep_00000009410)
Secondary id: BioDeep_00000177125
代谢物信息卡片
Cefroxadine
化学式: C16H19N3O5S (365.1045)
中文名称: 头孢沙定
谱图信息:
最多检出来源 Homo sapiens(blood) 87.5%
分子结构信息
SMILES: COC1=C(C(=O)O)N2C(=O)C(NC(=O)C(N)C3=CCC=CC3)C2SC1
InChI: InChI=1S/C16H19N3O5S/c1-24-9-7-25-15-11(14(21)19(15)12(9)16(22)23)18-13(20)10(17)8-5-3-2-4-6-8/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Same as: D01528
同义名列表
2 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:31379
- KEGG: C12979
- KEGGdrug: D01528
- PubChem: 5284529
- Metlin: METLIN69520
- DrugBank: DB11367
- ChEMBL: CHEMBL3186538
- CAS: 51762-05-1
- PMhub: MS000023191
- MetaboLights: MTBLC31379
- PubChem: 583368
- NIKKAJI: J3.191G
- KNApSAcK: 31379
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Young-Sook Kang, So-Young Lee, Na Hyung Kim, Hong-Mi Choi, Joug Sei Park, Won Kim, Hwa Jeong Lee. A specific and rapid HPLC assay for the determination of cefroxadine in human plasma and its application to pharmacokinetic study in Korean.
Journal of pharmaceutical and biomedical analysis.
2006 Feb; 40(2):369-74. doi:
10.1016/j.jpba.2005.07.026. [PMID: 16137854] - R Cadórniga, I T Molina, P Pastoriza, S Negro, C M Evora, J A Gutierrez. Pharmacokinetics of cefroxadine after infusion to healthy volunteers.
International journal of clinical pharmacology, therapy, and toxicology.
1990 Oct; 28(10):435-9. doi:
NULL. [PMID: 2258253] - M D Blanchin, M L Rondot-Dudragne. [Determination of cefaloglycine and cefroxadin in biological media with thin layer chromatography with fluorometric detection].
Journal of chromatography.
1988 Nov; 432(?):407-11. doi:
. [PMID: 3220913] - M C Rouan. Microbore liquid chromatographic determination of cadralazine and cephalexin in plasma with large-volume injection.
Journal of chromatography.
1988 Apr; 426(2):335-44. doi:
10.1016/s0378-4347(00)81960-x. [PMID: 3392145] - F Fraschini, F Scaglione, F Vago, E Bichisao, C Borghi, M Montanari. Correlation between plasma and tonsillar levels of cefroxadine.
Chemotherapy.
1988; 34(1):8-12. doi:
10.1159/000238540. [PMID: 3349862] - T Bergan. Pharmacokinetic properties of the cephalosporins.
Drugs.
1987; 34 Suppl 2(?):89-104. doi:
10.2165/00003495-198700342-00008. [PMID: 3319507] - S Iwata, T Yokota, Y Kusumoto, H Shiro, Y Sato, H Akita, S Nanri, T Oikawa, S Kusano, K Sunakawa. [Influence of cefroxadine dry syrup on intestinal bacterial flora].
The Japanese journal of antibiotics.
1986 Aug; 39(8):1967-74. doi:
. [PMID: 3540337] - O Daghero, G Andreoni, R Arione, L Bendiscioli, C Bramato, T Cimino, B Salassa, C Spezia, M L Soranzo. [Cephalosporins and enzymuria].
Minerva medica.
1986 Feb; 77(7-8):231-7. doi:
NULL. [PMID: 2869451] - J Hess, P Gammelgaard, B Holst, F Rasmussen, V F Thomsen. A randomized double-blind investigation of cefroxadine (CGP 9000) versus cephalexin in urinary tract infection.
Infection.
1984 Jul; 12(4):270-3. doi:
10.1007/bf01645959. [PMID: 6436182] - T Ahrens, K G Naber. Activity of cefroxadine and cephalexin in urinary tract infections: a double-blind comparative study.
Infection.
1983 Jan; 11(1):25-30. doi:
10.1007/bf01651353. [PMID: 6341252] - T Bergan, E K Brodwall, E W Larsen. Relationship between pharmacokinetics and bioavailability of cefroxadine (CGP 9000) and renal function.
Chemotherapy.
1983; 29(3):163-73. doi:
10.1159/000238192. [PMID: 6872614] - M J Nieto, J M Lanao, A Dominguez-Gil, J M Tabernero, J F Macias. Elimination of cefroxadine (CGP-9000) from patients undergoing dialysis.
European journal of clinical pharmacology.
1983; 24(1):109-12. doi:
10.1007/bf00613936. [PMID: 6832192] - K G Naber, T Ahrens. [Cefroxadine and cephalexin in urinary tract infections. Kinetics of germ elimination].
Fortschritte der Medizin.
1982 Oct; 100(39):1827-31. doi:
. [PMID: 6759334] - P Schneider, W Tosch, M Maurer, O Zak. Antibacterial effects of cefroxadine, cephalexin and cephradine in a new in vitro pharmacokinetic model.
The Journal of antibiotics.
1982 Jul; 35(7):843-9. doi:
10.7164/antibiotics.35.843. [PMID: 7174537] - J B Lecaillon, M C Rouan, C Souppart, N Febvre, F Juge. Determination of cefsulodin, cefotiam, cephalexin, cefotaxime, desacetyl-cefotaxime, cefuroxime and cefroxadin in plasma and urine by high-performance liquid chromatography.
Journal of chromatography.
1982 Mar; 228(?):257-67. doi:
10.1016/s0378-4347(00)80438-7. [PMID: 6281285] - A Gerardin, J B Lecaillon, J P Schoeller, G Humbert, J Guibert. Pharmacokinetics of cefroxadin (CGP 9000) in man.
Journal of pharmacokinetics and biopharmaceutics.
1982 Feb; 10(1):15-26. doi:
10.1007/bf01059181. [PMID: 7069577] - T Motohiro, Y Sakata, T Fujimoto, T Nishiyama, T Nakajima, K Ishimoto, K Tominaga, F Yamashita, N Takajo, H Araki, Y Shiozuki, S Takenaka, K Kamezaki, Y Yoshinaga, N Kawano, M Yamamoto, R Komatsu, M Ohta, Y Etoh, T Moroi, T Iriki, H Chou, S Okada, M Kinoshita, F Imuta, T Koga. [Absorption, excretion and clinical trials of cefroxadine in the field of pediatrics (author's transl)].
The Japanese journal of antibiotics.
1981 Dec; 34(12):1703-31. doi:
. [PMID: 7038189] - Y Iwasaki, S Iwata, T Kanemitsu, K Jozaki, H Hattori, H Akita, M Hotta, N Yamashita, S Nanri, K Sunakawa, T Oikawa, M Osano, Y Ichihashi, T Kuratsuji, Y Haginiwa. [Study of cefroxadine in pediatrics regarding clinical efficacy and serum levels (author's transl)].
The Japanese journal of antibiotics.
1981 Dec; 34(12):1595-603. doi:
. [PMID: 7334584] - Y Toyonaga, Y Kurosu, M Hori, S Kohno. [Fundamental and clinical studies of cefroxadine in pediatric field (author's transl)].
The Japanese journal of antibiotics.
1981 Dec; 34(12):1608-25. doi:
. [PMID: 7334586] - S Nakazawa, H Sato, K Niino, Y Hirama, A Narita, S Nakazawa. [Clinical studies with cefroxadine dry syrup in the field of pediatrics (author's transl)].
The Japanese journal of antibiotics.
1981 Dec; 34(12):1588-94. doi:
. [PMID: 7334583] - T Nishimura, K Tabuki, K Hiromatsu, T Takashima, Y Kotani. [Laboratory and clinical studies of cefroxadine (author's transl)].
The Japanese journal of antibiotics.
1981 Dec; 34(12):1634-46. doi:
. [PMID: 7334588] - N Iwai, A Sasaki, Y Taneda, K Inokuma, H Nakamura. [Evaluation of cefroxadine in the field of pediatrics (author's transl)].
The Japanese journal of antibiotics.
1981 Dec; 34(12):1663-79. doi:
. [PMID: 7334591] - M Minamitani, K Hachimori, M Suzuki, I Minamikawa. [Clinical evaluation of cefroxadine dry syrup in pediatric field (author's transl)].
The Japanese journal of antibiotics.
1981 Dec; 34(12):1626-33. doi:
. [PMID: 7334587] - Y Kawamura, T Nomura, T Ihara, S Shimizu, H Kamiya, M Sakurai, H Nishi. [Laboratory and clinical studies cefroxadine in pediatric field (author's transl)].
The Japanese journal of antibiotics.
1981 Dec; 34(12):1655-62. doi:
. [PMID: 7334590] - K Nishikawa, K Aso, Y Miyachi, A Ogawa, M Yafuso, K Kuno. [Laboratory and clinical studies on cefroxadine (author's transl)].
The Japanese journal of antibiotics.
1981 Dec; 34(12):1647-54. doi:
. [PMID: 7334589] - M Ohkawa, K Takamae, M Shimamura, K Kuroda, S Awazu. Pharmacokinetics of cefroxadine in healthy volunteers and patients with impaired renal function.
Chemotherapy.
1981; 27(3):149-54. doi:
10.1159/000237971. [PMID: 7226971] - M Kissling, M Xilinas, L Glaus. Efficacy and tolerability of CGP 9,000 ('Oraspor') in diabetic patients treated for urinary tract infections: a case control study.
Pharmatherapeutica.
1981; 2(9):575-80. doi:
NULL. [PMID: 7267675] - J B Lecaillon, J L Hirtz, J P Schoeller, G Humbert, W Vischer. Pharmacokinetic comparison of cefroxadin (CGP 9000) and cephalexin by simultaneous administration to humans.
Antimicrobial agents and chemotherapy.
1980 Nov; 18(5):656-60. doi:
10.1128/aac.18.5.656. [PMID: 7447423] - T Bergan. Pharmacokinetics of a new cephalosporin, CGP 9000 (cefroxadine), in healthy volunteers.
Chemotherapy.
1980; 26(4):225-30. doi:
10.1159/000237910. [PMID: 7389422]
