N-Deacetylcolchicine (BioDeep_00000897216)

   


代谢物信息卡片


N-Deacetylcolchicine

化学式: C20H23NO5 (357.1576)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=C2C(=CC1=O)C(CCC3=CC(=C(C(=C32)OC)OC)OC)N
InChI: InChI=1S/C20H23NO5/c1-23-16-8-6-12-13(10-15(16)22)14(21)7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12/h6,8-10,14H,5,7,21H2,1-4H3/t14-/m0/s1

描述信息

同义名列表

2 个代谢物同义名

N-Deacetylcolchicine; Deacetylcolchicine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, ADA, CST6, GAPDHS, LGMN, TUBB3, TUBB4B
Peripheral membrane protein 1 ADA
Nucleus 4 CST6, GAPDHS, TUBB3, TUBB4B
cytosol 4 ADA, CST6, GAPDHS, TUBB4B
dendrite 1 TUBB3
Cell membrane 3 ABCB1, ADA, P2RY12
lamellipodium 1 TUBB3
Cell projection, growth cone 1 TUBB3
Multi-pass membrane protein 2 ABCB1, P2RY12
cell junction 1 ADA
cell surface 3 ABCB1, ADA, P2RY12
growth cone 1 TUBB3
neuronal cell body 1 TUBB3
Lysosome 2 ADA, LGMN
plasma membrane 3 ABCB1, ADA, P2RY12
Membrane 3 ABCB1, ADA, P2RY12
apical plasma membrane 1 ABCB1
axon 1 TUBB3
extracellular exosome 6 ABCB1, CST6, LGMN, LYZ, TUBB3, TUBB4B
extracellular space 3 CST6, LYZ, TG
lysosomal lumen 1 LGMN
perinuclear region of cytoplasm 1 LGMN
filopodium 1 TUBB3
Secreted 2 CST6, TG
extracellular region 5 CST6, LGMN, LYZ, TG, TUBB4B
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
external side of plasma membrane 1 ADA
Extracellular vesicle 1 TUBB4B
microtubule cytoskeleton 2 TUBB3, TUBB4B
nucleolus 1 CST6
apical part of cell 1 LGMN
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 TUBB3
Cytoplasm, cytoskeleton 2 TUBB3, TUBB4B
microtubule 2 TUBB3, TUBB4B
spindle 1 TUBB3
collagen-containing extracellular matrix 1 CST6
Cell projection, filopodium 1 TUBB3
Late endosome 1 LGMN
cell periphery 1 TUBB3
mitotic spindle 2 TUBB3, TUBB4B
cytoskeleton 1 TUBB4B
intercellular bridge 2 TUBB3, TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
Cornified envelope 1 CST6
axonemal microtubule 1 TUBB4B
ficolin-1-rich granule lumen 1 CST6
secretory granule lumen 1 CST6
specific granule lumen 1 LYZ
tertiary granule lumen 2 CST6, LYZ
azurophil granule lumen 2 LYZ, TUBB4B
external side of apical plasma membrane 1 ABCB1
endolysosome lumen 1 LGMN
cell body membrane 1 P2RY12
cell projection membrane 1 P2RY12


文献列表

  • Francisco Bosca, Rosa Tormos. Behavior of drug excited states within macromolecules: binding of colchicine and derivatives to albumin. The journal of physical chemistry. B. 2013 Jun; 117(25):7528-34. doi: 10.1021/jp402489j. [PMID: 23730875]
  • N Skottová, R Vecera, D Walterová, V Simánek. The effect of N-deacetylcolchiceine on serum lipoproteins in rats. Planta medica. 1992 Feb; 58(1):26-30. doi: NULL. [PMID: 1620740]
  • R J Ko, W Y Li, R T Koda. Determination of the antimitotic agents N-desacetylcolchicine, demecolcine and colchicine in serum and urine. Journal of chromatography. 1990 Feb; 525(2):411-8. doi: 10.1016/s0378-4347(00)83417-9. [PMID: 2329167]
  • E Hu, R Ko, R Koda, P Rosen, S Jeffers, M Scholtz, F Muggia. Phase I toxicity and pharmacology study of trimethylcolchicinic acid in patients with advanced malignancies. Cancer chemotherapy and pharmacology. 1990; 26(5):359-64. doi: 10.1007/bf02897294. [PMID: 2208579]