2-Heptyl-3-hydroxy-quinolone (BioDeep_00000008909)
natural product
代谢物信息卡片
2-Heptyl-3-hydroxy-4(1H)-quinolone
化学式: C16H21NO2 (259.1572)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(feces) 2.82%
分子结构信息
SMILES: CCCCCCCC1=C(C(=O)C2=CC=CC=C2N1)O
InChI: InChI=1S/C16H21NO2/c1-2-3-4-5-6-11-14-16(19)15(18)12-9-7-8-10-13(12)17-14/h7-10,19H,2-6,11H2,1H3,(H,17,18)
描述信息
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:29472
- KEGG: C11848
- PubChem: 2763159
- Metlin: METLIN69243
- ChEMBL: CHEMBL2426244
- PMhub: MS000022623
- PubChem: 14010
- PDB-CCD: JWW
- NIKKAJI: J147.303D
- LOTUS: LTS0186467
分类词条
相关代谢途径
Reactome(0)
BioCyc(2)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis:
(2-aminobenzoyl)acetate + H+ + a [PqsC protein]-S-octanoyl-L-cysteine ⟶ 1-(2-aminophenyl)decane-1,3-dione + CO2 + a [PqsC protein]-L-cysteine - superpathway of quinolone and alkylquinolone biosynthesis:
(2-aminobenzoyl)acetyl-CoA ⟶ 4-hydroxy-2(1H)-quinolone + coenzyme A
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 2 - Bacteria: LTS0186467
- 1236 - Gammaproteobacteria: LTS0186467
- 135621 - Pseudomonadaceae: LTS0186467
- 286 - Pseudomonas: LTS0186467
- 287 - Pseudomonas aeruginosa: LTS0186467
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaolei Pan, Han Liang, Xinrui Zhao, Qionglin Zhang, Lei Chen, Zhuo Yue, Liwen Yin, Yongxin Jin, Fang Bai, Zhihui Cheng, Mark Bartlam, Weihui Wu. Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa.
Nucleic acids research.
2023 04; 51(6):2691-2708. doi:
10.1093/nar/gkad059. [PMID: 36744476] - Sandra C Wullich, Alba Arranz San Martín, Susanne Fetzner. An α/β-Hydrolase Fold Subfamily Comprising Pseudomonas Quinolone Signal-Cleaving Dioxygenases.
Applied and environmental microbiology.
2020 04; 86(9):. doi:
10.1128/aem.00279-20. [PMID: 32086305] - Benjamin Bouvier. Curvature as a Collective Coordinate in Enhanced Sampling Membrane Simulations.
Journal of chemical theory and computation.
2019 Dec; 15(12):6551-6561. doi:
10.1021/acs.jctc.9b00716. [PMID: 31665603] - Karmel Webb, Andrew Fogarty, David A Barrett, Edward F Nash, Joanna L Whitehouse, Alan R Smyth, Iain Stewart, Alan Knox, Paul Williams, Nigel Halliday, Miguel Cámara, Helen L Barr. Clinical significance of Pseudomonas aeruginosa 2-alkyl-4-quinolone quorum-sensing signal molecules for long-term outcomes in adults with cystic fibrosis.
Journal of medical microbiology.
2019 Dec; 68(12):1823-1828. doi:
10.1099/jmm.0.001099. [PMID: 31671047] - Viviana Teresa Orlandi, Fabrizio Bolognese, Eleonora Martegani, Vincenzo Cantaluppi, Claudio Medana, Paola Barbieri. Response to photo-oxidative stress of Pseudomonas aeruginosa PAO1 mutants impaired in different functions.
Microbiology (Reading, England).
2017 Nov; 163(11):1557-1567. doi:
10.1099/mic.0.000543. [PMID: 29022867] - Jiayue Yang, Masanori Toyofuku, Ryosuke Sakai, Nobuhiko Nomura. Influence of the alginate production on cell-to-cell communication in Pseudomonas aeruginosa PAO1.
Environmental microbiology reports.
2017 06; 9(3):239-249. doi:
10.1111/1758-2229.12521. [PMID: 28120378] - Lynne Turnbull, Masanori Toyofuku, Amelia L Hynen, Masaharu Kurosawa, Gabriella Pessi, Nicola K Petty, Sarah R Osvath, Gerardo Cárcamo-Oyarce, Erin S Gloag, Raz Shimoni, Ulrich Omasits, Satoshi Ito, Xinhui Yap, Leigh G Monahan, Rosalia Cavaliere, Christian H Ahrens, Ian G Charles, Nobuhiko Nomura, Leo Eberl, Cynthia B Whitchurch. Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms.
Nature communications.
2016 Apr; 7(?):11220. doi:
10.1038/ncomms11220. [PMID: 27075392] - Anitha Vadekeetil, V Alexandar, Sanjay Chhibber, Kusum Harjai. Adjuvant effect of cranberry proanthocyanidin active fraction on antivirulent property of ciprofloxacin against Pseudomonas aeruginosa.
Microbial pathogenesis.
2016 Jan; 90(?):98-103. doi:
10.1016/j.micpath.2015.11.024. [PMID: 26620081] - J N Gorantla, S Nishanth Kumar, G V Nisha, A S Sumandu, C Dileep, A Sudaresan, M M Sree Kumar, R S Lankalapalli, B S Dileep Kumar. Purification and characterization of antifungal phenazines from a fluorescent Pseudomonas strain FPO4 against medically important fungi.
Journal de mycologie medicale.
2014 Sep; 24(3):185-92. doi:
10.1016/j.mycmed.2014.02.003. [PMID: 24746721] - Thiba Krishnan, Wai-Fong Yin, Kok-Gan Chan. Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa PAO1 by Ayurveda spice clove (Syzygium aromaticum) bud extract.
Sensors (Basel, Switzerland).
2012; 12(4):4016-30. doi:
10.3390/s120404016. [PMID: 22666015] - Laurène Fito-Boncompte, Annelise Chapalain, Emeline Bouffartigues, Hichem Chaker, Olivier Lesouhaitier, Gwendoline Gicquel, Alexis Bazire, Amar Madi, Nathalie Connil, Wilfried Véron, Laure Taupin, Bertrand Toussaint, Pierre Cornelis, Qing Wei, Koki Shioya, Eric Déziel, Marc G J Feuilloley, Nicole Orange, Alain Dufour, Sylvie Chevalier. Full virulence of Pseudomonas aeruginosa requires OprF.
Infection and immunity.
2011 Mar; 79(3):1176-86. doi:
10.1128/iai.00850-10. [PMID: 21189321] - Jin-Hyung Lee, Moo Hwan Cho, Jintae Lee. 3-indolylacetonitrile decreases Escherichia coli O157:H7 biofilm formation and Pseudomonas aeruginosa virulence.
Environmental microbiology.
2011 Jan; 13(1):62-73. doi:
10.1111/j.1462-2920.2010.02308.x. [PMID: 20649646] - Gregory C Palmer, Jeffrey W Schertzer, Lauren Mashburn-Warren, Marvin Whiteley. Quantifying Pseudomonas aeruginosa quinolones and examining their interactions with lipids.
Methods in molecular biology (Clifton, N.J.).
2011; 692(?):207-17. doi:
10.1007/978-1-60761-971-0_15. [PMID: 21031314] - Giordano Rampioni, Christian Pustelny, Matthew P Fletcher, Victoria J Wright, Mary Bruce, Kendra P Rumbaugh, Stephan Heeb, Miguel Cámara, Paul Williams. Transcriptomic analysis reveals a global alkyl-quinolone-independent regulatory role for PqsE in facilitating the environmental adaptation of Pseudomonas aeruginosa to plant and animal hosts.
Environmental microbiology.
2010 Jun; 12(6):1659-73. doi:
10.1111/j.1462-2920.2010.02214.x. [PMID: 20406282] - Jennifer M Bomberger, Daniel P Maceachran, Bonita A Coutermarsh, Siying Ye, George A O'Toole, Bruce A Stanton. Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles.
PLoS pathogens.
2009 Apr; 5(4):e1000382. doi:
10.1371/journal.ppat.1000382. [PMID: 19360133] - Séverine Aendekerk, Stephen P Diggle, Zhijun Song, Niels Høiby, Pierre Cornelis, Paul Williams, Miguel Cámara. The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication.
Microbiology (Reading, England).
2005 Apr; 151(Pt 4):1113-1125. doi:
10.1099/mic.0.27631-0. [PMID: 15817779]
