BPP 9a (BioDeep_00000008823)

   


代谢物信息卡片


ethyl4-ethoxy-6-methylnicotinate

化学式: C53H76N14O12 (1100.5766856)
中文名称: 替普罗肽
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(C(=O)N1CCCC1C(=O)N2CCCC2C(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCN=C(N)N)NC(=O)C4CCCN4C(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C7CCC(=O)N7
InChI: InChI=1S/C53H76N14O12/c1-3-29(2)43(51(77)66-25-9-16-39(66)50(76)67-26-10-17-40(67)52(78)79)63-45(71)34(18-20-41(54)68)60-46(72)37-14-7-23-64(37)48(74)35(13-6-22-57-53(55)56)61-47(73)38-15-8-24-65(38)49(75)36(62-44(70)33-19-21-42(69)59-33)27-30-28-58-32-12-5-4-11-31(30)32/h4-5,11-12,28-29,33-40,43,58H,3,6-10,13-27H2,1-2H3,(H2,54,68)(H,59,69)(H,60,72)(H,61,73)(H,62,70)(H,63,71)(H,78,79)(H4,55,56,57)

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Same as: D06076
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

3 个代谢物同义名

Teprotide; BPP 9a; ethyl4-ethoxy-6-methylnicotinate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Raphael N Vuille-dit-Bille, Simone M Camargo, Luca Emmenegger, Tom Sasse, Eva Kummer, Julia Jando, Qeumars M Hamie, Chantal F Meier, Schirin Hunziker, Zsofia Forras-Kaufmann, Sena Kuyumcu, Mark Fox, Werner Schwizer, Michael Fried, Maja Lindenmeyer, Oliver Götze, François Verrey. Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors. Amino acids. 2015 Apr; 47(4):693-705. doi: 10.1007/s00726-014-1889-6. [PMID: 25534429]
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  • Giovambattista De Sarro, Eugenio Donato Di Paola, Santo Gratteri, Pietro Gareri, Vincenzo Rispoli, Antonio Siniscalchi, Giovanni Tripepi, Luca Gallelli, Rita Citraro, Emilio Russo. Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. Pharmacological research. 2012 Mar; 65(3):285-96. doi: 10.1016/j.phrs.2011.11.005. [PMID: 22107891]
  • Maxim N Petrov, Valery Y Shilo, Alexandr V Tarasov, David E Schwartz, Joe G N Garcia, Olga A Kost, Sergei M Danilov. Conformational changes of blood ACE in chronic uremia. PloS one. 2012; 7(11):e49290. doi: 10.1371/journal.pone.0049290. [PMID: 23166630]
  • Jung Keun Cho, Young Bae Ryu, Marcus J Curtis-Long, Ji Young Kim, Doman Kim, Sun Lee, Woo Song Lee, Ki Hun Park. Inhibition and structural reliability of prenylated flavones from the stem bark of Morus lhou on β-secretase (BACE-1). Bioorganic & medicinal chemistry letters. 2011 May; 21(10):2945-8. doi: 10.1016/j.bmcl.2011.03.060. [PMID: 21511472]
  • Yoshihiro Mori, Yasuhiro Nishikawa, Tomoko Iizuka, Natsuko Zenimura, Takuyuki Matsumoto, Katsutoshi Hiramatsu, Masahiro Komiya. Artist® tablets (carvedilol) for hypertensive patients in Japan: results of a drug use survey. Drugs in R&D. 2011; 11(2):171-90. doi: 10.2165/11592450-000000000-00000. [PMID: 21679007]
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  • Yan-hua Lu, Juan Chen, Dong-zhi Wei, Zheng-tao Wang, Xin-yi Tao. Tyrosinase inhibitory effect and inhibitory mechanism of tiliroside from raspberry. Journal of enzyme inhibition and medicinal chemistry. 2009 Oct; 24(5):1154-60. doi: 10.1080/14756360802694252. [PMID: 19772488]
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  • Pei Chia Eng, Wendy Chen-Nee Chua, Valerie Suk Peng Chew, Peter Tsun Hon Wong, Jian Lin Yin, Brett Hambly, Craig Steven McLachlan. Chronic angiotensin-converting enzyme inhibition up-regulates mouse kidney growth arrest specific-6 protein and the AXL subfamily of receptor tyrosine kinases. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2008 Dec; 9(4):238-41. doi: 10.1177/1470320308098342. [PMID: 19126665]
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  • Charles J Diskin, Thomas J Stokes, Linda M Dansby, Lautrec Radcliff, Thomas B Carter. Does the hyperfiltration of minoxidil result in increased proteinuria and loss of renoprotection conferred by angiotensin inhibition?. Kidney & blood pressure research. 2006; 29(1):54-9. doi: 10.1159/000092947. [PMID: 16645303]
  • George L Bakris, Vivian Fonseca, Richard E Katholi, Janet B McGill, Franz Messerli, Robert A Phillips, Philip Raskin, Jackson T Wright, Brian Waterhouse, Mary Ann Lukas, Karen M Anderson, David S H Bell. Differential effects of beta-blockers on albuminuria in patients with type 2 diabetes. Hypertension (Dallas, Tex. : 1979). 2005 Dec; 46(6):1309-15. doi: 10.1161/01.hyp.0000190585.54734.48. [PMID: 16286578]
  • Yukinobu Uchiyama, Junko Tagami, Shinji Kamisuki, Nobuyuki Kasai, Masahiko Oshige, Hiroyuki Chiku, Siroh Ibe, Osamu Koiwai, Fumio Sugawara, Kengo Sakaguchi. Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin. Biochimica et biophysica acta. 2005 Oct; 1725(3):298-304. doi: 10.1016/j.bbagen.2005.06.017. [PMID: 16099107]
  • Qing Ling Duan, Borzoo Nikpoor, Marie-Pierre Dube, Giuseppe Molinaro, Inge A Meijer, Patrick Dion, Daniel Rochefort, Judith Saint-Onge, Leah Flury, Nancy J Brown, James V Gainer, Jean L Rouleau, Angelo Agostoni, Massimo Cugno, Pierre Simon, Pierre Clavel, Jacky Potier, Bassem Wehbe, Seddik Benarbia, Julien Marc-Aurele, Jacques Chanard, Tatiana Foroud, Albert Adam, Guy A Rouleau. A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. American journal of human genetics. 2005 Oct; 77(4):617-26. doi: 10.1086/496899. [PMID: 16175507]
  • Nadia Canu, Roberta Tufi, Anna Lucia Serafino, Giuseppina Amadoro, Maria Teresa Ciotti, Pietro Calissano. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. Journal of neurochemistry. 2005 Mar; 92(5):1228-42. doi: 10.1111/j.1471-4159.2004.02956.x. [PMID: 15715672]
  • Anna Wasilewska, Walentyna Zoch-Zwierz, Barbara Tomaszewska, Edyta Tenderenda. [The effect of cyclosporine A in steroid-dependent nephrotic syndrome in children]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2005 Feb; 18(104):168-72. doi: NULL. [PMID: 17877123]
  • Henry Krum, Peter Carson, Csaba Farsang, Aldo P Maggioni, Robert D Glazer, Nora Aknay, Yann-Tong Chiang, Jay N Cohn. Effect of valsartan added to background ACE inhibitor therapy in patients with heart failure: results from Val-HeFT. European journal of heart failure. 2004 Dec; 6(7):937-45. doi: 10.1016/j.ejheart.2004.09.005. [PMID: 15556056]
  • Manuel Praga, Carlos Fernández Andrade, José Luño, Manuel Arias, Rafael Poveda, Jose Mora, Marti Valles Prat, Francisco Rivera, Jose María Galceran, Jorge Martínez Ara, Román Aguirre, Carmen Bernis, Rafael Marín, Jose María Campistol. Antiproteinuric efficacy of losartan in comparison with amlodipine in non-diabetic proteinuric renal diseases: a double-blind, randomized clinical trial. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2003 Sep; 18(9):1806-13. doi: 10.1093/ndt/gfg284. [PMID: 12937228]
  • Eike Wrenger, Regina Müller, Michael Moesenthin, Tobias Welte, Jürgen C Frölich, Klaus H Neumann. Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases. BMJ (Clinical research ed.). 2003 Jul; 327(7407):147-9. doi: 10.1136/bmj.327.7407.147. [PMID: 12869459]
  • Ingrid Os, Christina S Fredheim, Branimir Draganov, Aud Høieggen, Kjersti Svendsen Andersson. [Acute renal failure during the treatment of heart failure with ACE inhibitors]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 2003 Jan; 123(1):30-2. doi: NULL. [PMID: 12600146]
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  • Simona Daniela Ionescu, V Sandru, Elena Leuciuc, Paloma Manea, Alina Burdujan, Svetlana Tovarniţchi, A Cosovanu. [Undesirable effects and interaction to angiotensin converting enzyme inhibitors therapy]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 2002 Jan; 106(1):128-31. doi: NULL. [PMID: 12635373]
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  • L Barber, J Barrio, M D de Rojas, F Ibañez, C Añó, R Alepuz, R Montero. [Refractory hypotension sustained during general anesthesia due to chronic treatment with angiotensin-converting enzyme inhibitors]. Revista espanola de anestesiologia y reanimacion. 2001 Jan; 48(1):34-7. doi: NULL. [PMID: 11234604]
  • M Katoh, Y Ohmachi, Y Kurosawa, H Yoneda, N Tanaka, H Narita. Effects of imidapril and captopril on streptozotocin-induced diabetic nephropathy in mice. European journal of pharmacology. 2000 Jun; 398(3):381-7. doi: 10.1016/s0014-2999(00)00320-4. [PMID: 10862828]
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