Ticrynafen (BioDeep_00000008814)
Secondary id: BioDeep_00001871379
human metabolite blood metabolite
代谢物信息卡片
2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid
化学式: C13H8Cl2O4S (329.95203480000004)
中文名称: 替宁酸
谱图信息:
最多检出来源 Homo sapiens(blood) 97.62%
分子结构信息
SMILES: C1=CSC(=C1)C(=O)C2=C(C(=C(C=C2)OCC(=O)O)Cl)Cl
InChI: InChI=1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17)
描述信息
C - Cardiovascular system > C03 - Diuretics > C03C - High-ceiling diuretics > C03CC - Aryloxyacetic acid derivatives
D018501 - Antirheumatic Agents > D006074 - Gout Suppressants > D014528 - Uricosuric Agents
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49184 - Loop Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
C26170 - Protective Agent > C921 - Uricosuric Agent
D045283 - Natriuretic Agents > D004232 - Diuretics
Same as: D02386
同义名列表
19 个代谢物同义名
2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid; (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid; (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetate; 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid; (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid; 4-(2-Thienylketo)-2,3-dichlorophenoxyacetate; 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure; (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetate; Acidum tienilicum; Acide tienilique; Acido tienilico; Acid, thienylic; Acid, tienilic; Thienylic acid; Tienilic acid; Ticrynafen; Thienylate; Tienilate; Selacryn
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:9590
- KEGG: C11702
- PubChem: 38409
- HMDB: HMDB0259082
- Metlin: METLIN2854
- DrugBank: DB04831
- ChEMBL: CHEMBL267744
- Wikipedia: Tienilic_acid
- MeSH: Ticrynafen
- chemspider: 35204
- CAS: 40180-04-9
- PMhub: MS000022515
- PubChem: 13867
- NIKKAJI: J16.869F
- RefMet: Ticrynafen
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tomonori Miura, Shotaro Uehara, Makiko Shimizu, Norie Murayama, Masahiro Utoh, Hiroshi Suemizu, Hiroshi Yamazaki. Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice.
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Molecular pharmacology.
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Archives of pathology & laboratory medicine.
1980 Dec; 104(12):656. doi:
NULL. [PMID: 6893663] - B T Emmerson. Uricosuric diuretics.
Kidney international.
1980 Nov; 18(5):677-85. doi:
10.1038/ki.1980.185. [PMID: 7463959] - F A Hubbell, M A Weber, B B Megaffin, D D Brewer. Acute reversible renal impairment produced by a uricosuric diuretic.
The Western journal of medicine.
1980 Nov; 133(5):444-6. doi:
NULL. [PMID: 7467301] - J B Myers, A Gillies, S Waga, T O Morgan. Effect of tienilic acid and amiloride in healthy volunteers and in hypertensives with normal renal function.
British journal of clinical pharmacology.
1980 Oct; 10(4):345-51. doi:
10.1111/j.1365-2125.1980.tb01770.x. [PMID: 7004473] - NULL. Diuretics, hyperuricaemia, and tienilic acid.
Lancet (London, England).
1980 Sep; 2(8196):681-2. doi:
NULL. [PMID: 6106790] - R G Walker, C K Yeung, A S Hua, G W Thomas, J A Whitworth, P Kincaid-Smith. Tienilic acid in the treatment of mild to moderate hypertension.
Clinical and experimental pharmacology & physiology.
1980 Sep; 7(5):473-6. doi:
10.1111/j.1440-1681.1980.tb00094.x. [PMID: 7004678] - J A Reardon, J T Scott. Controlled inpatient study of tienilic acid in treatment of gout and hypertension.
Annals of the rheumatic diseases.
1980 Aug; 39(4):367-72. doi:
10.1136/ard.39.4.367. [PMID: 7436563] - C Oker-Blom, J Mäkinen, G Gothoni. Toxicological studies on tienilic acid in rats.
Toxicology letters.
1980 Jul; 6(2):93-9. doi:
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
1980 Jun; 57(26):1069-72. doi:
NULL. [PMID: 6996137] - C Eugène, C Patriarche, A Bergue, J Quevauvilliers. [Tienilic acid as a likely cause of "auto immune" active hepatitis (author's transl)].
La Nouvelle presse medicale.
1980 Jun; 9(27):1885-7. doi:
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La Nouvelle presse medicale.
1980 Jun; 9(27):1881-4. doi:
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British medical journal.
1980 May; 280(6225):1212. doi:
10.1136/bmj.280.6225.1212. [PMID: 7388469] - T G Murray, S Brown, J W Dubb, B Y Hwang, R M Stote. Ticrynafen in anephric patients: effects on uric acid and pharmacokinetics.
Clinical pharmacology and therapeutics.
1980 May; 27(5):686-9. doi:
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International journal of clinical pharmacology, therapy, and toxicology.
1980 Apr; 18(4):158-62. doi:
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Die Medizinische Welt.
1980 Feb; 31(7):III. doi:
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JAMA.
1980 Feb; 243(8):763-4. doi:
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JAMA.
1980 Feb; 243(8):764-5. doi:
NULL. [PMID: 7351818] - H Sawa, H Yamakawa, L E Renjel, M Fernandes. Acute renal failure during treatment with ticrynafen.
JAMA.
1980 Feb; 243(8):766-7. doi:
NULL. [PMID: 7351819] - C Plessas, A Benakis. Binding of Tienilic acid (Diflurex) to human plasma proteins and erythrocytes.
European journal of drug metabolism and pharmacokinetics.
1980; 5(2):107-12. doi:
10.1007/bf03189453. [PMID: 7398676] - J Prandota, J P Tillement, P d'Athis, T Drüeke, S Digiulio. Binding of tienilic acid (Diflurex) to human serum albumin and to plasma of normal subjects and uraemic patients.
European journal of drug metabolism and pharmacokinetics.
1980; 5(2):99-106. doi:
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JAMA.
1979 Dec; 242(26):2876-8. doi:
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The New England journal of medicine.
1979 Dec; 301(25):1378-82. doi:
10.1056/nejm197912203012505. [PMID: 503168] - A Lechi, G Covi, G Danti, A D Riva, E Pedrolli, S Pomari. An evaluation of tienilic acid, a new diuretic uricosuric agent, in the therapy of arterial hypertension.
Clinical science (London, England : 1979).
1979 Dec; 57 Suppl 5(?):367s-269s. doi:
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The New England journal of medicine.
1979 Nov; 301(21):1179-80. doi:
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The New England journal of medicine.
1979 Nov; 301(21):1180. doi:
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The New England journal of medicine.
1979 Nov; 301(21):1180-1. doi:
NULL. [PMID: 492285] - W C Randolph, V L Osborne, A P Intoccia. High-pressure liquid chromatographic analysis of ticrynafen and one of its metabolites in urine and serum.
Journal of pharmaceutical sciences.
1979 Nov; 68(11):1451-3. doi:
10.1002/jps.2600681131. [PMID: 512898] - C Ponticelli, A Lechi, T di Perri, B Redaelli, F Locatelli, E Rivolta, G Covi, G L Messa, G Pincella, L Pedrini, M Recchia, P Gouère. Multicentre comparative trial of tienilic acid and hydrochlorothiazide in hypertensive patients.
European journal of clinical pharmacology.
1979 Nov; 16(5):319-22. doi:
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British medical journal.
1979 Jan; 1(6158):224-6. doi:
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