BQ-123 (BioDeep_00000008741)

   


代谢物信息卡片


Cyclo[D-trp-D-asp-L-pro-D-val-L-leu]

化学式: C31H42N6O7 (610.3114822)
中文名称: BQ-123
谱图信息: 最多检出来源 Anoectochilus roxburghii(viridiplantae) 87.5%

分子结构信息

SMILES: CC(C)CC1C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43
InChI: InChI=1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1

描述信息

D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D065128 - Endothelin Receptor Antagonists
BQ-123 is a potent and selective endothelin A (ETA) receptor antagonist with an IC50 of 7.3 nM and a Ki of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension[1][2][3].

同义名列表

5 个代谢物同义名

Cyclo[D-trp-D-asp-L-pro-D-val-L-leu]; Cyclo(D-trp-D-asp-pro-D-val-leu); BQ 123; BQ-123; BCP29354



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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INOH(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xia Sun, Shuping Zhang, Haitao Song. Quercetin attenuates reduced uterine perfusion pressure -induced hypertension in pregnant rats through regulation of endothelin-1 and endothelin-1 type A receptor. Lipids in health and disease. 2020 Aug; 19(1):180. doi: 10.1186/s12944-020-01357-w. [PMID: 32758232]
  • Natalie K Jones, Kevin Stewart, Alicja Czopek, Robert I Menzies, Adrian Thomson, Carmel M Moran, Carolynn Cairns, Bryan R Conway, Laura Denby, Dawn E W Livingstone, John Wiseman, Patrick W Hadoke, David J Webb, Neeraj Dhaun, James W Dear, John J Mullins, Matthew A Bailey. Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation. Hypertension (Dallas, Tex. : 1979). 2020 05; 75(5):1213-1222. doi: 10.1161/hypertensionaha.119.14308. [PMID: 32200679]
  • Lobna M Abdel Moneim, Maged W Helmy, Hanan S El-Abhar. Co-targeting of endothelin-A and vitamin D receptors: a novel strategy to ameliorate cisplatin-induced nephrotoxicity. Pharmacological reports : PR. 2019 Oct; 71(5):917-925. doi: 10.1016/j.pharep.2019.04.018. [PMID: 31430707]
  • Nadir Planes, Michelle A Digman, Patrick P M L Vanderheyden, Enrico Gratton, Catherina Caballero-George. Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding. Biochimica et biophysica acta. General subjects. 2019 05; 1863(5):917-924. doi: 10.1016/j.bbagen.2019.03.004. [PMID: 30851407]
  • Quanyang Wu, Ruibin Zheng, Jiao Wang, Jiaqi Wang, Songbai Li. CT perfusion imaging of cerebral microcirculatory changes following subarachnoid hemorrhage in rabbits: Specific role of endothelin-1 receptor antagonist. Brain research. 2018 12; 1701(?):196-203. doi: 10.1016/j.brainres.2018.09.025. [PMID: 30244111]
  • Jérémy Bellien, Michèle Iacob, Christelle Monteil, Isabelle Rémy-Jouet, Clothilde Roche, Thomas Duflot, Cathy Vendeville, Laurence Gutierrez, Christian Thuillez, Vincent Richard, Robinson Joannidès. Physiological role of endothelin-1 in flow-mediated vasodilatation in humans and impact of cardiovascular risk factors. Journal of hypertension. 2017 06; 35(6):1204-1212. doi: 10.1097/hjh.0000000000001307. [PMID: 28441692]
  • Francesca Schinzari, Augusto Veneziani, Nadia Mores, Angela Barini, Nicola Di Daniele, Carmine Cardillo, Manfredi Tesauro. Vascular Effects of Obestatin in Lean and Obese Subjects. Diabetes. 2017 05; 66(5):1214-1221. doi: 10.2337/db16-1067. [PMID: 28174289]
  • Terry W Moody, Irene Ramos-Alvarez, Paula Moreno, Samuel A Mantey, Lisa Ridnour, David Wink, Robert T Jensen. Endothelin causes transactivation of the EGFR and HER2 in non-small cell lung cancer cells. Peptides. 2017 04; 90(?):90-99. doi: 10.1016/j.peptides.2017.01.012. [PMID: 28153500]
  • Yuan Sun, Xicheng Zhang, Zhaolei Chen, Miao Xu, Minghui Ou. Reduction of Uterine Perfusion Pressure Induced Redistribution of Endothelin Receptor Type-B Between the Intima and Media Contributes to the Pathogenesis of Pregnancy-Induced Hypertension. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 44(5):1715-1725. doi: 10.1159/000485777. [PMID: 29216636]
  • P Kleniewska, A Gorąca. Influence of endothelin 1 receptor blockers and a nitric oxide synthase inhibitor on reactive oxygen species formation in rat lungs. Physiological research. 2016 11; 65(5):789-798. doi: 10.33549/physiolres.933263. [PMID: 27429120]
  • Elizabeth Portugal Velloso, Renata Lúcia Pimentel, Janaína F Braga, Antônio Carlos Vieira Cabral, Zilma Silveira N Reis, Michael Bader, Robson Augusto S Santos, Gerd Wallukat. Identification of a Novel Agonist-Like Autoantibody in Preeclamptic Patients. American journal of hypertension. 2016 Mar; 29(3):405-12. doi: 10.1093/ajh/hpv099. [PMID: 26158852]
  • Stephanie Franzén, Fredrik Palm. Endothelin type A receptor inhibition normalises intrarenal hypoxia in rats used as a model of type 1 diabetes by improving oxygen delivery. Diabetologia. 2015 Oct; 58(10):2435-42. doi: 10.1007/s00125-015-3690-9. [PMID: 26173672]
  • Agata Kowalczyk, Paulina Kleniewska, Michal Kolodziejczyk, Beata Skibska, Anna Goraca. The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis. Archivum immunologiae et therapiae experimentalis. 2015 Feb; 63(1):41-52. doi: 10.1007/s00005-014-0310-1. [PMID: 25288367]
  • Yeo Ok Kim, In Ji Kim, Myung Ha Yoon. Antiallodynic effect through spinal endothelin-B receptor antagonism in rat models of complex regional pain syndrome. Neuroscience letters. 2015 Jan; 584(?):45-9. doi: 10.1016/j.neulet.2014.10.005. [PMID: 25451723]
  • Umarat Srisawat, Surachai Kongrat, Chatchai Muanprasat, Varanuj Chatsudthipong. Losartan and Sodium Nitroprusside Effectively Protect against Renal Impairments after Ischemia and Reperfusion in Rats. Biological & pharmaceutical bulletin. 2015; 38(5):753-62. doi: 10.1248/bpb.b14-00860. [PMID: 25947921]
  • C Adlbrecht, R Wurm, M Humenberger, M Andreas, B Redwan, K Distelmaier, G Klappacher, I M Lang. Peri-interventional endothelin--a receptor blockade improves long-term outcome in patients with ST-elevation acute myocardial infarction. Thrombosis and haemostasis. 2014 Jul; 112(1):176-82. doi: 10.1160/th13-10-0832. [PMID: 24695986]
  • Umberto Campia, Linda A Matuskey, Manfredi Tesauro, Carmine Cardillo, Julio A Panza. PPARγ activation does not affect endothelin activity in non-diabetic patients with hypertension or hypercholesterolemia. Atherosclerosis. 2014 Jun; 234(2):436-40. doi: 10.1016/j.atherosclerosis.2014.03.035. [PMID: 24769306]
  • Mai M Helmy, Maged W Helmy, Dina M Abd Allah, Ahmad M Abo Zaid, Mahmoud M Mohy El-Din. Selective ET(A) receptor blockade protects against cisplatin-induced acute renal failure in male rats. European journal of pharmacology. 2014 May; 730(?):133-9. doi: 10.1016/j.ejphar.2014.03.002. [PMID: 24632086]
  • Giuseppe Faraco, Ana Moraga, Jamie Moore, Joseph Anrather, Virginia M Pickel, Costantino Iadecola. Circulating endothelin-1 alters critical mechanisms regulating cerebral microcirculation. Hypertension (Dallas, Tex. : 1979). 2013 Oct; 62(4):759-66. doi: 10.1161/hypertensionaha.113.01761. [PMID: 23959559]
  • Jianjun Zhou, Daliao Xiao, Yali Hu, Zhiqun Wang, Alexandra Paradis, Eugenia Mata-Greenwood, Lubo Zhang. Gestational hypoxia induces preeclampsia-like symptoms via heightened endothelin-1 signaling in pregnant rats. Hypertension (Dallas, Tex. : 1979). 2013 Sep; 62(3):599-607. doi: 10.1161/hypertensionaha.113.01449. [PMID: 23817493]
  • I Brochu, M Houde, L Desbiens, E Simard, F Gobeil, W Semaan, G Bkaily, P D'Orléans-Juste. High salt-induced hypertension in B2 knockout mice is corrected by the ETA antagonist, A127722. British journal of pharmacology. 2013 Sep; 170(2):266-77. doi: 10.1111/bph.12259. [PMID: 23713522]
  • Francesca Schinzari, Manfredi Tesauro, Valentina Rovella, Nicola Di Daniele, Nadia Mores, Augusto Veneziani, Carmine Cardillo. Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome. The Journal of clinical endocrinology and metabolism. 2013 Mar; 98(3):1235-41. doi: 10.1210/jc.2012-3424. [PMID: 23372172]
  • Kelly A Hyndman, Alexander H MacDonell, Jennifer S Pollock. Extracellular signal-regulated kinases 1/2 signaling pathways are not involved in endothelin regulation of mouse inner medullary collecting duct nitric oxide production. Life sciences. 2012 Oct; 91(13-14):578-82. doi: 10.1016/j.lfs.2012.01.014. [PMID: 23293787]
  • Aleksandra Piechota-Polańczyk, Anna Gorąca. Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia. Pharmacological reports : PR. 2012; 64(6):1434-41. doi: 10.1016/s1734-1140(12)70941-6. [PMID: 23406754]
  • Ai-Dong Chen, Xiao-Qing Xiong, Xian-Bing Gan, Feng Zhang, Ye-Bo Zhou, Xing-Ya Gao, Ying Han. Endothelin-1 in paraventricular nucleus modulates cardiac sympathetic afferent reflex and sympathetic activity in rats. PloS one. 2012; 7(7):e40748. doi: 10.1371/journal.pone.0040748. [PMID: 22815806]
  • Aso Saeed, Gerald F Dibona, Gregor Guron. Effects of endothelin receptor antagonists on renal hemodynamics in angiotensin II-infused rats on high NaCl intake. Kidney & blood pressure research. 2012; 36(1):258-67. doi: 10.1159/000343415. [PMID: 23171921]
  • Wei Chen, Liang Liang, Tao Ma, Junjian Li, Guodong Xu, Yun Zhang, Xueli Bai, Tingbo Liang. Role of hepatic stellate cells on graft injury after small-for-size liver transplantation. Journal of gastroenterology and hepatology. 2011 Nov; 26(11):1659-68. doi: 10.1111/j.1440-1746.2011.06781.x. [PMID: 21592229]
  • Sven-Olof Granstam, Elisabet Granstam. Endothelin-induced changes in blood flow in STZ-diabetic and non-diabetic rats: relation to nitric oxide synthase and cyclooxygenase inhibition. The journal of physiological sciences : JPS. 2011 Nov; 61(6):497-505. doi: 10.1007/s12576-011-0171-x. [PMID: 21881977]
  • Shinji Takashimizu, Seiichiro Kojima, Yasuhiro Nishizaki, Tatehiro Kagawa, Koichi Shiraishi, Tetsuya Mine, Norihito Watanabe. Effect of endothelin A receptor antagonist on hepatic hemodynamics in cirrhotic rats. Implications for endothelin-1 in portal hypertension. The Tokai journal of experimental and clinical medicine. 2011 Jul; 36(2):37-43. doi: NULL. [PMID: 21769771]
  • I J Tsai, K D Croft, I B Puddey, L J Beilin, A Barden. 20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1. American journal of physiology. Heart and circulatory physiology. 2011 Apr; 300(4):H1194-200. doi: 10.1152/ajpheart.00733.2010. [PMID: 21239640]
  • Aleksandra Piechota, Andrzej Polańczyk, Anna Goraca. Protective effects of endothelin-A receptor antagonist BQ123 against LPS-induced oxidative stress in lungs. Pharmacological reports : PR. 2011; 63(2):494-500. doi: 10.1016/s1734-1140(11)70516-3. [PMID: 21602605]
  • Ulla C Kopp, Michael Z Cicha, Susan Y Jones. Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure. Canadian journal of physiology and pharmacology. 2010 Jun; 88(6):622-9. doi: 10.1139/y10-035. [PMID: 20628427]
  • Maria A Cavasin, Hillary Semus, Kelly Pitts, Yanyu Peng, Jennifer Sandoval, Joseph Chapo, Craig F Plato. Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats. Canadian journal of physiology and pharmacology. 2010 Jun; 88(6):636-43. doi: 10.1139/y10-038. [PMID: 20628429]
  • Y Chen, M Hanaoka, Y Droma, P Chen, N F Voelkel, K Kubo. Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats. The European respiratory journal. 2010 Apr; 35(4):904-12. doi: 10.1183/09031936.00003909. [PMID: 19897563]
  • Kazuya Miyagawa, Noriaki Emoto, Bambang Widyantoro, Kazuhiko Nakayama, Keiko Yagi, Yoshiyuki Rikitake, Takashi Suzuki, Ken-ichi Hirata. Attenuation of Doxorubicin-induced cardiomyopathy by endothelin-converting enzyme-1 ablation through prevention of mitochondrial biogenesis impairment. Hypertension (Dallas, Tex. : 1979). 2010 Mar; 55(3):738-46. doi: 10.1161/hypertensionaha.109.141903. [PMID: 20101000]
  • Li Han, Qing-yun Li, Ling Zhou, Xi Wang, Zhi-yao Bao, Min Li, Huan-ying Wan, Guo-chao Shi. Effects of thrombolytic drugs and a selective endothelin-1 receptor antagonist on acute pulmonary thromboembolism in dogs. Chinese medical journal. 2010 Feb; 123(4):395-400. doi: NULL. [PMID: 20193475]
  • Takayuki Matsumoto, Yuta Ozawa, Kumiko Taguchi, Tsuneo Kobayashi, Katsuo Kamata. Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction. Peptides. 2010 Feb; 31(2):346-53. doi: 10.1016/j.peptides.2009.11.029. [PMID: 19962413]
  • Navneet S Rehsia, Naranjan S Dhalla. Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure. Heart failure reviews. 2010 Jan; 15(1):85-101. doi: 10.1007/s10741-009-9152-z. [PMID: 19763821]
  • Chaoqin Xie, Donna H Wang. Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance. Hypertension (Dallas, Tex. : 1979). 2009 Dec; 54(6):1298-305. doi: 10.1161/hypertensionaha.109.132167. [PMID: 19858408]
  • Yao Wang, Zhuo-Jun Huang, Jun-Qiu Song, Yan-Na Wu, Yan-Xia Liu. [Cardioprotection of ramipril and BQ-123 against myocardial ischemia/reperfusion injury in vivo in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2009 Nov; 25(4):478-82. doi: NULL. [PMID: 21158037]
  • Jeremy P Langrish, Magnus Lundbäck, Nicholas L Mills, Neil R Johnston, David J Webb, Thomas Sandström, Anders Blomberg, David E Newby. Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans. Hypertension (Dallas, Tex. : 1979). 2009 Oct; 54(4):910-5. doi: 10.1161/hypertensionaha.109.135947. [PMID: 19687345]
  • Neeraj Dhaun, Iain M Macintyre, Vanessa Melville, Pajaree Lilitkarntakul, Neil R Johnston, Jane Goddard, David J Webb. Effects of endothelin receptor antagonism relate to the degree of renin-angiotensin system blockade in chronic proteinuric kidney disease. Hypertension (Dallas, Tex. : 1979). 2009 Sep; 54(3):e19-20. doi: 10.1161/hypertensionaha.109.138263. [PMID: 19652085]
  • Ulla C Kopp, Olaf Grisk, Michael Z Cicha, Lori A Smith, Antje Steinbach, Torsten Schlüter, Nicole Mähler, Tomas Hökfelt. Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 Aug; 297(2):R337-51. doi: 10.1152/ajpregu.91029.2008. [PMID: 19474389]
  • Neeraj Dhaun, Iain M Macintyre, Vanessa Melville, Pajaree Lilitkarntakul, Neil R Johnston, Jane Goddard, David J Webb. Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease. Hypertension (Dallas, Tex. : 1979). 2009 Jul; 54(1):113-9. doi: 10.1161/hypertensionaha.109.132670. [PMID: 19506099]
  • Ariela Benigni, Giuseppe Remuzzi. Treatment of chronic proteinuric kidney disease: what next?. Hypertension (Dallas, Tex. : 1979). 2009 Jul; 54(1):29-31. doi: 10.1161/hypertensionaha.109.133579. [PMID: 19506097]
  • Amie K Lund, JoAnn Lucero, Selitá Lucas, Michael C Madden, Jacob D McDonald, Jean-Clare Seagrave, Travis L Knuckles, Matthew J Campen. Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways. Arteriosclerosis, thrombosis, and vascular biology. 2009 Apr; 29(4):511-7. doi: 10.1161/atvbaha.108.176107. [PMID: 19150882]
  • Christopher D Mann, Matthew S Metcalfe, Michael L Nicholson. Normothermic perfusion of ischaemic porcine kidneys: an evaluation of ex vivo function and endothelin receptor antagonism. Journal of nephrology. 2009 Jan; 22(1):144-51. doi: . [PMID: 19229830]
  • Geoffrey Burnstock. Endothelium-derived vasoconstriction by purines and pyrimidines. Circulation research. 2008 Nov; 103(10):1056-7. doi: 10.1161/circresaha.108.187963. [PMID: 18988902]
  • Markus Tölle, Vera Jankowski, Mirjam Schuchardt, Annette Wiedon, Tao Huang, Franziska Hub, Joanna Kowalska, Jacek Jemielity, Andrzej Guranowski, Christoph Loddenkemper, Walter Zidek, Joachim Jankowski, Markus van der Giet. Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor. Circulation research. 2008 Nov; 103(10):1100-8. doi: 10.1161/circresaha.108.177865. [PMID: 18832747]
  • Fernando de Paiva Conte, Christina Barja-Fidalgo, Waldiceu A Verri, Fernando Queiroz Cunha, Giles A Rae, Carmen Penido, Maria das Graças M O Henriques. Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1. Journal of leukocyte biology. 2008 Sep; 84(3):652-60. doi: 10.1189/jlb.1207827. [PMID: 18515326]
  • Anjing Ren, Xiaohong Yan, Hong Lu, Jingsong Shi, Yuanjun Yin, Jie Bai, Wenjun Yuan, Li Lin. Antagonism of endothelin-1 inhibits hypoxia-induced apoptosis in cardiomyocytes. Canadian journal of physiology and pharmacology. 2008 Aug; 86(8):536-40. doi: 10.1139/y08-051. [PMID: 18758501]
  • C R Tirapelli, E Legros, I Brochu, J-C Honoré, V L Lanchote, S A Uyemura, A M de Oliveira, P D'Orléans-Juste. Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats. British journal of pharmacology. 2008 Jul; 154(5):971-81. doi: 10.1038/bjp.2008.157. [PMID: 18469849]
  • Kyan J Allahdadi, Tom W Cherng, Hemanth Pai, Ana Q Silva, Benjimen R Walker, Leif D Nelin, Nancy L Kanagy. Endothelin type A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia. American journal of physiology. Heart and circulatory physiology. 2008 Jul; 295(1):H434-40. doi: 10.1152/ajpheart.91477.2007. [PMID: 18515645]
  • Luca Bergamasco, Pier Paolo Sainaghi, Luigi Castello, Claudio Letizia, Ettore Bartoli. In vitro effect of cyclosporine-A on angiotensins secretion by glomerular cells. Nephrology (Carlton, Vic.). 2008 Jun; 13(4):302-8. doi: 10.1111/j.1440-1797.2008.00917.x. [PMID: 18331442]
  • Noreen F Rossi, Maria Maliszewska-Scislo, Haiping Chen. Central endothelin: effects on vasopressin and the arterial baroreflex in doxorubicin heart failure rats. Canadian journal of physiology and pharmacology. 2008 Jun; 86(6):343-52. doi: 10.1139/y08-027. [PMID: 18516097]
  • Matthew D Doerr, Madhusudan P Goravanahally, Justin D Rhinehart, E Keith Inskeep, Jorge A Flores. Effects of endothelin receptor type-A and type-B antagonists on prostaglandin F2alpha-induced luteolysis of the sheep corpus luteum. Biology of reproduction. 2008 Apr; 78(4):688-96. doi: 10.1095/biolreprod.107.064105. [PMID: 18077801]
  • Nicoletta Nitescu, Elisabeth Grimberg, Sven-Erik Ricksten, Hans Herlitz, Gregor Guron. Endothelin B receptors preserve renal blood flow in a normotensive model of endotoxin-induced acute kidney dysfunction. Shock (Augusta, Ga.). 2008 Mar; 29(3):402-9. doi: 10.1097/shk.0b013e3181454118. [PMID: 17693943]
  • Francesca Stillitano, Laura Sartiani, Petra DePaoli, Alessandro Mugelli, Elisabetta Cerbai. Expression of the hyperpolarization-activated current, I(f), in cultured adult rat ventricular cardiomyocytes and its modulation by hypertrophic factors. Pharmacological research. 2008 Feb; 57(2):100-9. doi: 10.1016/j.phrs.2007.12.002. [PMID: 18255311]
  • Jane Goddard, Neil R Johnston, Allan D Cumming, David J Webb. Fractional urinary excretion of endothelin-1 is reduced by acute ETB receptor blockade. American journal of physiology. Renal physiology. 2007 Nov; 293(5):F1433-8. doi: 10.1152/ajprenal.00101.2007. [PMID: 17855483]
  • S B Bender, R E Klabunde. Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes. American journal of physiology. Heart and circulatory physiology. 2007 Oct; 293(4):H2281-8. doi: 10.1152/ajpheart.00566.2007. [PMID: 17660396]
  • Ellena C Paulino, Lourenilson J de Souza, Nilza A T Molan, Marcel C C Machado, Sonia Jancar. Neutrophils from acute pancreatitis patients cause more severe in vitro endothelial damage compared with neutrophils from healthy donors and are differently regulated by endothelins. Pancreas. 2007 Jul; 35(1):37-41. doi: 10.1097/mpa.0b013e31805c177b. [PMID: 17575543]
  • Tzong-Shinn Chu, Ming-Shiou Wu, Kwan-Dun Wu, Bor-Shen Hsieh. Endothelin-1 activates MAPKs and modulates cell cycle proteins in OKP cells. Journal of the Formosan Medical Association = Taiwan yi zhi. 2007 Apr; 106(4):273-80. doi: 10.1016/s0929-6646(09)60252-7. [PMID: 17475603]
  • Yang Zhou, Jie Gu, Lie-ming Xu. [Effect and mechanism of salvianolic acid B in attenuating elevated portal pressure in a rat model of portal hypertension induced by endothelin-1]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2007 Jan; 5(1):61-4. doi: 10.3736/jcim20070112. [PMID: 17214938]
  • Ying Shi, Catherine Lau, William A Cupples. Interactive modulation of renal myogenic autoregulation by nitric oxide and endothelin acting through ET-B receptors. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Jan; 292(1):R354-61. doi: 10.1152/ajpregu.00440.2006. [PMID: 16990488]
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