Methyloxirane (BioDeep_00000008696)

Main id: BioDeep_00000014698

Secondary id: BioDeep_00000897267, BioDeep_00001872092

human metabolite Endogenous


代谢物信息卡片


(R)-(+)-Propylene oxide

化学式: C3H6O (58.0419)
中文名称: (R)-环氧丙烷, 环氧丙烷
谱图信息: 最多检出来源 Escherichia coli(natural_products) 100%

分子结构信息

SMILES: CC1CO1
InChI: InChI=1S/C3H6O/c1-3-2-4-3/h3H,2H2,1H3

描述信息

D009676 - Noxae > D002273 - Carcinogens

同义名列表

7 个代谢物同义名

(R)-(+)-Propylene oxide; (2R)-1,2-Epoxypropane; Propylene oxide; epoxypropane; 1,2-Epoxypropane; (2R)-1,2-Epoxypropane; Propylene oxide



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ALB, AXIN2, GBP4, GSTT1, HPGDS, PMP2, SH2D1A
Peripheral membrane protein 1 HSD17B6
Nucleus 6 ALB, AXIN2, GBP4, GCAT, HIVEP1, PMP2
cytosol 10 ALB, AXIN2, GBP4, GSTT1, HIVEP1, HPGDS, LIPE, PMP2, SH2D1A, UPB1
nuclear body 1 HIVEP1
centrosome 2 ALB, AXIN2
nucleoplasm 4 GCAT, HIVEP1, HPGDS, SCN5A
Cell membrane 4 ABCB1, LIPE, SCN5A, SLC38A5
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 3 ABCB1, SCN5A, SLC38A5
Golgi apparatus membrane 1 GBP4
cell junction 1 SCN5A
cell surface 2 ABCB1, SCN5A
Golgi apparatus 3 ALB, ATRN, GBP4
Golgi membrane 1 GBP4
mitochondrial inner membrane 1 GCAT
sarcolemma 1 SCN5A
Cytoplasm, cytosol 1 LIPE
plasma membrane 7 ABCB1, ATRN, AXIN2, BTC, GBP4, SCN5A, SLC38A5
Membrane 5 ABCB1, BTC, LIPE, SCN5A, SLC38A5
apical plasma membrane 1 ABCB1
caveola 2 LIPE, SCN5A
extracellular exosome 7 ABCB1, ALB, ATRN, GSTT1, LYZ, PMP2, UPB1
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 ALB, HSD17B6, SCN5A
extracellular space 5 ALB, ATRN, BTC, GNRH1, LYZ
perinuclear region of cytoplasm 2 GBP4, SCN5A
intercalated disc 1 SCN5A
mitochondrion 2 GCAT, HIVEP1
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 2 HPGDS, HSD17B6
Microsome membrane 1 HSD17B6
Single-pass type I membrane protein 1 ATRN
Secreted 1 ALB
extracellular region 4 ALB, BTC, GNRH1, LYZ
[Isoform 2]: Secreted 1 ATRN
anchoring junction 1 ALB
T-tubule 1 SCN5A
Z disc 1 SCN5A
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 GBP4
nucleolus 1 SCN5A
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 2 GBP4, SCN5A
lateral plasma membrane 1 SCN5A
nuclear speck 1 GCAT
ciliary basal body 1 ALB
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
[Isoform 3]: Secreted 1 ATRN
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
myelin sheath 1 PMP2
Cell membrane, sarcolemma, T-tubule 1 SCN5A
endoplasmic reticulum lumen 1 ALB
platelet alpha granule lumen 1 ALB
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
azurophil granule lumen 1 LYZ
clathrin-coated endocytic vesicle membrane 1 BTC
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 1 ATRN
voltage-gated sodium channel complex 1 SCN5A
ciliary transition fiber 1 ALB


文献列表

  • Wei Liu, Linling Yu, Min Zhou, Zi Ye, Ruyi Liang, Qiyou Tan, Jiahao Song, Jixuan Ma, Dongming Wang, Bin Wang, Weihong Chen. Cross-sectional and Longitudinal Associations Between Propylene Oxide Exposure and Lung Function Among Chinese Community Residents: Roles of Oxidative DNA Damage, Lipid Peroxidation, and Protein Carbonylation. Chest. 2023 Jun; 163(6):1395-1409. doi: 10.1016/j.chest.2022.12.004. [PMID: 36528066]
  • Wei Liu, Bin Wang, Shijie Yang, Tao Xu, Linling Yu, Xing Wang, Man Cheng, Min Zhou, Weihong Chen. Associations of propylene oxide exposure with fasting plasma glucose and diabetes: Roles of oxidative DNA damage and lipid peroxidation. Environmental pollution (Barking, Essex : 1987). 2022 Jan; 292(Pt B):118453. doi: 10.1016/j.envpol.2021.118453. [PMID: 34737025]
  • Scott W Myers, Mukti N Ghimire, Frank H Arthur, Thomas W Phillips. A Combination Sulfuryl Fluoride and Propylene Oxide Treatment for Trogoderma granarium (Coleoptera: Dermestidae). Journal of economic entomology. 2021 08; 114(4):1489-1495. doi: 10.1093/jee/toab124. [PMID: 34184059]
  • Marat I Kamalov, Trinh Đặng, Natalia V Petrova, Alexander V Laikov, Duong Luong, Rezeda A Akhmadishina, Andrei N Lukashkin, Timur I Abdullin. Self-assembled nanoformulation of methylprednisolone succinate with carboxylated block copolymer for local glucocorticoid therapy. Colloids and surfaces. B, Biointerfaces. 2018 Apr; 164(?):78-88. doi: 10.1016/j.colsurfb.2018.01.014. [PMID: 29413623]
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  • Renata Baranauskienė, Ramunė Rutkaitė, Laura Pečiulytė, Rita Kazernavičiūtė, Petras Rimantas Venskutonis. Preparation and characterization of single and dual propylene oxide and octenyl succinic anhydride modified starch carriers for the microencapsulation of essential oils. Food & function. 2016 Aug; 7(8):3555-65. doi: 10.1039/c6fo00775a. [PMID: 27465989]
  • Adam T Zarth, Steven G Carmella, Chap T Le, Stephen S Hecht. Effect of cigarette smoking on urinary 2-hydroxypropylmercapturic acid, a metabolite of propylene oxide. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Mar; 953-954(?):126-31. doi: 10.1016/j.jchromb.2014.02.001. [PMID: 24608133]
  • Oksana V Bondar, Yuriy V Badeev, Yurii G Shtyrlin, Timur I Abdullin. Lipid-like trifunctional block copolymers of ethylene oxide and propylene oxide: effective and cytocompatible modulators of intracellular drug delivery. International journal of pharmaceutics. 2014 Jan; 461(1-2):97-104. doi: 10.1016/j.ijpharm.2013.11.002. [PMID: 24239835]
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