For-Met-Leu-Phe-OH (BioDeep_00000859112)

Main id: BioDeep_00000008748

 


代谢物信息卡片


N-Formyl-L-methionyl-L-leucyl-L-phenylalanine

化学式: C21H31N3O5S (437.19843160000005)
中文名称: 酪胺盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
InChI: InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1

描述信息

N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.

同义名列表

5 个代谢物同义名

N-Formyl-L-methionyl-L-leucyl-L-phenylalanine; N-Formyl-Met-Leu-Phe; For-Met-Leu-Phe-OH; FMLP; N-Formyl-MLF



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(8)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yi Wang, Cheng-Long Zhu, Peng Li, Qiang Liu, Hui-Ru Li, Chang-Meng Yu, Xiao-Ming Deng, Jia-Feng Wang. The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome. Frontiers in immunology. 2023; 14(?):1112196. doi: 10.3389/fimmu.2023.1112196. [PMID: 36891309]
  • Hsiang-Ruei Liao, Yu-Yao Kao, Yann-Lii Leu, Fu-Chao Liu, Ching-Ping Tseng. Larixol inhibits fMLP-induced superoxide anion production and chemotaxis by targeting the βγ subunit of Gi-protein of fMLP receptor in human neutrophils. Biochemical pharmacology. 2022 07; 201(?):115091. doi: 10.1016/j.bcp.2022.115091. [PMID: 35569521]
  • Maïlis Lauwers, Gil Verschelden, Caroline Boero, Manon Baleine, Véronique Kerrels, Brigitte Cantinieaux. Optimization of the Transwell® assay for the analysis of neutrophil chemotaxis using flow cytometry to refine the clinical investigation of immunodeficient patients. Clinical immunology (Orlando, Fla.). 2022 05; 238(?):108994. doi: 10.1016/j.clim.2022.108994. [PMID: 35390547]
  • Leo Koenderman, Maarten J Siemers, Corneli van Aalst, Suzanne H Bongers, Roy Spijkerman, Bas J J Bindels, Giulio Giustarini, Harriët M R van Goor, Karin A H Kaasjager, Nienke Vrisekoop. The Systemic Immune Response in COVID-19 Is Associated with a Shift to Formyl-Peptide Unresponsive Eosinophils. Cells. 2021 05; 10(5):. doi: 10.3390/cells10051109. [PMID: 34062964]
  • Lu Li, Zhenfei Bi, Yuzhu Hu, Lu Sun, Yanlin Song, Siyuan Chen, Fei Mo, Jingyun Yang, Yuquan Wei, Xiawei Wei. Silver nanoparticles and silver ions cause inflammatory response through induction of cell necrosis and the release of mitochondria in vivo and in vitro. Cell biology and toxicology. 2021 04; 37(2):177-191. doi: 10.1007/s10565-020-09526-4. [PMID: 32367270]
  • Runa Kuley, Ryan D Stultz, Bhargavi Duvvuri, Ting Wang, Marvin J Fritzler, Roger Hesselstrand, J Lee Nelson, Christian Lood. N-Formyl Methionine Peptide-Mediated Neutrophil Activation in Systemic Sclerosis. Frontiers in immunology. 2021; 12(?):785275. doi: 10.3389/fimmu.2021.785275. [PMID: 35069556]
  • Sio-Hong Lam, Shu-Duan Jian, Tsong-Long Hwang, Po-Jen Chen, Hsin-Yi Hung, Ping-Chung Kuo, Tian-Shung Wu. A new dimeric protoberberine alkaloid and other compounds from the tubers of Tinospora dentata. Natural product research. 2021 Jan; 35(1):17-24. doi: 10.1080/14786419.2019.1611809. [PMID: 31135226]
  • Raquel Freitas Zambonatto, Renata Nakata Teixeira, Sarah de Oliveira Poma, Eliane Borges da Silva, Mariana Mendes de Almeida, Gerson Dos Santos Leite, Cesar Miguel Momesso Dos Santos, Heloisa Helena de Oliveira Alves, Renata Gorjão, Tania Cristina Pithon-Curi, Celso R F Carvalho, Rui Curi, Adriana Cristina Levada-Pires. Features of Neutrophils From Atopic and Non-Atopic Elite Endurance Runners. Frontiers in immunology. 2021; 12(?):670763. doi: 10.3389/fimmu.2021.670763. [PMID: 34177910]
  • Hao-Chiun Chang, Shih-Wei Wang, Chin-Yen Chen, Tsong-Long Hwang, Ming-Jen Cheng, Ping-Jyun Sung, Kuang-Wen Liao, Jih-Jung Chen. Secoiridoid Glucosides and Anti-Inflammatory Constituents from the Stem Bark of Fraxinus chinensis. Molecules (Basel, Switzerland). 2020 Dec; 25(24):. doi: 10.3390/molecules25245911. [PMID: 33327368]
  • Yu-Wei Lai, Shih-Wei Wang, Ya-Yun Hu, Tsong-Long Hwang, Ming-Jen Cheng, Ih-Sheng Chen, Ping-Jyun Sung, Jih-Jung Chen. Anti-inflammatory alkaloids from the root bark of Hernandia nymphaeifolia. Phytochemistry. 2020 May; 173(?):112326. doi: 10.1016/j.phytochem.2020.112326. [PMID: 32120117]
  • Amina Chniguir, Coralie Pintard, Dan Liu, Pham My-Chan Dang, Jamel El-Benna, Rafik Bachoual. Eugenol prevents fMLF-induced superoxide anion production in human neutrophils by inhibiting ERK1/2 signaling pathway and p47phox phosphorylation. Scientific reports. 2019 12; 9(1):18540. doi: 10.1038/s41598-019-55043-8. [PMID: 31811262]
  • Stephanie M Bozonet, Anitra C Carr. The Role of Physiological Vitamin C Concentrations on Key Functions of Neutrophils Isolated from Healthy Individuals. Nutrients. 2019 Jun; 11(6):. doi: 10.3390/nu11061363. [PMID: 31212992]
  • Alessandro Trentini, Francesca Murganti, Valentina Rosta, Carlo Cervellati, Maria Cristina Manfrinato, Savino Spadaro, Franco Dallocchio, Carlo Alberto Volta, Tiziana Bellini. Hydroxyethyl Starch 130/0.4 Binds to Neutrophils Impairing Their Chemotaxis through a Mac-1 Dependent Interaction. International journal of molecular sciences. 2019 Feb; 20(4):. doi: 10.3390/ijms20040817. [PMID: 30769810]
  • Tzu-Hsuan Chung, Yung-Peng Wu, Chee Ying Chew, Chak Hin Lam, Kui-Thong Tan. Imaging and Quantification of Secreted Peroxynitrite at the Cell Surface by a Streptavidin-Biotin-Controlled Binding Probe. Chembiochem : a European journal of chemical biology. 2018 12; 19(24):2584-2590. doi: 10.1002/cbic.201800542. [PMID: 30352141]
  • Xiao Wang, Emily Jodoin, Julianne Jorgensen, Jarone Lee, James J Markmann, Sule Cataltepe, Daniel Irimia. Progressive mechanical confinement of chemotactic neutrophils induces arrest, oscillations, and retrotaxis. Journal of leukocyte biology. 2018 12; 104(6):1253-1261. doi: 10.1002/jlb.5ta0318-110rrr. [PMID: 30129679]
  • Sungjin Chung, Jessica M Overstreet, Yan Li, Yinqiu Wang, Aolei Niu, Suwan Wang, Xiaofeng Fan, Kensuke Sasaki, Guan-Nan Jin, Stellor Nlandu Khodo, Leslie Gewin, Ming-Zhi Zhang, Raymond C Harris. TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration. JCI insight. 2018 11; 3(21):. doi: 10.1172/jci.insight.123563. [PMID: 30385721]
  • Elzbieta Kaczmarek, Carl J Hauser, Woon Yong Kwon, Ingred Riça, Li Chen, Nicola Sandler, Leo E Otterbein, Yan Campbell, Charles H Cook, Michael B Yaffe, Michael F Marusich, Kiyoshi Itagaki. A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils. The journal of trauma and acute care surgery. 2018 11; 85(5):936-943. doi: 10.1097/ta.0000000000001971. [PMID: 29787548]
  • Chen Yang, Zhefeng Sui, Tingshuang Xu, Wenai Liu, Xiaoguang Wang, Xianlu Zeng. Lipid raft‑associated β‑adducin participates in neutrophil migration. Molecular medicine reports. 2018 Aug; 18(2):1353-1360. doi: 10.3892/mmr.2018.9113. [PMID: 29901076]
  • Hsiang-Ruei Liao, Ih-Sheng Chen, Fu-Chao Liu, Shinn-Zhi Lin, Ching-Ping Tseng. 2',3-dihydroxy-5-methoxybiphenyl suppresses fMLP-induced superoxide anion production and cathepsin G release by targeting the β-subunit of G-protein in human neutrophils. European journal of pharmacology. 2018 Jun; 829(?):26-37. doi: 10.1016/j.ejphar.2018.03.037. [PMID: 29601810]
  • Monika E Czerwińska, Marta K Dudek, Karolina A Pawłowska, Anna Pruś, Maria Ziaja, Sebastian Granica. The influence of procyanidins isolated from small-leaved lime flowers (Tilia cordata Mill.) on human neutrophils. Fitoterapia. 2018 Jun; 127(?):115-122. doi: 10.1016/j.fitote.2018.02.018. [PMID: 29447978]
  • Jun Gao, Tian Zhang, Zhanfang Kang, Weijen Ting, Lingqing Xu, Dazhong Yin. The F0F1 ATP synthase regulates human neutrophil migration through cytoplasmic proton extrusion coupled with ATP generation. Molecular immunology. 2017 10; 90(?):219-226. doi: 10.1016/j.molimm.2017.08.004. [PMID: 28843171]
  • Roya M Dayam, Chun X Sun, Christopher H Choy, Gemma Mancuso, Michael Glogauer, Roberto J Botelho. The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase. Journal of immunology (Baltimore, Md. : 1950). 2017 09; 199(6):2096-2105. doi: 10.4049/jimmunol.1601466. [PMID: 28779020]
  • Terukazu Sanui, Masaaki Takeshita, Takao Fukuda, Urara Tanaka, Rehab Alshargabi, Yoshitomi Aida, Fusanori Nishimura. Adhesion attenuates respiratory burst induced by different modes of triggering in resting or LPS-primed neutrophils. Immunobiology. 2017 08; 222(8-9):865-871. doi: 10.1016/j.imbio.2017.05.001. [PMID: 28551079]
  • Lin-Yang Cheng, Hsiang-Ruei Liao, Li-Chai Chen, Shih-Wei Wang, Yueh-Hsiung Kuo, Mei-Ing Chung, Jih-Jung Chen. Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils. Fitoterapia. 2017 Mar; 117(?):16-21. doi: 10.1016/j.fitote.2016.12.008. [PMID: 28012920]
  • Renee M Potera, Melissa J Jensen, Brieanna M Hilkin, Gina K South, Jessica S Hook, Emily A Gross, Jessica G Moreland. Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase. Innate immunity. 2016 11; 22(8):635-646. doi: 10.1177/1753425916668980. [PMID: 27655046]
  • Igor A Schepetkin, Svetlana V Kushnarenko, Gulmira Özek, Liliya N Kirpotina, Pritam Sinharoy, Gulzhakhan A Utegenova, Karime T Abidkulova, Temel Özek, Kemal Hüsnü Can Başer, Anastasia R Kovrizhina, Andrei I Khlebnikov, Derek S Damron, Mark T Quinn. Modulation of Human Neutrophil Responses by the Essential Oils from Ferula akitschkensis and Their Constituents. Journal of agricultural and food chemistry. 2016 Sep; 64(38):7156-70. doi: 10.1021/acs.jafc.6b03205. [PMID: 27586050]
  • Haibin Tong, Guiquan Jiang, Xingang Guan, Hong Wu, Kangxing Song, Kuan Cheng, Xin Sun. Characterization of a polysaccharide from Rosa davurica and inhibitory activity against neutrophil migration. International journal of biological macromolecules. 2016 Aug; 89(?):111-7. doi: 10.1016/j.ijbiomac.2016.04.062. [PMID: 27112979]
  • Kohji Nozoe, Yoshitomi Aida, Takao Fukuda, Terukazu Sanui, Fusanori Nishimura. Mechanisms of the Macrolide-Induced Inhibition of Superoxide Generation by Neutrophils. Inflammation. 2016 Jun; 39(3):1039-48. doi: 10.1007/s10753-016-0333-3. [PMID: 26983705]
  • Wulin Aerbajinai, Lunhua Liu, Jianqiong Zhu, Chutima Kumkhaek, Kyung Chin, Griffin P Rodgers. Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin. The Journal of biological chemistry. 2016 Apr; 291(16):8549-64. doi: 10.1074/jbc.m115.674200. [PMID: 26895964]
  • Camilla Ferreira Wenceslau, Theodora Szasz, Cameron G McCarthy, Babak Baban, Elizabeth NeSmith, R Clinton Webb. Mitochondrial N-formyl peptides cause airway contraction and lung neutrophil infiltration via formyl peptide receptor activation. Pulmonary pharmacology & therapeutics. 2016 04; 37(?):49-56. doi: 10.1016/j.pupt.2016.02.005. [PMID: 26923940]
  • Shukranul Mawa, Ibrahim Jantan, Khairana Husain. Isolation of Terpenoids from the Stem of Ficus aurantiaca Griff and their Effects on Reactive Oxygen Species Production and Chemotactic Activity of Neutrophils. Molecules (Basel, Switzerland). 2016 Jan; 21(1):9. doi: 10.3390/molecules21010009. [PMID: 26742027]
  • Carin Wallquist, Ladan Mansouri, Mattias Norrbäck, Britta Hylander, Stefan H Jacobson, Joachim Lundahl. Early Changes in Monocyte Adhesion Molecule Expression and Tumor Necrosis Factor-α Levels in Chronic Kidney Disease - A 5-Year Prospective Study. American journal of nephrology. 2016; 44(4):268-275. doi: 10.1159/000449290. [PMID: 27603798]
  • Chun-Yu Chen, Yann-Lii Leu, Yu Fang, Chwan-Fwu Lin, Liang-Mou Kuo, Wei-Che Sung, Yung-Fong Tsai, Pei-Jen Chung, Ming-Chung Lee, Yu-Ting Kuo, Hsuan-Wu Yang, Tsong-Long Hwang. Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium. Scientific reports. 2015 Dec; 5(?):18204. doi: 10.1038/srep18204. [PMID: 26659126]
  • Li-Chai Chen, Hsiang-Ruei Liao, Pei-Yu Chen, Wen-Lung Kuo, Tsung-Hsien Chang, Ping-Jyun Sung, Zhi-Hong Wen, Jih-Jung Chen. Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities. Molecules (Basel, Switzerland). 2015 Oct; 20(10):18551-64. doi: 10.3390/molecules201018551. [PMID: 26473818]
  • Christopher B Hergott, Aoife M Roche, Nikhil A Naidu, Clementina Mesaros, Ian A Blair, Jeffrey N Weiser. Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. The Journal of clinical investigation. 2015 Oct; 125(10):3878-90. doi: 10.1172/jci81888. [PMID: 26426079]
  • Tianshu Wang, Jiyang Liu, Jiangtao Ren, Jin Wang, Erkang Wang. Mimetic biomembrane-AuNPs-graphene hybrid as matrix for enzyme immobilization and bioelectrocatalysis study. Talanta. 2015 Oct; 143(?):438-441. doi: 10.1016/j.talanta.2015.05.022. [PMID: 26078181]
  • Per Venge, Lena Douhan Håkansson, Daniel Garwicz, Christer Peterson, Shengyuan Xu, Karlis Pauksen. Human neutrophil lipocalin in fMLP-activated whole blood as a diagnostic means to distinguish between acute bacterial and viral infections. Journal of immunological methods. 2015 Sep; 424(?):85-90. doi: 10.1016/j.jim.2015.05.004. [PMID: 26002155]
  • Falco Hietbrink, Leo Koenderman, Karlijn J P van Wessem, Luke P H Leenen. The Impact of Intramedullary Nailing of Tibia Fractures on the Innate Immune System. Shock (Augusta, Ga.). 2015 Sep; 44(3):209-14. doi: 10.1097/shk.0000000000000405. [PMID: 26009818]
  • Hsiang-Ruei Liao, Ching-Ru Chien, Jih-Jung Chen, Tzung-Yan Lee, Shinn-Zhi Lin, Ching-Ping Tseng. The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils. Chemico-biological interactions. 2015 Jul; 236(?):90-101. doi: 10.1016/j.cbi.2015.05.004. [PMID: 25980585]
  • Saifei Liu, Doan T M Ngo, Cher-Rin Chong, Anjalee T Amarasekera, Nathan E K Procter, Giovanni Licari, Rustem F Dautov, Simon Stewart, Yuliy Y Chirkov, John D Horowitz. Suppression of neutrophil superoxide generation by BNP is attenuated in acute heart failure: a case for 'BNP resistance'. European journal of heart failure. 2015 May; 17(5):475-83. doi: 10.1002/ejhf.242. [PMID: 25684282]
  • Hannah Caitlin Cohen, Dustin C Frost, Tyler Jacob Lieberthal, Lingjun Li, W John Kao. Biomaterials differentially regulate Src kinases and phosphoinositide 3-kinase-γ in polymorphonuclear leukocyte primary and tertiary granule release. Biomaterials. 2015 May; 50(?):47-55. doi: 10.1016/j.biomaterials.2015.01.050. [PMID: 25736495]
  • Bernadette Eberlein, Rebekka Hann, Stefanie Eyerich, Davide Pennino, Johannes Ring, Carsten B Schmidt-Weber, Jeroen Buters. Optimizing of the basophil activation test: Comparison of different basophil identification markers. Cytometry. Part B, Clinical cytometry. 2015 May; 88(3):183-9. doi: 10.1002/cyto.b.21203. [PMID: 25399741]
  • Jih-Jung Chen, Chieh-Kai Yang, Yueh-Hsiung Kuo, Tsong-Long Hwang, Wen-Lung Kuo, Yun-Ping Lim, Ping-Jyun Sung, Tsung-Hsien Chang, Ming-Jen Cheng. New Coumarin Derivatives and Other Constituents from the Stem Bark of Zanthoxylum avicennae: Effects on Neutrophil Pro-Inflammatory Responses. International journal of molecular sciences. 2015 Apr; 16(5):9719-31. doi: 10.3390/ijms16059719. [PMID: 25938967]
  • Tuo Wang, Jonathan K Williams, Klaus Schmidt-Rohr, Mei Hong. Relaxation-compensated difference spin diffusion NMR for detecting 13C-13C long-range correlations in proteins and polysaccharides. Journal of biomolecular NMR. 2015 Feb; 61(2):97-107. doi: 10.1007/s10858-014-9889-0. [PMID: 25510834]
  • Mélanie R Tardif, Julie Andrea Chapeton-Montes, Alma Posvandzic, Nathalie Pagé, Caroline Gilbert, Philippe A Tessier. Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux. Journal of immunology research. 2015; 2015(?):296149. doi: 10.1155/2015/296149. [PMID: 27057553]
  • Piotr Jan Nowak, Anna Zasowska-Nowak, Piotr Bialasiewicz, Jeffrey de Graft-Johnson, Dariusz Nowak, Michal Nowicki. Inhibitory effect of plant phenolics on fMLP-induced intracellular calcium rise and chemiluminescence of human polymorphonuclear leukocytes and their chemotactic activity in vitro. Pharmaceutical biology. 2015; 53(11):1661-70. doi: 10.3109/13880209.2014.1001403. [PMID: 25856712]
  • Zenib Aljadi, Ladan Mansouri, Anna Nopp, Josefin M Paulsson, Ola Winqvist, Aman Russom, Mårten Ståhl, Britta Hylander, Stefan H Jacobson, Joachim Lundahl. Activation of basophils is a new and sensitive marker of biocompatibility in hemodialysis. Artificial organs. 2014 Nov; 38(11):945-53. doi: 10.1111/aor.12297. [PMID: 24712758]
  • Marco Cosentino, Alessandra Luini, Raffaella Bombelli, Maria T Corasaniti, Giacinto Bagetta, Franca Marino. The essential oil of bergamot stimulates reactive oxygen species production in human polymorphonuclear leukocytes. Phytotherapy research : PTR. 2014 Aug; 28(8):1232-9. doi: 10.1002/ptr.5121. [PMID: 24458921]
  • Ashley Taylor, Wenwen Tang, Emanuela M Bruscia, Ping-Xia Zhang, Aiping Lin, Peter Gaines, Dianqing Wu, Stephanie Halene. SRF is required for neutrophil migration in response to inflammation. Blood. 2014 May; 123(19):3027-36. doi: 10.1182/blood-2013-06-507582. [PMID: 24574460]
  • Lunhua Liu, Derek Gritz, Carole A Parent. PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils. Molecular biology of the cell. 2014 May; 25(9):1446-57. doi: 10.1091/mbc.e14-01-0037. [PMID: 24600048]
  • Steven J Henry, John C Crocker, Daniel A Hammer. Ligand density elicits a phenotypic switch in human neutrophils. Integrative biology : quantitative biosciences from nano to macro. 2014 Mar; 6(3):348-56. doi: 10.1039/c3ib40225h. [PMID: 24480897]
  • Gurpreet K Aulakh, Yadu Balachandran, Lixin Liu, Baljit Singh. Angiostatin inhibits activation and migration of neutrophils. Cell and tissue research. 2014 Feb; 355(2):375-96. doi: 10.1007/s00441-013-1753-0. [PMID: 24297047]
  • Akira Yamauchi, Mikako Degawa-Yamauchi, Futoshi Kuribayashi, Shiro Kanegasaki, Tomoko Tsuchiya. Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. Journal of immunological methods. 2014 Feb; 404(?):59-70. doi: 10.1016/j.jim.2013.12.005. [PMID: 24370750]
  • Yao Qin, Zi-wei Li, Yong Yang, Chun-mei Yu, Dan-dan Gu, Hong Deng, Tao Zhang, Xin Wang, Ai-ping Wang, Wei-zao Luo. Liposomes formulated with fMLP-modified cholesterol for enhancing drug concentration at inflammatory sites. Journal of drug targeting. 2014 Feb; 22(2):165-74. doi: 10.3109/1061186x.2013.851683. [PMID: 24392736]
  • Izabela Burzynska-Pedziwiatr, Malgorzata Bukowiecka-Matusiak, Marzena Wojcik, Waldemar Machala, Malgorzata Bienkiewicz, Grzegorz Spolnik, Witold Danikiewicz, Lucyna Alicja Wozniak. Dual stimulus-dependent effect of Oenothera paradoxa extract on the respiratory burst in human leukocytes: suppressing for Escherichia coli and phorbol myristate acetate and stimulating for formyl-methionyl-leucyl-phenylalanine. Oxidative medicine and cellular longevity. 2014; 2014(?):764367. doi: 10.1155/2014/764367. [PMID: 25298860]
  • Shun-Chin Yang, Ping-Jyun Sung, Chwan-Fwu Lin, Jimmy Kuo, Chun-Yu Chen, Tsong-Long Hwang. Anti-inflammatory effects of secondary metabolites of marine Pseudomonas sp. in human neutrophils are through inhibiting P38 MAPK, JNK, and calcium pathways. PloS one. 2014; 9(12):e114761. doi: 10.1371/journal.pone.0114761. [PMID: 25474595]
  • Marie-Hélène Ruchaud-Sparagano, Helen Gertig, Katy L M Hester, James G Macfarlane, Paul A Corris, A John Simpson, Anthony De Soyza. Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis. Respirology (Carlton, Vic.). 2013 Nov; 18(8):1230-5. doi: 10.1111/resp.12138. [PMID: 23730995]
  • Nathalie Neirynck, Griet Glorieux, Jente Boelaert, Eva Schepers, Sophie Liabeuf, Annemieke Dhondt, Ziad Massy, Raymond Vanholder. Uremia-related oxidative stress in leukocytes is not triggered by β2-microglobulin. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2013 Nov; 23(6):456-63. doi: 10.1053/j.jrn.2013.07.002. [PMID: 24016624]
  • Diane I Bitzinger, York A Zausig, Christoph Paech, Michael Gruber, Hendrik Busse, Barbara Sinner, Bernhard M Graf, Benedikt Trabold. Modulation of immune functions in polymorphonuclear neutrophils induced by physostigmine, but not neostigmine, independent of cholinergic neurons. Immunobiology. 2013 Aug; 218(8):1049-54. doi: 10.1016/j.imbio.2013.01.003. [PMID: 23434434]
  • Tsong-Long Hwang, Chih-Hao Hung, Ching-Yun Hsu, Yin-Ting Huang, Yu-Chi Tsai, Pei-Wen Hsieh. Design and synthesis of tryptophan containing dipeptide derivatives as formyl peptide receptor 1 antagonist. Organic & biomolecular chemistry. 2013 Jun; 11(22):3742-55. doi: 10.1039/c3ob40215k. [PMID: 23629449]
  • Hiroshi Tsukao, Kenichi Kokubo, Haruko Takahashi, Mina Nagasato, Takanori Endo, Naoto Iizuka, Toshihiro Shinbo, Minoru Hirose, Hirosuke Kobayashi. Activation of platelets upon contact with a vitamin E-coated/non-coated surface. Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 2013 Jun; 16(2):193-205. doi: 10.1007/s10047-013-0686-4. [PMID: 23381644]
  • Bahjat Al-Ani. Simvastatin inhibits neutrophil degranulation induced by anti-neutrophil cytoplasm auto-antibodies and N-formyl-methionine-leucine-phenylalanine (fMLP) peptide. Saudi medical journal. 2013 May; 34(5):477-83. doi: . [PMID: 23677263]
  • Jingyu Yang, Qing Wang, Ruijun Zhao, Baoshan Sun, Lihui Wang, Yue Hou, Xiaoqin Li, Chunfu Wu. Identification of oligomer proanthocyanidins (F2) isolated from grape seeds as a formyl peptide receptor 1 partial agonist. International immunopharmacology. 2013 Apr; 15(4):756-63. doi: 10.1016/j.intimp.2013.03.007. [PMID: 23523627]
  • Michelle B Visser, Chun-Xiang Sun, Adeline Koh, Richard P Ellen, Michael Glogauer. Treponema denticola major outer sheath protein impairs the cellular phosphoinositide balance that regulates neutrophil chemotaxis. PloS one. 2013; 8(6):e66209. doi: 10.1371/journal.pone.0066209. [PMID: 23755300]
  • Takanobu Sato, Tsunaki Hongu, Megumi Sakamoto, Yuji Funakoshi, Yasunori Kanaho. Molecular mechanisms of N-formyl-methionyl-leucyl-phenylalanine-induced superoxide generation and degranulation in mouse neutrophils: phospholipase D is dispensable. Molecular and cellular biology. 2013 Jan; 33(1):136-45. doi: 10.1128/mcb.00869-12. [PMID: 23109426]
  • Lunhua Liu, Wulin Aerbajinai, Syed M Ahmed, Griffin P Rodgers, Stephane Angers, Carole A Parent. Radil controls neutrophil adhesion and motility through β2-integrin activation. Molecular biology of the cell. 2012 Dec; 23(24):4751-65. doi: 10.1091/mbc.e12-05-0408. [PMID: 23097489]
  • I V Gorudko, V A Kostevich, A V Sokolov, E V Shamova, I V Buko, E E Konstantinova, V B Vasiliev, S N Cherenkevich, O M Panasenko. Functional activity of neutrophils in diabetes mellitus and coronary heart disease: role of myeloperoxidase in the development of oxidative stress. Bulletin of experimental biology and medicine. 2012 Nov; 154(1):23-6. doi: 10.1007/s10517-012-1865-7. [PMID: 23330081]
  • Min-Jung Kang, Hyojeong Han, Oh-Seung Kwon, Hyun Ok Kim, Byung-Hwa Jung. Multireaction monitoring of 12 peptides for lowered immunity screening. Analytical and bioanalytical chemistry. 2012 Nov; 404(8):2249-58. doi: 10.1007/s00216-012-6344-5. [PMID: 22941069]
  • Karama Makni-Maalej, Tarek Boussetta, Margarita Hurtado-Nedelec, Sahra Amel Belambri, Marie-Anne Gougerot-Pocidalo, Jamel El-Benna. The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1. Journal of immunology (Baltimore, Md. : 1950). 2012 Nov; 189(9):4657-65. doi: 10.4049/jimmunol.1201007. [PMID: 23002436]
  • Yu-Chieh Chien, Chu-Hung Lin, Michael Y Chiang, Hsun-Shuo Chang, Chang-Hui Liao, Ih-Sheng Chen, Chien-Fang Peng, Ian-Lih Tsai. Secondary metabolites from the root of Ehretia longiflora and their biological activities. Phytochemistry. 2012 Aug; 80(?):50-7. doi: 10.1016/j.phytochem.2012.04.013. [PMID: 22626966]
  • Hsiang-Ruei Liao, Jih-Jung Chen, Yin-Huan Chien, Shinn-Zhi Lin, Shunchih Lin, Ching-Ping Tseng. 5-Hydroxy-7-methoxyflavone inhibits N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils. Biochemical pharmacology. 2012 Jul; 84(2):182-91. doi: 10.1016/j.bcp.2012.03.015. [PMID: 22484311]
  • Kristin Blidberg, Lena Palmberg, Barbro Dahlén, Ann-Sofie Lantz, Kjell Larsson. Increased neutrophil migration in smokers with or without chronic obstructive pulmonary disease. Respirology (Carlton, Vic.). 2012 Jul; 17(5):854-60. doi: 10.1111/j.1440-1843.2012.02181.x. [PMID: 22509802]
  • Mamdouh M Karima, Thomas E Van Dyke. Enamel matrix derivative promotes superoxide production and chemotaxis but reduces matrix metalloproteinase-8 expression by polymorphonuclear leukocytes. Journal of periodontology. 2012 Jun; 83(6):780-6. doi: 10.1902/jop.2011.110397. [PMID: 22050547]
  • José Alex C Farias, Jamylle Nunes S Ferro, Juliane P Silva, Isabela Karine R Agra, Fernando M Oliveira, André Luiz P Candea, Fernando P Conte, Fausto K Ferraris, Maria das Graças M O Henriques, Lucia M Conserva, Emiliano Barreto. Modulation of inflammatory processes by leaves extract from Clusia nemorosa both in vitro and in vivo animal models. Inflammation. 2012 Apr; 35(2):764-71. doi: 10.1007/s10753-011-9372-y. [PMID: 21842373]
  • Rudolf Lampé. [Superoxide-anion production by neutrophil granulocytes in healthy and preeclamptic pregnant women]. Orvosi hetilap. 2012 Mar; 153(11):425-34. doi: 10.1556/oh.2012.29322. [PMID: 22390867]
  • Shihu Wei, Wenfei He, Jincai Lu, Zhonghuan Wang, Koichi Yamashita, Masanori Yokoyama, Hiroyuki Kodama. Effects of five oleanolic acid triterpenoid saponins from the rhizome of Anemone raddeana on stimulus-induced superoxide generation, phosphorylation of proteins and translocation of cytosolic compounds to cell membrane in human neutrophils. Fitoterapia. 2012 Mar; 83(2):402-7. doi: 10.1016/j.fitote.2011.12.002. [PMID: 22178681]
  • Shihu Wei, Guang Chen, Wenfei He, Haidong Chi, Hideki Abe, Koichi Yamashita, Masanori Yokoyama, Hiroyuki Kodama. Inhibitory effects of secoiridoids from the roots of Gentiana straminea on stimulus-induced superoxide generation, phosphorylation and translocation of cytosolic compounds to plasma membrane in human neutrophils. Phytotherapy research : PTR. 2012 Feb; 26(2):168-73. doi: 10.1002/ptr.3496. [PMID: 21584870]
  • Daniel R Ambruso, Michael A Ellison, Gail W Thurman, Thomas L Leto. Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity. Biochimica et biophysica acta. 2012 Feb; 1823(2):306-15. doi: 10.1016/j.bbamcr.2011.11.014. [PMID: 22178385]
  • Pia Chedid, Margarita Hurtado-Nedelec, Benoit Marion-Gaber, Odile Bournier, Gilles Hayem, Marie-Anne Gougerot-Pocidalo, Jan Frystyk, Alan Flyvbjerg, Jamel El Benna, Jean-Claude Marie. Adiponectin and its globular fragment differentially modulate the oxidative burst of primary human phagocytes. The American journal of pathology. 2012 Feb; 180(2):682-92. doi: 10.1016/j.ajpath.2011.10.013. [PMID: 22119038]
  • Flávia V Santa-Cecília, Gérsika B Santos, Carolina N Fuzissaki, Priscilla B M C Derogis, Lissara A S Freitas, Vanessa S Gontijo, Paulo C Stringheta, Tanus J Nagem, Maísa R P L Brigagão, Marcelo H Dos Santos. 7-epiclusianone, the natural prenylated benzophenone, inhibits superoxide anions in the neutrophil respiratory burst. Journal of medicinal food. 2012 Feb; 15(2):200-5. doi: 10.1089/jmf.2011.0043. [PMID: 22191630]
  • Lívia de Paulo Pereira, Racquel Oliveira da Silva, Pedro Henrique de Souza Ferreira Bringel, Kaira Emanuella Sales da Silva, Ana Maria Sampaio Assreuy, Maria Gonçalves Pereira. Polysaccharide fractions of Caesalpinia ferrea pods: potential anti-inflammatory usage. Journal of ethnopharmacology. 2012 Jan; 139(2):642-8. doi: 10.1016/j.jep.2011.12.012. [PMID: 22178173]
  • Inger Gjertsson, Ing-Marie Jonsson, Andreas Peschel, Andrej Tarkowski, Catharina Lindholm. Formylated peptides are important virulence factors in Staphylococcus aureus arthritis in mice. The Journal of infectious diseases. 2012 Jan; 205(2):305-11. doi: 10.1093/infdis/jir713. [PMID: 22102735]
  • Rafael de Liz, Heros Horst, Moacir Geraldo Pizzolatti, Tânia Silvia Fröde, Denis Girard. Activation of human neutrophils by the anti-inflammatory mediator Esenbeckia leiocarpa leads to atypical apoptosis. Mediators of inflammation. 2012; 2012(?):198382. doi: 10.1155/2012/198382. [PMID: 22649276]
  • Barry D Hock, Katarzyna A Mackenzie, Nicholas B Cross, Karen G Taylor, Margaret J Currie, Bridget A Robinson, Jeremy W Simcock, Judith L McKenzie. Renal transplant recipients have elevated frequencies of circulating myeloid-derived suppressor cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 Jan; 27(1):402-10. doi: 10.1093/ndt/gfr264. [PMID: 21617199]
  • Sokratis Trellakis, Alena Rydleuskaya, Cornelia Fischer, Ali Canbay, Sefik Tagay, André Scherag, Kirsten Bruderek, Patrick J Schuler, Sven Brandau. Low adiponectin, high levels of apoptosis and increased peripheral blood neutrophil activity in healthy obese subjects. Obesity facts. 2012; 5(3):305-18. doi: 10.1159/000339452. [PMID: 22722748]
  • Alessandro Corti, Maria Franzini, Silvana Cianchetti, Gabriella Bergamini, Evelina Lorenzini, Paola Melotti, Aldo Paolicchi, Pierluigi Paggiaro, Alfonso Pompella. Contribution by polymorphonucleate granulocytes to elevated gamma-glutamyltransferase in cystic fibrosis sputum. PloS one. 2012; 7(4):e34772. doi: 10.1371/journal.pone.0034772. [PMID: 22496859]
  • Douglas Côbo Micheli, Paulo Cesar Fernandes, João Celso Garcia Cruvinel, Isabela Destro Nomelini, Eddie Fernando Candido Murta, Beatriz Martins Tavares-Murta. Circulating Cytokines and Nitric Oxide are Involved in the Inhibition of Neutrophil Migration in Patients with Uterine Cervical Neoplasia. Clinical Medicine Insights. Oncology. 2012; 6(?):233-42. doi: 10.4137/cmo.s9518. [PMID: 22693424]
  • Herbert H Lipowsky, Lujia Gao, Ann Lescanic. Shedding of the endothelial glycocalyx in arterioles, capillaries, and venules and its effect on capillary hemodynamics during inflammation. American journal of physiology. Heart and circulatory physiology. 2011 Dec; 301(6):H2235-45. doi: 10.1152/ajpheart.00803.2011. [PMID: 21926341]
  • Falco Hietbrink, Leo Koenderman, Luke Ph Leenen. Intramedullary nailing of the femur and the systemic activation of monocytes and neutrophils. World journal of emergency surgery : WJES. 2011 Oct; 6(?):34. doi: 10.1186/1749-7922-6-34. [PMID: 22040874]
  • André Luiz Teroso Ribeiro, Ana Lúcia Borges Shimada, Cristina Bichels Hebeda, Tiago Franco de Oliveira, Ana Paula de Melo Loureiro, Walter Dos Reis Pereira Filho, Alcinéa Meigikos Dos Anjos Santos, Wothan Tavares de Lima, Sandra Helena Poliselli Farsky. In vivo hydroquinone exposure alters circulating neutrophil activities and impairs LPS-induced lung inflammation in mice. Toxicology. 2011 Oct; 288(1-3):1-7. doi: 10.1016/j.tox.2011.05.009. [PMID: 21664406]
  • Shou-Fang Wu, Tsong-Long Hwang, Shu-Li Chen, Chin-Chung Wu, Emika Ohkoshi, Kuo-Hsiung Lee, Fang-Rong Chang, Yang-Chang Wu. Bioactive components from the heartwood of Pterocarpus santalinus. Bioorganic & medicinal chemistry letters. 2011 Sep; 21(18):5630-2. doi: 10.1016/j.bmcl.2011.06.036. [PMID: 21784631]
  • Ji-Liang Gao, Erich H Schneider, Eugene L Dimitrov, Forrest Haun, Therese M Pham, Abdul H Mohammed, Ted B Usdin, Philip M Murphy. Reduced fear memory and anxiety-like behavior in mice lacking formylpeptide receptor 1. Behavior genetics. 2011 Sep; 41(5):724-33. doi: 10.1007/s10519-011-9467-0. [PMID: 21484271]
  • Di-xian Luo, Mei C Huang, Jun Ma, Zachary Gao, Duan-fang Liao, Deliang Cao. Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway. The Biochemical journal. 2011 Aug; 438(1):71-80. doi: 10.1042/bj20110111. [PMID: 21585341]
  • Ines Kaufmann, Matthias Feuerecker, Alex Salam, Gustav Schelling, Manfred Thiel, Alexander Choukèr. Adenosine A2(A) receptor modulates the oxidative stress response of primed polymorphonuclear leukocytes after parabolic flight. Human immunology. 2011 Jul; 72(7):547-52. doi: 10.1016/j.humimm.2011.03.021. [PMID: 21513753]
  • Amit Prasad, Yonghui Jia, Anutosh Chakraborty, Yitang Li, Supriya K Jain, Jia Zhong, Saurabh Ghosh Roy, Fabien Loison, Subhanjan Mondal, Jiro Sakai, Catlyn Blanchard, Solomon H Snyder, Hongbo R Luo. Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nature immunology. 2011 Jun; 12(8):752-60. doi: 10.1038/ni.2052. [PMID: 21685907]
  • Huang-Ping Yu, Pei-Wen Hsieh, Yi-Ju Chang, Pei-Jen Chung, Liang-Mou Kuo, Tsong-Long Hwang. 2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats. Free radical biology & medicine. 2011 Jun; 50(12):1737-48. doi: 10.1016/j.freeradbiomed.2011.03.026. [PMID: 21457779]
  • Rafik Bachoual, Wifak Talmoudi, Tarek Boussetta, Françoise Braut, Jamel El-Benna. An aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Jun; 49(6):1224-8. doi: 10.1016/j.fct.2011.02.024. [PMID: 21376769]
  • Edna Sayuri Suyenaga, Eduardo Luis Konrath, Roger Remy Dresch, Miriam Anders Apel, José Angelo Zuanazzi, Célia Gervásio Chaves, Amélia Teresinha Henriques. Appraisal of the antichemotactic activity of flavonoids on polymorphonuclear neutrophils. Planta medica. 2011 May; 77(7):698-704. doi: 10.1055/s-0030-1250516. [PMID: 21058242]
  • Rudolf Lampé, Sándor Szucs, Róza Adány, Robert Póka. Granulocyte superoxide anion production and regulation by plasma factors in normal and preeclamptic pregnancy. Journal of reproductive immunology. 2011 May; 89(2):199-206. doi: 10.1016/j.jri.2011.01.019. [PMID: 21529965]