FMLP OMe (BioDeep_00000008548)

   


代谢物信息卡片


Formylmethionyl-leucyl-phenylalanine methyl ester

化学式: C22H33N3O5S (451.2141)
中文名称:
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)OC)NC(=O)C(CCSC)NC=O
InChI: InChI=1S/C22H33N3O5S/c1-15(2)12-18(24-20(27)17(23-14-26)10-11-31-4)21(28)25-19(22(29)30-3)13-16-8-6-5-7-9-16/h5-9,14-15,17-19H,10-13H2,1-4H3,(H,23,26)(H,24,27)(H,25,28)/t17-,18-,19-/m0/s1



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 FPR1, GLO1, IL1A, MAPK14
Nucleus 3 IL1A, MAPK14, ZBTB7B
cytosol 3 GLO1, IL1A, MAPK14
nucleoplasm 3 GLO1, MAPK14, ZBTB7B
Cell membrane 2 FPR1, TNF
Multi-pass membrane protein 1 FPR1
cell surface 3 IL1A, TNF, UMOD
glutamatergic synapse 1 MAPK14
neuronal cell body 1 TNF
plasma membrane 4 FPR1, GLO1, KNG1, TNF
Membrane 2 FPR1, UMOD
apical plasma membrane 1 UMOD
basolateral plasma membrane 1 UMOD
extracellular exosome 4 GLO1, KNG1, LYZ, UMOD
endoplasmic reticulum 1 UMOD
extracellular space 6 IL1A, IL2, KNG1, LYZ, TNF, UMOD
mitochondrion 1 MAPK14
Secreted 3 IL1A, IL2, UMOD
extracellular region 6 IL1A, IL2, KNG1, LYZ, MAPK14, TNF
ciliary membrane 1 UMOD
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 UMOD
Membrane raft 1 TNF
collagen-containing extracellular matrix 1 KNG1
nuclear speck 1 MAPK14
cilium 1 UMOD
phagocytic cup 1 TNF
Secreted, extracellular space 1 KNG1
spindle pole 2 MAPK14, UMOD
blood microparticle 1 KNG1
Basolateral cell membrane 1 UMOD
Lipid-anchor, GPI-anchor 1 UMOD
side of membrane 1 UMOD
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
secretory granule membrane 1 FPR1
Golgi lumen 1 UMOD
endoplasmic reticulum lumen 1 KNG1
platelet alpha granule lumen 1 KNG1
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
extrinsic component of membrane 1 UMOD
azurophil granule membrane 1 FPR1
azurophil granule lumen 1 LYZ
ficolin-1-rich granule membrane 1 FPR1
Cell projection, cilium membrane 1 UMOD
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Uromodulin, secreted form]: Secreted 1 UMOD
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Tsong-Long Hwang, Yann-Lii Leu, Shu-Hui Kao, Ming-Chi Tang, Han-Lin Chang. Viscolin, a new chalcone from Viscum coloratum, inhibits human neutrophil superoxide anion and elastase release via a cAMP-dependent pathway. Free radical biology & medicine. 2006 Nov; 41(9):1433-41. doi: 10.1016/j.freeradbiomed.2006.08.001. [PMID: 17023270]
  • Akio Jinnouchi, Yoshitomi Aida, Kohji Nozoe, Katsumasa Maeda, Michael J Pabst. Local anesthetics inhibit priming of neutrophils by lipopolysaccharide for enhanced release of superoxide: suppression of cytochrome b558 expression by disparate mechanisms. Journal of leukocyte biology. 2005 Dec; 78(6):1356-65. doi: 10.1189/jlb.0305169. [PMID: 16204644]
  • Kuo-Tong Liou, Yuh-Chiang Shen, Chieh-Fu Chen, Cheng-Ming Tsao, Shen-Kou Tsai. Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production. Brain research. 2003 Dec; 992(2):159-66. doi: 10.1016/j.brainres.2003.08.026. [PMID: 14625055]
  • M Karst, D Scheinichen, T Rueckert, T Wagner, B Wiese, S Piepenbrock, M Fink. Effect of acupuncture on the neutrophil respiratory burst: a placebo-controlled single-blinded study. Complementary therapies in medicine. 2003 Mar; 11(1):4-10. doi: 10.1016/s0965-2299(02)00117-6. [PMID: 12667969]
  • Supriya Srinivasan, Fei Wang, Suzana Glavas, Alexander Ott, Fred Hofmann, Klaus Aktories, Daniel Kalman, Henry R Bourne. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. The Journal of cell biology. 2003 Feb; 160(3):375-85. doi: 10.1083/jcb.200208179. [PMID: 12551955]
  • Hiroshi Mitsuoka, Erik B Kistler, Geert W Schmid-Schönbein. Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. Shock (Augusta, Ga.). 2002 Mar; 17(3):205-9. doi: 10.1097/00024382-200203000-00008. [PMID: 11900339]
  • T Hiran, M Dinauer, C Johnson, K Clay, J Travers. Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. Prostaglandins & other lipid mediators. 2001 Dec; 66(4):305-15. doi: 10.1016/s0090-6980(01)00163-0. [PMID: 11785782]
  • M J Borgnia, G D Eytan, Y G Assaraf. Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. The Journal of biological chemistry. 1996 Feb; 271(6):3163-71. doi: 10.1074/jbc.271.6.3163. [PMID: 8621716]
  • G Briheim, B Coble, O Stendahl, C Dahlgren. Exudate polymorphonuclear leukocytes isolated from skin chambers are primed for enhanced response to subsequent stimulation with chemoattractant f-Met-Leu-Phe and C3-opsonized yeast particles. Inflammation. 1988 Apr; 12(2):141-52. doi: 10.1007/bf00916397. [PMID: 3391683]
  • R M Epand, K E Raymer. Comparison of the interaction of methionine and norleucine-containing peptides with phospholipid bilayers. International journal of peptide and protein research. 1987 Oct; 30(4):515-21. doi: 10.1111/j.1399-3011.1987.tb03360.x. [PMID: 3429131]