1,2,3,4-Tetrachlorodibenzo-P-dioxin (BioDeep_00000008469)

 

Secondary id: BioDeep_00001874164

human metabolite blood metabolite


代谢物信息卡片


1,2,3,4-Tetrachlorodibenzo[b,e][1,4]dioxin

化学式: C12H4Cl4O2 (319.8965404)
中文名称: 1,2,3,4-四氯二苯并-对-二恶英
谱图信息: 最多检出来源 Mus musculus(blood) 50%

分子结构信息

SMILES: C1=CC=C2C(=C1)OC3=C(O2)C(=C(C(=C3Cl)Cl)Cl)Cl
InChI: InChI=1S/C12H4Cl4O2/c13-7-8(14)10(16)12-11(9(7)15)17-5-3-1-2-4-6(5)18-12/h1-4H

描述信息

D009676 - Noxae > D013723 - Teratogens > D000072317 - Polychlorinated Dibenzodioxins

同义名列表

6 个代谢物同义名

1,2,3,4-Tetrachlorodibenzo[b,e][1,4]dioxin; 1,2,3,4-Tetrachlorodibenzo-para-dioxin; 1,2,3,4-TETRACHLORODIBENZO-P-DIOXIN; 1,2,3,4-Tetrachlorodibenzodioxin; 1,2,3,4-Tetrachlorooxanthrene; 1,2,3,4-TCDD



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu-Cheng Chen, Perng-Jy Tsai, Jin-Luh Mou, Yu-Chieh Kuo, Shih-Min Wang, Li-Hao Young, Ya-Fen Wang. A pilot study for determining the optimal operation condition for simultaneously controlling the emissions of PCDD/Fs and PAHs from the iron ore sintering process. Chemosphere. 2012 Sep; 88(11):1324-31. doi: 10.1016/j.chemosphere.2012.05.031. [PMID: 22704976]
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  • Giovanni Lonati, Francesca Zanoni. Probabilistic health risk assessment of carcinogenic emissions from a MSW gasification plant. Environment international. 2012 Sep; 44(?):80-91. doi: 10.1016/j.envint.2012.01.013. [PMID: 22364891]
  • Jana Chovancová, Kamil Conka, Anna Fabišiková, Zuzana Stachová Sejáková, Milena Dömötörová, Beáta Drobná, Soňa Wimmerová. PCDD/PCDF, dl-PCB and PBDE serum levels of Slovak general population. Chemosphere. 2012 Sep; 88(11):1383-9. doi: 10.1016/j.chemosphere.2012.05.060. [PMID: 22704218]
  • Yury I Chernyak, Andrey A Shelepchikov, Efim S Brodsky, Jean A Grassman. PCDD, PCDF, and PCB exposure in current and former firefighters from Eastern Siberia. Toxicology letters. 2012 Aug; 213(1):9-14. doi: 10.1016/j.toxlet.2011.09.021. [PMID: 21979175]
  • J W Chang, H L Chen, H J Su, P C Liao, C C Lee. Biochemical study of retired pentachlorophenol workers with and without following dietary exposure to PCDD/Fs. Chemosphere. 2012 Aug; 88(7):813-9. doi: 10.1016/j.chemosphere.2012.03.087. [PMID: 22579452]
  • Baoqin Zhang, Haijun Zhang, Jing Jin, Yuwen Ni, Jiping Chen. PCDD/Fs-induced oxidative damage and antioxidant system responses in tobacco cell suspension cultures. Chemosphere. 2012 Aug; 88(7):798-805. doi: 10.1016/j.chemosphere.2012.03.085. [PMID: 22564455]
  • Michael Staff, Vicky Sheppeard, Samanthi Abeywardana, Bradley Forssman, Alison Rutherford, Jochen F Mueller, Olaf Paepke. Blood dioxin biomonitoring to assess local residents' exposure from a large urban remediation project. Chemosphere. 2012 Jul; 88(3):316-22. doi: 10.1016/j.chemosphere.2012.03.003. [PMID: 22483731]
  • Bo Deng, JianQing Zhang, Lishi Zhang, YouSheng Jiang, Jian Zhou, Daokui Fang, Huiming Zhang, HaiYan Huang. Levels and profiles of PCDD/Fs, PCBs in mothers' milk in Shenzhen of China: estimation of breast-fed infants' intakes. Environment international. 2012 Jul; 42(?):47-52. doi: 10.1016/j.envint.2011.03.022. [PMID: 21531025]
  • Haitao Shen, Gangqiang Ding, Yongning Wu, Guoshao Pan, Xiaoping Zhou, Jianlong Han, Jingguang Li, Sheng Wen. Polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) in breast milk from Zhejiang, China. Environment international. 2012 Jul; 42(?):84-90. doi: 10.1016/j.envint.2011.04.004. [PMID: 21575990]
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  • Wataru Yoshioka, Keiko Aida-Yasuoka, Nozomi Fujisawa, Tatsuya Kawaguchi, Seiichiroh Ohsako, Shuntaro Hara, Satoshi Uematsu, Shizuo Akira, Chiharu Tohyama. Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Jun; 127(2):547-54. doi: 10.1093/toxsci/kfs115. [PMID: 22430074]
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  • Peter Bui, Parrisa Solaimani, Xiaomeng Wu, Oliver Hankinson. 2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment alters eicosanoid levels in several organs of the mouse in an aryl hydrocarbon receptor-dependent fashion. Toxicology and applied pharmacology. 2012 Mar; 259(2):143-51. doi: 10.1016/j.taap.2011.12.009. [PMID: 22230337]
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  • Pao Chen Hung, Kai Hsien Chi, Mei Lien Chen, Moo Been Chang. Characteristics of dioxin emissions from a Waelz plant with acid and basic kiln mode. Journal of hazardous materials. 2012 Jan; 201-202(?):229-35. doi: 10.1016/j.jhazmat.2011.11.075. [PMID: 22178278]
  • Ying Chen, Mansi Krishan, Daniel W Nebert, Howard G Shertzer. Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis. Chemical research in toxicology. 2012 Jan; 25(1):94-100. doi: 10.1021/tx200242a. [PMID: 22082335]
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  • Jürgen Wittsiepe, Michael Wilhelm, Thomas Kraus. Levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) in blood samples of occupationally exposed workers from a transformer recycling plant in Dortmund, Germany-initial findings. Journal of toxicology and environmental health. Part A. 2012; 75(8-10):423-8. doi: 10.1080/15287394.2012.674906. [PMID: 22686301]
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  • Jean-Hilaire Saurat, Guerkan Kaya, Nikolina Saxer-Sekulic, Bruno Pardo, Minerva Becker, Lionel Fontao, Florence Mottu, Pierre Carraux, Xuan-Cuong Pham, Caroline Barde, Fabienne Fontao, Markus Zennegg, Peter Schmid, Olivier Schaad, Patrick Descombes, Olivier Sorg. The cutaneous lesions of dioxin exposure: lessons from the poisoning of Victor Yushchenko. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Jan; 125(1):310-7. doi: 10.1093/toxsci/kfr223. [PMID: 21998131]
  • Filomena Fiorito, Roberto Ciarcia, Giovanna Elvira Granato, Gabriella Marfe, Valentina Iovane, Salvatore Florio, Luisa De Martino, Ugo Pagnini. 2,3,7,8-tetrachlorodibenzo-p-dioxin induced autophagy in a bovine kidney cell line. Toxicology. 2011 Dec; 290(2-3):258-70. doi: 10.1016/j.tox.2011.10.004. [PMID: 22015590]
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  • Takashi Todaka, Hironori Hirakawa, Jumboku Kajiwara, Daisuke Onozuka, Seiko Sasaki, Chihiro Miyashita, Eiji Yoshioka, Motoyuki Yuasa, Reiko Kishi, Takao Iida, Hiroshi Uchi, Masutaka Furue. Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City, Japan. Chemosphere. 2011 Dec; 85(11):1694-700. doi: 10.1016/j.chemosphere.2011.09.014. [PMID: 22004731]
  • Michelle M Angrish, A D Jones, Jack R Harkema, Timothy R Zacharewski. Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Dec; 124(2):299-310. doi: 10.1093/toxsci/kfr226. [PMID: 21890736]
  • Hasan Turkez, Fatime Geyikoglu. The effect of laurel leaf extract against toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured rat hepatocytes. Arhiv za higijenu rada i toksikologiju. 2011 Dec; 62(4):309-15. doi: 10.2478/10004-1254-62-2011-2118. [PMID: 22202464]
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