1,2,3,4-Tetrachlorodibenzo-P-dioxin (BioDeep_00000008469)
Secondary id: BioDeep_00001874164
human metabolite blood metabolite
代谢物信息卡片
1,2,3,4-Tetrachlorodibenzo[b,e][1,4]dioxin
化学式: C12H4Cl4O2 (319.8965)
中文名称: 1,2,3,4-四氯二苯并-对-二恶英, 1,2,3,4-四氯二苯并对二恶英
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: C1=CC=C2C(=C1)OC3=C(O2)C(=C(C(=C3Cl)Cl)Cl)Cl
InChI: InChI=1S/C12H4Cl4O2/c13-7-8(14)10(16)12-11(9(7)15)17-5-3-1-2-4-6(5)18-12/h1-4H
描述信息
D009676 - Noxae > D013723 - Teratogens > D000072317 - Polychlorinated Dibenzodioxins
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:27785
- KEGG: C11058
- PubChem: 35454
- HMDB: HMDB0244113
- Metlin: METLIN68803
- ChEMBL: CHEMBL343583
- chemspider: 32611
- CAS: 30746-58-8
- PMhub: MS000022090
- PubChem: 13240
- NIKKAJI: J74.777G
- KNApSAcK: 27785
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Chemosphere.
2011 Aug; 84(7):894-9. doi:
10.1016/j.chemosphere.2011.06.016. [PMID: 21724227] - Kenneth S Ramos, Diego E Montoya-Durango, Ivo Teneng, Adrian Nanez, Vilius Stribinskis. Epigenetic control of embryonic renal cell differentiation by L1 retrotransposon.
Birth defects research. Part A, Clinical and molecular teratology.
2011 Aug; 91(8):693-702. doi:
10.1002/bdra.20786. [PMID: 21384534] - Edward Dere, Raymond Lo, Trine Celius, Jason Matthews, Timothy R Zacharewski. Integration of genome-wide computation DRE search, AhR ChIP-chip and gene expression analyses of TCDD-elicited responses in the mouse liver.
BMC genomics.
2011 Jul; 12(?):365. doi:
10.1186/1471-2164-12-365. [PMID: 21762485] - S Dhanabalan, R Jubendradass, P Latha, P P Mathur. Effect of restraint stress on 2,3,7,8 tetrachloro dibenzo-p-dioxin induced testicular and epididymal toxicity in rats.
Human & experimental toxicology.
2011 Jul; 30(7):567-78. doi:
10.1177/0960327110376548. [PMID: 20610472] - Alvin L Young, Paul F Cecil. Agent Orange exposure and attributed health effects in Vietnam veterans.
Military medicine.
2011 Jul; 176(7 Suppl):29-34. doi:
10.7205/milmed-d-11-00082. [PMID: 21916327] - E C Rada, M Ragazzi, D Zardi, L Laiti, A Ferrari. PCDD/F enviromental impact from municipal solid waste bio-drying plant.
Chemosphere.
2011 Jun; 84(3):289-95. doi:
10.1016/j.chemosphere.2011.04.019. [PMID: 21550632] - R G Ahmed. Perinatal TCDD exposure alters developmental neuroendocrine system.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Jun; 49(6):1276-84. doi:
10.1016/j.fct.2011.03.008. [PMID: 21414370] - Fatemeh Saberi Hosnijeh, Daisy Boers, Lützen Portengen, H Bas Bueno-de-Mesquita, Dick Heederik, Roel Vermeulen. Long-term effects on humoral immunity among workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Occupational and environmental medicine.
2011 Jun; 68(6):419-24. doi:
10.1136/oem.2010.058016. [PMID: 21097950] - Osman Ciftci, Ilknur Ozdemir, Sadettin Tanyildizi, Sedat Yildiz, Hakan Oguzturk. Antioxidative effects of curcumin, β-myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver.
Toxicology and industrial health.
2011 Jun; 27(5):447-53. doi:
10.1177/0748233710388452. [PMID: 21245202] - J S Lim, H-K Son, S-K Park, D R Jacobs, D-H Lee. Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants.
International journal of obesity (2005).
2011 May; 35(5):744-7. doi:
10.1038/ijo.2010.188. [PMID: 20820170] - Yuan Kang, Kwai Chung Cheung, Zong Wei Cai, Ming H Wong. Chemical and bioanalytical characterization of dioxins in indoor dust in Hong Kong.
Ecotoxicology and environmental safety.
2011 May; 74(4):947-52. doi:
10.1016/j.ecoenv.2011.01.006. [PMID: 21300406] - Sonja Kaisarevic, Klara Hilscherova, Roland Weber, Kristina L Sundqvist, Mats Tysklind, Ernest Voncina, Stanka Bobic, Nebojsa Andric, Kristina Pogrmic-Majkic, Mirjana Vojinovic-Miloradov, John Paul Giesy, Radmila Kovacevic. Characterization of dioxin-like contamination in soil and sediments from the 'hot spot' area of petrochemical plant in Pancevo (Serbia).
Environmental science and pollution research international.
2011 May; 18(4):677-86. doi:
10.1007/s11356-010-0418-8. [PMID: 21104203] - Ivano Vassura, Fabrizio Passarini, Laura Ferroni, Elena Bernardi, Luciano Morselli. PCDD/Fs atmospheric deposition fluxes and soil contamination close to a municipal solid waste incinerator.
Chemosphere.
2011 May; 83(10):1366-73. doi:
10.1016/j.chemosphere.2011.02.072. [PMID: 21459405] - Hamdy A A Aly, Rasha M Khafagy. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cytotoxicity accompanied by oxidative stress in rat Sertoli cells: Possible role of mitochondrial fractions of Sertoli cells.
Toxicology and applied pharmacology.
2011 May; 252(3):273-80. doi:
10.1016/j.taap.2011.02.019. [PMID: 21382395] - Rita Santamaria, Filomena Fiorito, Carlo Irace, Luisa De Martino, Carmen Maffettone, Giovanna Elvira Granato, Antonio Di Pascale, Valentina Iovane, Ugo Pagnini, Alfredo Colonna. 2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs iron homeostasis by modulating iron-related proteins expression and increasing the labile iron pool in mammalian cells.
Biochimica et biophysica acta.
2011 May; 1813(5):704-12. doi:
10.1016/j.bbamcr.2011.02.003. [PMID: 21333694] - Jing-Fang Hsu, How-Ran Guo, Hsueh Wen Wang, Chin-Kun Liao, Pao-Chi Liao. An occupational exposure assessment of polychlorinated dibenzo-p-dioxin and dibenzofurans in firefighters.
Chemosphere.
2011 May; 83(10):1353-9. doi:
10.1016/j.chemosphere.2011.02.079. [PMID: 21458022] - Edward Dere, Andrea W Lee, Lyle D Burgoon, Timothy R Zacharewski. Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells.
BMC genomics.
2011 Apr; 12(?):193. doi:
10.1186/1471-2164-12-193. [PMID: 21496263] - Barna Bordás, Iván Bélai, Tamás Koomíves. Theoretical molecular descriptors relevant to the uptake of persistent organic pollutants from soil by zucchini. A QSAR study.
Journal of agricultural and food chemistry.
2011 Apr; 59(7):2863-9. doi:
10.1021/jf1038772. [PMID: 21244025] - Jin-Seon Lee, Eun-Young Kim, Kohei Iwabuchi, Hisato Iwata. Molecular and functional characterization of aryl hydrocarbon receptor nuclear translocator 1 (ARNT1) and ARNT2 in chicken (Gallus gallus).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2011 Apr; 153(3):269-79. doi:
10.1016/j.cbpc.2010.11.005. [PMID: 21134488] - Junya Nagayama, Takashi Todaka, Hironori Hirakawa, Jumboku Kajiwara, Takao Iida, Satoko Shibata, Hiroshi Tsuji, Teruaki Iwasaki. [Promotive excretion of causative agents of Yusho by fermented brown rice with Aspergillus oryze in Yusho patients].
Fukuoka igaku zasshi = Hukuoka acta medica.
2011 Apr; 102(4):123-9. doi:
". [PMID: 21706891] - Steven D Holladay, Amjad Mustafa, Robert M Gogal. Prenatal TCDD in mice increases adult autoimmunity.
Reproductive toxicology (Elmsford, N.Y.).
2011 Apr; 31(3):312-8. doi:
10.1016/j.reprotox.2010.08.001. [PMID: 20728533] - Qiang Ju, Sabine Fimmel, Norbert Hinz, Ralf Stahlmann, Longqing Xia, Christos C Zouboulis. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro.
Experimental dermatology.
2011 Apr; 20(4):320-5. doi:
10.1111/j.1600-0625.2010.01204.x. [PMID: 21410761] - Hyo-Bang Moon, Duk-Hee Lee, Yoon Soon Lee, Kurunthachalam Kannan. Concentrations and accumulation profiles of PCDDs, PCDFs and dioxin-like PCBs in adipose fat tissues of Korean women.
Journal of environmental monitoring : JEM.
2011 Apr; 13(4):1096-101. doi:
10.1039/c0em00730g. [PMID: 21359368] - Courtney E W Sulentic, Norbert E Kaminski. The long winding road toward understanding the molecular mechanisms for B-cell suppression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicological sciences : an official journal of the Society of Toxicology.
2011 Mar; 120 Suppl 1(?):S171-91. doi:
10.1093/toxsci/kfq324. [PMID: 20952503] - Jun Ozeki, Shigeyuki Uno, Michitaka Ogura, Mihwa Choi, Tetsuyo Maeda, Kenichi Sakurai, Sadanori Matsuo, Sadao Amano, Daniel W Nebert, Makoto Makishima. Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice.
Toxicology.
2011 Feb; 280(1-2):10-7. doi:
10.1016/j.tox.2010.11.003. [PMID: 21095216] - Joaquim Rovira, Montse Mari, Marta Schuhmacher, Martí Nadal, José L Domingo. Monitoring environmental pollutants in the vicinity of a cement plant: a temporal study.
Archives of environmental contamination and toxicology.
2011 Feb; 60(2):372-84. doi:
10.1007/s00244-010-9628-9. [PMID: 21140142] - Narendra P Singh, Ugra S Singh, Mitzi Nagarkatti, Prakash S Nagarkatti. Resveratrol (3,5,4'-trihydroxystilbene) protects pregnant mother and fetus from the immunotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Molecular nutrition & food research.
2011 Feb; 55(2):209-19. doi:
10.1002/mnfr.201000206. [PMID: 20715097] - Jin-Seon Lee, Eun-Young Kim, Koji Nomaru, Hisato Iwata. Molecular and functional characterization of Aryl hydrocarbon receptor repressor from the chicken (Gallus gallus): interspecies similarities and differences.
Toxicological sciences : an official journal of the Society of Toxicology.
2011 Feb; 119(2):319-34. doi:
10.1093/toxsci/kfq336. [PMID: 21047992] - J Rivera-Austrui, M A Borrajo, K Martinez, M A Adrados, M Abalos, B Van Bavel, J Rivera, E Abad. Assessment of polychlorinated dibenzo-p-dioxin and dibenzofuran emissions from a hazardous waste incineration plant using long-term sampling equipment.
Chemosphere.
2011 Feb; 82(9):1343-9. doi:
10.1016/j.chemosphere.2010.11.054. [PMID: 21193220] - Amjad Mustafa, Steven Holladay, Sharon Witonsky, Kurt Zimmerman, Ashley Manari, Sheryl Countermarsh, Ebru Karpuzoglu, Robert Gogal. Prenatal TCDD causes persistent modulation of the postnatal immune response, and exacerbates inflammatory disease, in 36-week-old lupus-like autoimmune SNF1 mice.
Birth defects research. Part B, Developmental and reproductive toxicology.
2011 Feb; 92(1):82-94. doi:
10.1002/bdrb.20285. [PMID: 21312323] - Abdulqader A Alhaider, Mohamed A M El Gendy, Hesham M Korashy, Ayman O S El-Kadi. Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line.
Journal of ethnopharmacology.
2011 Jan; 133(1):184-90. doi:
10.1016/j.jep.2010.09.012. [PMID: 20883769] - Lirong Gao, Minghui Zheng, Bing Zhang, Wenbin Liu, Ke Xiao, Guijin Su, Qinghua Zhang. Polychlorinated dibenzo-p-dioxins and dibenzofurans in different tissues of the cormorants (Phalacrocorax carbo) from Dongting Lake, China.
Journal of environmental sciences (China).
2011; 23(10):1709-13. doi:
10.1016/s1001-0742(10)60588-8. [PMID: 22432267] - Joaquim Rovira, Montse Mari, Martí Nadal, Marta Schuhmacher, José L Domingo. Use of sewage sludge as secondary fuel in a cement plant: human health risks.
Environment international.
2011 Jan; 37(1):105-11. doi:
10.1016/j.envint.2010.08.004. [PMID: 20817299] - Yimei Wang, Chunfeng Lu, Zhiguo Sheng, Gang Liu, Ze Fu, Benzhan Zhu, Shuangqing Peng. Enhanced hepatotoxicity induced by repeated exposure to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin in combination in male rats.
Journal of environmental sciences (China).
2011; 23(1):119-24. doi:
10.1016/s1001-0742(10)60382-8. [PMID: 21476350] - Daniela Pelclova, Tomas Navratil, Zdenka Fenclova, Stepanka Vlckova, Karel Kupka, Pavel Urban, Petr Ridzon, Vit Zikan, Ludmila Landova, Kamila Syslova, Marek Kuzma, Petr Kacer. Increased oxidative/nitrosative stress markers measured non- invasively in patients with high 2,3,7,8-tetrachloro-dibenzo-p-dioxin plasma level.
Neuro endocrinology letters.
2011; 32 Suppl 1(?):71-6. doi:
. [PMID: 22167218] - Maurizio Onofrio, Roberta Spataro, Serena Botta. The role of a steel plant in north-west Italy to the local air concentrations of PCDD/Fs.
Chemosphere.
2011 Jan; 82(5):708-17. doi:
10.1016/j.chemosphere.2010.10.095. [PMID: 21094976] - Joaquim Rovira, Montse Mari, Martí Nadal, Marta Schuhmacher, José L Domingo. Levels of metals and PCDD/Fs in the vicinity of a cement plant: assessment of human health risks.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2011; 46(10):1075-84. doi:
10.1080/10934529.2011.590383. [PMID: 21762008] - Chiharu Tohyama, Iwao Uchiyama, Shuji Hoshi, Masaki Hijiya, Hideaki Miyata, Masaki Nagai, Satoshi Nakai, Mariko Yauchi, Satsuki Ohkubo. Polychlorinated dioxins, furans, and biphenyls in blood of children and adults living in a dioxin-contaminated area in Tokyo.
Environmental health and preventive medicine.
2011 Jan; 16(1):6-15. doi:
10.1007/s12199-010-0156-z. [PMID: 21432212] - Kokichi Arisawa, Hirokazu Uemura, Mineyoshi Hiyoshi, Atsushi Kitayama, Hidenobu Takami, Fusakazu Sawachika, Yuki Nishioka, Manabu Hasegawa, Masaharu Tanto, Hiroshi Satoh, Masayuki Shima, Yoshio Sumiyoshi, Kenji Morinaga, Kazunori Kodama, Taka-Ichiro Suzuki, Masaki Nagai. Dietary patterns and blood levels of PCDDs, PCDFs, and dioxin-like PCBs in 1656 Japanese individuals.
Chemosphere.
2011 Jan; 82(5):656-62. doi:
10.1016/j.chemosphere.2010.11.008. [PMID: 21138777] - Pao Chen Hung, Wei Chiao Lo, Kai Hsien Chi, Shu Hao Chang, Moo Been Chang. Reduction of dioxin emission by a multi-layer reactor with bead-shaped activated carbon in simulated gas stream and real flue gas of a sinter plant.
Chemosphere.
2011 Jan; 82(1):72-7. doi:
10.1016/j.chemosphere.2010.10.004. [PMID: 21040943]
