N-(3,5-Dichlorophenyl)succinimide (BioDeep_00000008435)

 

Secondary id: BioDeep_00001874368

human metabolite blood metabolite


代谢物信息卡片


1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione

化学式: C10H7Cl2NO2 (242.9853822)
中文名称: 菌核净
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C1CC(=O)N(C1=O)C2=CC(=CC(=C2)Cl)Cl
InChI: InChI=1S/C10H7Cl2NO2/c11-6-3-7(12)5-8(4-6)13-9(14)1-2-10(13)15/h3-5H,1-2H2

描述信息

D016573 - Agrochemicals
D010575 - Pesticides

同义名列表

5 个代谢物同义名

1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione; N-(3,5-Dichlorophenyl)succinimide; NDPS, Succinimide; Dimethachlon; NDPS



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gary O Rankin, Suk K Hong, Dianne K Anestis, John G Ball, Monica A Valentovic, Vincent A Graffeo. Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats. Toxicology. 2012 Oct; 300(1-2):92-9. doi: 10.1016/j.tox.2012.06.003. [PMID: 22706168]
  • Gary O Rankin, Suk-kil Hong, Dianne K Anestis. Nephrotoxicity induced by N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid in male and female Fischer 344 rats. Journal of applied toxicology : JAT. 2008 Oct; 28(7):867-73. doi: 10.1002/jat.1350. [PMID: 18418842]
  • Donghui Cui, Gary O Rankin, Peter J Harvison. Transamination in the metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats. Drug metabolism and disposition: the biological fate of chemicals. 2005 Dec; 33(12):1765-70. doi: 10.1124/dmd.105.006593. [PMID: 16174804]
  • Erica L Kennedy, Ruy Tchao, Peter J Harvison. Nephrotoxic and hepatotoxic potential of imidazolidinedione-, oxazolidinedione- and thiazolidinedione-containing analogues of N-(3,5-dichlorophenyl)succinimide (NDPS) in Fischer 344 rats. Toxicology. 2003 Apr; 186(1-2):79-91. doi: 10.1016/s0300-483x(02)00692-3. [PMID: 12604172]
  • Caroline M Henesey, Peter J Harvison. Renal damage, metabolism and covalent binding following administration of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide (NDPS) to male Fischer 344 rats. Toxicology. 2002 Jan; 170(3):187-200. doi: 10.1016/s0300-483x(01)00543-1. [PMID: 11788156]
  • S K Hong, D K Anestis, M A Valentovic, J G Ball, P I Brown, G O Rankin. Gender differences in the potentiation of N-(3,5-dichlorophenyl)succinimide metabolite nephrotoxicity by phenobarbital. Journal of toxicology and environmental health. Part A. 2001 Oct; 64(3):241-56. doi: 10.1080/15287390152543717. [PMID: 11594702]
  • G O Rankin, S K Hong, D K Anestis, L H Lash, S L Miles. In vitro nephrotoxicity induced by N-(3,5-dichlorophenyl)succinimide (NDPS) metabolites in isolated renal cortical cells from male and female Fischer 344 rats: evidence for a nephrotoxic sulfate conjugate metabolite. Toxicology. 2001 Jun; 163(2-3):73-82. doi: 10.1016/s0300-483x(01)00376-6. [PMID: 11516516]
  • D Cui, P J Harvison. Determination of the site of glucuronidation in an N-(3,5-dichlorophenyl)succinimide metabolite by electrospray ionization tandem mass spectrometry following derivatization to picolinyl esters. Rapid communications in mass spectrometry : RCM. 2000; 14(21):1985-90. doi: 10.1002/1097-0231(20001115)14:21<1985::aid-rcm122>3.0.co;2-f. [PMID: 11085408]
  • C M Henesey, G L Kellner-Weibel, J B Tarloff, P J Harvison. Comparative disposition of the nephrotoxicant N-(3, 5-dichlorophenyl)succinimide and the non-nephrotoxicant N-(3, 5-difluorophenyl)succinimide in Fischer 344 rats. Drug metabolism and disposition: the biological fate of chemicals. 1999 Jun; 27(6):674-80. doi: NULL. [PMID: 10348796]
  • S K Hong, D K Anestis, S Kennedy, G O Rankin. Effect of sulfation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxocity in Fischer 344 rats. Journal of toxicology and environmental health. Part A. 1999 May; 57(1):47-62. doi: 10.1080/009841099157854. [PMID: 10321901]
  • S K Hong, D K Anestis, P I Brown, G O Rankin. Effect of glucuronidation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats. Toxicology. 1999 Jan; 132(1):43-55. doi: 10.1016/s0300-483x(98)00140-1. [PMID: 10199580]
  • R J Griffin, P J Harvison. In vivo metabolism and disposition of the nephrotoxicant N-(3, 5-dichlorophenyl)succinimide in Fischer 344 rats. Drug metabolism and disposition: the biological fate of chemicals. 1998 Sep; 26(9):907-13. doi: . [PMID: 9733670]
  • G O Rankin, S K Hong, M A Valentovic, K W Beers, D K Anestis, D W Nicoll, J G Ball, P I Brown. Effects of sodium sulfate on acute N-(3,5-dichlorophenyl)succinimide (NDPS) nephrotoxicity in the Fischer 344 rat. Toxicology. 1997 Nov; 123(1-2):1-13. doi: 10.1016/s0300-483x(97)00097-8. [PMID: 9347919]
  • A K Nyarko, G L Kellner-Weibel, P J Harvison. Cytochrome P450-mediated metabolism and nephrotoxicity of N-(3,5-dichlorophenyl)succinimide in Fischer 344 rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1997 Jun; 37(2):117-24. doi: 10.1006/faat.1997.2321. [PMID: 9242584]
  • G O Rankin, K W Beers, V J Teets, D W Nicoll, D K Anestis. Buthionine sulfoximine (BSO) and N-(3,5-dichlorophenyl)succinimide nephrotoxicity: temporal aspects of BSO administration and BSO effects on renal transport systems. Toxicology. 1997 Feb; 117(2-3):207-17. doi: 10.1016/s0300-483x(96)03581-0. [PMID: 9057900]
  • G L Kellner-Weibel, A K Nyarko, R Tchao, C M Henesey, P J Harvison. The effect of aromatic fluorine substitution on the nephrotoxicity and metabolism of N-(3,5-dichlorophenyl)succinimide in Fischer 344 rats. Toxicology. 1997 Feb; 117(1):73-83. doi: 10.1016/s0300-483x(96)03556-1. [PMID: 9020201]
  • S K Hong, D K Anestis, N M Hawco, M A Valentovic, P I Brown, G O Rankin. Nephrotoxicity of N-(3-bromophenyl)-2-hydroxysuccinimide: role of halogen groups in the nephrotoxic potential of N-(halophenyl) succinimides. Toxicology. 1996 Jun; 110(1-3):17-25. doi: 10.1016/0300-483x(96)03328-8. [PMID: 8658556]
  • R I Griffin, D B Rutt, C M Henesey, P J Harvison. In vitro metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in the Fischer 344 rat and New Zealand white rabbit. Xenobiotica; the fate of foreign compounds in biological systems. 1996 Apr; 26(4):369-80. doi: 10.3109/00498259609046716. [PMID: 9173678]
  • C M Henesey, P J Harvison. Potential metabolism and cytotoxicity of N-(3,5-dichlorophenyl)succinimide and its hepatic metabolites in isolated rat renal cortical tubule cells. Toxicology. 1995 Dec; 104(1-3):9-16. doi: 10.1016/0300-483x(95)03116-w. [PMID: 8560506]
  • G L Kellner-Weibel, R Tchao, P J Harvison. Nephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaramic acid in Fischer 344 rats. Toxicology letters. 1995 Oct; 80(1-3):123-9. doi: 10.1016/0378-4274(95)03386-y. [PMID: 7482579]
  • G O Rankin, K W Beers, D W Nicoll, D K Anestis, J G Ball, M A Valentovic, P I Brown. Effect of dimethyl sulfoxide on N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity. Toxicology. 1995 Jun; 100(1-3):79-88. doi: 10.1016/0300-483x(95)93709-d. [PMID: 7624885]
  • G O Rankin, H C Shih, S K Hong, D W Nicoll, D K Anestis, J G Ball, P I Brown, M A Valentovic. Role of chloride groups in the nephrotoxic potential of N-(3,5-dichlorophenyl)-2-hydroxysuccinimide, an oxidative metabolite of N-(3,5-dichlorophenyl)succinimide. Toxicology letters. 1995 Jun; 78(1):49-56. doi: 10.1016/0378-4274(94)03232-v. [PMID: 7604399]
  • M Valentovic, P Williams, J Carl, G O Rankin. Urinary enzyme excretion as a parameter for detection of acute renal damage mediated by N-(3,5-dichlorophenyl)succinimide (NDPS) in Fischer 344 rats. Journal of applied toxicology : JAT. 1994 Jul; 14(4):281-5. doi: 10.1002/jat.2550140407. [PMID: 7963241]
  • G O Rankin, K W Beers, V J Teets, D W Nicoll, D K Anestis, P I Brown, R T Wang. Acute N-(3,5-dichlorophenyl)succinimide nephrotoxicity in female Fischer 344 rats. Toxicology. 1994 Mar; 88(1-3):151-64. doi: 10.1016/0300-483x(94)90117-1. [PMID: 8160197]
  • P J Harvison, R J Griffin, V J Teets, D W Nicoll, P I Brown, G O Rankin. Nephrotoxic potential of N-(3,5-dichloro-4-hydroxyphenyl)succinimide and N-(3,5-dichloro-4-hydroxyphenyl)succinamic acid in Fischer-344 rats. Toxicology letters. 1992 Apr; 60(2):221-6. doi: 10.1016/0378-4274(92)90277-q. [PMID: 1570636]
  • K A Bachmann, M S Madhira, G O Rankin. The effects of cobalt chloride, SKF-525A, and N-(3,5-dichlorophenyl)succinimide on in vivo hepatic mixed function oxidase activity as determined by single-sample plasma clearances. Xenobiotica; the fate of foreign compounds in biological systems. 1992 Jan; 22(1):27-31. doi: 10.3109/00498259209053099. [PMID: 1615705]
  • G O Rankin, M A Valentovic, V J Teets, D W Nicoll, C H Sutherland, P I Brown. Effect of calcium antagonism by nifedipine and chlorpromazine on acute N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in Fischer 344 rats. Toxicology. 1991 Feb; 66(1):19-34. doi: 10.1016/0300-483x(91)90175-z. [PMID: 1996465]
  • G O Rankin, V J Teets, D W Nicoll, P I Brown. Interactions among nephrotoxicants: N-(3,5-dichlorophenyl)succinimide and cephaloridine. Toxicology. 1991 Feb; 66(1):47-62. doi: 10.1016/0300-483x(91)90177-3. [PMID: 1996467]
  • G O Rankin, M A Valentovic, V J Teets, D W Nicoll, D K Anestis, P I Brown. Effect of autacoid modulation on N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity. Toxicology. 1991; 70(3):327-44. doi: 10.1016/0300-483x(91)90007-n. [PMID: 1771640]
  • G O Rankin, H C Shih, V J Teets, D J Yang, D W Nicoll, P I Brown. N-(3,5-dichlorophenyl)succinimide nephrotoxicity: evidence against the formation of nephrotoxic glutathione or cysteine conjugates. Toxicology. 1991; 68(3):307-25. doi: 10.1016/0300-483x(91)90077-e. [PMID: 1680251]
  • M D Aleo, G O Rankin, T J Cross, R G Schnellmann. Toxicity of N-(3,5-dichlorophenyl)succinimide and metabolites to rat renal proximal tubules and mitochondria. Chemico-biological interactions. 1991; 78(1):109-21. doi: 10.1016/0009-2797(91)90107-i. [PMID: 2009578]
  • M A Valentovic, V J Teets, D Nicoll, J Stern, D Leppla, G O Rankin. N-(3,5-dichlorophenyl)succinimide nephrotoxicity in streptozotocin-induced diabetic rats. Toxicology. 1990 Sep; 63(3):327-39. doi: 10.1016/0300-483x(90)90194-l. [PMID: 2145659]
  • G O Rankin, M A Valentovic, V J Teets, D W Nicoll, P I Brown. Autacoid modulation and N-(3,5-dichlorophenyl)succinimide nephrotoxicity. Toxicology letters. 1990 Sep; 53(1-2):207-9. doi: 10.1016/0378-4274(90)90128-9. [PMID: 2219169]
  • G O Rankin, V J Teets, D W Nicoll, P I Brown. Effect of buthionine sulfoximine on acute N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in Fischer 344 rats. Toxicology letters. 1990 Jun; 52(1):91-100. doi: 10.1016/0378-4274(90)90169-m. [PMID: 2356574]
  • G O Rankin, H Shih, V J Teets, D W Nicoll, P I Brown. Acute nephrotoxicity induced by N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid in Fischer 344 rats. Toxicology letters. 1989 Sep; 48(3):217-23. doi: 10.1016/0378-4274(89)90047-7. [PMID: 2781590]
  • G O Rankin, V J Teets, D W Nicoll, P I Brown. Comparative acute renal effects of three N-(3,5-dichlorophenyl)carboximide fungicides: N-(3,5-dichlorophenyl)succinimide, vinclozolin and iprodione. Toxicology. 1989 Jun; 56(3):263-72. doi: 10.1016/0300-483x(89)90090-5. [PMID: 2734805]
  • G O Rankin, H C Shih, D J Yang, C D Richmond, V J Teets, P I Brown. Nephrotoxicity of N-(3,5-dichlorophenyl)succinimide metabolites in vivo and in vitro. Toxicology and applied pharmacology. 1988 Dec; 96(3):405-16. doi: 10.1016/0041-008x(88)90001-4. [PMID: 3206523]
  • M Valentovic, C Elliott, V J Teets, P I Brown, D Yang, G O Rankin. Enzyme induction produced by N-(3,5-dichlorophenyl)succinimide (NDPS) in rats. Biochemical pharmacology. 1988 Feb; 37(4):768-70. doi: 10.1016/0006-2952(88)90156-6. [PMID: 3342106]
  • G O Rankin, D J Yang, C D Richmond, V J Teets, R T Wang, P I Brown. Effect of microsomal enzyme activity modulation on N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity. Toxicology. 1987 Sep; 45(3):269-89. doi: 10.1016/0300-483x(87)90018-7. [PMID: 3629611]
  • H H Lo, V J Teets, D J Yang, P I Brown, G O Rankin. Acetone effects on N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity. Toxicology letters. 1987 Sep; 38(1-2):161-8. doi: 10.1016/0378-4274(87)90124-x. [PMID: 3629627]
  • D J Yang, V J Teets, B Bolton, P I Brown, G O Rankin. Role of glutathione in acute N-(3,5-dichlorophenyl) succinimide-induced nephrotoxicity in Sprague-Dawley and Fischer 344 rats. Toxicology. 1987 Jul; 45(1):25-44. doi: 10.1016/0300-483x(87)90112-0. [PMID: 3603574]
  • G O Rankin, D J Yang, V J Teets, H H Lo, P I Brown. The effect of probenecid on acute N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in the Fischer 344 rat. Toxicology. 1987 May; 44(2):181-92. doi: 10.1016/0300-483x(87)90148-x. [PMID: 3564052]
  • D J Yang, H H Lo, V J Teets, P I Brown, G O Rankin. Nephrotoxicity of N-(3,5-dihalophenyl)succinimides in Fischer 344 rats. Journal of toxicology and environmental health. 1987; 20(4):333-46. doi: 10.1080/15287398709530987. [PMID: 3560257]
  • G O Rankin, D J Yang, V J Teets, P I Brown. Deuterium isotope effect in acute N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity. Life sciences. 1986 Oct; 39(14):1291-9. doi: 10.1016/0024-3205(86)90191-8. [PMID: 3762309]
  • D J Yang, E P Lahoda, P I Brown, G O Rankin. Acute N-(3,4,5-trichlorophenyl)succinimide-induced nephrotoxicity in Sprague-Dawley and Fischer-344 rats. Toxicology letters. 1986 Jun; 31(3):219-28. doi: 10.1016/0378-4274(86)90129-3. [PMID: 3726898]
  • D J Yang, E P Lahoda, P I Brown, G O Rankin. Acute nephrotoxicity of isomeric N-(dichlorophenyl)succinimides in Sprague-Dawley and Fischer 344 rats. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1985 Dec; 5(6 Pt 1):1119-27. doi: 10.1016/0272-0590(85)90148-4. [PMID: 4092874]
  • D J Yang, C D Richmond, V J Teets, P I Brown, G O Rankin. Effect of succinimide ring modification on N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in Sprague-Dawley and Fischer 344 rats. Toxicology. 1985 Oct; 37(1-2):65-77. doi: 10.1016/0300-483x(85)90113-1. [PMID: 4060170]
  • G O Rankin, D J Yang, E P Lahoda, K Cressey-Veneziano, M L Bailey, P I Brown. Acute nephrotoxicity of N-phenyl and N-(monochlorophenyl) succinimides in Fischer 344 and Sprague-Dawley rats. Toxicology. 1985 Mar; 34(4):299-308. doi: 10.1016/0300-483x(85)90140-4. [PMID: 3992588]
  • G O Rankin, D J Yang, K Cressey-Veneziano, P I Brown. N-(3,5-Dichlorophenyl)succinimide nephrotoxicity in the Fischer-344 rat. Toxicology letters. 1985 Jan; 24(1):99-105. doi: 10.1016/0378-4274(85)90146-8. [PMID: 3975935]
  • G O Rankin, K Cressey-Veneziano, P I Brown. Onset of and recovery from acute N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in Sprague-Dawley rats. Toxicology. 1984 Apr; 30(3):205-16. doi: 10.1016/0300-483x(84)90092-1. [PMID: 6710545]
  • T Shirai, M Ohshima, A Masuda, S Tamano, N Ito. Promotion of 2-(ethylnitrosamino)ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate. Journal of the National Cancer Institute. 1984 Feb; 72(2):477-82. doi: . [PMID: 6582330]
  • M C Barrett, S J Cashman, J Moss. Experimental interstitial renal fibrosis in rats: nephritis induced by N-(3,5-dichlorophenyl)succinimide. British journal of experimental pathology. 1983 Aug; 64(4):425-36. doi: . [PMID: 6311237]
  • G O Rankin. Nephrotoxicity following acute administration of N-(3,5-dichlorophenyl)succinimide in rats. Toxicology. 1982; 23(1):21-31. doi: 10.1016/0300-483x(82)90038-5. [PMID: 7089982]
  • Y Shinohara, Y Miyata, G Murasaki, K Nakanishi, T Yoshimura, N Ito. Effect of N-(3,5-dichlorophenyl)succinimide on the histological pattern and incidence of kidney tumors induced by streptozotocin rats. Gan. 1977 Aug; 68(4):397-404. doi: . [PMID: 211064]
  • Y Shinohara, M Arai, K Hirao, S Sugihara, K Nakanishi. Combination effect of citrinin and other chemicals on rat kidney tumorigenesis. Gan. 1976 Apr; 67(2):147-55. doi: . [PMID: 964548]
  • N Ito, S Sugihara, S Makiura, M Arai, K Hirao. Effect of N-(3,5-dichlorophenyl)succinimide on the histological pattern and incidence of kidney tumors in rats induced by dimethylnitrosoamine. Gan. 1974 Apr; 65(2):131-8. doi: . [PMID: 4366073]