Classification Term: 331

Phenylpyrrolidines (ontology term: CHEMONTID:0002336)

Polycyclic aromatic compounds containing a benzene ring linked to a pyrrolidine ring through a CC or CN bond. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms." []

found 21 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Ancestor: Pyrrolidines

Child Taxonomies: There is no child term of current ontology term.

Phensuximide

1-methyl-3-phenylpyrrolidine-2,5-dione

C11H11NO2 (189.0789746)

Phensuximide is an anticonvulsant in the succinimide class. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex. N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AD - Succinimide derivatives C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent

N-(3,5-Dichlorophenyl)succinimide

1-(3,5-dichlorophenyl)pyrrolidine-2,5-dione

C10H7Cl2NO2 (242.9853822)

D016573 - Agrochemicals D010575 - Pesticides

Flurochloridone

3-chloro-4-(chloromethyl)-1-[3-(trifluoromethyl)phenyl]pyrrolidin-2-one

C12H10Cl2F3NO (311.00915060000005)

Methsuximide

alpha-Methyl-alpha-phenyl N-methyl succinimide

C12H13NO2 (203.09462380000002)

Methsuximide is only found in individuals that have used or taken this drug. It is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin. [Wikipedia]Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AD - Succinimide derivatives C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

(±)-Clausenamide

3-hydroxy-5-[hydroxy(phenyl)methyl]-1-methyl-4-phenylpyrrolidin-2-one

C18H19NO3 (297.13648639999997)

Neoclausenamide is found in fruits. Neoclausenamide is isolated from Clausena lansium (wampee). Isolated from the leaves of Clausena lansium (wampee). (±)-Clausenamide is found in fruits.

Lansimide 3

3-hydroxy-5-[methoxy(phenyl)methyl]-1-methyl-4-phenylpyrrolidin-2-one

C19H21NO3 (311.15213560000007)

Lansimide 3 is found in fruits. Lansimide 3 is a constituent of Clausena lansium (wampee)

Vitisin B

11-hydroxy-7-(4-hydroxy-3,5-dimethoxyphenyl)-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2λ⁴,8-dioxatricyclo[7.3.1.0⁵,¹³]trideca-1,3,5(13),6,9,11-hexaen-2-ylium

C25H25O12 (517.134595)

Vitisin B is found in alcoholic beverages. Vitisin B is a constituent of some red wines.

(2S,3S,4R)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid

C29H38N2O6 (510.2729728)

N-(3,5-Dichlorophenyl)-2-hydroxysuccinimide

1-(3,5-dichlorophenyl)-3-hydroxypyrrolidine-2,5-dione

C10H7Cl2NO3 (258.9802972)

1-(3-Chlorophenyl)pyrrolidine-2,5-dione

C10H8ClNO2 (209.0243538)

2-Methyl-2-phenylsuccinimide

3-methyl-3-phenylpyrrolidine-2,5-dione

C11H11NO2 (189.0789746)

Evocalcet

2-[4-(3-{[1-(naphthalen-1-yl)ethyl]amino}pyrrolidin-1-yl)phenyl]acetic acid

C24H26N2O2 (374.1994176)

N-(3-Methyl-2-pyridyl)-3-phenylsuccinimide

1-(3-methylpyridin-2-yl)-3-phenylpyrrolidine-2,5-dione

C16H14N2O2 (266.1055224)

N-(3-Methyl-2-pyridyl)-3-(4-chlorophenyl)succinimide

3-(4-chlorophenyl)-1-(3-methylpyridin-2-yl)pyrrolidine-2,5-dione

C16H13ClN2O2 (300.0665508)

N-Phenylsuccinimide

1-phenylpyrrolidine-2,5-dione

C10H9NO2 (175.0633254)

4-(4-Butyl-2,5-dioxo-3-methyl-3-phenyl-1-pyrrolidinyl)benzenesulfonamide

4-(4-Butyl-3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulphonamide

C21H24N2O4S (400.14567040000003)

2-Ethyl-2-methyl-N-(6-chloro-4-sulfamoyl-o-tolyl)succinimide

3-chloro-4-(3-ethyl-3-methyl-2,5-dioxopyrrolidin-1-yl)-5-methylbenzene-1-sulfonamide

C14H17ClN2O4S (344.05975120000005)

Rolipram

3-[3-(cyclopentyloxy)-4-methoxyphenyl]-3,4-dihydro-2H-pyrrol-5-ol

C16H21NO3 (275.1521356)

D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058988 - Phosphodiesterase 4 Inhibitors D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor