DL-THREO-DIHYDROSPHINGOSINE (BioDeep_00000841079)
Main id: BioDeep_00000001327
代谢物信息卡片
DL-1,3-DIHYDROXY-2-AMINO-OCTADECANE
化学式: C18H39NO2 (301.2981)
中文名称: D,L-赤型-二氢鞘氨醇, DL-苏式-二氢鞘氨醇, DL-二氢鞘氨醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(C(CO)N)O
InChI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3
描述信息
D004791 - Enzyme Inhibitors
DL-erythro-Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2)[1][2].
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:46968
- PubChem: 3126
- PubChem: 5746414
- CAS: 73938-69-9
- CAS: 13552-09-5
- CAS: 3102-56-5
- CAS: 6036-86-8
- CAS: 2304-75-8
- medchemexpress: HY-101195
- LOTUS: LTS0188376
- wikidata: Q27120740
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sicong Ma, Roger Sandhoff, Xiu Luo, Fuwei Shang, Qiaozhen Shi, Zhaolong Li, Jingxia Wu, Yanan Ming, Frank Schwarz, Alaa Madi, Nina Weisshaar, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Xin Yan, Kerstin Mohr, Nora Ten Bosch, Zhe Li, Gernot Poschet, Hans-Reimer Rodewald, Nina Papavasiliou, Xi Wang, Pu Gao, Guoliang Cui. Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos.
Science immunology.
2024 Apr; 9(94):eadg8817. doi:
10.1126/sciimmunol.adg8817. [PMID: 38640251] - Scotland Farley, Frank Stein, Per Haberkant, Fikadu G Tafesse, Carsten Schultz. Trifunctional Sphinganine: A New Tool to Dissect Sphingolipid Function.
ACS chemical biology.
2024 Jan; ?(?):. doi:
10.1021/acschembio.3c00554. [PMID: 38284972] - Yongxian Bi, Jinjun Liu, Hao Li, Jinyue Sun, Wenyu Ding, Congfen He, Yan Jia. Lipidomics-based analysis of lipid differences between dry skin of women aged 22-28 years and 29-35 years.
Journal of cosmetic dermatology.
2024 Jan; ?(?):. doi:
10.1111/jocd.16137. [PMID: 38214419] - Mohamed Ibrahim Madkour, Md Torikul Islam, Trevor S Tippetts, Kamrul H Chowdhury, Lisa A Lesniewski, Scott A Summers, Falak Zeb, Dana N Abdelrahim, Refat AlKurd, Husam M Khraiwesh, Katia H AbuShihab, Asma AlBakri, Khaled Obaideen, MoezAlIslam E Faris. Ramadan intermittent fasting is associated with ameliorated inflammatory markers and improved plasma sphingolipids/ceramides in subjects with obesity: lipidomics analysis.
Scientific reports.
2023 Oct; 13(1):17322. doi:
10.1038/s41598-023-43862-9. [PMID: 37833312] - Eija Ahonen, Annelie Damerau, Kaisa M Linderborg. Antioxidative Effect of Dihydrosphingosine (d18:0) and α-Tocopherol on Tridocosahexaenoin (DHA-TAG).
Journal of agricultural and food chemistry.
2023 Oct; 71(40):14769-14781. doi:
10.1021/acs.jafc.3c02668. [PMID: 37751317] - Haixia Wang, Yueqi Zhang, Jingrui Wang, Yun Chen, Tingjun Hou, Youfu Zhao, Zhonghua Ma. The sphinganine C4-hydroxylase FgSur2 regulates sensitivity to azole antifungal agents and virulence of Fusarium graminearum.
Microbiological research.
2023 Mar; 271(?):127347. doi:
10.1016/j.micres.2023.127347. [PMID: 36907072] - Aissa Miriam Röhrig, Katja Jakobi, Julia Dietz, Dominique Thomas, Eva Herrmann, Christoph Welsch, Christoph Sarrazin, Josef Pfeilschifter, Stefan Zeuzem, Georgios Grammatikos. The role of serum sphingolipids as potential biomarkers of non-response to direct acting antiviral therapy in chronic hepatitis C virus infection.
Journal of viral hepatitis.
2023 Feb; 30(2):138-147. doi:
10.1111/jvh.13776. [PMID: 36463431] - Yudai Iino, Tatsuro Naganuma, Makoto Arita. Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1.
Journal of lipid research.
2023 Feb; 64(2):100329. doi:
10.1016/j.jlr.2023.100329. [PMID: 36639058] - Keqi Zeng, Xin Zhou, Wanyi Liu, Cong Nie, Yingfeng Zhang. Determination of endogenous sphingolipid content in stroke rats and HT22 cells subjected to oxygen-glucose deprivation by LC‒MS/MS.
Lipids in health and disease.
2023 Jan; 22(1):13. doi:
10.1186/s12944-022-01762-3. [PMID: 36698123] - Fragoso-Vázquez Manuel Jonathan, Duclosel Darling, Rosales-Hernández Martha Cecilia, Estrada-Pérez Alan, Mendoza-Figueroa Humberto Lubriel, Olivares-Corichi Ivonne, Mendieta-Wejebe Jessica Elena, Reyes-López Cesar Augusto, Velasco-Quijano Jessica Sayuri, Gil-Ruiz Luis Angel, Correa-Basurto José. UHPLC-MS/MS Studies and Antiproliferative Effects in Breast Cancer Cells of Mexican Sargassum.
Anti-cancer agents in medicinal chemistry.
2023; 23(1):76-86. doi:
10.2174/1871520622666220412125740. [PMID: 35418289] - Dev K Ranjit, Zachary D Moye, Fernanda G Rocha, Gregory Ottenberg, Frank C Nichols, Hey-Min Kim, Alejandro R Walker, Frank C Gibson, Mary E Davey. Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P.
Microbiology spectrum.
2022 04; 10(2):e0000222. doi:
10.1128/spectrum.00002-22. [PMID: 35286133] - Einat B Vitner, Roy Avraham, Boaz Politi, Sharon Melamed, Tomer Israely. Elevation in sphingolipid upon SARS-CoV-2 infection: possible implications for COVID-19 pathology.
Life science alliance.
2022 01; 5(1):. doi:
10.26508/lsa.202101168. [PMID: 34764206] - Andrej Kováčik, Petra Pullmannová, Lukáš Opálka, Michaela Šilarová, Jaroslav Maixner, Kateřina Vávrová. Effects of (R)- and (S)-α-Hydroxylation of Acyl Chains in Sphingosine, Dihydrosphingosine, and Phytosphingosine Ceramides on Phase Behavior and Permeability of Skin Lipid Models.
International journal of molecular sciences.
2021 Jul; 22(14):. doi:
10.3390/ijms22147468. [PMID: 34299088] - Li Wang, Xiaodong Suo, Yujie Liu, Chen Liu, Ming Luo. Sphingosine Promotes Embryo Biomass in Upland Cotton: A Biochemical and Transcriptomic Analysis.
Biomolecules.
2021 04; 11(4):. doi:
10.3390/biom11040525. [PMID: 33915924] - Kevin Eade, Sarah Giles, Sarah Harkins-Perry, Martin Friedlander. Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery.
Journal of visualized experiments : JoVE.
2021 03; ?(169):. doi:
10.3791/62269. [PMID: 33749682] - David R Adams, Susan Pyne, Nigel J Pyne. Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases.
Cellular signalling.
2020 12; 76(?):109806. doi:
10.1016/j.cellsig.2020.109806. [PMID: 33035646] - Zhong-Xing Rao, Mike D Tokach, Jason C Woodworth, Joel M DeRouchey, Robert D Goodband, Hilda I Calderón, Steve S Dritz. Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs.
Toxins.
2020 09; 12(9):. doi:
10.3390/toxins12090604. [PMID: 32961935] - Vincent Mignard, Nolwenn Dubois, Didier Lanoé, Marie-Pierre Joalland, Lisa Oliver, Claire Pecqueur, Dominique Heymann, François Paris, François M Vallette, Lisenn Lalier. Sphingolipid distribution at mitochondria-associated membranes (MAMs) upon induction of apoptosis.
Journal of lipid research.
2020 07; 61(7):1025-1037. doi:
10.1194/jlr.ra120000628. [PMID: 32350079] - Ruzica Jurakic Toncic, Ivone Jakasa, Suzana Ljubojevic Hadzavdic, Susan Mi Goorden, Karen Jm Ghauharali-van der Vlugt, Femke S Stet, Anamaria Balic, Mikela Petkovic, Borna Pavicic, Kristina Zuzul, Branka Marinovic, Sanja Kezic. Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu.
International journal of molecular sciences.
2020 Mar; 21(6):. doi:
10.3390/ijms21061958. [PMID: 32183011] - Ilaria Del Gaudio, Linda Sasset, Annarita Di Lorenzo, Christian Wadsack. Sphingolipid Signature of Human Feto-Placental Vasculature in Preeclampsia.
International journal of molecular sciences.
2020 Feb; 21(3):. doi:
10.3390/ijms21031019. [PMID: 32033121] - Norihiro Isogai, Yuta Shiono, Tetsuya Kuramoto, Kenji Yoshioka, Hiroko Ishihama, Haruki Funao, Masaya Nakamura, Morio Matsumoto, Ken Ishii. Potential osteomyelitis biomarkers identified by plasma metabolome analysis in mice.
Scientific reports.
2020 01; 10(1):839. doi:
10.1038/s41598-020-57619-1. [PMID: 31964942] - Vadim Dolgin, Rachel Straussberg, Ruijuan Xu, Izolda Mileva, Yuval Yogev, Raed Khoury, Osnat Konen, Yael Barhum, Alex Zvulunov, Cungui Mao, Ohad S Birk. DEGS1 variant causes neurological disorder.
European journal of human genetics : EJHG.
2019 11; 27(11):1668-1676. doi:
10.1038/s41431-019-0444-z. [PMID: 31186544] - Marin L Gantner, Kevin Eade, Martina Wallace, Michal K Handzlik, Regis Fallon, Jennifer Trombley, Roberto Bonelli, Sarah Giles, Sarah Harkins-Perry, Tjebo F C Heeren, Lydia Sauer, Yoichiro Ideguchi, Michelle Baldini, Lea Scheppke, Michael I Dorrell, Maki Kitano, Barbara J Hart, Carolyn Cai, Takayuki Nagasaki, Mehmet G Badur, Mali Okada, Sasha M Woods, Catherine Egan, Mark Gillies, Robyn Guymer, Florian Eichler, Melanie Bahlo, Marcus Fruttiger, Rando Allikmets, Paul S Bernstein, Christian M Metallo, Martin Friedlander. Serine and Lipid Metabolism in Macular Disease and Peripheral Neuropathy.
The New England journal of medicine.
2019 10; 381(15):1422-1433. doi:
10.1056/nejmoa1815111. [PMID: 31509666] - Rachel S Kelly, Bo L Chawes, Feng Guo, Li Zhang, Kevin Blighe, Augusto A Litonjua, Benjamin A Raby, Bruce D Levy, Daniela Rago, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Xiaobo Zhou, Jessica A Lasky-Su, Scott T Weiss. The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D.
The European respiratory journal.
2019 10; 54(4):. doi:
10.1183/13993003.00761-2019. [PMID: 31439681] - Graham Brogden, Diab M Husein, Pablo Steinberg, Hassan Y Naim. Isolation and Quantification of Sphingosine and Sphinganine from Rat Serum Revealed Gender Differences.
Biomolecules.
2019 09; 9(9):. doi:
10.3390/biom9090459. [PMID: 31500283] - Walter Boiten, Richard Helder, Jeroen van Smeden, Joke Bouwstra. Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 09; 1864(9):1206-1213. doi:
10.1016/j.bbalip.2019.05.003. [PMID: 31112754] - Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W Denning, Olaf Kniemeyer, Axel A Brakhage, David S Perlin. Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus.
mBio.
2019 06; 10(3):. doi:
10.1128/mbio.00779-19. [PMID: 31164462] - Ruth Nabwire Wangia, David Peter Githanga, Kathy Siyu Xue, Lili Tang, Omu Aggrey Anzala, Jia-Sheng Wang. Validation of urinary sphingolipid metabolites as biomarker of effect for fumonisins exposure in Kenyan children.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2019 Jun; 24(4):379-388. doi:
10.1080/1354750x.2019.1587510. [PMID: 30821509] - Hwang Eui Cho, Barry J Maurer, C Patrick Reynolds, Min H Kang. Hydrophilic interaction liquid chromatography-tandem mass spectrometric approach for simultaneous determination of safingol and D-erythro-sphinganine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Apr; 1112(?):16-23. doi:
10.1016/j.jchromb.2019.02.023. [PMID: 30836314] - Anders P E Backman, Josefin Halin, Matti A Kjellberg, Peter Mattjus. Indirect Lipid Transfer Protein Activity Measurements Using Quantification of Glycosphingolipid Production.
Methods in molecular biology (Clifton, N.J.).
2019; 1949(?):105-114. doi:
10.1007/978-1-4939-9136-5_9. [PMID: 30790252] - Anna Małgorzata Chabowska, Barbara Boczkowska Radziwon, Bartlomiej Lukaszuk, Alina Lipska, Adrian Chabowski, Dorota Kaczerska, Piotr Siermontowski, Piotr Radziwon. Fatty acids and sphingolipids profile in the blood plasma of experienced divers in response to hyperbaric exposure.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc.
2018 Sep; 45(?):521-529. doi:
. [PMID: 30428241] - Arvin B Tam, Lindsay S Roberts, Vivek Chandra, Io Guane Rivera, Daniel K Nomura, Douglass J Forbes, Maho Niwa. The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms.
Developmental cell.
2018 08; 46(3):327-343.e7. doi:
10.1016/j.devcel.2018.04.023. [PMID: 30086303] - Monika Książek, Urszula Baranowska, Adrian Chabowski, Marcin Baranowski. Arteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(1):67-77. doi:
10.1159/000486223. [PMID: 29316552] - Marzena Wątek, Bonita Durnaś, Tomasz Wollny, Marcin Pasiarski, Stanisław Góźdź, Michał Marzec, Anna Chabowska, Przemysław Wolak, Małgorzata Żendzian-Piotrowska, Robert Bucki. Unexpected profile of sphingolipid contents in blood and bone marrow plasma collected from patients diagnosed with acute myeloid leukemia.
Lipids in health and disease.
2017 Dec; 16(1):235. doi:
10.1186/s12944-017-0624-1. [PMID: 29216917] - B Grenier, H E Schwartz-Zimmermann, C Gruber-Dorninger, I Dohnal, M Aleschko, G Schatzmayr, W D Moll, T J Applegate. Enzymatic hydrolysis of fumonisins in the gastrointestinal tract of broiler chickens.
Poultry science.
2017 Dec; 96(12):4342-4351. doi:
10.3382/ps/pex280. [PMID: 29053869] - Agnieszka Zmyslowska, Michal Ciborowski, Maciej Borowiec, Wojciech Fendler, Karolina Pietrowska, Ewa Parfieniuk, Karolina Antosik, Aleksandra Pyziak, Arleta Waszczykowska, Adam Kretowski, Wojciech Mlynarski. Serum Metabolic Fingerprinting Identified Putatively Annotated Sphinganine Isomer as a Biomarker of Wolfram Syndrome.
Journal of proteome research.
2017 11; 16(11):4000-4008. doi:
10.1021/acs.jproteome.7b00401. [PMID: 28895401] - Lili Song, Pengwei Zhuang, Mengya Lin, Mingqin Kang, Hongyue Liu, Yuping Zhang, Zhen Yang, Yunlong Chen, Yanjun Zhang. Urine Metabonomics Reveals Early Biomarkers in Diabetic Cognitive Dysfunction.
Journal of proteome research.
2017 09; 16(9):3180-3189. doi:
10.1021/acs.jproteome.7b00168. [PMID: 28722418] - Alexander Koch, Georgios Grammatikos, Sandra Trautmann, Yannick Schreiber, Dominique Thomas, Franziska Bruns, Josef Pfeilschifter, Klaus Badenhoop, Marissa Penna-Martinez. Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients.
International journal of molecular sciences.
2017 Jul; 18(7):. doi:
10.3390/ijms18071532. [PMID: 28714882] - Yanyan Chen, Shiyuan Wen, Miaomiao Jiang, Yan Zhu, Liqin Ding, Hong Shi, Pengzhi Dong, Jing Yang, Yue Yang. Atherosclerotic dyslipidemia revealed by plasma lipidomics on ApoE-/- mice fed a high-fat diet.
Atherosclerosis.
2017 07; 262(?):78-86. doi:
10.1016/j.atherosclerosis.2017.05.010. [PMID: 28527370] - Barbora Školová, Andrej Kováčik, Ondřej Tesař, Lukáš Opálka, Kateřina Vávrová. Phytosphingosine, sphingosine and dihydrosphingosine ceramides in model skin lipid membranes: permeability and biophysics.
Biochimica et biophysica acta. Biomembranes.
2017 May; 1859(5):824-834. doi:
10.1016/j.bbamem.2017.01.019. [PMID: 28109750] - Daiki Yanagawa, Toshiki Ishikawa, Hiroyuki Imai. Synthesis and degradation of long-chain base phosphates affect fumonisin B1-induced cell death in Arabidopsis thaliana.
Journal of plant research.
2017 May; 130(3):571-585. doi:
10.1007/s10265-017-0923-7. [PMID: 28303405] - Meng Yu, Hong-Mei Jia, Feng-Xia Cui, Yong Yang, Yang Zhao, Mao-Hua Yang, Zhong-Mei Zou. The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations.
International journal of molecular sciences.
2017 Mar; 18(3):. doi:
10.3390/ijms18030602. [PMID: 28287417] - Hongmin Xu, Lei Zhang, Huan Kang, Jiandong Zhang, Jie Liu, Shuye Liu. Serum Metabonomics of Mild Acute Pancreatitis.
Journal of clinical laboratory analysis.
2016 Nov; 30(6):990-998. doi:
10.1002/jcla.21969. [PMID: 27169745] - Ambroise Testard, Daniel Da Silva, Mélanie Ormancey, Carole Pichereaux, Cécile Pouzet, Alain Jauneau, Sabine Grat, Eugénie Robe, Christian Brière, Valérie Cotelle, Christian Mazars, Patrice Thuleau. Calcium- and Nitric Oxide-Dependent Nuclear Accumulation of Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase in Response to Long Chain Bases in Tobacco BY-2 Cells.
Plant & cell physiology.
2016 Oct; 57(10):2221-2231. doi:
10.1093/pcp/pcw137. [PMID: 27585463] - T Vijai Kumar Reddy, A Jyotsna, B L A Prabhavathi Devi, R B N Prasad, Y Poornachandra, C Ganesh Kumar. Design, synthesis and in vitro biological evaluation of short-chain C12-sphinganine and its 1,2,3-triazole analogs as potential antimicrobial and anti-biofilm agents.
European journal of medicinal chemistry.
2016 Aug; 118(?):98-106. doi:
10.1016/j.ejmech.2016.04.020. [PMID: 27128176] - Huijuan Gao, Gaofu Qi, Rong Yin, Hongchun Zhang, Chenggang Li, Xiuyun Zhao. Bacillus cereus strain S2 shows high nematicidal activity against Meloidogyne incognita by producing sphingosine.
Scientific reports.
2016 06; 6(?):28756. doi:
10.1038/srep28756. [PMID: 27338781] - Georgios Grammatikos, Julia Dietz, Nerea Ferreiros, Alexander Koch, Georg Dultz, Dimitra Bon, Ioannis Karakasiliotis, Thomas Lutz, Gaby Knecht, Peter Gute, Eva Herrmann, Stefan Zeuzem, Penelope Mavromara, Christoph Sarrazin, Josef Pfeilschifter. Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels.
International journal of molecular sciences.
2016 Jun; 17(6):. doi:
10.3390/ijms17060922. [PMID: 27304952] - Silvina L Arias, Verónica S Mary, Santiago N Otaiza, Daniel A Wunderlin, Héctor R Rubinstein, Martín G Theumer. Toxin distribution and sphingoid base imbalances in Fusarium verticillioides-infected and fumonisin B1-watered maize seedlings.
Phytochemistry.
2016 May; 125(?):54-64. doi:
10.1016/j.phytochem.2016.02.006. [PMID: 26903312] - Sabine Masching, Karin Naehrer, Heidi-Elisabeth Schwartz-Zimmermann, Mihai Sărăndan, Simone Schaumberger, Ilse Dohnal, Veronika Nagl, Dian Schatzmayr. Gastrointestinal Degradation of Fumonisin B₁ by Carboxylesterase FumD Prevents Fumonisin Induced Alteration of Sphingolipid Metabolism in Turkey and Swine.
Toxins.
2016 Mar; 8(3):. doi:
10.3390/toxins8030084. [PMID: 27007395] - Kyle D Luttgeharm, Edgar B Cahoon, Jonathan E Markham. Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis.
The Biochemical journal.
2016 Mar; 473(5):593-603. doi:
10.1042/bj20150824. [PMID: 26635357] - Daniel Pastor-Flores, Jörg O Schulze, Anna Bahí, Evelyn Süß, Antonio Casamayor, Ricardo M Biondi. Lipid regulators of Pkh2 in Candida albicans, the protein kinase ortholog of mammalian PDK1.
Biochimica et biophysica acta.
2016 Mar; 1861(3):249-59. doi:
10.1016/j.bbalip.2015.12.016. [PMID: 26743850] - Maryline Magnin-Robert, Doriane Le Bourse, Jonathan Markham, Stéphan Dorey, Christophe Clément, Fabienne Baillieul, Sandrine Dhondt-Cordelier. Modifications of Sphingolipid Content Affect Tolerance to Hemibiotrophic and Necrotrophic Pathogens by Modulating Plant Defense Responses in Arabidopsis.
Plant physiology.
2015 Nov; 169(3):2255-74. doi:
10.1104/pp.15.01126. [PMID: 26378098] - Shuntaro Tsukamoto, Yuhui Huang, Motofumi Kumazoe, Connie Lesnick, Shuhei Yamada, Naoki Ueda, Takashi Suzuki, Shuya Yamashita, Yoon Hee Kim, Yoshinori Fujimura, Daisuke Miura, Neil E Kay, Tait D Shanafelt, Hirofumi Tachibana. Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs.
Molecular cancer therapeutics.
2015 Oct; 14(10):2303-12. doi:
10.1158/1535-7163.mct-15-0185. [PMID: 26264277] - Bertrand Grenier, Heidi E Schwartz-Zimmermann, Sylvia Caha, Wulf Dieter Moll, Gerd Schatzmayr, Todd J Applegate. Dose-dependent effects on sphingoid bases and cytokines in chickens fed diets prepared with fusarium verticillioides culture material containing fumonisins.
Toxins.
2015 Apr; 7(4):1253-72. doi:
10.3390/toxins7041253. [PMID: 25871822] - Muzaffer Denli, Juan C Blandon, Silvia Salado, Maria E Guynot, Josefina Casas, Jose F Pérez. Efficacy of AdiDetox™ in reducing the toxicity of fumonisin B1 in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2015 Apr; 78(?):60-3. doi:
10.1016/j.fct.2015.01.024. [PMID: 25660482] - B Boczkowska-Radziwon, A M Chabowska, A Blachnio-Zabielska, B Lukaszuk, A Lipska, A Chabowski, P Radziwon. Ozonation of human blood increases sphingosine-1-phosphate in plasma.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2015 Apr; 66(2):267-72. doi:
NULL. [PMID: 25903957] - Irene Hahn, Veronika Nagl, Heidi Elisabeth Schwartz-Zimmermann, Elisabeth Varga, Christiane Schwarz, Veronika Slavik, Nicole Reisinger, Alexandra Malachová, Martina Cirlini, Silvia Generotti, Chiara Dall'Asta, Rudolf Krska, Wulf-Dieter Moll, Franz Berthiller. Effects of orally administered fumonisin B₁ (FB₁), partially hydrolysed FB₁, hydrolysed FB₁ and N-(1-deoxy-D-fructos-1-yl) FB₁ on the sphingolipid metabolism in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2015 Feb; 76(?):11-8. doi:
10.1016/j.fct.2014.11.020. [PMID: 25475052] - Wei Wang, Michael Fromm. Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes.
PloS one.
2015; 10(4):e0119005. doi:
10.1371/journal.pone.0119005. [PMID: 25906159] - Kuan-Boone Tan, Leong-Uung Ling, Ralph M Bunte, Wee-Joo Chng, Gigi N C Chiu. Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia.
Nanomedicine (London, England).
2014 Aug; 9(11):1665-79. doi:
10.2217/nnm.13.123. [PMID: 24294981] - Yoel A Klug, Avraham Ashkenazi, Mathias Viard, Ziv Porat, Robert Blumenthal, Yechiel Shai. Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site.
The Biochemical journal.
2014 Jul; 461(2):213-22. doi:
10.1042/bj20140189. [PMID: 24766462] - Mark J Dekker, Chris Baker, Mark Naples, Josh Samsoondar, Rianna Zhang, Wei Qiu, Jennifer Sacco, Khosrow Adeli. Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction.
Atherosclerosis.
2013 May; 228(1):98-109. doi:
10.1016/j.atherosclerosis.2013.01.041. [PMID: 23466071] - Christine Burel, Mael Tanguy, Philippe Guerre, Eric Boilletot, Roland Cariolet, Marilyne Queguiner, Gilbert Postollec, Philippe Pinton, Gilles Salvat, Isabelle P Oswald, Philippe Fravalo. Effect of low dose of fumonisins on pig health: immune status, intestinal microbiota and sensitivity to Salmonella.
Toxins.
2013 Apr; 5(4):841-64. doi:
10.3390/toxins5040841. [PMID: 23612754] - C L Fischer, K S Walters, D R Drake, D R Blanchette, D V Dawson, K A Brogden, P W Wertz. Sphingoid bases are taken up by Escherichia coli and Staphylococcus aureus and induce ultrastructural damage.
Skin pharmacology and physiology.
2013; 26(1):36-44. doi:
10.1159/000343175. [PMID: 23128426] - M Knapp, A Lisowska, P Knapp, M Baranowski. Dose-dependent effect of aspirin on the level of sphingolipids in human blood.
Advances in medical sciences.
2013; 58(2):274-81. doi:
10.2478/ams-2013-0021. [PMID: 24101372] - R H Rauber, P Dilkin, A O Mallmann, A Marchioro, C A Mallmann, A Borsoi, V P Nascimento. Individual and combined effects of Salmonella typhimurium lipopolysaccharide and fumonisin B1 in broiler chickens.
Poultry science.
2012 Nov; 91(11):2785-91. doi:
10.3382/ps.2012-02489. [PMID: 23091133] - Małgorzata Knapp, Małgorzata Zendzian-Piotrowska, Agnieszka Błachnio-Zabielska, Piotr Zabielski, Krzysztof Kurek, Jan Górski. Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat.
Basic research in cardiology.
2012 Nov; 107(6):294. doi:
10.1007/s00395-012-0294-0. [PMID: 22961594] - Avraham Ashkenazi, Mathias Viard, Linor Unger, Robert Blumenthal, Yechiel Shai. Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2012 Nov; 26(11):4628-36. doi:
10.1096/fj.12-215111. [PMID: 22872679] - Janee Gelineau-van Waes, Mark A Rainey, Joyce R Maddox, Kenneth A Voss, Andrew J Sachs, Nicole M Gardner, Justin D Wilberding, Ronald T Riley. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720.
Birth defects research. Part A, Clinical and molecular teratology.
2012 Oct; 94(10):790-803. doi:
10.1002/bdra.23074. [PMID: 22991331] - Hyun Joon Kim, Qiao Qiao, Hamish D Toop, Jonathan C Morris, Anthony S Don. A fluorescent assay for ceramide synthase activity.
Journal of lipid research.
2012 Aug; 53(8):1701-7. doi:
10.1194/jlr.d025627. [PMID: 22661289] - Carol L Fischer, David R Drake, Deborah V Dawson, Derek R Blanchette, Kim A Brogden, Philip W Wertz. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria.
Antimicrobial agents and chemotherapy.
2012 Mar; 56(3):1157-61. doi:
10.1128/aac.05151-11. [PMID: 22155833] - Kyong-Oh Shin, Myong-Yong Park, Cho-Hee Seo, Yong-Ill Lee, Hyun Sik Kim, Hwan-Soo Yoo, Jin Tae Hong, Jae-Kyung Jung, Yong-Moon Lee. Terpene alcohols inhibit de novo sphingolipid biosynthesis.
Planta medica.
2012 Mar; 78(5):434-9. doi:
10.1055/s-0031-1298155. [PMID: 22274813] - Emad Benlasher, Xiuyu Geng, Ngoc Thanh Xuan Nguyen, Didier Tardieu, Jean-Denis Bailly, Alain Auvergne, Philippe Guerre. Comparative effects of fumonisins on sphingolipid metabolism and toxicity in ducks and turkeys.
Avian diseases.
2012 Mar; 56(1):120-7. doi:
10.1637/9853-071911-reg.1. [PMID: 22545537] - Mariana Saucedo-García, Ariadna González-Solís, Priscila Rodríguez-Mejía, Teresa de Jesús Olivera-Flores, Sonia Vázquez-Santana, Edgar B Cahoon, Marina Gavilanes-Ruiz. Reactive oxygen species as transducers of sphinganine-mediated cell death pathway.
Plant signaling & behavior.
2011 Oct; 6(10):1616-9. doi:
10.4161/psb.6.10.16981. [PMID: 21921699] - Mariana Saucedo-García, Arturo Guevara-García, Ariadna González-Solís, Felipe Cruz-García, Sonia Vázquez-Santana, Jonathan E Markham, M Guadalupe Lozano-Rosas, Charles R Dietrich, Maricela Ramos-Vega, Edgar B Cahoon, Marina Gavilanes-Ruíz. MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis.
The New phytologist.
2011 Sep; 191(4):943-957. doi:
10.1111/j.1469-8137.2011.03727.x. [PMID: 21534970] - Itsuo Murakami, Yukari Wakasa, Shinji Yamashita, Toshio Kurihara, Kota Zama, Naoyuki Kobayashi, Yukiko Mizutani, Susumu Mitsutake, Tatsuro Shigyo, Yasuyuki Igarashi. Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.
Lipids in health and disease.
2011 Aug; 10(?):150. doi:
10.1186/1476-511x-10-150. [PMID: 21861924] - G Cano-Sancho, S Marin, V Sanchis, C Colom, M B Coronel, A J Ramos. Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2011 Aug; 28(8):1055-65. doi:
10.1080/19440049.2011.576437. [PMID: 21644119] - B Alvarez Sánchez, F Priego Capote, M D Luque de Castro. Targeted analysis of sphingoid precursors in human biofluids by solid-phase extraction with in situ derivatization prior to μ-LC-LIF determination.
Analytical and bioanalytical chemistry.
2011 May; 400(3):757-65. doi:
10.1007/s00216-011-4821-x. [PMID: 21394454] - Daniel Da Silva, Christophe Lachaud, Valérie Cotelle, Christian Brière, Sabine Grat, Christian Mazars, Patrice Thuleau. Nitric oxide production is not required for dihydrosphingosine-induced cell death in tobacco BY-2 cells.
Plant signaling & behavior.
2011 May; 6(5):736-9. doi:
10.4161/psb.6.5.15126. [PMID: 21455022] - Mark A Dickson, Richard D Carvajal, Alfred H Merrill, Mithat Gonen, Lauren M Cane, Gary K Schwartz. A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2011 Apr; 17(8):2484-92. doi:
10.1158/1078-0432.ccr-10-2323. [PMID: 21257722] - Christophe Lachaud, Daniel Da Silva, Nicolas Amelot, Chloé Béziat, Christian Brière, Valérie Cotelle, Annick Graziana, Sabine Grat, Christian Mazars, Patrice Thuleau. Dihydrosphingosine-induced programmed cell death in tobacco BY-2 cells is independent of H₂O₂ production.
Molecular plant.
2011 Mar; 4(2):310-8. doi:
10.1093/mp/ssq077. [PMID: 21199880] - Piotr Zabielski, Agnieszka Blachnio-Zabielska, Marcin Baranowski, Malgorzata Zendzian-Piotrowska, Jan Gorski. Activation of PPARα by bezafibrate negatively affects de novo synthesis of sphingolipids in regenerating rat liver.
Prostaglandins & other lipid mediators.
2010 Nov; 93(3-4):120-5. doi:
10.1016/j.prostaglandins.2010.09.001. [PMID: 20851774] - Piotr Zabielski, Marcin Baranowski, Agnieszka Błachnio-Zabielska, Małgorzata Zendzian-Piotrowska, Jan Górski. The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver.
Prostaglandins & other lipid mediators.
2010 Nov; 93(3-4):75-83. doi:
10.1016/j.prostaglandins.2010.06.006. [PMID: 20599517] - Agnieszka Blachnio-Zabielska, Marcin Baranowski, Piotr Zabielski, Jan Gorski. Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle.
Journal of cellular physiology.
2010 Nov; 225(3):786-91. doi:
10.1002/jcp.22283. [PMID: 20568228] - Markus Peer, Martin Stegmann, Martin J Mueller, Frank Waller. Pseudomonas syringae infection triggers de novo synthesis of phytosphingosine from sphinganine in Arabidopsis thaliana.
FEBS letters.
2010 Sep; 584(18):4053-6. doi:
10.1016/j.febslet.2010.08.027. [PMID: 20732322] - L Xu, Q Cai, L Tang, S Wang, X Hu, J Su, G Sun, J-S Wang. Evaluation of fumonisin biomarkers in a cross-sectional study with two high-risk populations in China.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2010 Aug; 27(8):1161-9. doi:
10.1080/19440049.2010.481638. [PMID: 20589550] - Masataka Oda, Masaya Takahashi, Takayuki Matsuno, Kana Uoo, Masahiro Nagahama, Jun Sakurai. Hemolysis induced by Bacillus cereus sphingomyelinase.
Biochimica et biophysica acta.
2010 Jun; 1798(6):1073-80. doi:
10.1016/j.bbamem.2010.03.004. [PMID: 20214877] - P Dilkin, G Direito, M M S Simas, C A Mallmann, B Corrêa. Toxicokinetics and toxicological effects of single oral dose of fumonisin B1 containing Fusarium verticillioides culture material in weaned piglets.
Chemico-biological interactions.
2010 May; 185(3):157-62. doi:
10.1016/j.cbi.2010.03.025. [PMID: 20338158] - Christophe Lachaud, Daniel Da Silva, Valérie Cotelle, Patrice Thuleau, Tou Cheu Xiong, Alain Jauneau, Christian Brière, Annick Graziana, Yannick Bellec, Jean-Denis Faure, Raoul Ranjeva, Christian Mazars. Nuclear calcium controls the apoptotic-like cell death induced by d-erythro-sphinganine in tobacco cells.
Cell calcium.
2010 Jan; 47(1):92-100. doi:
10.1016/j.ceca.2009.11.011. [PMID: 20022633] - Ana-Marija Domijan, Maja Peraica, Ksenija Markov, Radovan Fuchs. Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia.
Arhiv za higijenu rada i toksikologiju.
2009 Dec; 60(4):387-93. doi:
10.2478/10004-1254-60-2009-1938. [PMID: 20061238] - Thorsten Hornemann, Anke Penno, Markus F Rütti, Daniela Ernst, Fatma Kivrak-Pfiffner, Lucia Rohrer, Arnold von Eckardstein. The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases.
The Journal of biological chemistry.
2009 Sep; 284(39):26322-30. doi:
10.1074/jbc.m109.023192. [PMID: 19648650] - Liliana J G Silva, Celeste M Lino, Angelina Pena. Sphinganine-sphingosine ratio in urine from two Portuguese populations as biomarker to fumonisins exposure.
Toxicon : official journal of the International Society on Toxinology.
2009 Sep; 54(4):390-8. doi:
10.1016/j.toxicon.2009.05.011. [PMID: 19477192] - Jie Zhang, Lijuan Yan, Wengui Chen, Lin Lin, Xiuyu Song, Xiaomei Yan, Wei Hang, Benli Huang. Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system.
Analytica chimica acta.
2009 Sep; 650(1):16-22. doi:
10.1016/j.aca.2009.02.027. [PMID: 19720167] - Małgorzata Knapp, Marcin Baranowski, Dariusz Czarnowski, Anna Lisowska, Piotr Zabielski, Jan Górski, Włodzimierz Musiał. Plasma sphingosine-1-phosphate concentration is reduced in patients with myocardial infarction.
Medical science monitor : international medical journal of experimental and clinical research.
2009 Sep; 15(9):CR490-3. doi:
. [PMID: 19721401] - Wei Hu, Jacek Bielawski, Fahumiya Samad, Alfred H Merrill, L Ashley Cowart. Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity.
Journal of lipid research.
2009 Sep; 50(9):1852-62. doi:
10.1194/jlr.m800635-jlr200. [PMID: 19369694] - Frédéric Darios, Catherine Wasser, Anastasia Shakirzyanova, Artur Giniatullin, Kerry Goodman, Jose L Munoz-Bravo, Jesica Raingo, Jernej Jorgacevski, Marko Kreft, Robert Zorec, Juliana M Rosa, Luis Gandia, Luis M Gutiérrez, Thomas Binz, Rashid Giniatullin, Ege T Kavalali, Bazbek Davletov. Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis.
Neuron.
2009 Jun; 62(5):683-94. doi:
10.1016/j.neuron.2009.04.024. [PMID: 19524527] - Jorge Cerbon, Teresa Olguin, Pindaro R Alvarez-Grave, Rosa C López-Sánchez. Entamoeba invadens: sphingolipids metabolic regulation is the main component of a PKC signaling pathway in controlling cell growth and proliferation.
Experimental parasitology.
2009 Jun; 122(2):106-11. doi:
10.1016/j.exppara.2009.02.011. [PMID: 19249300] - Glória M Direito, Adriana P Almeida, Simone Aquino, Tatiana Alves dos Reis, Claudia Rodrigues Pozzi, Benedito Corrêa. Evaluation of sphingolipids in Wistar rats treated to prolonged and single oral doses of fumonisin b₁.
International journal of molecular sciences.
2009 Jan; 10(1):50-61. doi:
10.3390/ijms10010050. [PMID: 19333435] - L van der Westhuizen, G S Shephard, J P Rheeder, N I M Somdyala, W F O Marasas. Sphingoid base levels in humans consuming fumonisin-contaminated maize in rural areas of the former Transkei, South Africa: a cross-sectional study.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2008 Nov; 25(11):1385-91. doi:
10.1080/02652030802226195. [PMID: 19680846] - Sarah T Pruett, Anatoliy Bushnev, Kerri Hagedorn, Madhura Adiga, Christopher A Haynes, M Cameron Sullards, Dennis C Liotta, Alfred H Merrill. Biodiversity of sphingoid bases ('sphingosines') and related amino alcohols.
Journal of lipid research.
2008 Aug; 49(8):1621-39. doi:
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