Uvaretin (BioDeep_00000000793)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1- [ 2,4-Dihydroxy-3- [ (2-hydroxyphenyl) methyl ] -6-methoxyphenyl ] -3-phenyl-1-propanone

化学式: C23H22O5 (378.1467)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 81.82%

分子结构信息

SMILES: C1(O)C=C(OC)C(C(=O)CCC2C=CC=CC=2)=C(O)C=1CC1C=CC=CC=1O
InChI: InChI=1S/C23H22O5/c1-28-21-14-20(26)17(13-16-9-5-6-10-18(16)24)23(27)22(21)19(25)12-11-15-7-3-2-4-8-15/h2-10,14,24,26-27H,11-13H2,1H3

描述信息

Uvaretin is a member of the class of dihydrochalcones that is 1,3-diphenylpropan-1-one in which the phenyl group that is bonded to the carbonyl group is substituted by hydroxy groups at positions 2 and 4, an o-hydroxybenzyl group at position 3, and a methoxy group at position 6. A cytotoxic natural product found particularly in Uvaria acuminata and Uvaria chamae. It has a role as an antineoplastic agent and a plant metabolite. It is a resorcinol, an aromatic ether, a polyketide and a member of dihydrochalcones.
Uvaretin is a natural product found in Desmos chinensis, Uvaria chamae, and other organisms with data available.
A member of the class of dihydrochalcones that is 1,3-diphenylpropan-1-one in which the phenyl group that is bonded to the carbonyl group is substituted by hydroxy groups at positions 2 and 4, an o-hydroxybenzyl group at position 3, and a methoxy group at position 6. A cytotoxic natural product found particularly in Uvaria acuminata and Uvaria chamae.

同义名列表

15 个代谢物同义名

1-PROPANONE, 1-(2,4-DIHYDROXY-3-((2-HYDROXYPHENYL)METHYL)-6-METHOXYPHENYL)-3-PHENYL-; 1-[2,4-dihydroxy-3-[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenylpropan-1-one; 1-[2,4-Dihydroxy-3-[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenyl-1-propanone; 1-(2,4-Dihydroxy-3-((2-hydroxyphenyl)methyl)-6-methoxyphenyl)-3-phenyl-1-propanone; 1-Propanone,4-dihydroxy-3-[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenyl-; 1-[2,4-dihydroxy-3-(2-hydroxybenzyl)-6-methoxyphenyl]-3-phenylpropan-1-one; 1-(2,4-dihydroxy-3-(2-hydroxybenzyl)-6-methoxyphenyl)-3-phenyl-1-propanone; UNII-VZ5C9UL7V1; MEGxp0_001394; NCI60_001940; ACon1_001408; VZ5C9UL7V1; Uvaretin; 1- [ 2,4-Dihydroxy-3- [ (2-hydroxyphenyl) methyl ] -6-methoxyphenyl ] -3-phenyl-1-propanone; Uvaretin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

50 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gasper Maeda, Pieter J Gilissen, Anastasia Rudenko, Jelle van der Wal, Catarina Bourgard, Arvind Kumar Gupta, Per Sunnerhagen, Joan J E Munissi, Stephen S Nyandoro, Máté Erdélyi. Oxygenated Cyclohexene Derivatives from the Stem and Root Barks of Uvaria pandensis. Journal of natural products. 2021 12; 84(12):3080-3089. doi: 10.1021/acs.jnatprod.1c00811. [PMID: 34802242]
  • Gasper Maeda, Jelle van der Wal, Arvind Kumar Gupta, Joan J E Munissi, Andreas Orthaber, Per Sunnerhagen, Stephen S Nyandoro, Máté Erdélyi. Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa. Journal of natural products. 2020 02; 83(2):210-215. doi: 10.1021/acs.jnatprod.9b00363. [PMID: 31986029]
  • Tulika Mishra, Madhu Khullar, Aruna Bhatia. Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):. doi: 10.1155/2011/765029. [PMID: 20953391]
  • Momoyo Ichimaru, Noriyoshi Nakatani, Tomoko Takahashi, Yumi Nishiyama, Masataka Moriyasu, Atsushi Kato, Simon G Mathenge, Francis D Juma, Joseph N Nganga. Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata. Chemical & pharmaceutical bulletin. 2004 Jan; 52(1):138-41. doi: 10.1248/cpb.52.138. [PMID: 14709883]
  • John J Makangara, Stephan A Jonker, Mayunga H H Nkunya. A novel phenanthrenolide and C-benzyl dihydrochalcones from Uvaria puguensis. Natural product letters. 2002 Aug; 16(4):267-72. doi: 10.1080/10575630290020604. [PMID: 12168763]
  • J R Cole, S J Torrance, R M Wiedhopf, S K Arora, R B Bates. Uvaretin, a new antitumor agent from Uvaria acuminata (Annonaceae). The Journal of organic chemistry. 1976 May; 41(10):1852-5. doi: 10.1021/jo00872a037. [PMID: 1262991]