Acetone oxime (BioDeep_00000007779)

 

Secondary id: BioDeep_00001868216

human metabolite blood metabolite


代谢物信息卡片


N-(propan-2-ylidene)hydroxylamine

化学式: C3H7NO (73.0528)
中文名称: 丙酮肟
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 32.41%

分子结构信息

SMILES: CC(=NO)C
InChI: InChI=1S/C3H7NO/c1-3(2)4-5/h5H,1-2H3



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AHR, ALB, AOC3, CAT, CYP1A1, CYP2E1, EDN1, GUCY1A1, HPGDS, IDO1, PMP2, SULT1A1
Peripheral membrane protein 3 CYP1A1, CYP1B1, CYP2E1
Endoplasmic reticulum membrane 3 CYP1A1, CYP1B1, CYP2E1
Nucleus 3 AHR, ALB, PMP2
cytosol 8 AHR, ALB, CAT, GUCY1A1, HPGDS, IDO1, PMP2, SULT1A1
centrosome 1 ALB
nucleoplasm 2 AHR, HPGDS
Cell membrane 1 AOC3
Multi-pass membrane protein 1 SLC45A2
cell surface 1 AOC3
glutamatergic synapse 1 GUCY1A1
Golgi apparatus 2 ALB, AOC3
Golgi membrane 1 C1GALT1
mitochondrial inner membrane 2 CYP1A1, CYP2E1
Cytoplasm, cytosol 1 IDO1
plasma membrane 4 ACVR1, AOC3, F2, IFNLR1
Membrane 7 ACVR1, AOC3, C1GALT1, CAT, CYP1B1, IFNLR1, SLC45A2
extracellular exosome 4 ALB, CAT, F2, PMP2
endoplasmic reticulum 2 ALB, AOC3
extracellular space 3 ALB, EDN1, F2
mitochondrion 3 CAT, CYP1A1, CYP1B1
protein-containing complex 3 AHR, ALB, CAT
intracellular membrane-bounded organelle 5 CAT, CYP1A1, CYP1B1, CYP2E1, HPGDS
Microsome membrane 3 CYP1A1, CYP1B1, CYP2E1
Single-pass type I membrane protein 2 ACVR1, IFNLR1
Secreted 3 ALB, EDN1, F2
extracellular region 4 ALB, CAT, EDN1, F2
basal part of cell 1 EDN1
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
transcription regulator complex 1 AHR
Melanosome membrane 1 SLC45A2
Early endosome 1 AOC3
apical part of cell 1 ACVR1
Single-pass type II membrane protein 2 AOC3, C1GALT1
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
focal adhesion 1 CAT
GABA-ergic synapse 1 GUCY1A1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 F2
ciliary basal body 1 ALB
chromatin 1 AHR
stereocilium bundle 1 IDO1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, F2
microvillus 1 AOC3
aryl hydrocarbon receptor complex 1 AHR
myelin sheath 1 PMP2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 ALB, F2
platelet alpha granule lumen 1 ALB
transport vesicle 1 EDN1
guanylate cyclase complex, soluble 1 GUCY1A1
rough endoplasmic reticulum lumen 1 EDN1
catalase complex 1 CAT
Weibel-Palade body 1 EDN1
BMP receptor complex 1 ACVR1
smooth muscle contractile fiber 1 IDO1
activin receptor complex 1 ACVR1
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Mykola Zdioruk, Jorge-Luis Jimenez-Macias, Michal Oskar Nowicki, Katherine E Manz, Kurt D Pennell, Marilin S Koch, Tomer Finkelberg, Bin Wu, Paul Boucher, Yuji Takeda, Weiyi Li, Raziye Piranlioglu, Alexander L Ling, E Antonio Chiocca, Sean E Lawler. PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models. Cell reports. Medicine. 2023 Apr; ?(?):101019. doi: 10.1016/j.xcrm.2023.101019. [PMID: 37060903]
  • C Kohl, C D Schiller, A Gescher, P B Farmer, E Bailey. Acetoxime is metabolized by human and rodent hepatic cytochrome P450 enzymes to the genotoxicant and carcinogen propane 2-nitronate. Carcinogenesis. 1992 Jul; 13(7):1091-4. doi: 10.1093/carcin/13.7.1091. [PMID: 1638672]
  • N Guo, C C Conaway, N S Hussain, E S Fiala. Sex and organ differences in oxidative DNA and RNA damage due to treatment of Sprague-Dawley rats with acetoxime or 2-nitropropane. Carcinogenesis. 1990 Sep; 11(9):1659-62. doi: 10.1093/carcin/11.9.1659. [PMID: 1698128]