Azaleatin (BioDeep_00000007758)

   

PANOMIX_OTCML-2023 natural product PANOMIX_OTCML-2025


Metabolite Card


2-(3,4-DIHYDROXYPHENYL)-3,7-DIHYDROXY-5-METHOXY-4H-1-BENZOPYRAN-4-ONE 5-O-METHYLQUERCETIN

  Formula: C16H12O7 (316.0583)
Chinese Names: 杜鹃黄素, 2-(3,4-二羟基苯基)-3,7-二羟基-5-甲氧基苯并吡喃-4-酮
  Spectrum Hits: Top Source Arabidopsis thaliana(otcml) 62.5%

Reviewed

Last reviewed on 2025-07-01.

Cite this Page

Azaleatin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/azaleatin (retrieved 2026-01-21) (BioDeep RN: BioDeep_00000007758). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Molecular Structure

SMILES: C1(O)=CC2OC(C3C=C(O)C(O)=CC=3)=C(O)C(=O)C=2C(OC)=C1
InChI: InChI=1S/C16H12O7/c1-22-11-5-8(17)6-12-13(11)14(20)15(21)16(23-12)7-2-3-9(18)10(19)4-7/h2-6,17-19,21H,1H3


Description

Azaleatin is a monomethoxyflavone that is quercetin in which the hydroxy group at position 5 is replaced by a methoxy group. It has a role as a plant metabolite. It is a 7-hydroxyflavonol, a tetrahydroxyflavone and a monomethoxyflavone. It is functionally related to a quercetin.
Azaleatin is a natural product found in Rhododendron mucronulatum, Senna lindheimeriana, and other organisms with data available.
A monomethoxyflavone that is quercetin in which the hydroxy group at position 5 is replaced by a methoxy group.
Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity[1][2].
Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity[1][2].

Synonyms

21 synonym names

2-(3,4-DIHYDROXYPHENYL)-3,7-DIHYDROXY-5-METHOXY-4H-1-BENZOPYRAN-4-ONE 5-O-METHYLQUERCETIN; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-5-methoxy-; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-5-methoxy-4H-1-benzopyran-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-5-methoxy-4H-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-5-methoxychromen-4-one; 5-O-MethylquercetinQuercetin 5-methyl ether; FLAVONE, 3,3,4,7-TETRAHYDROXY-5-METHOXY-; 5-METHOXY-3,3,4,7-TETRAHYDROXYFLAVONE; 3,3,4,7-Tetrahydroxy-5-methoxyflavone; Quercetin 5-methyl ether; O-METHYLQUERCETIN, 5-; 5-O-Methyl Quercetin; 5-O-Methylquercetin; Azaleatin; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-5-methoxy-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-5-methoxy-4-chromenone; 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-5-methoxy-chromone; 529-51-1; C10022; 3,7,3,4-Tetrahydroxy-5-methoxyflavone; Azaleatin



Cross Reference

19 cross reference id

Classification Terms

Related Pathways

Reactome()

BioCyc()

PlantCyc()

Biological Process

related biological process reactions.

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

136 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

Sub-cellular location Genes
Cytoplasm 4 ATF4, NOX4, TGFB1, TNFSF11
Endoplasmic reticulum membrane 1 NOX4
Nucleus 3 ATF4, NOX4, TGFB1
cytosol 2 ATF4, TNFRSF11A
centrosome 1 ATF4
nucleoplasm 1 ATF4
RNA polymerase II transcription regulator complex 1 ATF4
Cell membrane 4 ATF4, NOX4, TNF, TNFSF11
Multi-pass membrane protein 1 NOX4
cell surface 2 TGFB1, TNF
neuronal cell body 2 TGFB1, TNF
plasma membrane 5 NOX4, TGFB1, TNF, TNFRSF11A, TNFSF11
Membrane 2 NOX4, TNFSF11
axon 1 TGFB1
extracellular exosome 2 QPCT, TIMP1
endoplasmic reticulum 1 NOX4
extracellular space 4 TGFB1, TIMP1, TNF, TNFSF11
perinuclear region of cytoplasm 1 NOX4
mitochondrion 1 NOX4
protein-containing complex 1 ATF4
Single-pass type I membrane protein 1 TNFRSF11A
Secreted 4 QPCT, TGFB1, TIMP1, TNFSF11
extracellular region 5 QPCT, TGFB1, TIMP1, TNF, TNFSF11
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 ATF4
external side of plasma membrane 2 TNF, TNFRSF11A
Secreted, extracellular space, extracellular matrix 1 TGFB1
nucleolus 1 NOX4
recycling endosome 1 TNF
Single-pass type II membrane protein 2 TNF, TNFSF11
Cytoplasm, perinuclear region 1 NOX4
Membrane raft 2 TNF, TNFRSF11A
Cell junction, focal adhesion 1 NOX4
focal adhesion 1 NOX4
extracellular matrix 2 TGFB1, TIMP1
basement membrane 1 TIMP1
collagen trimer 1 TIMP1
collagen-containing extracellular matrix 1 TGFB1
secretory granule 1 TGFB1
nuclear speck 1 ATF4
neuron projection 1 ATF4
chromatin 1 ATF4
phagocytic cup 1 TNF
[Isoform 5]: Cytoplasm 1 NOX4
Nucleus, nucleolus 1 NOX4
blood microparticle 1 TGFB1
Nucleus speckle 1 ATF4
[Isoform 3]: Cytoplasm 1 NOX4
ficolin-1-rich granule lumen 1 QPCT
Golgi lumen 1 TGFB1
endoplasmic reticulum lumen 1 TIMP1
platelet alpha granule lumen 2 TGFB1, TIMP1
specific granule lumen 1 QPCT
tertiary granule lumen 1 QPCT
perinuclear endoplasmic reticulum 1 NOX4
[Isoform 2]: Cytoplasm 1 TNFSF11
[Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted 1 TNFSF11
[Isoform 1]: Cell membrane 1 TNFRSF11A
dendrite membrane 1 ATF4
nuclear periphery 1 ATF4
[Isoform 4]: Nucleus 1 NOX4
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix 1 TGFB1
[Transforming growth factor beta-1]: Secreted 1 TGFB1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
NADPH oxidase complex 1 NOX4
[Isoform 6]: Cytoplasm 1 NOX4
ATF4-CREB1 transcription factor complex 1 ATF4
ATF1-ATF4 transcription factor complex 1 ATF4
CHOP-ATF4 complex 1 ATF4
Lewy body core 1 ATF4
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform RANK-e5a]: Cell membrane 1 TNFRSF11A


Literature Reference

  • Xiaoan Li, Tiantian Guo, Qian Feng, Tiantian Bai, Lei Wu, Yubo Liu, Xu Zheng, Jianzhong Jia, Jin Pei, Shaoping Wu, Yiming Song, Yongmin Zhang. Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs. European journal of medicinal chemistry. 2022 Jan; 228(?):114035. doi: 10.1016/j.ejmech.2021.114035. [PMID: 34902735]
  • Komei Kato, Masayuki Ninomiya, Kaori Tanaka, Mamoru Koketsu. Effects of Functional Groups and Sugar Composition of Quercetin Derivatives on Their Radical Scavenging Properties. Journal of natural products. 2016 07; 79(7):1808-14. doi: 10.1021/acs.jnatprod.6b00274. [PMID: 27314621]