Trichothecin (BioDeep_00000007584)

   

natural product


代谢物信息卡片


Trichothec-9-en-8-one, 12,13-epoxy-4-hydroxy-, crotonate

化学式: C19H24O5 (332.1624)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C=C\C(=O)O[C@@H]1C[C@H]2O[C@@H]3C=C(C)C(=O)C[C@]3(C)[C@]1(C)[C@]21CO1
InChI: InChI=1S/C19H24O5/c1-5-6-16(21)24-14-8-15-19(10-22-19)18(14,4)17(3)9-12(20)11(2)7-13(17)23-15/h5-7,13-15H,8-10H2,1-4H3/b6-5-/t13-,14-,15-,17+,18-,19+/m1/s1

描述信息

A trichothecene mycototoxin isolated from the endophytic fungus Trichothecium sp. and it exhibits anti-cancer properties.
D009676 - Noxae > D011042 - Poisons > D014255 - Trichothecenes
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins

同义名列表

3 个代谢物同义名

Trichothecin; Trichothec-9-en-8-one, 12,13-epoxy-4-hydroxy-, crotonate; Trichothecin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

26 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 BCL2, BCL2L1, BIRC5, CASP3, CASP9, CCND1, PYGL, STAT1, STAT3, TTN, XIAP
Peripheral membrane protein 1 GORASP1
Endoplasmic reticulum membrane 1 BCL2
Mitochondrion membrane 1 BCL2L1
Nucleus 9 BCL2, BIRC5, CASP3, CASP9, CCND1, STAT1, STAT3, TTN, XIAP
cytosol 11 BCL2, BCL2L1, BIRC5, CASP3, CASP9, CCND1, PYGL, STAT1, STAT3, TTN, XIAP
dendrite 1 STAT1
centrosome 2 BCL2L1, CCND1
nucleoplasm 6 BIRC5, CASP3, CCND1, STAT1, STAT3, XIAP
RNA polymerase II transcription regulator complex 2 STAT1, STAT3
Cytoplasmic side 2 BCL2L1, GORASP1
Golgi apparatus membrane 1 GORASP1
glutamatergic synapse 1 CASP3
Golgi apparatus 1 GORASP1
Golgi membrane 1 GORASP1
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 1 CASP3
Cytoplasm, cytosol 2 BCL2L1, PYGL
plasma membrane 1 STAT3
synaptic vesicle membrane 1 BCL2L1
Membrane 1 BCL2
axon 1 STAT1
extracellular exosome 2 PYGL, TTN
endoplasmic reticulum 2 BCL2, BCL2L1
perinuclear region of cytoplasm 1 STAT1
bicellular tight junction 1 CCND1
mitochondrion 3 BCL2, BCL2L1, CASP9
protein-containing complex 4 BCL2, BIRC5, CASP9, STAT1
postsynaptic density 1 CASP3
extracellular region 2 PYGL, TTN
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 2 BCL2, BCL2L1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
transcription regulator complex 1 STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 3 BCL2, BCL2L1, CCND1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, CCND1
Z disc 1 TTN
microtubule cytoskeleton 1 BIRC5
nucleolus 1 STAT1
midbody 1 BIRC5
pore complex 1 BCL2
Cytoplasm, cytoskeleton, spindle 1 BIRC5
microtubule 1 BIRC5
spindle 1 BIRC5
cis-Golgi network 1 GORASP1
interphase microtubule organizing center 1 BIRC5
chromatin 2 STAT1, STAT3
Chromosome 1 BIRC5
centriole 1 BIRC5
nuclear chromosome 1 BIRC5
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
I band 1 TTN
M band 1 TTN
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 PYGL
secretory granule lumen 1 PYGL
transcription repressor complex 1 CCND1
kinetochore 1 BIRC5
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
apoptosome 1 CASP9
condensed nuclear chromosome 1 TTN
chromosome, centromeric region 1 BIRC5
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
death-inducing signaling complex 1 CASP3
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
cyclin D1-CDK6 complex 1 CCND1
striated muscle thin filament 1 TTN
ISGF3 complex 1 STAT1
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
organelle 1 TTN


文献列表

  • Chaoliang Liao, Min Li, Xiang Li, Namei Li, Xu Zhao, Xiaoyi Wang, Yawen Song, Jing Quan, Can Cheng, Jikai Liu, Ann M Bode, Ya Cao, Xiangjian Luo. Trichothecin inhibits invasion and metastasis of colon carcinoma associating with SCD-1-mediated metabolite alteration. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 02; 1865(2):158540. doi: 10.1016/j.bbalip.2019.158540. [PMID: 31678511]
  • Xiangjian Luo, Namei Li, Xu Zhao, Chaoliang Liao, Runxin Ye, Can Cheng, Zhijie Xu, Jing Quan, Jikai Liu, Ya Cao. DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma. Journal of experimental & clinical cancer research : CR. 2019 Jul; 38(1):300. doi: 10.1186/s13046-019-1301-1. [PMID: 31291971]
  • Karl G Kugler, Zeljkica Jandric, Reinhard Beyer, Eva Klopf, Walter Glaser, Marc Lemmens, Mehrdad Shams, Klaus Mayer, Gerhard Adam, Christoph Schüller. Ribosome quality control is a central protection mechanism for yeast exposed to deoxynivalenol and trichothecin. BMC genomics. 2016 06; 17(?):417. doi: 10.1186/s12864-016-2718-y. [PMID: 27245696]
  • John E McLaughlin, Mohamed Anwar Bin-Umer, Thomas Widiez, Daniel Finn, Susan McCormick, Nilgun E Tumer. A Lipid Transfer Protein Increases the Glutathione Content and Enhances Arabidopsis Resistance to a Trichothecene Mycotoxin. PloS one. 2015; 10(6):e0130204. doi: 10.1371/journal.pone.0130204. [PMID: 26057253]
  • Jia Su, Peiji Zhao, Lingmei Kong, Xingyao Li, Juming Yan, Ying Zeng, Yan Li. Trichothecin induces cell death in NF-κB constitutively activated human cancer cells via inhibition of IKKβ phosphorylation. PloS one. 2013; 8(8):e71333. doi: 10.1371/journal.pone.0071333. [PMID: 23936501]
  • Mohamed Anwar Bin-Umer, John E McLaughlin, Debaleena Basu, Susan McCormick, Nilgun E Tumer. Trichothecene mycotoxins inhibit mitochondrial translation--implication for the mechanism of toxicity. Toxins. 2011 12; 3(12):1484-501. doi: 10.3390/toxins3121484. [PMID: 22295173]
  • Petr Karlovsky. Biological detoxification of the mycotoxin deoxynivalenol and its use in genetically engineered crops and feed additives. Applied microbiology and biotechnology. 2011 Aug; 91(3):491-504. doi: 10.1007/s00253-011-3401-5. [PMID: 21691789]
  • XiaoMei Zhang, GuoHong Li, Juan Ma, Ying Zeng, WeiGuang Ma, PeiJi Zhao. Endophytic fungus Trichothecium roseum LZ93 antagonizing pathogenic fungi in vitro and its secondary metabolites. Journal of microbiology (Seoul, Korea). 2010 Dec; 48(6):784-90. doi: 10.1007/s12275-010-0173-z. [PMID: 21221935]
  • Anne E Desjardins. Natural product chemistry meets genetics: when is a genotype a chemotype?. Journal of agricultural and food chemistry. 2008 Sep; 56(17):7587-92. doi: 10.1021/jf801239j. [PMID: 18690691]
  • . . . . doi: . [PMID: 22069741]