Dexniguldipine (BioDeep_00000749326)
Secondary id: BioDeep_00000008553
代谢物信息卡片
Dexniguldipine
化学式: C36H39N3O6 (609.2838714)
中文名称: 右尼古地平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC
InChI: InChI=1S/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3
描述信息
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
D000970 - Antineoplastic Agents
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
C1744 - Multidrug Resistance Modulator
C93038 - Cation Channel Blocker
同义名列表
3 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:7572
- ChEBI: CHEBI:103932
- KEGG: C11236
- PubChem: 1236
- PubChem: 6918097
- DrugBank: DB14068
- ChEMBL: CHEMBL1275655
- ChEMBL: CHEMBL2051956
- ChEMBL: CHEMBL436150
- CAS: 102993-22-6
- CAS: 120054-86-6
- PubChem: 13415
- NIKKAJI: J484.606K
- KNApSAcK: 7572
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Mia Niklasson, Gianluca Maddalo, Zuzana Sramkova, Ercan Mutlu, Shimei Wee, Petra Sekyrova, Linnéa Schmidt, Nicolas Fritz, Ivar Dehnisch, Gregorios Kyriatzis, Michaela Krafcikova, Brittany B Carson, Jennifer M Feenstra, Voichita D Marinescu, Anna Segerman, Martin Haraldsson, Anna-Lena Gustavsson, Lars G J Hammarström, Annika Jenmalm Jensen, Lene Uhrbom, A F Maarten Altelaar, Sten Linnarsson, Per Uhlén, Lukas Trantirek, C Theresa Vincent, Sven Nelander, Per Øyvind Enger, Michael Andäng. Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.
Cancer research.
2017 04; 77(7):1741-1752. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
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10.1016/s0304-3835(98)00094-9. [PMID: 9719457] - K K Borowicz, M Gasior, Z Kleinrok, S J Czuczwar. Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
European journal of pharmacology.
1997 Mar; 323(1):45-51. doi:
10.1016/s0014-2999(97)00020-4. [PMID: 9105875] - V Nuessler, M E Scheulen, R Oberneder, M Kriegmair, K J Goebel, F Rathgeb, W Wurst, K Zech, W Wilmanns. Phase I and pharmacokinetic study of the P-glycoprotein modulator dexniguldipine-HCL.
European journal of medical research.
1997 Feb; 2(2):55-61. doi:
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Cancer chemotherapy and pharmacology.
1997; 41(1):48-52. doi:
10.1007/s002800050706. [PMID: 9443613] - R Chess-Williams, C R Chapple, F Verfurth, A J Noble, C J Couldwell, M C Michel. The effects of SB 216469, an antagonist which discriminates between the alpha 1A-adrenoceptor and the human prostatic alpha 1-adrenoceptor.
British journal of pharmacology.
1996 Nov; 119(6):1093-100. doi:
10.1111/j.1476-5381.1996.tb16009.x. [PMID: 8937710] - A M van Rhee, J L Jiang, N Melman, M E Olah, G L Stiles, K A Jacobson. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.
Journal of medicinal chemistry.
1996 Jul; 39(15):2980-9. doi:
10.1021/jm9600205. [PMID: 8709132] - G Stubauer, D Obendorf. Determination of trace levels of niguldipine in urine and blood by adsorptive stripping voltammetry at the hanging mercury drop electrode.
The Analyst.
1996 Mar; 121(3):351-6. doi:
10.1039/an9962100351. [PMID: 8729657] - W Van de Vrie, J H Schellens, W J Loss, H J Kolker, J Verwey, G Stoter, N M Durante, A M Eggermont. Modulation of multidrug resistance with dexniguldipine hydrochloride (B8509-035) in the CC531 rat colon carcinoma model.
Journal of cancer research and clinical oncology.
1996; 122(7):403-8. doi:
10.1007/bf01212879. [PMID: 8690750] - L Goedhals, W R Bezwoda, R P Abratt, F Rathgeb, K J Goebel, W Wurst. Bioavailability and pharmacokinetic characteristics of dexniguldipine-HCl, a new anticancer drug.
International journal of clinical pharmacology and therapeutics.
1995 Dec; 33(12):664-9. doi:
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British journal of haematology.
1995 Nov; 91(3):652-7. doi:
10.1111/j.1365-2141.1995.tb05362.x. [PMID: 8555069] - D R Ferry, P J Malkhandi, M A Russell, D J Kerr. Allosteric regulation of [3H]vinblastine binding to P-glycoprotein of MCF-7 ADR cells by dexniguldipine.
Biochemical pharmacology.
1995 Jun; 49(12):1851-61. doi:
10.1016/0006-2952(94)00517-p. [PMID: 7598747] - D R Blue, D W Bonhaus, A P Ford, J R Pfister, N A Sharif, I A Shieh, R L Vimont, T J Williams, D E Clarke. Functional evidence equating the pharmacologically-defined alpha 1A- and cloned alpha 1C-adrenoceptor: studies in the isolated perfused kidney of rat.
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1995 May; 115(2):283-94. doi:
10.1111/j.1476-5381.1995.tb15875.x. [PMID: 7670730] - T A Esbenshade, A Hirasawa, G Tsujimoto, T Tanaka, J Yano, K P Minneman, T J Murphy. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.
Molecular pharmacology.
1995 May; 47(5):977-85. doi:
NULL. [PMID: 7746284] - D Ukena, C Boewer, B Oldenkott, F Rathgeb, W Wurst, K Zech, G W Sybrecht. Tolerance, safety, and kinetics of the new antineoplastic compound dexniguldipine-HCl after oral administration: a phase I dose-escalation trial.
Cancer chemotherapy and pharmacology.
1995; 36(2):160-4. doi:
10.1007/bf00689202. [PMID: 7767953] - J Drímal, L Bohácik. The effect of photogenerated site-directed free radicals on surface dihydropyridine binding sites identified with photoaffinity probe (-)-[3H]-azidopine on cultured monkey renal cells.
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1994 Apr; 13(2):137-48. doi:
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1993 Feb; 347(2):180-5. doi:
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1992 Jun; 43(12):2601-8. doi:
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1991 Aug; 553(1-2):55-63. doi:
10.1016/s0021-9673(01)88472-7. [PMID: 1787169] - M P Drozd, K Gietzen. Effects of the novel dihydropyridine derivative niguldipine on the cytoplasmic free calcium concentration of mouse thymocytes.
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1990 Sep; 40(5):955-9. doi:
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