calophyllolid (BioDeep_00000007205)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Calophyllolide

化学式: C26H24O5 (416.1624)
中文名称: 红厚壳内酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 77.38%

分子结构信息

SMILES: C/C=C(\C)/C(=O)c1c(c2C=CC(C)(C)Oc2c2c(cc(=O)oc12)c1ccccc1)OC
InChI: InChI=1S/C26H24O5/c1-6-15(2)22(28)21-23(29-5)17-12-13-26(3,4)31-24(17)20-18(14-19(27)30-25(20)21)16-10-8-7-9-11-16/h6-14H,1-5H3/b15-6+

描述信息

同义名列表

3 个代谢物同义名

Calophyllolide; calophyllolid; Calophyllolide



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 BGLAP, CASP3, CASP9, PTGS1, PTGS2
Peripheral membrane protein 2 PTGS1, PTGS2
Endoplasmic reticulum membrane 2 PTGS1, PTGS2
Nucleus 2 CASP3, CASP9
cytosol 2 CASP3, CASP9
dendrite 1 BGLAP
nucleoplasm 1 CASP3
Cell membrane 1 TNF
cell surface 1 TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 1 PTGS1
neuronal cell body 2 CASP3, TNF
plasma membrane 1 TNF
caveola 1 PTGS2
extracellular exosome 2 BMP3, PTGS1
endoplasmic reticulum 1 PTGS2
extracellular space 5 BGLAP, BMP3, CTRL, IL10, TNF
mitochondrion 1 CASP9
protein-containing complex 2 CASP9, PTGS2
intracellular membrane-bounded organelle 1 PTGS1
Microsome membrane 2 PTGS1, PTGS2
postsynaptic density 1 CASP3
Secreted 3 BGLAP, BMP3, IL10
extracellular region 4 BGLAP, BMP3, IL10, TNF
photoreceptor outer segment 1 PTGS1
external side of plasma membrane 1 TNF
perikaryon 1 BGLAP
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 BGLAP
Membrane raft 1 TNF
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 2 PTGS1, PTGS2
phagocytic cup 1 TNF
Endomembrane system 1 PTGS1
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 2 BGLAP, PTGS2
apoptosome 1 CASP9
death-inducing signaling complex 1 CASP3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Van-Linh Nguyen, Cong-Tri Truong, Binh Cao Quan Nguyen, Thanh-Niem Van Vo, Trong-Thuc Dao, Van-Dan Nguyen, Dieu-Thuong Thi Trinh, Hieu Kim Huynh, Chi-Bao Bui. Anti-inflammatory and wound healing activities of calophyllolide isolated from Calophyllum inophyllum Linn. PloS one. 2017; 12(10):e0185674. doi: 10.1371/journal.pone.0185674. [PMID: 29020015]
  • Wei-Hsien Liu, Yen-Wenn Liu, Zih-Fong Chen, Wen-Fei Chiou, Ying-Chieh Tsai, Chien-Chih Chen. Calophyllolide content in Calophyllum inophyllum at different stages of maturity and its osteogenic activity. Molecules (Basel, Switzerland). 2015 Jul; 20(7):12314-27. doi: 10.3390/molecules200712314. [PMID: 26198219]
  • Frédéric Laure, Phila Raharivelomanana, Jean-François Butaud, Jean-Pierre Bianchini, Emile M Gaydou. Screening of anti-HIV-1 inophyllums by HPLC-DAD of Calophyllum inophyllum leaf extracts from French Polynesia Islands. Analytica chimica acta. 2008 Aug; 624(1):147-53. doi: 10.1016/j.aca.2008.06.046. [PMID: 18706320]
  • Marie C Yimdjo, Anatole G Azebaze, Augustin E Nkengfack, A Michele Meyer, Bernard Bodo, Zacharias T Fomum. Antimicrobial and cytotoxic agents from Calophyllum inophyllum. Phytochemistry. 2004 Oct; 65(20):2789-95. doi: 10.1016/j.phytochem.2004.08.024. [PMID: 15474565]
  • Ya-Ching Shen, Meng-Chieh Hung, Li-Tang Wang, Ching-Yu Chen. Inocalophyllins A, B and their methyl esters from the seeds of Calophyllum inophyllum. Chemical & pharmaceutical bulletin. 2003 Jul; 51(7):802-6. doi: 10.1248/cpb.51.802. [PMID: 12843586]