Metipranolol (BioDeep_00000006630)

 

Secondary id: BioDeep_00001868038

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


Acetic acid 4-(2-hydroxy-3-isopropylamino-propoxy)-2,3,6-trimethyl-phenyl ester

化学式: C17H27NO4 (309.194)
中文名称: 美替洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 38%

分子结构信息

SMILES: CC(=O)Oc1c(C)cc(OCC(O)CNC(C)C)c(C)c1C
InChI: InChI=1S/C17H27NO4/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4/h7,10,15,18,20H,8-9H2,1-6H3

描述信息

Metipranolol is only found in individuals that have used or taken this drug. It is a beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent. [PubChem]Although it is known that metipranolol binds the beta1 and beta2 adrenergic receptors, the mechanism of metipranolols action is not known. It has no significant intrinsic sympathomimetic activity, and has only weak local anesthetic (membrane-stabilizing) and myocardial depressant activity. It appears that the ophthalmic beta-adrenergic blocking agents reduce aqueous humor production, as demonstrated by tonography and fluorophotometry. A slight increase in aqueous humor outflow may be an additional mechanism.
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01ED - Beta blocking agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
Metipranolol is a nonselective and orally active β-adrenergic receptor antagonist. Metipranolol can be used for hypertension and glaucoma research[1][2].

同义名列表

11 个代谢物同义名

Acetic acid 4-(2-hydroxy-3-isopropylamino-propoxy)-2,3,6-trimethyl-phenyl ester; Acetate 4-(2-hydroxy-3-isopropylamino-propoxy)-2,3,6-trimethyl-phenyl ester; 4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-2,3,6-trimethylphenyl acetate; 1-(4-Acetoxy-2,3,5-trimethylphenoxy)-3-isopropylamino-2-propanol; (+-)-Metipranolol; Metipranololum; Metipranolol; Trimepranol; Methypranol; Disorat; Metipranolol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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COVID-19 Disease Map(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, ARR3, BCL2, CASP3, GRK1, MARK2, MTOR, PIK3CA, PIK3CG
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 2 BCL2, MTOR
Nucleus 4 ALB, BCL2, CASP3, MTOR
cytosol 8 ALB, BCL2, CASP3, MTOR, PIK3CA, PIK3CG, PRKCQ, RPE
dendrite 2 MARK2, MTOR
phagocytic vesicle 1 MTOR
centrosome 1 ALB
nucleoplasm 4 CASP3, MARK2, MTOR, SCNN1G
Cell membrane 2 ADRB3, PIK3CG
Lipid-anchor 1 GRK1
Cytoplasmic side 1 MTOR
lamellipodium 1 PIK3CA
Multi-pass membrane protein 4 ADRB3, CACNA1I, RHO, SCNN1G
Golgi apparatus membrane 1 MTOR
Synapse 1 ARR3
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ALB, RHO
Golgi membrane 3 INS, MTOR, RHO
lysosomal membrane 1 MTOR
neuronal cell body 1 CASP3
Lysosome 1 MTOR
plasma membrane 11 ADRB3, CACNA1I, EDNRA, F2, MARK2, PIK3CA, PIK3CG, PRKCQ, REN, RHO, SCNN1G
Membrane 8 BCL2, CACNA1I, GRK1, MARK2, MTOR, PIK3CG, REN, RHO
apical plasma membrane 1 SCNN1G
extracellular exosome 4 ALB, F2, RPE, SCNN1G
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ALB, BCL2
extracellular space 5 ALB, F2, GH1, INS, REN
perinuclear region of cytoplasm 1 PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, MARK2
protein-containing complex 2 ALB, BCL2
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 5 ALB, F2, GH1, INS, REN
extracellular region 5 ALB, F2, GH1, INS, REN
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
ciliary membrane 1 RHO
photoreceptor inner segment 2 ARR3, RHO
photoreceptor outer segment 2 ARR3, RHO
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 SCNN1G
apical part of cell 1 REN
cell-cell junction 1 RHO
Apical cell membrane 1 SCNN1G
pore complex 1 BCL2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 F2
lateral plasma membrane 1 MARK2
receptor complex 1 ADRB3
ciliary basal body 1 ALB
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 3 ARR3, GRK1, RHO
spindle pole 1 ALB
actin filament 1 MARK2
blood microparticle 2 ALB, F2
sperm midpiece 1 RHO
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 2 GH1, INS
sodium channel complex 1 SCNN1G
Cell projection, dendrite 1 MARK2
Golgi-associated vesicle membrane 1 RHO
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 ALB, F2, INS
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3CG
Photoreceptor inner segment membrane 1 RHO
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
death-inducing signaling complex 1 CASP3
photoreceptor outer segment membrane 1 RHO
sperm head plasma membrane 1 RHO
Cytoplasmic vesicle, phagosome 1 MTOR
photoreceptor disc membrane 2 GRK1, RHO
growth hormone receptor complex 1 GH1
rod photoreceptor outer segment 1 RHO
BAD-BCL-2 complex 1 BCL2
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3CG
ciliary transition fiber 1 ALB
microtubule bundle 1 MARK2


文献列表

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