Triethylenemelamine (BioDeep_00000006561)
Secondary id: BioDeep_00001867940
human metabolite blood metabolite
代谢物信息卡片
2,4,6-Tris(aziridin-1-yl)-1,3,5-triazine
化学式: C9H12N6 (204.1123)
中文名称: 曲他胺, 三亚乙基三聚氰胺
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C1CN1C1=NC(=NC(=N1)N1CC1)N1CC1
InChI: InChI=1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
D000970 - Antineoplastic Agents
同义名列表
14 个代谢物同义名
2,4,6-Tris(aziridin-1-yl)-1,3,5-triazine; 2,4,6-Tris(1-aziridinyl)-1,3,5-triazine; 2,4,6-Tri(1-aziridinyl)-1,3,5-triazine; 2,4,6-Tris(1-aziridinyl)-S-triazine; 2,4,6-Triethylimino-1,3,5-triazine; tris(aziridin-1-yl)-1,3,5-triazine; Trisaziridinyltriazine; Melamine, triethylene; Triethylene melamine; Triethylenemelamine; tretamine; TEM; Triethylenemelamine; Triethylenemelamine
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:27919
- KEGG: C07642
- PubChem: 5799
- HMDB: HMDB0259195
- Metlin: METLIN66702
- DrugBank: DB14031
- ChEMBL: CHEMBL502384
- Wikipedia: Triethylenemelamine
- MeSH: Triethylenemelamine
- chemspider: 5594
- CAS: 51-18-3
- PMhub: MS000019623
- PubChem: 9844
- NIKKAJI: J4.112B
- KNApSAcK: 27919
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A E Kusi-Appiah, T W Lowry, E M Darrow, K A Wilson, B P Chadwick, M W Davidson, S Lenhert. Quantitative dose-response curves from subcellular lipid multilayer microarrays.
Lab on a chip.
2015 Aug; 15(16):3397-404. doi:
10.1039/c5lc00478k. [PMID: 26167949] - R Rieger, A Michaelis. Combined application of MH and TEM for conditioning treatment simultaneously triggers two protective functions against induction of chromatid aberrations in Vicia faba root tip meristem cells.
Mutation research.
1993 Jul; 302(3):161-4. doi:
10.1016/0165-7992(93)90043-u. [PMID: 7686626] - A Michaelis, R Rieger. Inhibition of protein synthesis by cycloheximide does not prevent adaptive responses triggered by heavy metal salts in Vicia faba.
Mutation research.
1993 Jul; 302(3):157-60. doi:
10.1016/0165-7992(93)90042-t. [PMID: 7686625] - J W Bickham, V L Sawin, D W Burton, K McBee. Flow-cytometric analysis of the effects of triethylenemelamine on somatic and testicular tissues of the rat.
Cytometry.
1992; 13(4):368-73. doi:
10.1002/cyto.990130406. [PMID: 1526195] - R Rieger, A Michaelis, S Takehisa. Involvement of phytochelatins in NiCl2-triggered protection against induction of chromatid aberrations by TEM and MH in Vicia faba root tip meristems?.
Mutation research.
1990 May; 244(1):31-5. doi:
10.1016/0165-7992(90)90104-r. [PMID: 2336070] - Y Timbal, J Rodier. [Apropos of a case of renal oncocytoma with hepatic localization].
Annales d'urologie.
1984 Dec; 18(6):415-7. doi:
NULL. [PMID: 6532315] - K H Antman, R L Ruxer, J Aisner, G Vawter. Mesothelioma following Wilms' tumor in childhood.
Cancer.
1984 Jul; 54(2):367-9. doi:
10.1002/1097-0142(19840715)54:2<367::aid-cncr2820540232>3.0.co;2-y. [PMID: 6327010] - M K Sanyal, F Naftolin. In vitro development of the mammalian embryo.
The Journal of experimental zoology.
1983 Nov; 228(2):235-51. doi:
10.1002/jez.1402280209. [PMID: 6420506] - F N Dulout, M L Larramendy, O A Olivero. Enhancement by caffeine of the frequency of anaphase-telophase chromatin bridges induced by triethylenemelamine (TEM).
Experientia.
1980 Mar; 36(3):346-7. doi:
10.1007/bf01952318. [PMID: 7371798] - W Raake, K Tempel, R Hollatz. E1On the effect of 6-methyluracil on mice damaged by 2,4,6-triethylene-imino-1,3,5-triazine or by X-irradiation (author's transl).
Arzneimittel-Forschung.
1977; 27(1):132-7. doi:
. [PMID: 576813] - H Losse. Treatment of renal hypertension.
Clinical nephrology.
1975 Nov; 4(5):194-7. doi:
. [PMID: 167] - E Weber, K Bidwell, M S Legator. An evaluation of the micronuclei test using triethylenemelamine, trimethylphosphate, hycanthone and niridazole.
Mutation research.
1975 Apr; 28(1):101-6. doi:
10.1016/0027-5107(75)90319-x. [PMID: 1095914] - K Tempel, M Wulffius. [Deoxyribonuclease I in the mouse kidney after whole-body radiation or administration of 2,4,6-triethyleneimino-1,3,5 triazine under the influence of polyanions].
Experientia.
1973 Aug; 29(8):997-9. doi:
10.1007/bf01930426. [PMID: 4733333] - E K Zsigmond, G Robins. The effect of a series of anti-cancer drugs on plasma cholinesterase activity.
Canadian Anaesthetists' Society journal.
1972 Jan; 19(1):75-82. doi:
10.1007/bf03006910. [PMID: 4257896] - T I Lawhorn, H H Stone, J D Martin. Chemotherapy in solid tumors of childhood.
Oncology.
1972; 26(2):250-8. doi:
10.1159/000224673. [PMID: 4559041] - P Höcker, C Geisler, A Stacher, M Wiser. [Distribution of free amino acids in plasma in patients with a chronic lymphatic and acute leukemia].
Wiener klinische Wochenschrift.
1971 Apr; 83(14):245-8. doi:
NULL. [PMID: 5283980] - R L Cornwell, R M Jones. Immunity to Dictyocaulus viviparus infection in the guinea pig produced by normal and triethylene melamine-attenuated larvae.
Journal of comparative pathology.
1971 Jan; 81(1):97-103. doi:
10.1016/0021-9975(71)90060-0. [PMID: 4253674] - K Tempel, K Beurer. [Deoxyribonucleases and phosphatases in the rat kidney as effected by whole-body x-ray radiation and 2,4,6-triethylene amino-s-triazine].
Strahlentherapie.
1971; 141(1):106-13. doi:
NULL. [PMID: 5137497] - M H Donaldson, J S Horsley. Nonhormonal chemotherapy of tumors metastatic to bone.
Clinical orthopaedics and related research.
1970 Nov; 73(?):64-72. doi:
NULL. [PMID: 4320328] - R Pichlmayr. Immunosuppressive methods and antilymphocytic serum.
Studium generale; Zeitschrift fur die Einheit der Wissenschaften im Zusammenhang ihrer Begriffsbildungen und Forschungsmethoden.
1970; 23(4):344-52. doi:
NULL. [PMID: 4988857] - R T Silver. The treatment of chronic lymphocytic leukemia.
Seminars in hematology.
1969 Oct; 6(4):344-56. doi:
NULL. [PMID: 4900651] - M N Teller, D Abraham, M Bowie, P P Carbone. Transplantable mouse plasma cell tumors in experimental chemotherapy.
Journal of the National Cancer Institute.
1969 Jul; 43(1):123-31. doi:
NULL. [PMID: 5816022] - M E Whisson, J Siracký. Increased sensitivity of a plasma cell tumour to T.E.M. on conversion to the ascitic form: relationship to karyotype and cycle kinetics.
Neoplasma.
1969; 16(4):347-61. doi:
NULL. [PMID: 5344223] - H Bartelheimer, H Frenzel. [Desired and undesirable effects of cytostatic therapy].
Medizinische Klinik.
1967 Oct; 62(43):1653-9. doi:
". [PMID: 5594047] - J Louis, N B Louis, J W Linman, W J Donnelly, B L Isaacs, S O Schwartz. The clinical pharmacology of hexamethylmelamine: Phase I study.
Clinical pharmacology and therapeutics.
1967 Jan; 8(1):55-64. doi:
10.1002/cpt196781part155. [PMID: 4959523] - R Rieger, A Michaelis. Chemical induction of heat-reversible 'potential lesions' in Vicia faba chromosome.
Nature.
1965 May; 206(985):741-2. doi:
10.1038/206741a0. [PMID: 5832872] - G CELLE, M DODERO. [BEHAVIOR OF SERUM ANTI-TRYPSIN ACTIVITY AFTER TREATMENT WITH ANTIBLASTICS AND STEROIDS].
Archivio "E. Maragliano" di patologia e clinica.
1964 Dec; 20(?):533-43. doi:
NULL. [PMID: 14277930] - T A CONNORS, L A ELSON, C L LEESE. THE EFFECT OF GLUCOSE PRETREATMENT ON THE ANTI-TUMOUR ACTION OF MANNITOL MYLERAN.
Biochemical pharmacology.
1964 Jul; 13(?):963-8. doi:
10.1016/0006-2952(64)90092-9. [PMID: 14201138] - W F DUNNING, M R CURTIS. COMPARATIVE RESPONSE OF A SPECTRUM OF TRANSPLANTABLE RAT NEOPLASMS TO NITROGEN MUSTARD, TRIETHYLENEMELAMINE, AND A GROUP OF BENZALDEHYDE MUSTARD DERIVATIVES.
Cancer chemotherapy reports.
1964 Mar; 36(?):5-19. doi:
". [PMID: 14152277] - E V COONRAD, R W RUNDLES. Mustard chemotherapy in ovarian carcinoma.
Annals of internal medicine.
1959 Jun; 50(6):1449-61. doi:
10.7326/0003-4819-50-6-1449. [PMID: 13661772] - G M MARIUZZI. [Histological changes in the ovary caused by combined serum gonadotropin and an antimitotic].
Archivio "de Vecchi" per l'anatomia patologica e la medicina clinica.
1956 Jun; 24(2):563-77. doi:
NULL. [PMID: 13363591] - P MANIL, J FOURNEAU. [Action of synthetic mitostatic substances on crown gall].
Annales de l'Institut Pasteur.
1956 Apr; 90(4):381-7. doi:
". [PMID: 13327493] - G LENTI, F GAVOSTO. [Behavior of uric acid in urine during triethylenemelamine therapy].
Giornale italiano di chemioterapia.
1954 Jan; 1(1):107-8. doi:
NULL. [PMID: 13191597]
