Desogestrel (BioDeep_00000006555)

 

Secondary id: BioDeep_00000637527

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1S,2R,10S,11S,14R,15S)-15-ethyl-14-ethynyl-17-methylidenetetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-ol

化学式: C22H30O (310.229653)
中文名称: 去氧孕烯
谱图信息: 最多检出来源 Homo sapiens(blood) 9.52%

分子结构信息

SMILES: C#CC1(O)CCC2C3CCC4=CCCCC4C3C(=C)CC21CC
InChI: InChI=1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1

描述信息

Desogestrel is only found in individuals that have used or taken this drug. It is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. [PubChem]Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like desogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents

同义名列表

14 个代谢物同义名

(1S,2R,10S,11S,14R,15S)-15-ethyl-14-ethynyl-17-methylidenetetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-ol; alpha-Pregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-18,19-dinor-17; 13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol; 13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol; 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol; 13-Ethyl-11-methylene-18,19-dinor-17a-pregn-4-en-20-yn-17-ol; 13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17alpha-ol; 13-Ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17-ol; Organon brand OF desogestrel; Desogestrelum; Desogestrel; Cerazette; mircette; Marvelon



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jingwen Gan, Shi-Yang Zhu, Xiao Ma, Xue-Song Ding, Yan Deng, Yanfang Wang, Ai-Jun Sun. The effect of Ding-kun-dan comparing with Marvelon on primary dysmenorrhea: A prospective, double-blind, multicenter, randomized controlled trial. Journal of ethnopharmacology. 2023 Jul; ?(?):116975. doi: 10.1016/j.jep.2023.116975. [PMID: 37517569]
  • Shiyang Zhu, Xiao Ma, Xuesong Ding, Jingwen Gan, Yan Deng, Yanfang Wang, Aijun Sun. Comparative evaluation of low-level light therapy and ethinyl estradiol and desogestrel combined oral contraceptive for clinical efficacy and regulation of serum biochemical parameters in primary dysmenorrhoea: a prospective randomised multicentre trial. Lasers in medical science. 2022 Jun; 37(4):2239-2248. doi: 10.1007/s10103-021-03490-z. [PMID: 35028764]
  • Farhad Kafi Mallak, Helena Kopp Kallner. Migration of a subdermal contraceptive implant into a subsegmental pulmonary artery and etonogestrel serum concentration over time - a case report. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2022 Jun; 27(3):261-264. doi: 10.1080/13625187.2022.2036977. [PMID: 35174737]
  • Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal. Variability in repeat serum etonogestrel concentrations among contraceptive implant users during the steady-release pharmacokinetic period. Contraception. 2022 04; 108(?):65-68. doi: 10.1016/j.contraception.2021.12.008. [PMID: 34973207]
  • Aaron Lazorwitz, Morgan Pena, Jeanelle Sheeder, Stephanie Teal. Effect of Topiramate on Serum Etonogestrel Concentrations Among Contraceptive Implant Users. Obstetrics and gynecology. 2022 04; 139(4):579-587. doi: 10.1097/aog.0000000000004697. [PMID: 35594123]
  • Le-Kai Nie, Hong-Li Zou, Lei Cheng, Pei-Hai Zhang. Subcutaneous etonogestrel implant combined with endometrial ablation for the treatment of adenomyosis: two case reports. The journal of obstetrics and gynaecology research. 2022 Jan; 48(1):262-265. doi: 10.1111/jog.15084. [PMID: 34713941]
  • Regis Kreitchmann, Alice Stek, Brookie M Best, Edmund Capparelli, JiaJia Wang, David Shapiro, Nahida Chakhtoura, Mark Mirochnick, Ahizechukwu C Eke. Interactions between etonogestrel-releasing contraceptive implant and 3 antiretroviral regimens. Contraception. 2022 01; 105(?):67-74. doi: 10.1016/j.contraception.2021.08.006. [PMID: 34407424]
  • Santiago Palacios, Enrico Colli, Pedro A Regidor. Metabolic and laboratory effects of a progestin-only pill containing drospirenone 4 mg in comparison to desogestrel 75 µg: a double-blind, double-dummy, prospective, randomised study. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2021 Dec; 26(6):454-461. doi: 10.1080/13625187.2021.1957094. [PMID: 34348526]
  • Aaron Lazorwitz, Christina L Aquilante, Jonathan A Shortt, Jeanelle Sheeder, Stephanie Teal, Christopher R Gignoux. Applicability of ancestral genotyping in pharmacogenomic research with hormonal contraception. Clinical and translational science. 2021 09; 14(5):1713-1718. doi: 10.1111/cts.13014. [PMID: 33650294]
  • Lekai Nie, Hongli Zou, Xiaotian Ma, Lei Cheng, Jun Jiao, Fenghua Wang, Weifeng Liang, Peihai Zhang. A clinical observational study on the efficacy of subcutaneous etonogestrel implants for adenomyosis in 20 patients. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2021 Aug; 37(8):735-739. doi: 10.1080/09513590.2021.1922886. [PMID: 34160336]
  • Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal. An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2021 Aug; 26(4):323-325. doi: 10.1080/13625187.2021.1887475. [PMID: 33596152]
  • Mariane Massaini Barbieri, Thuany Bento Herculano, Amanda Dantas Silva, Luis Bahamondes, Cassia Raquel Teatin Juliato, Fernanda Garanhani Surita. Acceptability of ENG-releasing subdermal implants among postpartum Brazilian young women during the COVID-19 pandemic. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2021 Jul; 154(1):106-112. doi: 10.1002/ijgo.13663. [PMID: 33656758]
  • Alida M Gertz, Ian J Bishop, Boikhutso Simon, Kwana Lechiile, Opelo Badubi, Aamirah Mussa, Carolyn L Westhoff, Chelsea Morroni. Comparison of plasma etonogestrel concentrations sampled from the contralateral-to-implant and ipsilateral-to-implant arms of contraceptive implant users. Contraception. 2020 12; 102(6):403-405. doi: 10.1016/j.contraception.2020.08.011. [PMID: 32858051]
  • Cesare Battaglia, Bruno Battaglia, Paolo Casadio, Roberta Rizzo, Paolo G Artini. Metformin metabolic and vascular effects in normal weight hyperinsulinemic polycystic ovary syndrome patients treated with contraceptive vaginal ring. A pilot study. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2020 Dec; 36(12):1062-1069. doi: 10.1080/09513590.2020.1770213. [PMID: 32544018]
  • Ian J Bishop, Alida M Gertz, Boikhutso Simon, Leabaneng Tawe, Kwana Lechiile, Serena Liu, Nicholas Teodoro, Aamirah Mussa, Ava Avalos, Sifelani Malima, Tshego Maotwe, Lesego Mokganya, Carolyn L Westhoff, Chelsea Morroni. Etonogestrel concentrations among contraceptive implant users in Botswana using and not using dolutegravir-based antiretroviral therapy. Contraception. 2020 09; 102(3):174-179. doi: 10.1016/j.contraception.2020.04.019. [PMID: 32387328]
  • Aaron Lazorwitz, Rebecca Seale, Anne Davis, Maryam Guiahi. A pilot study on the effect of isotretinoin on serum etonogestrel concentrations in contraceptive implant users. Contraception. 2020 07; 102(1):58-60. doi: 10.1016/j.contraception.2020.04.011. [PMID: 32325076]
  • Meilin He, Guozhong Yang, Xiaoyu Zhao, Suohui Zhang, Yunhua Gao. Intradermal Implantable PLGA Microneedles for Etonogestrel Sustained Release. Journal of pharmaceutical sciences. 2020 06; 109(6):1958-1966. doi: 10.1016/j.xphs.2020.02.009. [PMID: 32084376]
  • Deborah Margatho, Nelsilene Mota Carvalho, Luis Bahamondes. Endometriosis-associated pain scores and biomarkers in users of the etonogestrel-releasing subdermal implant or the 52-mg levonorgestrel-releasing intrauterine system for up to 24 months. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2020 Apr; 25(2):133-140. doi: 10.1080/13625187.2020.1725461. [PMID: 32069126]
  • David W Haas, Yoninah S Cramer, Catherine Godfrey, Susan L Rosenkranz, Francesca Aweeka, Baiba Berzins, Robert Coombs, Kristine Coughlin, Laura E Moran, David Gingrich, Carmen D Zorrilla, Paxton Baker, Susan E Cohn, Kimberly K Scarsi. Pharmacogenetic interactions between antiretroviral drugs and vaginally administered hormonal contraceptives. Pharmacogenetics and genomics. 2020 04; 30(3):45-53. doi: 10.1097/fpc.0000000000000396. [PMID: 32106141]
  • Lisa B Haddad, Alison Swaims-Kohlmeier, C Christina Mehta, Richard E Haaland, Nakita L Brown, Anandi N Sheth, Hsin Chien, Kehmia Titanji, Sharon L Achilles, Davis Lupo, Clyde E Hart, Igho Ofotokun. Impact of etonogestrel implant use on T-cell and cytokine profiles in the female genital tract and blood. PloS one. 2020; 15(3):e0230473. doi: 10.1371/journal.pone.0230473. [PMID: 32214321]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Rena C Patel, Randy M Stalter, Katherine K Thomas, Bani Tamraz, Steven W Blue, David W Erikson, Christina J Kim, Edward J Kelly, Kavita Nanda, Athena P Kourtis, Jairam R Lingappa, Nelly Mugo, Jared M Baeten, Kimberly K Scarsi. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS (London, England). 2019 11; 33(13):1995-2004. doi: 10.1097/qad.0000000000002308. [PMID: 31306173]
  • Francisca Martínez, Jorge Rodriguez-Purata, Elisabet Clua, Sandra Garcia, Buenaventura Coroleu, Nikolaos Polyzos. Ovarian response in oocyte donation cycles under LH suppression with GnRH antagonist or desogestrel progestin: retrospective and comparative study. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2019 Oct; 35(10):884-889. doi: 10.1080/09513590.2019.1604662. [PMID: 31081407]
  • Aaron Lazorwitz, Christina L Aquilante, Eva Dindinger, Margaret Harrison, Jeanelle Sheeder, Stephanie Teal. Relationship Between Etonogestrel Concentrations and Bleeding Patterns in Contraceptive Implant Users. Obstetrics and gynecology. 2019 10; 134(4):807-813. doi: 10.1097/aog.0000000000003452. [PMID: 31503152]
  • Kimberly K Scarsi, Yoninah S Cramer, Susan L Rosenkranz, Francesca Aweeka, Baiba Berzins, Robert W Coombs, Kristine Coughlin, Laura E Moran, Carmen D Zorrilla, Victor Akelo, Mariam Aziz, Ruth K Friedman, David Gingrich, Shobha Swaminathan, Catherine Godfrey, Susan E Cohn. Antiretroviral therapy and vaginally administered contraceptive hormones: a three-arm, pharmacokinetic study. The lancet. HIV. 2019 09; 6(9):e601-e612. doi: 10.1016/s2352-3018(19)30155-9. [PMID: 31498109]
  • Aaron Lazorwitz, Christina L Aquilante, Jeanelle Sheeder, Maryam Guiahi, Stephanie Teal. Relationship between patient characteristics and serum etonogestrel concentrations in contraceptive implant users. Contraception. 2019 07; 100(1):37-41. doi: 10.1016/j.contraception.2019.03.045. [PMID: 30980827]
  • Amihai Rottenstreich, Ram Elazary, Uriel Elchalal, Gabriel Levin. Re: Plasma concentrations of etonogestrel in obese women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study. BJOG : an international journal of obstetrics and gynaecology. 2019 04; 126(5):676-677. doi: 10.1111/1471-0528.15556. [PMID: 30461162]
  • Charlotte Ginstman, Jan Brynhildsen. Authors' reply re: Plasma concentrations of etonogestrel in obese women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study. BJOG : an international journal of obstetrics and gynaecology. 2019 04; 126(5):677. doi: 10.1111/1471-0528.15557. [PMID: 30461174]
  • Aaron Lazorwitz, Christina L Aquilante, Kris Oreschak, Jeanelle Sheeder, Maryam Guiahi, Stephanie Teal. Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users. Obstetrics and gynecology. 2019 04; 133(4):783-794. doi: 10.1097/aog.0000000000003189. [PMID: 30870275]
  • C Ginstman, J Frisk, B Carlsson, A Ärlemalm, S Hägg, J Brynhildsen. Plasma concentrations of etonogestrel in women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study. BJOG : an international journal of obstetrics and gynaecology. 2019 Mar; 126(4):486-492. doi: 10.1111/1471-0528.15511. [PMID: 30347490]
  • Lyndsey R Buckner, Erma Z Drobnis, Molly S Augustine, Lynette K Rogers, Jill Akers, Patricia D Mott, Thomas J Hope, Alison J Quayle, Danny J Schust. Cervical and systemic concentrations of long acting hormonal contraceptive (LARC) progestins depend on delivery method: Implications for the study of HIV transmission. PloS one. 2019; 14(5):e0214152. doi: 10.1371/journal.pone.0214152. [PMID: 31095572]
  • Deborah Margatho, Nelsilene Mota Carvalho, Larissa Eloy, Luis Bahamondes. Assessment of biomarkers in women with endometriosis-associated pain using the ENG contraceptive implant or the 52 mg LNG-IUS: a non-inferiority randomised clinical trial. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2018 Oct; 23(5):344-350. doi: 10.1080/13625187.2018.1531117. [PMID: 30372645]
  • Rachel E Zigler, Tessa Madden, Caitlin Ashby, Leping Wan, Colleen McNicholas. Ulipristal Acetate for Unscheduled Bleeding in Etonogestrel Implant Users: A Randomized Controlled Trial. Obstetrics and gynecology. 2018 10; 132(4):888-894. doi: 10.1097/aog.0000000000002810. [PMID: 30130351]
  • Joe-Elie Salem, Pauline Dureau, Anne Bachelot, Marine Germain, Pascal Voiriot, Bruno Lebourgeois, David-Alexandre Trégouët, Jean-Sébastien Hulot, Christian Funck-Brentano. Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women. JAMA cardiology. 2018 09; 3(9):877-882. doi: 10.1001/jamacardio.2018.2251. [PMID: 30073300]
  • Jianbo Wu, Yuxiu Huang, Lihong Chen, Jifen Hu, Yilu Zou. Treatment of Adenomyosis with Subcutaneous Etonogestrel Implants: A Clinical Observational Study in 17 Patients. Medical science monitor : international medical journal of experimental and clinical research. 2018 Sep; 24(?):6085-6092. doi: 10.12659/msm.908979. [PMID: 30171680]
  • Wataru Isono, Osamu Wada-Hiraike, Yumiko Kawamura, Tomoyuki Fujii, Yutaka Osuga, Hiroki Kurihara. Administration of Oral Contraceptives Could Alleviate Age-Related Fertility Decline Possibly by Preventing Ovarian Damage in a Mouse Model. Reproductive sciences (Thousand Oaks, Calif.). 2018 09; 25(9):1413-1423. doi: 10.1177/1933719117746758. [PMID: 29237349]
  • Jun Zhang, Mi Su, Liangzhi Xu, Zhilan Yang, Weiyao Yin, Ying Nie, Xiaoyong Qiao, Ran Cheng, Yaxian Ma. [Efficacy and metabolic safety of long-term treatment with ethinyl oestradiol/cyproterone and desogestrel/ethinyl oestradiol tablets in women with polycystic ovary syndrome]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2018 Jul; 38(8):917-922. doi: 10.3969/j.issn.1673-4254.2018.08.03. [PMID: 30187872]
  • Sneha G Nair, Daxesh P Patel, Frank J Gonzalez, Bhargav M Patel, Puran Singhal, Darshan V Chaudhary. Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC-MS/MS and its pharmacokinetic study. Biomedical chromatography : BMC. 2018 May; 32(5):e4165. doi: 10.1002/bmc.4165. [PMID: 29228469]
  • Meilin He, Guozhong Yang, Suohui Zhang, Xiaoyu Zhao, Yunhua Gao. Dissolving Microneedles Loaded With Etonogestrel Microcrystal Particles for Intradermal Sustained Delivery. Journal of pharmaceutical sciences. 2018 04; 107(4):1037-1045. doi: 10.1016/j.xphs.2017.11.013. [PMID: 29175412]
  • Andreas J T Pedersen, Tore Bjerregaard Stage, Dorte Glintborg, Marianne Andersen, Mette Marie Hougaard Christensen. The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial. Basic & clinical pharmacology & toxicology. 2018 Feb; 122(2):239-244. doi: 10.1111/bcpt.12874. [PMID: 28834135]
  • Feng Xu, Cuifang Liu, Xiaobo Huang. Oral contraceptives caused venous sinus thrombosis complicated with cerebral artery infarction and secondary epileptic seizures: A case report and literature review. Medicine. 2017 Dec; 96(51):e9383. doi: 10.1097/md.0000000000009383. [PMID: 29390539]
  • Jaime Algorta, Maria Diaz, Raquel de Benito, Marc Lefebvre, Eric Sicard, Milton Furtado, Pedro Antonio Regidor, Celestino Ronchi. Pharmacokinetic bioequivalence, safety and acceptability of Ornibel®, a new polymer composition contraceptive vaginal ring (etonogestrel/ethinylestradiol 11.00/3.474 mg) compared with Nuvaring® (etonogestrel/ethinylestradiol 11.7/2.7 mg). The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2017 Dec; 22(6):429-438. doi: 10.1080/13625187.2017.1413179. [PMID: 29336615]
  • Aaron Lazorwitz, Anne Davis, Maryke Swartz, Maryam Guiahi. The effect of carbamazepine on etonogestrel concentrations in contraceptive implant users. Contraception. 2017 Jun; 95(6):571-577. doi: 10.1016/j.contraception.2017.03.004. [PMID: 28288788]
  • Colleen McNicholas, Erin Swor, Leping Wan, Jeffrey F Peipert. Prolonged use of the etonogestrel implant and levonorgestrel intrauterine device: 2 years beyond Food and Drug Administration-approved duration. American journal of obstetrics and gynecology. 2017 06; 216(6):586.e1-586.e6. doi: 10.1016/j.ajog.2017.01.036. [PMID: 28147241]
  • Katharine B Simmons, Alison B Edelman, Rongwei Fu, Jeffrey T Jensen. Tamoxifen for the treatment of breakthrough bleeding with the etonogestrel implant: a randomized controlled trial. Contraception. 2017 Feb; 95(2):198-204. doi: 10.1016/j.contraception.2016.10.001. [PMID: 27725164]
  • Jaqueline Villas-Boas, Luiz C Vilodre, Helena Malerba, Mila Pontremoli Salcedo, Mirela Foresti Jiménez, Patrícia El Beitune. Metabolic safety of the etonogestrel contraceptive implant in healthy women over a 3-year period. European journal of obstetrics, gynecology, and reproductive biology. 2016 Jul; 202(?):51-4. doi: 10.1016/j.ejogrb.2016.04.025. [PMID: 27164485]
  • Manuela Menezes Máximo, Patrícia Silveira Silva, Carolina Sales Vieira, Thaís Mangetti Gonçalvez, Júlio Cesar Rosa-E-Silva, Francisco José Candido-Dos-Reis, Antonio Alberto Nogueira, Omero Benedicto Poli-Neto. Low-dose progestin-releasing contraceptives are associated with a higher pain threshold in healthy women. Fertility and sterility. 2015 Nov; 104(5):1182-9. doi: 10.1016/j.fertnstert.2015.07.1165. [PMID: 26341277]
  • Larry Seidman, Robin Kroll, Brandon Howard, Nancy Ricciotti, Jennifer Hsieh, Herman Weiss. Ovulatory effects of three oral contraceptive regimens: a randomized, open-label, descriptive trial. Contraception. 2015 Jun; 91(6):495-502. doi: 10.1016/j.contraception.2015.03.001. [PMID: 25746294]
  • Colleen McNicholas, Ragini Maddipati, Qiuhong Zhao, Erin Swor, Jeffrey F Peipert. Use of the etonogestrel implant and levonorgestrel intrauterine device beyond the U.S. Food and Drug Administration-approved duration. Obstetrics and gynecology. 2015 Mar; 125(3):599-604. doi: 10.1097/aog.0000000000000690. [PMID: 25730221]
  • Ingrid J M Duijkers, Doris Heger-Mahn, Dominique Drouin, Sven Skouby. A randomised study comparing the effect on ovarian activity of a progestogen-only pill (POP) containing desogestrel and a new POP containing drospirenone in a 24/4 regimen. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2015; 20(6):419-27. doi: 10.3109/13625187.2015.1044082. [PMID: 26073333]
  • Jesus Hernandez-Juarez, Ethel A Garcia-Latorre, Manuel Moreno-Hernandez, Jose Fernando Moran-Perez, Miguel Angel Rodriguez-Escobedo, Gerardo Cogque-Hernandez, Rubén Julián-Nacer, Xochitl Hernandez-Giron, Rosalia Palafox-Gomez, Irma Isordia-Salas, Abraham Majluf-Cruz. Metabolic effects of the contraceptive skin patch and subdermal contraceptive implant in Mexican women: a prospective study. Reproductive health. 2014 Apr; 11(?):33. doi: 10.1186/1742-4755-11-33. [PMID: 24767248]
  • Tiffany Thomas, Kelsey Petrie, Joonho Shim, Kirsten M Abildskov, Carolyn L Westhoff, Serge Cremers. A UPLC-MS/MS method for therapeutic drug monitoring of etonogestrel. Therapeutic drug monitoring. 2013 Dec; 35(6):844-8. doi: 10.1097/ftd.0b013e31829a10fa. [PMID: 24081205]
  • Luis Bahamondes, M Valeria Bahamondes, Waleska Modesto, Ian B Tilley, Alviclér Magalhães, João Luiz Pinto e Silva, Eliana Amaral, Daniel R Mishell. Effect of hormonal contraceptives during breastfeeding on infant's milk ingestion and growth. Fertility and sterility. 2013 Aug; 100(2):445-50. doi: 10.1016/j.fertnstert.2013.03.039. [PMID: 23623474]
  • Nadia Kancheva Landolt, Nittaya Phanuphak, Sasiwimol Ubolyam, Suteeraporn Pinyakorn, Rosalin Kriengsinyot, Jennisa Ahluwalia, Parawee Thongpaeng, Meena Gorowara, Narukjaporn Thammajaruk, Surasith Chaithongwongwatthana, Joep M A Lange, Jintanat Ananworanich. Efavirenz, in contrast to nevirapine, is associated with unfavorable progesterone and antiretroviral levels when coadministered with combined oral contraceptives. Journal of acquired immune deficiency syndromes (1999). 2013 Apr; 62(5):534-9. doi: 10.1097/qai.0b013e31827e8f98. [PMID: 23187949]
  • Sanna Kallio, Johanna Puurunen, Aimo Ruokonen, Tommi Vaskivuo, Terhi Piltonen, Juha S Tapanainen. Antimüllerian hormone levels decrease in women using combined contraception independently of administration route. Fertility and sterility. 2013 Apr; 99(5):1305-10. doi: 10.1016/j.fertnstert.2012.11.034. [PMID: 23260855]
  • Monica Dragoman, Kelsey Petrie, Anupama Torgal, Tiffany Thomas, Serge Cremers, Carolyn L Westhoff. Contraceptive vaginal ring effectiveness is maintained during 6 weeks of use: a prospective study of normal BMI and obese women. Contraception. 2013 Apr; 87(4):432-6. doi: 10.1016/j.contraception.2012.12.001. [PMID: 23312933]
  • Frans J M E Roumen, Daniel R Mishell. The contraceptive vaginal ring, NuvaRing(®), a decade after its introduction. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2012 Dec; 17(6):415-27. doi: 10.3109/13625187.2012.713535. [PMID: 23113828]
  • Zoltán Lőcsei, Dóra Horváth, Károly Rácz, István Szabolcs, Gábor L Kovács, Erzsébet Toldy. Progestin-dependent effect of oral contraceptives on plasma aldosterone/renin ratio. Clinical biochemistry. 2012 Nov; 45(16-17):1516-8. doi: 10.1016/j.clinbiochem.2012.06.025. [PMID: 22750772]
  • K Bremme, R Rafik Hamad, Elisabeth Berg, K Strandberg, J Stenflo. The APC-PCI concentration as an early marker of activation of blood coagulation: a study of women on combined oral contraceptives. Thrombosis research. 2012 Oct; 130(4):636-9. doi: 10.1016/j.thromres.2011.11.006. [PMID: 22154243]
  • Sara Mornar, Lingtak-Neander Chan, Stephanie Mistretta, Amy Neustadt, Summer Martins, Melissa Gilliam. Pharmacokinetics of the etonogestrel contraceptive implant in obese women. American journal of obstetrics and gynecology. 2012 Aug; 207(2):110.e1-6. doi: 10.1016/j.ajog.2012.05.002. [PMID: 22717269]
  • Hanna Xu, Jennifer A Wade, Jeffrey F Peipert, Qiuhong Zhao, Tessa Madden, Gina M Secura. Contraceptive failure rates of etonogestrel subdermal implants in overweight and obese women. Obstetrics and gynecology. 2012 Jul; 120(1):21-6. doi: 10.1097/aog.0b013e318259565a. [PMID: 22678035]
  • Carolyn L Westhoff, Anupama H Torgal, Elizabeth Rose Mayeda, Kelsey Petrie, Tiffany Thomas, Monica Dragoman, Serge Cremers. Pharmacokinetics and ovarian suppression during use of a contraceptive vaginal ring in normal-weight and obese women. American journal of obstetrics and gynecology. 2012 Jul; 207(1):39.e1-6. doi: 10.1016/j.ajog.2012.04.022. [PMID: 22727346]
  • M Raps, F Helmerhorst, K Fleischer, S Thomassen, F Rosendaal, J Rosing, B Ballieux, H VAN Vliet. Sex hormone-binding globulin as a marker for the thrombotic risk of hormonal contraceptives. Journal of thrombosis and haemostasis : JTH. 2012 Jun; 10(6):992-7. doi: 10.1111/j.1538-7836.2012.04720.x. [PMID: 22469296]
  • María Ángeles Pena, Emilio Sanz, Silvia Francisco, Ainhara Alonso, Zurine Abajo, Izaskun Felipe, Jaume Pascual, Digna Tost, Sandra Bailac. Randomized, Crossover and Single-Dose Bioquivalence Study of Two Oral Desogestrel Formulations (Film-Coated Tablets of 75 μg) in Healthy Female Volunteers. Scientia pharmaceutica. 2012 Apr; 80(2):419-31. doi: 10.3797/scipharm.1111-18. [PMID: 22896827]
  • Christine Klipping, Ingrid Duijkers, Michel P Fortier, Joachim Marr, Dietmar Trummer, Jörg Elliesen. Long-term tolerability of ethinylestradiol 20 μg/drospirenone 3 mg in a flexible extended regimen: results from a randomised, controlled, multicentre study. The journal of family planning and reproductive health care. 2012 Apr; 38(2):84-93. doi: 10.1136/jfprhc-2011-100214. [PMID: 22454004]
  • Cristina Aparecida Falbo Guazzelli, Fernando Augusto Barreiros, Ricardo Barbosa, Maria Regina Torloni, Marcia Barbieri. Extended regimens of the contraceptive vaginal ring versus hormonal oral contraceptives: effects on lipid metabolism. Contraception. 2012 Apr; 85(4):389-93. doi: 10.1016/j.contraception.2011.08.014. [PMID: 22067754]
  • Hatem Abu Hashim, Waleed Alsherbini, Mohamed Bazeed. Contraceptive vaginal ring treatment of heavy menstrual bleeding: a randomized controlled trial with norethisterone. Contraception. 2012 Mar; 85(3):246-52. doi: 10.1016/j.contraception.2011.07.012. [PMID: 22067765]
  • Julie Bouquier, Virginie Fulda, Anne-Sophie Bats, Fabrice Lécuru, Cyrille Huchon. A life-threatening ectopic pregnancy with etonogestrel implant. Contraception. 2012 Feb; 85(2):215-7. doi: 10.1016/j.contraception.2011.07.008. [PMID: 22067768]
  • Sudhindra Mohan Bhattacharya, Mainak Ghosh, Ranjan Basu. Effects of ethinyl estradiol and desogestrel on clinical and metabolic parameters in Indian patients with polycystic ovary syndrome. The journal of obstetrics and gynaecology research. 2012 Jan; 38(1):285-90. doi: 10.1111/j.1447-0756.2011.01682.x. [PMID: 22070369]
  • Cécile Ciangura, Nicola Corigliano, Arnaud Basdevant, Stéphane Mouly, Xavier Declèves, Philippe Touraine, Celia Lloret-Linares. Etonorgestrel concentrations in morbidly obese women following Roux-en-Y gastric bypass surgery: three case reports. Contraception. 2011 Dec; 84(6):649-51. doi: 10.1016/j.contraception.2011.03.015. [PMID: 22078197]
  • Gabriele S Merki-Feld, Marinella Rosselli, Bruno Imthurn, Katharina Spanaus. No effect of Implanon® on inflammatory cardiovascular parameters. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2011 Nov; 27(11):951-5. doi: 10.3109/09513590.2011.564684. [PMID: 21438668]
  • Cristina A F Guazzelli, Flaviano Teixeira de Queiroz, Marcia Barbieri, Fernando A Barreiros, Maria Regina Torloni, Fabio F Araujo. Metabolic effects of contraceptive implants in adolescents. Contraception. 2011 Oct; 84(4):409-12. doi: 10.1016/j.contraception.2011.02.006. [PMID: 21920197]
  • Juan A Garcia-Velasco, Alfonso Bermejo, Francisco Ruiz, Javier Martinez-Salazar, Antonio Requena, Antonio Pellicer. Cycle scheduling with oral contraceptive pills in the GnRH antagonist protocol vs the long protocol: a randomized, controlled trial. Fertility and sterility. 2011 Sep; 96(3):590-3. doi: 10.1016/j.fertnstert.2011.06.022. [PMID: 21718992]
  • Fernando Augusto Barreiros, Cristina Aparecida Falbo Guazzelli, Ricardo Barbosa, Maria Regina Torloni, Marcia Barbieri, Fabio F Araujo. Extended regimens of the combined contraceptive vaginal ring containing etonogestrel and ethinyl estradiol: effects on lipid metabolism. Contraception. 2011 Aug; 84(2):155-9. doi: 10.1016/j.contraception.2010.11.002. [PMID: 21757057]
  • Ahmed M M Mohamed, Wael S M El-Sherbiny, Walaa A I Mostafa. Combined contraceptive ring versus combined oral contraceptive (30-μg ethinylestradiol and 3-mg drospirenone). International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2011 Aug; 114(2):145-8. doi: 10.1016/j.ijgo.2011.03.008. [PMID: 21669426]
  • Costantino Di Carlo, Giovanni A Tommaselli, Nicoletta De Rosa, Annamaria Fabozzi, Romina Santoro, Giuseppe Bifulco, Stefania Sparice, Carmine Nappi. Plasma leptin and adiponectin levels in hormone replacement therapy and contraception: effects of different progestogens. Fertility and sterility. 2011 Jul; 96(1):214-9. doi: 10.1016/j.fertnstert.2011.05.004. [PMID: 21645895]
  • Beata Banaszewska, Robert Z Spaczyński, Katarzyna Ozegowska, Leszek Pawelczyk. [The influence of low-dose oral contraceptive pill on clinical and metabolic parameters in young women with polycystic ovary syndrome]. Ginekologia polska. 2011 Jun; 82(6):430-5. doi: ". [PMID: 21853932]
  • Ali R Odabaşi, Mert Küçük, Hasan Yüksel, Zekeriya Güner, Selda D Sezer. Effects of two different low-dose oral contraceptives on plasma homocysteine levels. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2011 Mar; 27(3):176-9. doi: 10.3109/09513590.2010.488777. [PMID: 20504105]
  • Ney Carter do Carmo Borges, Rafael Barrientos Astigarraga, Carlos Eduardo Sverdloff, Bruno Carter Borges, Thaís Rodrigues Paiva, Paulo Rebelo Galvinas, Ronilson Agnaldo Moreno. Budesonide quantification by HPLC coupled to atmospheric pressure photoionization (APPI) tandem mass spectrometry. Application to a comparative systemic bioavailability of two budesonide formulations in healthy volunteers. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Feb; 879(3-4):236-42. doi: 10.1016/j.jchromb.2010.12.003. [PMID: 21233029]
  • Jennifer Kerns, Philip Darney. Vaginal ring contraception. Contraception. 2011 Feb; 83(2):107-15. doi: 10.1016/j.contraception.2010.07.008. [PMID: 21237335]
  • Jason L Dragoo, Tiffany N Castillo, Tatiana A Korotkova, Ashleigh C Kennedy, Hyeon Joo Kim, Dennis R Stewart. Trends in serum relaxin concentration among elite collegiate female athletes. International journal of women's health. 2011 Jan; 3(?):19-24. doi: 10.2147/ijwh.s14188. [PMID: 21339934]
  • Gabriele S Merki-Feld, Bruno Imthurn, Marinella Rosselli, Katharina Spanaus. Implanon use lowers plasma concentrations of high-molecular-weight adiponectin. Fertility and sterility. 2011 Jan; 95(1):23-7. doi: 10.1016/j.fertnstert.2010.05.018. [PMID: 20576266]
  • Abbey B Berenson, Patricia van den Berg, Karen J Williams, Mahbubur Rahman. Effect of injectable and oral contraceptives on glucose and insulin levels. Obstetrics and gynecology. 2011 Jan; 117(1):41-47. doi: 10.1097/aog.0b013e318202ac23. [PMID: 21173642]
  • Moradan Sanam, Omidvar Ziba. Desogestrel+ethinylestradiol versus levonorgestrel+ethinylestradiol. Which one has better affect on acne, hirsutism, and weight change. Saudi medical journal. 2011 Jan; 32(1):23-6. doi: . [PMID: 21212911]
  • J T Mutihir, D D Nyango. Indications for removal of etonogestrel implant within two years of use in Jos, Nigeria. East African medical journal. 2010 Nov; 87(11):461-4. doi: NULL. [PMID: 23457809]
  • Johan Verhaeghe. Hormonal contraception in women with the metabolic syndrome: a narrative review. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2010 Oct; 15(5):305-13. doi: 10.3109/13625187.2010.502583. [PMID: 20695771]
  • Vincenzo De Leo, Alessandra Di Sabatino, Maria C Musacchio, Giuseppe Morgante, Valeria Scolaro, Antonio Cianci, Felice Petraglia. Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome. Contraception. 2010 Sep; 82(3):276-80. doi: 10.1016/j.contraception.2010.04.002. [PMID: 20705157]
  • Alka Kriplani, Anurekha Janaki Periyasamy, Nutan Agarwal, Vidushi Kulshrestha, Anand Kumar, Ariachery Chinnama Ammini. Effect of oral contraceptive containing ethinyl estradiol combined with drospirenone vs. desogestrel on clinical and biochemical parameters in patients with polycystic ovary syndrome. Contraception. 2010 Aug; 82(2):139-46. doi: 10.1016/j.contraception.2010.02.009. [PMID: 20654754]
  • Anastasios Makedos, Dimitrios G Goulis, Alexis Papanikolaou, Dimitrios Panidis. Serum high-sensitivity C-reactive protein and homocysteine changes during hormonal therapy in women with polycystic ovary syndrome: a prospective, matched study. Angiology. 2010 Aug; 61(6):595-601. doi: 10.1177/0003319709361198. [PMID: 20395229]
  • Konrad Bork. Diagnosis and treatment of hereditary angioedema with normal C1 inhibitor. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 2010 Jul; 6(1):15. doi: 10.1186/1710-1492-6-15. [PMID: 20667118]
  • Berna Dilbaz, Ozlem Ozdegirmenci, Eray Caliskan, Serdar Dilbaz, Ali Haberal. Effect of etonogestrel implant on serum lipids, liver function tests and hemoglobin levels. Contraception. 2010 Jun; 81(6):510-4. doi: 10.1016/j.contraception.2010.01.014. [PMID: 20472118]
  • Ulrich H Winkler, Petra Röhm, Kornelia Höschen. An open-label, comparative study of the effects of a dose-reduced oral contraceptive containing 0.02 mg ethinylestradiol/2 mg chlormadinone acetate on hemostatic parameters and lipid and carbohydrate metabolism variables. Contraception. 2010 May; 81(5):391-400. doi: 10.1016/j.contraception.2009.12.005. [PMID: 20399945]
  • D M Paternoster, F Riboni, M Bertolino, G Garofalo, E Lazzarich, N Surico, P Stratta. The contraceptive vaginal ring in women with renal and liver transplantation: analysis of preliminary results. Transplantation proceedings. 2010 May; 42(4):1162-5. doi: 10.1016/j.transproceed.2010.03.132. [PMID: 20534250]
  • Mariangela Massaro, Costantino Di Carlo, Virginia Gargano, Carmen Formisano, Giuseppe Bifulco, Carmine Nappi. Effects of the contraceptive patch and the vaginal ring on bone metabolism and bone mineral density: a prospective, controlled, randomized study. Contraception. 2010 Mar; 81(3):209-14. doi: 10.1016/j.contraception.2009.09.011. [PMID: 20159176]
  • E F Hynes, K A Handasyde, Geoff Shaw, Marilyn B Renfree. Levonorgestrel, not etonogestrel, provides contraception in free-ranging koalas. Reproduction, fertility, and development. 2010; 22(6):913-9. doi: 10.1071/rd09253. [PMID: 20591325]
  • Giovanni Fazio, Filippo Ferrara, Giuseppe Barbaro, Gullotti Alessandro, Giovanni Ferrro, Giuseppina Novo, Salvatore Novo. Protrhombotic effects of contraceptives. Current pharmaceutical design. 2010; 16(31):3490-6. doi: 10.2174/138161210793563374. [PMID: 20858187]
  • Xiao-Fen Liu, Cun-Gang Ding, Qing-Hua Ge, Zhen Zhou, Xiao-Jin Zhi. [Simultaneous determination of gestodene, etonogestrel and ethinylestradiol in plasma by LC-MS/MS following derivatization]. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Jan; 45(1):87-92. doi: NULL. [PMID: 21351455]
  • Milena Bastos Brito, Rui Alberto Ferriani, Silvana Maria Quintana, Marta Edna Holanda Diogenes Yazlle, Marcos Felipe Silva de Sá, Carolina Sales Vieira. Safety of the etonogestrel-releasing implant during the immediate postpartum period: a pilot study. Contraception. 2009 Dec; 80(6):519-26. doi: 10.1016/j.contraception.2009.05.124. [PMID: 19913145]
  • Chao-Chin Hsu, Hsin-Chih Kuo, Chao-Tien Hsu, Qing Gu. The absorption and uptake of recombinant human follicle-stimulating hormone through vaginal subcutaneous injections--a pharmacokinetic study. Reproductive biology and endocrinology : RB&E. 2009 Oct; 7(?):107. doi: 10.1186/1477-7827-7-107. [PMID: 19807931]