Quazepam (BioDeep_00000006475)
Secondary id: BioDeep_00001868237
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C17H11ClF4N2S (386.0268)
中文名称: 夸西泮
谱图信息:
最多检出来源 Homo sapiens(blood) 68.41%
分子结构信息
SMILES: C1C(=S)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CC(F)(F)F
InChI: InChI=1S/C17H11ClF4N2S/c18-10-5-6-14-12(7-10)16(11-3-1-2-4-13(11)19)23-8-15(25)24(14)9-17(20,21)22/h1-7H,8-9H2
描述信息
Quazepam is only found in individuals that have used or taken this drug. It is a drug which is a benzodiazepine derivative. It induces impairment of motor function and has hypnotic properties. Quazepam is used to treat insomnia.Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
同义名列表
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:8694
- KEGG: C07336
- KEGGdrug: D00457
- PubChem: 4999
- HMDB: HMDB0015528
- Metlin: METLIN43321
- DrugBank: DB01589
- ChEMBL: CHEMBL1200472
- Wikipedia: Quazepam
- chemspider: 4825
- CAS: 36735-22-5
- PMhub: MS000019522
- PubChem: 9543
- NIKKAJI: J17.787C
- KNApSAcK: 8694
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jing Zhou, Koji Yamaguchi, Youkichi Ohno. Quantitative analysis of quazepam and its metabolites in human blood, urine, and bile by liquid chromatography-tandem mass spectrometry.
Forensic science international.
2014 Aug; 241(?):e5-12. doi:
10.1016/j.forsciint.2014.04.027. [PMID: 24856286] - Masaru Terada, Tatsuo Shinozuka, Chika Hasegawa, Einosuke Tanaka, Makiko Hayashida, Youkichi Ohno, Kunihiko Kurosaki. Analysis of quazepam and its metabolites in human urine by gas chromatography-mass spectrometry: application to a forensic case.
Forensic science international.
2013 Apr; 227(1-3):95-9. doi:
10.1016/j.forsciint.2012.11.017. [PMID: 23290298] - Mitsuhiro Nakamura, Tomofumi Ohmori, Yoshinori Itoh, Masato Terashita, Kazuyuki Hirano. Simultaneous determination of benzodiazepines and their metabolites in human serum by liquid chromatography-tandem mass spectrometry using a high-resolution octadecyl silica column compatible with aqueous compounds.
Biomedical chromatography : BMC.
2009 Apr; 23(4):357-64. doi:
10.1002/bmc.1122. [PMID: 18937304] - Angelo A Izzo, Edzard Ernst. Interactions between herbal medicines and prescribed drugs: an updated systematic review.
Drugs.
2009; 69(13):1777-98. doi:
10.2165/11317010-000000000-00000. [PMID: 19719333] - A Yamazaki, Y Kumagai, T Fujita, T Hasunuma, S Yokota, M Maeda, Y Otani, M Majima. Different effects of light food on pharmacokinetics and pharmacodynamics of three benzodiazepines, quazepam, nitrazepam and diazepam.
Journal of clinical pharmacy and therapeutics.
2007 Feb; 32(1):31-9. doi:
10.1111/j.1365-2710.2007.00795.x. [PMID: 17286787] - Tomoki Nishiyama, Koichi Yamashita, Takeshi Yokoyama, Akinobu Imoto, Masanobu Manabe. Effects of quazepam as a preoperative night hypnotic: comparison with brotizolam.
Journal of anesthesia.
2007; 21(1):7-12. doi:
10.1007/s00540-006-0445-2. [PMID: 17285406] - Koh-ichi Sugimoto, Nobutaka Araki, Masami Ohmori, Ken-ichi Harada, Yimin Cui, Shuichi Tsuruoka, Atsuhiro Kawaguchi, Akio Fujimura. Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam.
European journal of clinical pharmacology.
2006 Mar; 62(3):209-15. doi:
10.1007/s00228-005-0071-1. [PMID: 16416305] - Boni Elewski, Amir Tavakkol. Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality.
Therapeutics and clinical risk management.
2005 Dec; 1(4):299-306. doi:
. [PMID: 18360572] - M Miura, T Ohkubo. In vitro metabolism of quazepam in human liver and intestine and assessment of drug interactions.
Xenobiotica; the fate of foreign compounds in biological systems.
2004 Nov; 34(11-12):1001-11. doi:
10.1080/02772240400015214. [PMID: 15801544] - Atsuhiro Kawaguchi, Masami Ohmori, Shu-Ichi Tsuruoka, Kenta Nishiki, Kenichi Harada, Isamu Miyamori, Ryo-Ichi Yano, Toshiaki Nakamura, Mikio Masada, Akio Fujimura. Drug interaction between St John's Wort and quazepam.
British journal of clinical pharmacology.
2004 Oct; 58(4):403-10. doi:
10.1111/j.1365-2125.2004.02171.x. [PMID: 15373933] - Takashi Fukasawa, Norio Yasui-Furukori, Toshiaki Aoshima, Akihito Suzuki, Tomonori Tateishi, Koichi Otani. Single oral dose pharmacokinetics of quazepam is influenced by CYP2C19 activity.
Therapeutic drug monitoring.
2004 Oct; 26(5):529-33. doi:
10.1097/00007691-200410000-00011. [PMID: 15385836] - Hideto Kanda, Norio Yasui-Furukori, Takashi Fukasawa, Toshiaki Aoshima, Akihito Suzuki, Koichi Otani. Interaction study between fluvoxamine and quazepam.
Journal of clinical pharmacology.
2003 Dec; 43(12):1392-7. doi:
10.1177/0091270003258667. [PMID: 14615476] - Youngho Kim, Masayuki Morikawa, Hiroyoshi Ohsawa, Motoasa Kou, Eiwa Ishida, Jun Igarashi, Takaya Kajimoto, Tetsuya Danno, Masaki Nakata, Takateru Yokoyama, Akihiro Tokuyama, Yu Nakamura, Toshifumi Kishimoto. Effects of foods on the pharmacokinetics and clinical efficacy of quazepam.
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.
2003 Oct; 23(5):205-10. doi:
NULL. [PMID: 14653226] - Kimiyasu Kato, Norio Yasui-Furukori, Takashi Fukasawa, Toshiaki Aoshima, Akihito Suzuki, Muneaki Kanno, Koichi Otani. Effects of itraconazole on the plasma kinetics of quazepam and its two active metabolites after a single oral dose of the drug.
Therapeutic drug monitoring.
2003 Aug; 25(4):473-7. doi:
10.1097/00007691-200308000-00010. [PMID: 12883232] - Norio Yasui-Furukori, Takenori Takahata, Tsuyoshi Kondo, Kazuo Mihara, Sunao Kaneko, Tomonori Tateishi. Time effects of food intake on the pharmacokinetics and pharmacodynamics of quazepam.
British journal of clinical pharmacology.
2003 Apr; 55(4):382-8. doi:
10.1046/j.1365-2125.2003.01775.x. [PMID: 12680887] - Norio Yasui-Furukori, Tsuyoshi Kondo, Takenori Takahata, Kazuo Mihara, Shingo Ono, Sunao Kaneko, Tomonori Tateishi. Effect of dietary fat content in meals on pharmacokinetics of quazepam.
Journal of clinical pharmacology.
2002 Dec; 42(12):1335-40. doi:
10.1177/0091270002042012004. [PMID: 12463728] - T G Roth, T A Roehrs, G L Koshorek, D J Greenblatt, L D Rosenthal. Hypnotic effects of low doses of quazepam in older insomniacs.
Journal of clinical psychopharmacology.
1997 Oct; 17(5):401-6. doi:
10.1097/00004714-199710000-00009. [PMID: 9315991] - J Arnold. Determinants of pharmacologic effects and toxicity of benzodiazepine hypnotics: role of lipophilicity and plasma elimination rates.
The Journal of clinical psychiatry.
1991 Sep; 52 Suppl(?):11-4. doi:
. [PMID: 1654317] - J M Hilbert, D Battista. Quazepam and flurazepam: differential pharmacokinetic and pharmacodynamic characteristics.
The Journal of clinical psychiatry.
1991 Sep; 52 Suppl(?):21-6. doi:
. [PMID: 1680120] - D J Greenblatt. Benzodiazepine hypnotics: sorting the pharmacokinetic facts.
The Journal of clinical psychiatry.
1991 Sep; 52 Suppl(?):4-10. doi:
". [PMID: 1680125] - K Schaffler, G Kauert, C H Wauschkuhn, W Klausnitzer. Longitudinal study on pharmacodynamics and pharmacokinetics of acute, steady-state and withdrawn quazepam.
Arzneimittel-Forschung.
1989 Feb; 39(2):276-83. doi:
. [PMID: 2567171] - S K Gupta, E H Ellinwood. Liquid chromatographic assay and pharmacokinetics of quazepam and its metabolites following sublingual administration of quazepam.
Pharmaceutical research.
1988 Jun; 5(6):365-8. doi:
10.1023/a:1015907611170. [PMID: 3244647] - A S Gevins, R K Stone, S D Ragsdale. Differentiating the effects of three benzodiazepines on non-REM sleep EEG spectra. A neural-network pattern classification analysis.
Neuropsychobiology.
1988; 19(2):108-15. doi:
10.1159/000118444. [PMID: 2906410] - J M Hilbert, L Iorio, V Moritzen, A Barnett, S Symchowicz, N Zampaglione. Relationships of brain and plasma levels of quazepam, flurazepam, and their metabolites with pharmacological activity in mice.
Life sciences.
1986 Jul; 39(2):161-8. doi:
10.1016/0024-3205(86)90451-0. [PMID: 3724367] - H Bun, P Coassolo, B Ba, C Aubert, J P Cano. Plasma quantification of quazepam and its 2-oxo and N-desmethyl metabolites by capillary gas chromatography.
Journal of chromatography.
1986 May; 378(1):137-45. doi:
10.1016/s0378-4347(00)80706-9. [PMID: 3733966] - J M Hilbert, J Ning, S Symchowicz, N Zampaglione. Placental transfer of quazepam in mice.
Drug metabolism and disposition: the biological fate of chemicals.
1986 May; 14(3):310-2. doi:
. [PMID: 2872030] - N Zampaglione, J M Hilbert, J Ning, M Chung, R Gural, S Symchowicz. Disposition and metabolic fate of 14C-quazepam in man.
Drug metabolism and disposition: the biological fate of chemicals.
1985 Jan; 13(1):25-9. doi:
. [PMID: 2858372] - J M Hilbert, R P Gural, S Symchowicz, N Zampaglione. Excretion of quazepam into human breast milk.
Journal of clinical pharmacology.
1984 Oct; 24(10):457-62. doi:
10.1002/j.1552-4604.1984.tb01819.x. [PMID: 6150944] - J M Hilbert, M Chung, E Radwanski, R Gural, S Symchowicz, N Zampaglione. Quazepam kinetics in the elderly.
Clinical pharmacology and therapeutics.
1984 Oct; 36(4):566-9. doi:
10.1038/clpt.1984.220. [PMID: 6478742] - J Hilbert, B Pramanik, S Symchowicz, N Zampaglione. The disposition and metabolism of a hypnotic benzodiazepine, quazepam, in the hamster and mouse.
Drug metabolism and disposition: the biological fate of chemicals.
1984 Jul; 12(4):452-9. doi:
NULL. [PMID: 6148212] - J M Hilbert, M Chung, G Maier, R Gural, S Symchowicz, N Zampaglione. Effect of sleep on quazepam kinetics.
Clinical pharmacology and therapeutics.
1984 Jul; 36(1):99-104. doi:
10.1038/clpt.1984.146. [PMID: 6734056] - J M Hilbert, J M Ning, G Murphy, A Jimenez, N Zampaglione. Gas chromatographic determination of quazepam and two major metabolites in human plasma.
Journal of pharmaceutical sciences.
1984 Apr; 73(4):516-9. doi:
10.1002/jps.2600730421. [PMID: 6726637] - M Chung, J M Hilbert, R P Gural, E Radwanski, S Symchowicz, N Zampaglione. Multiple-dose quazepam kinetics.
Clinical pharmacology and therapeutics.
1984 Apr; 35(4):520-4. doi:
10.1038/clpt.1984.70. [PMID: 6705450]
