azane;dichloroplatinum (BioDeep_00000006379)

   


代谢物信息卡片


trans-Dichlorodiamineplatinum(II)

化学式: H6Cl2N2Pt (298.9555866)
中文名称: 反式-二氨二氯合铂(II)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: N.N.Cl[Pt]Cl
InChI: /q

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XA - Platinum compounds
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents

同义名列表

2 个代谢物同义名

trans-Dichlorodiamineplatinum(II); azane;dichloroplatinum



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Odra Pinato, Caterina Musetti, Nicholas P Farrell, Claudia Sissi. Platinum-based drugs and proteins: reactivity and relevance to DNA adduct formation. Journal of inorganic biochemistry. 2013 May; 122(?):27-37. doi: 10.1016/j.jinorgbio.2013.01.007. [PMID: 23435290]
  • Leticia Cubo, Angela Casini, Chiara Gabbiani, Guido Mastrobuoni, Luigi Messori, Jesús Jiménez-Barbero, Carmen Navarro-Ranninger, Adoración G Quiroga. Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands. Chemistry (Weinheim an der Bergstrasse, Germany). 2009 Sep; 15(36):9139-46. doi: 10.1002/chem.200901090. [PMID: 19655350]
  • Richard David Wainford, Richard J Weaver, Gabrielle M Hawksworth. The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures. Toxicology in vitro : an international journal published in association with BIBRA. 2009 Aug; 23(5):780-8. doi: 10.1016/j.tiv.2009.04.004. [PMID: 19383537]
  • Henryk Chojnacki, Janina Kuduk-Jaworska, Iwona Jaroszewicz, Jerzy J Jański. In silico approach to cisplatin toxicity. Quantum chemical studies on platinum(II)-cysteine systems. Journal of molecular modeling. 2009 Jun; 15(6):659-64. doi: 10.1007/s00894-009-0469-2. [PMID: 19221812]
  • Mark S Bali, Damian P Buck, Andrew J Coe, Anthony I Day, J Grant Collins. Cucurbituril binding of trans-[{PtCl(NH3)2}2(micro-NH2(CH2)8NH2)]2+ and the effect on the reaction with cysteine. Dalton transactions (Cambridge, England : 2003). 2006 Dec; ?(45):5337-44. doi: 10.1039/b609881a. [PMID: 17102858]
  • A Németh, E Nádasi, A Beró, L Olasz, A Ember, A Kvarda, L Bujdosó, I Arany, A Csejtei, Zs Faluhelyi, I Ember. Early effects of transplatin on oncogene activation in vivo. Anticancer research. 2004 Nov; 24(6):3997-4001. doi: NULL. [PMID: 15736445]
  • Q Huang, R T Dunn, S Jayadev, O DiSorbo, F D Pack, S B Farr, R E Stoll, K T Blanchard. Assessment of cisplatin-induced nephrotoxicity by microarray technology. Toxicological sciences : an official journal of the Society of Toxicology. 2001 Oct; 63(2):196-207. doi: 10.1093/toxsci/63.2.196. [PMID: 11568363]
  • O Hosokawa, M Okabe, S Saito, T Saito, M Kurasaki. Protective role of metallothionein on DNA damage in rat kidney caused by cis-diamminedichloroplatinum. Pharmacology & toxicology. 2000 Jun; 86(6):276-82. doi: 10.1111/j.0901-9928.2000.860606.x. [PMID: 10895991]
  • T Endo, O Kimura, M Sakata. Carrier-mediated uptake of cisplatin by the OK renal epithelial cell line. Toxicology. 2000 May; 146(2-3):187-95. doi: 10.1016/s0300-483x(00)00176-1. [PMID: 10814851]
  • L Trynda-Lemiesz, H Kozłowski, B K Keppler. Effect of cis-, trans-diamminedichloroplatinum(II) and DBP on human serum albumin. Journal of inorganic biochemistry. 1999 Nov; 77(3-4):141-6. doi: 10.1016/s0162-0134(99)00183-x. [PMID: 10643655]
  • R J Mauthe, E Sideras-Haddad, K W Turteltaub, G Bench. Quantitative imaging microscopy for the sensitive detection of administered metal containing drugs in single cells and tissue slices--a demonstration using platinum based chemotherapeutic agent. Journal of pharmaceutical and biomedical analysis. 1998 Aug; 17(4-5):651-63. doi: 10.1016/s0731-7085(97)00225-2. [PMID: 9682148]
  • L Dalla Via, V Di Noto, M Vidali, F Scomazzon, D Ni, R Deana. Action of antitumoral platinum complexes on in vitro platelet functions. Chemico-biological interactions. 1998 Apr; 110(3):203-20. doi: 10.1016/s0009-2797(98)00014-3. [PMID: 9609387]
  • T Saito, Z J Zhang, T Yamada, T Yamamoto, Y Shibamori, H Saito. Similar pharmacokinetics and differential ototoxicity after administration with cisplatin and transplatin in guinea pigs. Acta oto-laryngologica. 1997 Jan; 117(1):61-5. doi: 10.3109/00016489709117993. [PMID: 9039483]
  • B Olas, B Wachowicz. Cisplatin-induced changes in biological activity of blood platelets: thiol-related mechanisms. Anti-cancer drugs. 1996 Jun; 7(4):476-82. doi: 10.1097/00001813-199606000-00013. [PMID: 8826616]
  • B Zhang, H Huang, W Tang. Interaction of cis- and trans-diamminedichloroplatinum with metallothionein in vivo. Journal of inorganic biochemistry. 1995 Apr; 58(1):1-8. doi: 10.1016/0162-0134(94)00030-e. [PMID: 7738537]
  • F Courjault, D Leroy, L Coquery, H Toutain. Platinum complex-induced dysfunction of cultured renal proximal tubule cells. A comparative study of carboplatin and transplatin with cisplatin. Archives of toxicology. 1993; 67(5):338-46. doi: 10.1007/bf01973705. [PMID: 8396390]
  • H Toutain, J P Morin. Renal proximal tubule cell cultures for studying drug-induced nephrotoxicity and modulation of phenotype expression by medium components. Renal failure. 1992; 14(3):371-83. doi: 10.3109/08860229209106645. [PMID: 1509170]
  • K S Blisard, D A Harrington, D A Long, J E Jackson. Relative lack of toxicity of transplatin compared with cisplatin in rodents. Journal of comparative pathology. 1991 Nov; 105(4):367-75. doi: 10.1016/s0021-9975(08)80106-5. [PMID: 1770175]
  • J Hannemann, J Duwe, K Baumann. Iron- and ascorbic acid-induced lipid peroxidation in renal microsomes isolated from rats treated with platinum compounds. Cancer chemotherapy and pharmacology. 1991; 28(6):427-33. doi: 10.1007/bf00685818. [PMID: 1934247]
  • J Hannemann, K Baumann. Nephrotoxicity of cisplatin, carboplatin and transplatin. A comparative in vitro study. Archives of toxicology. 1990; 64(5):393-400. doi: 10.1007/bf01973462. [PMID: 2169720]
  • J Hannemann, K Baumann. Inhibition of lactate-dehydrogenase by cisplatin and other platinum-compounds: enzyme leakage of LDH is not a suitable method to measure platinum-compound-induced kidney cell damage in vitro. Research communications in chemical pathology and pharmacology. 1988 Jun; 60(3):371-9. doi: NULL. [PMID: 3175335]
  • S V Pizzo, M W Swaim, P A Roche, S L Gonias. Selectivity and stereospecificity of the reactions of dichlorodiammineplatinum(II) with three purified plasma proteins. Journal of inorganic biochemistry. 1988 May; 33(1):67-76. doi: 10.1016/0162-0134(88)80035-7. [PMID: 2454291]
  • S L Gonias, M W Swaim, M F Massey, S V Pizzo. cis-dichlorodiammineplatinum (II) as a selective modifier of the oxidation-sensitive reactive-center methionine in alpha 1-antitrypsin. The Journal of biological chemistry. 1988 Jan; 263(1):393-7. doi: . [PMID: 3257210]
  • G Singh, J Koropatnick. Differential toxicity of cis and trans isomers of dichlorodiammineplatinum. Journal of biochemical toxicology. 1988; 3(?):223-33. doi: 10.1002/jbt.2570030308. [PMID: 3199415]
  • R Gantt. A cell cycle-associated pathway for repair of DNA-protein crosslinks in mammalian cells. Mutation research. 1987 Jan; 183(1):75-87. doi: 10.1016/0167-8817(87)90048-4. [PMID: 3025724]
  • K Uchida, Y Tanaka, T Nishimura, Y Hashimoto, T Watanabe, I Harada. Effect of serum on inhibition of DNA synthesis in leukemia cells by cis- and trans-(Pt (NH3) 2C1(2)). Biochemical and biophysical research communications. 1986 Jul; 138(2):631-7. doi: 10.1016/s0006-291x(86)80543-5. [PMID: 3741425]
  • A E Balber, S L Gonias, S V Pizzo. Trypanosoma brucei gambiense: growth in vitro of bloodstream forms inhibited by dichlorodiammineplatinum (II) compounds and hypolipidemic drugs. Experimental parasitology. 1985 Feb; 59(1):74-80. doi: 10.1016/0014-4894(85)90059-1. [PMID: 4038488]
  • A J Zelazowski, J S Garvey, J D Hoeschele. In vivo and in vitro binding of platinum to metallothionein. Archives of biochemistry and biophysics. 1984 Feb; 229(1):246-52. doi: 10.1016/0003-9861(84)90150-4. [PMID: 6538400]
  • E De Clercq, D Hermann, W Guschlbauer. Interferon induction by platinum(II)-poly(I).poly(C) complexes. Biochimica et biophysica acta. 1983 Dec; 741(3):358-63. doi: 10.1016/0167-4781(83)90156-2. [PMID: 6686061]
  • R S Goldstein, G H Mayor, R L Gingerich, J B Hook, R W Rosenbaum, J T Bond. The effects of cisplatin and other divalent platinum compounds on glucose metabolism and pancreatic endocrine function. Toxicology and applied pharmacology. 1983 Jul; 69(3):432-41. doi: 10.1016/0041-008x(83)90266-1. [PMID: 6349015]
  • H Gerad, M J Egorin, M Whitacre, D A Van Echo, J Aisner. Renal failure and platinum pharmacokinetics in three patients treated with cis-diamminedichloroplatinum(II) and whole-body hyperthermia. Cancer chemotherapy and pharmacology. 1983; 11(3):162-6. doi: 10.1007/bf00254197. [PMID: 6685578]
  • A J Fornace, J B Little. Malignant transformation by the DNA-protein crosslinking agent trans-Pt(II) diamminedichloride. Carcinogenesis. 1980; 1(12):989-94. doi: 10.1093/carcin/1.12.989. [PMID: 11272115]