azane;dichloroplatinum (BioDeep_00000006379)

   


代谢物信息卡片


trans-Dichlorodiamineplatinum(II)

化学式: H6Cl2N2Pt (298.9556)
中文名称: 反式-二氨二氯合铂(II)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: N.N.Cl[Pt]Cl
InChI: /q

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01X - Other antineoplastic agents > L01XA - Platinum compounds
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents

同义名列表

3 个代谢物同义名

trans-Dichlorodiamineplatinum(II); azane;dichloroplatinum; Cisplatin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AFP, BIRC5, BRCA1, CAT, HIF1A, HPGDS, MDM2, POU5F1, STAT3, TP73, XIAP
Endoplasmic reticulum membrane 1 IFI27
Mitochondrion membrane 1 IFI27
Nucleus 11 BIRC5, BRCA1, HIF1A, JUN, MDM2, NANOG, POU5F1, SMUG1, STAT3, TP73, XIAP
cytosol 10 BIRC5, CAT, HIF1A, HPGDS, MDM2, POU5F1, SMUG1, STAT3, TP73, XIAP
mitochondrial membrane 1 IFI27
nuclear body 2 BRCA1, HIF1A
nucleoplasm 12 BIRC5, BRCA1, HIF1A, HPGDS, JUN, MDM2, NANOG, POU5F1, SMUG1, STAT3, TP73, XIAP
RNA polymerase II transcription regulator complex 3 HIF1A, JUN, STAT3
Cell membrane 2 HTR3A, SLC31A1
Cleavage furrow 1 HTR3A
Early endosome membrane 1 SLC31A1
Multi-pass membrane protein 3 HTR3A, IFI27, SLC31A1
Synapse 1 HTR3A
cell junction 1 TP73
glutamatergic synapse 1 MDM2
Golgi apparatus 1 TP73
postsynapse 1 HTR3A
plasma membrane 6 BRCA1, HTR3A, MDM2, MUC16, SLC31A1, STAT3
Membrane 6 BRCA1, CAT, HTR3A, IFI27, MUC16, SLC31A1
apical plasma membrane 1 SLC31A1
basolateral plasma membrane 1 SLC31A1
extracellular exosome 2 CAT, MUC16
extracellular space 2 AFP, IL2
intercalated disc 1 SLC31A1
mitochondrion 3 CAT, IFI27, POU5F1
protein-containing complex 5 BIRC5, BRCA1, CAT, HIF1A, MDM2
intracellular membrane-bounded organelle 4 CAT, HPGDS, NANOG, TP73
postsynaptic density 1 MDM2
Secreted 3 AFP, CGB5, IL2
extracellular region 3 CAT, CGB5, IL2
mitochondrial outer membrane 1 IFI27
mitochondrial matrix 1 CAT
transcription regulator complex 3 JUN, POU5F1, STAT3
motile cilium 1 HIF1A
external side of plasma membrane 1 MUC16
microtubule cytoskeleton 1 BIRC5
nucleolus 3 MDM2, NANOG, SMUG1
axon cytoplasm 1 HIF1A
midbody 1 BIRC5
vesicle 1 MUC16
postsynaptic membrane 1 HTR3A
Apical cell membrane 1 SLC31A1
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 1 CAT
microtubule 1 BIRC5
spindle 1 BIRC5
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 SLC31A1
nuclear speck 1 HIF1A
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 IFI27
nuclear inner membrane 1 IFI27
Postsynaptic cell membrane 1 HTR3A
neuron projection 1 HTR3A
chromatin 6 HIF1A, JUN, NANOG, POU5F1, STAT3, TP73
Late endosome membrane 1 SLC31A1
Chromosome 2 BIRC5, BRCA1
centriole 1 BIRC5
[Isoform 5]: Cytoplasm 1 BRCA1
Nucleus, nucleolus 1 MDM2
nuclear chromosome 2 BIRC5, JUN
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
Basolateral cell membrane 1 SLC31A1
fibrillar center 1 SMUG1
nuclear envelope 1 IFI27
Recycling endosome membrane 1 SLC31A1
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
lateral element 1 BRCA1
Nucleus, nucleoplasm 1 MDM2
Nucleus speckle 1 HIF1A
euchromatin 2 HIF1A, JUN
ubiquitin ligase complex 1 BRCA1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 MUC16
endoplasmic reticulum lumen 1 AFP
transcription repressor complex 1 MDM2
male germ cell nucleus 1 BRCA1
kinetochore 1 BIRC5
endocytic vesicle membrane 1 MDM2
XY body 1 BRCA1
chromosome, centromeric region 1 BIRC5
chromosome passenger complex 1 BIRC5
ribonucleoprotein complex 1 BRCA1
cytoplasmic microtubule 1 BIRC5
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
intracellular non-membrane-bounded organelle 1 BRCA1
DNA repair complex 1 BRCA1
BRCA1-C complex 1 BRCA1
transcription factor AP-1 complex 1 JUN
catalase complex 1 CAT
BRCA1-A complex 1 BRCA1
BRCA1-B complex 1 BRCA1
BRCA1-BARD1 complex 1 BRCA1
gamma-tubulin ring complex 1 BRCA1
nuclear ubiquitin ligase complex 1 BRCA1


文献列表

  • Odra Pinato, Caterina Musetti, Nicholas P Farrell, Claudia Sissi. Platinum-based drugs and proteins: reactivity and relevance to DNA adduct formation. Journal of inorganic biochemistry. 2013 May; 122(?):27-37. doi: 10.1016/j.jinorgbio.2013.01.007. [PMID: 23435290]
  • Leticia Cubo, Angela Casini, Chiara Gabbiani, Guido Mastrobuoni, Luigi Messori, Jesús Jiménez-Barbero, Carmen Navarro-Ranninger, Adoración G Quiroga. Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands. Chemistry (Weinheim an der Bergstrasse, Germany). 2009 Sep; 15(36):9139-46. doi: 10.1002/chem.200901090. [PMID: 19655350]
  • Richard David Wainford, Richard J Weaver, Gabrielle M Hawksworth. The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures. Toxicology in vitro : an international journal published in association with BIBRA. 2009 Aug; 23(5):780-8. doi: 10.1016/j.tiv.2009.04.004. [PMID: 19383537]
  • Henryk Chojnacki, Janina Kuduk-Jaworska, Iwona Jaroszewicz, Jerzy J Jański. In silico approach to cisplatin toxicity. Quantum chemical studies on platinum(II)-cysteine systems. Journal of molecular modeling. 2009 Jun; 15(6):659-64. doi: 10.1007/s00894-009-0469-2. [PMID: 19221812]
  • Mark S Bali, Damian P Buck, Andrew J Coe, Anthony I Day, J Grant Collins. Cucurbituril binding of trans-[{PtCl(NH3)2}2(micro-NH2(CH2)8NH2)]2+ and the effect on the reaction with cysteine. Dalton transactions (Cambridge, England : 2003). 2006 Dec; ?(45):5337-44. doi: 10.1039/b609881a. [PMID: 17102858]
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