Acetohexamide (BioDeep_00000006351)
Secondary id: BioDeep_00000413078
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
4-Acetyl-N-((cyclohexylamino)carbonyl)benzenesulphonamide
化学式: C15H20N2O4S (324.1144)
中文名称: 乙酰己酰胺
谱图信息:
最多检出来源 Homo sapiens(blood) 2.15%
分子结构信息
SMILES: CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1
InChI: InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)
描述信息
Acetohexamide is only found in individuals that have used or taken this drug. It is a sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. [PubChem]Sulfonylureas such as acetohexamide bind to an ATP-dependent K+ channel on the cell membrane of pancreatic beta cells. This inhibits a tonic, hyperpolarizing outflux of potassium, which causes the electric potential over the membrane to become more positive. This depolarization opens voltage-gated Ca2+ channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BB - Sulfonylureas
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C97936 - Sulfonylurea Antidiabetic Agent
D007004 - Hypoglycemic Agents
同义名列表
19 个代谢物同义名
4-Acetyl-N-((cyclohexylamino)carbonyl)benzenesulphonamide; 4-Acetyl-N-((cyclohexylamino)carbonyl)benzenesulfonamide; 1-((p-Acetylphenyl)sulphonyl)-3-cyclohexylurea; 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea; N-(p-Acetylphenylsulphonyl)-n-cyclohexylurea; 3-(4-acetylbenzenesulfonyl)-1-cyclohexylurea; N-(p-Acetylphenylsulfonyl)-n-cyclohexylurea; Salvat brand OF acetohexamide; Lilly brand OF acetohexamide; Acetohexamide salvat brand; Acetohexamide lilly brand; Acetohexamidum; Acetohexamida; acetohexamide; Acetohexamid; Gamadiabet; Dimelor; Dymelor; Acetohexamide
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:28052
- KEGG: C06806
- KEGGdrug: D00219
- PubChem: 1989
- HMDB: HMDB0014558
- Metlin: METLIN3921
- DrugBank: DB00414
- ChEMBL: CHEMBL1589
- Wikipedia: Acetohexamide
- MeSH: Acetohexamide
- chemspider: 1912
- CAS: 968-81-0
- PMhub: MS000019377
- PubChem: 9025
- PDB-CCD: TF9
- NIKKAJI: J3.355C
- RefMet: Acetohexamide
- KNApSAcK: 28052
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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