Thioperamide (BioDeep_00000600890)

Main id: BioDeep_00000011972

 


代谢物信息卡片


N-cyclohexyl-4-(1H-imidazol-5-yl)-(2Z)-2-butenedioate-1-piperidinecarbothioamide

化学式: C15H24N4S (292.1721584)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC(CC1)NC(=S)N2CCC(CC2)C3=CN=CN3
InChI: InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)

描述信息

D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
Thioperamide (MR-12842) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a Ki of 4.3 nM for inhibition of [3H]histamine release. Thioperamide inhibits [3H]histamine synthesis with a Ki of 31 nM[1].

同义名列表

3 个代谢物同义名

Thioperamide; N-cyclohexyl-4-(1H-imidazol-5-yl)-(2Z)-2-butenedioate-1-piperidinecarbothioamide; MR-12842



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • C Hass, B P Panda, R Khanam, A K Najmi, M Akhtar. Histamine H3 Receptor Agonist Imetit Attenuated Isoproterenol Induced Renin Angiotensin System and Sympathetic Nervous System Overactivity in Myocardial Infarction of Rats. Drug research. 2016 Jun; 66(6):324-9. doi: 10.1055/s-0035-1569448. [PMID: 27011384]
  • Detlef Neumann, Silke Beermann, Heike Burhenne, Silke Glage, Christina Hartwig, Roland Seifert. The dual H3/4R antagonist thioperamide does not fully mimic the effects of the 'standard' H4R antagonist JNJ 7777120 in experimental murine asthma. Naunyn-Schmiedeberg's archives of pharmacology. 2013 Nov; 386(11):983-90. doi: 10.1007/s00210-013-0898-4. [PMID: 23820873]
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  • Seungheon Lee, Dong Hyun Kim, Ji Hye Lee, Eun Seong Ko, Won Bo Oh, Yong Taek Seo, Young Pyo Jang, Jong Hoon Ryu, Ji Wook Jung. Involvement of histaminergic system in the anxiolytic-like activities of Morus alba leaves in mice. Biological & pharmaceutical bulletin. 2013; 36(11):1692-9. doi: 10.1248/bpb.b13-00126. [PMID: 23965748]
  • Katsuya Nagai, Mamoru Tanida, Akira Niijima, Nobuo Tsuruoka, Yoshinobu Kiso, Yuko Horii, Jiao Shen, Nobuaki Okumura. Role of L-carnosine in the control of blood glucose, blood pressure, thermogenesis, and lipolysis by autonomic nerves in rats: involvement of the circadian clock and histamine. Amino acids. 2012 Jul; 43(1):97-109. doi: 10.1007/s00726-012-1251-9. [PMID: 22367578]
  • Ramakrishna Nirogi, Vishwottam Kandikere, Gopinadh Bhyrapuneni, Nageswararao Muddana, Ramanatha Saralaya, Ranjith Kumar Ponnamaneni, Arun Kumar Manoharan. In vivo receptor occupancy assay of histamine H₃ receptor antagonist in rats using non-radiolabeled tracer. Journal of pharmacological and toxicological methods. 2012 May; 65(3):115-21. doi: 10.1016/j.vascn.2012.03.003. [PMID: 22487318]
  • Yi-Fang Li, Rong-Rong He, Bun Tsoi, Xiao-Di Li, Wei-Xi Li, Keiichi Abe, Hiroshi Kurihara. Anti-stress effects of carnosine on restraint-evoked immunocompromise in mice through spleen lymphocyte number maintenance. PloS one. 2012; 7(4):e33190. doi: 10.1371/journal.pone.0033190. [PMID: 22511917]
  • Atsuo Kuramasu, Jun Sukegawa, Takeya Sato, Eiko Sakurai, Takehiko Watanabe, Teruyuki Yanagisawa, Kazuhiko Yanai. The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling. Cellular signalling. 2011 Nov; 23(11):1843-9. doi: 10.1016/j.cellsig.2011.06.021. [PMID: 21749919]
  • Parisa Hasanein. Effects of histamine H3 receptors on chemical hyperalgesia in diabetic rats. Neuropharmacology. 2011 May; 60(6):886-91. doi: 10.1016/j.neuropharm.2011.01.004. [PMID: 21237180]
  • Melanie B Henry, Shuqin Zheng, Chenxia Duan, Bhuneshwari Patel, Galya Vassileva, Christopher Sondey, Jean Lachowicz, Joyce J Hwa. Antidiabetic properties of the histamine H3 receptor protean agonist proxyfan. Endocrinology. 2011 Mar; 152(3):828-35. doi: 10.1210/en.2010-0757. [PMID: 21239440]
  • Yuko Horii, Mamoru Tanida, Jiao Shen, Yosiyuki Fujisaki, Risa Fuyuki, Kazuko Hashimoto, Akira Niijima, Toshihiro Nakashima, Katsuya Nagai. Skin application of urea-containing cream affected cutaneous arterial sympathetic nerve activity, blood flow, and water evaporation. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2011 Feb; 17(1):75-81. doi: 10.1111/j.1600-0846.2010.00469.x. [PMID: 20923465]
  • Daiki Kubomura, Yoshiharu Matahira, Katsuya Nagai, Akira Niijima. Effect of anserine ingestion on hyperglycemia and the autonomic nerves in rats and humans. Nutritional neuroscience. 2010 Aug; 13(4):183-8. doi: 10.1179/147683010x12611460764363. [PMID: 20670474]
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  • Herman D Lim, Chris de Graaf, Wen Jiang, Payman Sadek, Patricia M McGovern, Enade P Istyastono, Remko A Bakker, Iwan J P de Esch, Robin L Thurmond, Rob Leurs. Molecular determinants of ligand binding to H4R species variants. Molecular pharmacology. 2010 May; 77(5):734-43. doi: 10.1124/mol.109.063040. [PMID: 20103609]
  • Neide Galvão Nascimento, Marlos Cortez Sampaio, Renata Amaral Olivo, Catarina Teixeira. Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved. Toxicon : official journal of the International Society on Toxinology. 2010 Feb; 55(2-3):343-52. doi: 10.1016/j.toxicon.2009.08.009. [PMID: 19703484]
  • Hiroe Toba, Ayako Nakamori, Yoshimi Tanaka, Ryosuke Yukiya, Keisuke Tatsuoka, Masako Narutaki, Masaaki Tokitaka, Hitoshi Hariu, Miyuki Kobara, Tetsuo Nakata. Oral L-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. 2010 Jan; 37(1):62-8. doi: 10.1111/j.1440-1681.2009.05227.x. [PMID: 19566844]
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  • Christian Brabant, Livia Alleva, Thierry Grisar, Etienne Quertemont, Bernard Lakaye, Hiroshi Ohtsu, Jian-Sheng Lin, Peter Jatlow, Marina R Picciotto, Ezio Tirelli. Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions. Psychopharmacology. 2009 Mar; 202(4):673-87. doi: 10.1007/s00213-008-1345-y. [PMID: 18843481]
  • Mamoru Tanida, Jun Satomi, Jiao Shen, Katsuya Nagai. Autonomic and cardiovascular effects of central neuromedin U in rats. Physiology & behavior. 2009 Feb; 96(2):282-8. doi: 10.1016/j.physbeh.2008.10.008. [PMID: 18977236]
  • Jiao Shen, Mamoru Tanida, Jia-Fei Yao, Akira Niijima, Katsuya Nagai. Biphasic effects of orexin-A on autonomic nerve activity and lipolysis. Neuroscience letters. 2008 Oct; 444(2):166-71. doi: 10.1016/j.neulet.2008.08.031. [PMID: 18755242]
  • M Akhtar, Kk Pillai, D Vohora. Effect of thioperamide on oxidative stress markers in middle cerebral artery occlusion model of focal cerebral ischemia in rats. Human & experimental toxicology. 2008 Oct; 27(10):761-7. doi: 10.1177/0960327108094608. [PMID: 19042962]
  • Jiao Shen, Jia-Fei Yao, Mamoru Tanida, Katsuya Nagai. Regulation of sympathetic nerve activity by L-carnosine in mammalian white adipose tissue. Neuroscience letters. 2008 Aug; 441(1):100-4. doi: 10.1016/j.neulet.2008.06.027. [PMID: 18599216]
  • Mamoru Tanida, Nobuo Tsuruoka, Jiao Shen, Yoshinobu Kiso, Katsuya Nagai. Effects of oolong tea on renal sympathetic nerve activity and spontaneous hypertension in rats. Metabolism: clinical and experimental. 2008 Apr; 57(4):526-34. doi: 10.1016/j.metabol.2007.11.016. [PMID: 18328356]
  • Brendan A Gavin, Susan E Arruda, Patrick J Dolph. The role of carcinine in signaling at the Drosophila photoreceptor synapse. PLoS genetics. 2007 Dec; 3(12):e206. doi: 10.1371/journal.pgen.0030206. [PMID: 18069895]
  • Yuji Sugata, Mitsuhiro Okano, Tazuko Fujiwara, Rie Matsumoto, Hisashi Hattori, Miki Yamamoto, Masahiro Nishibori, Kazunori Nishizaki. Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun; 121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. [PMID: 17346280]
  • Takuo Nakamura, Mamoru Tanida, Akira Niijima, Hiroshi Hibino, Jiao Shen, Katsuya Nagai. Auditory stimulation affects renal sympathetic nerve activity and blood pressure in rats. Neuroscience letters. 2007 Apr; 416(2):107-12. doi: 10.1016/j.neulet.2007.01.080. [PMID: 17363164]
  • Mamoru Tanida, Hidekazu Kaneko, Jiao Shen, Katsuya Nagai. Involvement of the histaminergic system in renal sympathetic and cardiovascular responses to leptin and ghrelin. Neuroscience letters. 2007 Feb; 413(1):88-92. doi: 10.1016/j.neulet.2006.11.035. [PMID: 17166664]
  • Jacob Raber. Role of apolipoprotein E in anxiety. Neural plasticity. 2007; 2007(?):91236. doi: 10.1155/2007/91236. [PMID: 17710250]
  • Mamoru Tanida, Akira Niijima, Jiao Shen, Shigeru Yamada, Hajime Sawai, Yutaka Fukuda, Katsuya Nagai. Dose-different effects of orexin-A on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats. Experimental biology and medicine (Maywood, N.J.). 2006 Nov; 231(10):1616-25. doi: 10.1177/153537020623101006. [PMID: 17060682]
  • Hayato Kurata, Toshihide Fujii, Hidenobu Tsutsui, Tomoaki Katayama, Mamoru Ohkita, Masanori Takaoka, Nobuo Tsuruoka, Yoshinobu Kiso, Yukihiro Ohno, Yoshihide Fujisawa, Takatoshi Shokoji, Akira Nishiyama, Youichi Abe, Yasuo Matsumura. Renoprotective effects of l-carnosine on ischemia/reperfusion-induced renal injury in rats. The Journal of pharmacology and experimental therapeutics. 2006 Nov; 319(2):640-7. doi: 10.1124/jpet.106.110122. [PMID: 16916994]
  • Ryo Yoshimoto, Yasuhisa Miyamoto, Ken Shimamura, Akane Ishihara, Kazuhiko Takahashi, Hidehito Kotani, Airu S Chen, Howard Y Chen, Douglas J Macneil, Akio Kanatani, Shigeru Tokita. Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America. 2006 Sep; 103(37):13866-71. doi: 10.1073/pnas.0506104103. [PMID: 16954192]
  • Naoto Adachi, Keyue Liu, Atsuko Motoki, Masahiro Nishibori, Tatsuru Arai. Suppression of ischemia/reperfusion liver injury by histamine H4 receptor stimulation in rats. European journal of pharmacology. 2006 Aug; 544(1-3):181-7. doi: 10.1016/j.ejphar.2006.06.053. [PMID: 16860312]
  • Mamoru Tanida, Akira Niijima, Jiao Shen, Takuo Nakamura, Katsuya Nagai. Olfactory stimulation with scent of lavender oil affects autonomic neurotransmission and blood pressure in rats. Neuroscience letters. 2006 May; 398(1-2):155-60. doi: 10.1016/j.neulet.2005.12.076. [PMID: 16442729]
  • Florence Gbahou, Ludwig Vincent, Marie Humbert-Claude, Joel Tardivel-Lacombe, Claude Chabret, Jean-Michel Arrang. Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. British journal of pharmacology. 2006 Apr; 147(7):744-54. doi: 10.1038/sj.bjp.0706666. [PMID: 16432504]
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  • Mamoru Tanida, Toshihiko Yamano, Keiko Maeda, Nobuaki Okumura, Yoichi Fukushima, Katsuya Nagai. Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats. Neuroscience letters. 2005 Dec; 389(2):109-14. doi: 10.1016/j.neulet.2005.07.036. [PMID: 16118039]
  • Jiao Shen, Akira Niijima, Mamoru Tanida, Yuko Horii, Keiko Maeda, Katsuya Nagai. Olfactory stimulation with scent of lavender oil affects autonomic nerves, lipolysis and appetite in rats. Neuroscience letters. 2005 Jul; 383(1-2):188-93. doi: 10.1016/j.neulet.2005.04.010. [PMID: 15878236]
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  • V O Chaĭka, L I Havrysh, T D Khil'ko, L I Ostapchenko. [Participation of cyclic nucleotides and phospholipidis in signal transduction of histamin receptor H3 of the gastric mucosa parietal cells in rats with experimental ulcer]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2005 Mar; 77(2):118-22. doi: NULL. [PMID: 16335243]
  • Mamoru Tanida, Akira Niijima, Yutaka Fukuda, Hajime Sawai, Nobuo Tsuruoka, Jiao Shen, Shigeru Yamada, Yoshinobu Kiso, Katsuya Nagai. Dose-dependent effects of L-carnosine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats. American journal of physiology. Regulatory, integrative and comparative physiology. 2005 Feb; 288(2):R447-55. doi: 10.1152/ajpregu.00275.2004. [PMID: 15498968]
  • Artur Dembiński, Zygmunt Warzecha, Piotr Ceranowicz, Tomasz Brzozowski, Marcin Dembiński, Stanisław J Konturek, Wiesław W Pawlik. Role of capsaicin-sensitive nerves and histamine H1, H2, and H3 receptors in the gastroprotective effect of histamine against stress ulcers in rats. European journal of pharmacology. 2005 Jan; 508(1-3):211-21. doi: 10.1016/j.ejphar.2004.11.059. [PMID: 15680274]
  • Takashi Nakayama, Yoshiko Kato, Kunio Hieshima, Daisuke Nagakubo, Yuichi Kunori, Takao Fujisawa, Osamu Yoshie. Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor. Journal of immunology (Baltimore, Md. : 1950). 2004 Aug; 173(3):2078-83. doi: 10.4049/jimmunol.173.3.2078. [PMID: 15265943]
  • Katsuya Nagai, Akira Niijima, Toshihiko Yamano, Hiroto Otani, Nobuaki Okumra, Nobuo Tsuruoka, Masaaki Nakai, Yoshinobu Kiso. Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nerves. Experimental biology and medicine (Maywood, N.J.). 2003 Nov; 228(10):1138-45. doi: 10.1177/153537020322801007. [PMID: 14610252]
  • Kazuhiko Takahashi, Shigeru Tokita, Hidehito Kotani. Generation and characterization of highly constitutive active histamine H3 receptors. The Journal of pharmacology and experimental therapeutics. 2003 Oct; 307(1):213-8. doi: 10.1124/jpet.103.053249. [PMID: 12954820]
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