Magnoline (BioDeep_00000005740)

代谢物信息卡片

(1S)-1,2,3,4-Tetrahydro-1-[[4-[2-hydroxy-5-[[(1R)-1,2,3,4- tetrahydro-7-hydroxy-6-methoxy-2-methyl-1- isoquinolinyl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-7- isoquinolinol

化学式: C36H40N2O6 (596.288622)
中文名称: 木兰脂素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.21%

分子结构信息

SMILES: CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)O)O)O)OC
InChI: InChI=1S/C36H40N2O6/c1-37-13-11-24-18-34(42-3)32(40)20-27(24)29(37)15-22-5-8-26(9-6-22)44-36-17-23(7-10-31(36)39)16-30-28-21-33(41)35(43-4)19-25(28)12-14-38(30)2/h5-10,17-21,29-30,39-41H,11-16H2,1-4H3

描述信息

同义名列表

3 个代谢物同义名

Berbamunine; Magnoline; (1S)-1,2,3,4-Tetrahydro-1-[[4-[2-hydroxy-5-[[(1R)-1,2,3,4- tetrahydro-7-hydroxy-6-methoxy-2-methyl-1- isoquinolinyl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-7- isoquinolinol

数据库引用编号

22 个数据库交叉引用编号

ChEBI: CHEBI:16777
ChEBI: CHEBI:6642
KEGG: C05177
KEGG: C06515
PubChem: 440585
PubChem: 362563
Metlin: METLIN64382
ChEMBL: CHEMBL1187468
ChEMBL: CHEMBL503882
MetaCyc: CPD-8925
KNApSAcK: C00025880
CAS: 6859-66-1
CAS: 485-18-7
PMhub: MS000018599
MetaboLights: MTBLC16777
MetaboLights: MTBLC6642
PubChem: 7588
KNApSAcK: C00025262
3DMET: B01820
NIKKAJI: J2.403.084I
PubChem: 8746
NIKKAJI: J8.848J

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

54732 Magnolia kobus: 10.1016/J.JCHROMB.2011.10.023
1433312 Berberis heteropoda:
1433307 Berberis cretica: 10.1021/NP50043A025
258209 Berberis vulgaris:
1439896 Berberis nummularia:
295132 Trepobates: 10.1021/NP50064A031
1924984 Stephania pierrei: 10.1021/NP50064A031
2761039 Berberis iliensis: 10.1007/BF00631020
33814 Berberis stolonifera:
2294045 Berberis papillifera: 10.1016/S0031-9422(00)82337-7
38786 Berberis dictyophylla: 10.1016/S0031-9422(00)82337-7
2602268 Berberis taliensis: 10.1016/S0031-9422(00)82337-7
258147 Berberis canadensis: 10.1016/S0031-9422(00)82337-7
752791 Berberis angulosa: 10.1016/S0031-9422(00)82337-7
258178 Berberis julianae: 10.1016/S0031-9422(00)82337-7
258211 Berberis wilsoniae: 10.1016/S0031-9422(00)82337-7
2602266 Berberis salicaria: 10.1016/S0031-9422(00)82337-7
186724 Berberis empetrifolia: 10.1016/S0031-9422(00)82337-7
258140 Berberis amurensis: 10.1007/BF00630534
659594 Berberis lycium:
54732 Magnolia kobus: 10.1016/J.JCHROMB.2011.10.023
1433312 Berberis heteropoda:
1433307 Berberis cretica: 10.1021/NP50043A025
258209 Berberis vulgaris:
1439896 Berberis nummularia:
295132 Trepobates: 10.1021/NP50064A031
1924984 Stephania pierrei: 10.1021/NP50064A031
2761039 Berberis iliensis: 10.1007/BF00631020
33814 Berberis stolonifera:
2294045 Berberis papillifera: 10.1016/S0031-9422(00)82337-7
38786 Berberis dictyophylla: 10.1016/S0031-9422(00)82337-7
2602268 Berberis taliensis: 10.1016/S0031-9422(00)82337-7
258147 Berberis canadensis: 10.1016/S0031-9422(00)82337-7
752791 Berberis angulosa: 10.1016/S0031-9422(00)82337-7
258178 Berberis julianae: 10.1016/S0031-9422(00)82337-7
258211 Berberis wilsoniae: 10.1016/S0031-9422(00)82337-7
2602266 Berberis salicaria: 10.1016/S0031-9422(00)82337-7
186724 Berberis empetrifolia: 10.1016/S0031-9422(00)82337-7
258140 Berberis amurensis: 10.1007/BF00630534
659594 Berberis lycium:

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

James T Payne, Timothy R Valentic, Christina D Smolke. Complete biosynthesis of the bisbenzylisoquinoline alkaloids guattegaumerine and berbamunine in yeast. Proceedings of the National Academy of Sciences of the United States of America. 2021 12; 118(51):. doi: 10.1073/pnas.2112520118. [PMID: 34903659]
Hui Sun, Ai-Hua Zhang, Shao-Bo Liu, Shi Qiu, Xian-Na Li, Tian-Lei Zhang, Liang Liu, Xi-Jun Wang. Cell metabolomics identify regulatory pathways and targets of magnoline against prostate cancer. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Dec; 1102-1103(?):143-151. doi: 10.1016/j.jchromb.2018.10.017. [PMID: 30391728]
Yang Zhou, Feng Wang, Lirong Hao, Niansong Wang. Effects of magnoline on P-selectin's expression in diabetic rats and its reno-protection. Kidney & blood pressure research. 2013; 37(2-3):211-20. doi: 10.1159/000350146. [PMID: 23736780]
Maria Francesca Cometa, Stefano Fortuna, Giovanna Palazzino, Maria Teresa Volpe, Elsa Rengifo Salgado, Marcello Nicoletti, Lamberto Tomassini. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia. Fitoterapia. 2012 Apr; 83(3):476-80. doi: 10.1016/j.fitote.2011.12.015. [PMID: 22230193]
Nobuhiro Ikezawa, Kinuko Iwasa, Fumihiko Sato. Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells. The Journal of biological chemistry. 2008 Apr; 283(14):8810-21. doi: 10.1074/jbc.m705082200. [PMID: 18230623]
T M Kutchan. Heterologous expression of alkaloid biosynthetic genes--a review. Gene. 1996 Nov; 179(1):73-81. doi: 10.1016/s0378-1119(96)00426-x. [PMID: 8955631]