Glycineamideribotide (BioDeep_00000005325)

   

human metabolite Endogenous


代谢物信息卡片


{[(2R,3S,4R,5R)-5-(2-aminoacetamido)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

化学式: C7H15N2O8P (286.0566)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 6.59%

分子结构信息

SMILES: C(C(=O)N[C@H]1[C@@H]([C@@H]([C@@H](COP(=O)(O)O)O1)O)O)N
InChI: InChI=1S/C7H15N2O8P/c8-1-4(10)9-7-6(12)5(11)3(17-7)2-16-18(13,14)15/h3,5-7,11-12H,1-2,8H2,(H,9,10)(H2,13,14,15)/t3-,5-,6-,7-/m1/s1

描述信息

Glycinamidoribotide conversion to N-formylglycinamide ribonucleotide is the third reaction of the de novo purine biosynthesis, a reaction catalyzed by the enzyme Glycinamide ribonucleotide transformylase (EC 2.1.2.2), with concomitant conversion of 10-formyltetrahydrofolate to tetrahydrofolate. (PMID: 9143358). Glycineamideribotide formation is stimulated by Luteinizing hormone (LH) and Chorionic gonadotropin (HCG) via activation of Glc-6-P-dehydrogenase (EC 1.1.1.49). (PMID: 4366083) [HMDB]
Glycinamidoribotide conversion to N-formylglycinamide ribonucleotide is the third reaction of the de novo purine biosynthesis, a reaction catalyzed by the enzyme Glycinamide ribonucleotide transformylase (EC 2.1.2.2), with concomitant conversion of 10-formyltetrahydrofolate to tetrahydrofolate. (PMID: 9143358). Glycineamideribotide formation is stimulated by Luteinizing hormone (LH) and Chorionic gonadotropin (HCG) via activation of Glc-6-P-dehydrogenase (EC 1.1.1.49). (PMID: 4366083).

同义名列表

23 个代谢物同义名

{[(2R,3S,4R,5R)-5-(2-aminoacetamido)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid; 2-Amino-N-(5-O-phosphono-beta-D-ribofuranosyl)acetamide; 2-Amino-N-(5-O-phosphono-β-D-ribofuranosyl)acetamide; N-(Aminoacetyl)-5-O-phosphonopentofuranosylamine; N-Glycyl-5-O-phosphono-D-ribofuranosylamine; N1-(5-Phospho-beta-D-ribosyl)glycinamide; N(1)-(5-phospho-D-Ribosyl)glycinamide; N1-(5-Phospho-β-D-ribosyl)glycinamide; 5-Phospho-beta-D-ribosyl-glycineamide; N1-(5-Phospho-b-D-ribosyl)glycinamide; N1-(5-Phospho-D-ribosyl)glycinamide; 5-Phospho-β-D-ribosyl-glycineamide; 5-Phosphoribosylglycinamide (GAR); 5-Phosphoribosyl-glycineamide; 5’-Phosphoribosylglycineamide; 5’-Phosphoribosylglycinamide; 5-Phosphoribosylglycineamide; 5-Phosphoribosylglycinamide; Glycineamide ribonucleotide; Glycinamide ribonucleotide; Glycineamideribotide; GAR; 5'-Phosphoribosylglycinamide



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

56 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(5)

WikiPathways(0)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(49)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CD36, DHFR, FPGS, SLC46A1
Endosome membrane 1 SLC46A1
Endoplasmic reticulum membrane 1 CD4
Nucleus 1 VGLL3
cytosol 5 ADSL, DHFR, FPGS, GSS, RRM1
phagocytic vesicle 1 CD36
Cell membrane 4 CD36, CD4, CD8A, SLC46A1
Multi-pass membrane protein 2 CD36, SLC46A1
cell surface 2 CD36, SLC46A1
Golgi apparatus 1 CD36
mitochondrial inner membrane 1 FPGS
neuronal cell body 1 RRM1
endosome 1 SLC46A1
plasma membrane 4 CD36, CD4, CD8A, SLC46A1
Membrane 3 CD36, RRM1, SLC46A1
apical plasma membrane 2 CD36, SLC46A1
basolateral plasma membrane 1 SLC46A1
caveola 1 CD36
extracellular exosome 1 GSS
extracellular space 1 CD36
mitochondrion 3 DHFR, FPGS, RRM1
protein-containing complex 1 ADSL
Single-pass type I membrane protein 2 CD4, CD8A
extracellular region 1 CD8A
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 FPGS
mitochondrial matrix 1 FPGS
external side of plasma membrane 3 CD36, CD4, CD8A
Early endosome 1 CD4
Apical cell membrane 2 CD36, SLC46A1
Membrane raft 2 CD36, CD4
collagen trimer 1 CD36
receptor complex 2 CD36, CD8A
cell projection 1 RRM1
cell periphery 1 CD36
brush border membrane 2 CD36, SLC46A1
Basolateral cell membrane 1 SLC46A1
nuclear envelope 1 RRM1
specific granule membrane 1 CD36
plasma membrane raft 1 CD8A
endoplasmic reticulum lumen 1 CD4
endocytic vesicle membrane 1 CD36
[Isoform 2]: Cytoplasm 1 FPGS
clathrin-coated endocytic vesicle membrane 1 CD4
[Isoform 1]: Cell membrane 1 CD8A
platelet alpha granule membrane 1 CD36
T cell receptor complex 2 CD4, CD8A
ribonucleoside-diphosphate reductase complex 1 RRM1
[Isoform 1]: Mitochondrion inner membrane 1 FPGS


文献列表

  • T S Taha, T L Deits. Detection of glycinamide ribonucleotide by HPLC with pulsed amperometry: application to the assay for glutamine: 5-phosphoribosyl-1-pyrophosphate amidotransferase (EC 2.4.2.14). Analytical biochemistry. 1993 Sep; 213(2):323-8. doi: 10.1006/abio.1993.1428. [PMID: 8238909]