Phorbol-12 (BioDeep_00000005265)
PANOMIX_OTCML-2023
代谢物信息卡片
Phorbol 12,13-dibutanoate
化学式: C28H40O8 (504.2723)
中文名称: 佛波醇 12,13-二丁酸酯
谱图信息:
最多检出来源 Homo sapiens(feces) 18.9%
分子结构信息
SMILES: CCCC(=O)OC1C(C)C2(O)C(C=C(CO)CC3(O)C(=O)C(C)=CC32)C2C(C)(C)C12OC(=O)CCC
InChI: InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1
描述信息
D009676 - Noxae > D002273 - Carcinogens > D010703 - Phorbol Esters
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:17598
- KEGG: C03634
- PubChem: 37783
- Metlin: METLIN66015
- ChEMBL: CHEMBL27768
- MeSH: Phorbol 12,13-Dibutyrate
- CAS: 37558-16-0
- CAS: 61557-88-8
- PMhub: MS000018013
- PubChem: 6417
- PDB-CCD: WTS
- NIKKAJI: J246.188I
- RefMet: Phorbol 12,13-dibutanoate
- KNApSAcK: 17598
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alexandre Bergeron, Andra Brezai, Rami Shukr, Louis Villeneuve, Bruce G Allen, Wasay M S Qureshi, Kathryn E Hentges, Angelino Calderone. Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.
Journal of cellular physiology.
2021 02; 236(2):1281-1294. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2019; 52(1):76-93. doi:
10.33594/000000006. [PMID: 30790506] - Joydip Das, Noemi Kedei, Jessica S Kelsey, Youngki You, Satyabrata Pany, Gary A Mitchell, Nancy E Lewin, Peter M Blumberg. Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation.
Biochemistry.
2018 02; 57(5):732-741. doi:
10.1021/acs.biochem.7b00764. [PMID: 29244485] - Jihyae Ann, Suyoung Yoon, Jisoo Baek, Da Hye Kim, Nancy E Lewin, Colin S Hill, Peter M Blumberg, Jeewoo Lee. Design and synthesis of protein kinase C epsilon selective diacylglycerol lactones (DAG-lactones).
European journal of medicinal chemistry.
2015 Jan; 90(?):332-41. doi:
10.1016/j.ejmech.2014.11.025. [PMID: 25437619] - Lia C Garcia, Lucia Gandolfi Donadío, Ella Mann, Sofiya Kolusheva, Noemi Kedei, Nancy E Lewin, Colin S Hill, Jessica S Kelsey, Jing Yang, Timothy E Esch, Marina Santos, Megan L Peach, James A Kelley, Peter M Blumberg, Raz Jelinek, Victor E Marquez, Maria J Comin. Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.
Bioorganic & medicinal chemistry.
2014 Jun; 22(12):3123-40. doi:
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Diabetes research and clinical practice.
2013 Apr; 100(1):69-73. doi:
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American journal of physiology. Renal physiology.
2013 Jan; 304(2):F233-8. doi:
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PloS one.
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The Journal of biological chemistry.
2012 Nov; 287(45):37891-906. doi:
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The Journal of pharmacy and pharmacology.
2012 Aug; 64(8):1155-64. doi:
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Neuroscience.
2012 Jan; 201(?):34-45. doi:
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Frontiers in plant science.
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Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):852362. doi:
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Frontiers in immunology.
2012; 3(?):85. doi:
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World journal of gastroenterology.
2011 Mar; 17(12):1569-73. doi:
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Journal of ethnopharmacology.
2011 Jan; 133(2):484-9. doi:
10.1016/j.jep.2010.10.024. [PMID: 20965238] - Yanhua Wang, Janet D Klein, Carole M Liedtke, Jeff M Sands. Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.
American journal of physiology. Renal physiology.
2010 Dec; 299(6):F1401-6. doi:
10.1152/ajprenal.00322.2010. [PMID: 20861079] - Junji Takaya, Fumiko Yamato, Yuichi Kuroyanagi, Hirohiko Higashino, Kazunari Kaneko. Intracellular magnesium of obese and type 2 diabetes mellitus children.
Diabetes therapy : research, treatment and education of diabetes and related disorders.
2010 Aug; 1(1):25-31. doi:
10.1007/s13300-010-0003-7. [PMID: 22127671] - Lide Arana, Patricia Gangoiti, Alberto Ouro, Miguel Trueba, Antonio Gómez-Muñoz. Ceramide and ceramide 1-phosphate in health and disease.
Lipids in health and disease.
2010 Feb; 9(?):15. doi:
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Biochemistry.
2009 Sep; 48(34):8171-8. doi:
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American journal of physiology. Cell physiology.
2009 Feb; 296(2):C372-84. doi:
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American journal of physiology. Renal physiology.
2009 Jan; 296(1):F107-17. doi:
10.1152/ajprenal.90440.2008. [PMID: 18945825] - Rudolf Lampé, Sándor Szucs, Márk Ormos, Róza Adány, Robert Póka. Effect of normal and preeclamptic plasma on superoxide-anion production of neutrophils from healthy non-pregnant women.
Journal of reproductive immunology.
2008 Oct; 79(1):63-9. doi:
10.1016/j.jri.2008.04.001. [PMID: 18538415] - Sónia Simão, Rui Pedrosa, Ulrich Hopfer, David B Mount, Pedro A Jose, Patrício Soares-da-Silva. Short-term regulation of the Cl-/HCO3(-) exchanger in immortalized SHR proximal tubular epithelial cells.
Biochemical pharmacology.
2008 Jun; 75(11):2224-33. doi:
10.1016/j.bcp.2008.03.003. [PMID: 18407247] - D P Poole, S Amadesi, E Rozengurt, M Thacker, N W Bunnett, J B Furness. Stimulation of the neurokinin 3 receptor activates protein kinase C epsilon and protein kinase D in enteric neurons.
American journal of physiology. Gastrointestinal and liver physiology.
2008 May; 294(5):G1245-56. doi:
10.1152/ajpgi.00521.2007. [PMID: 18308856] - Miho Terunuma, Jianwei Xu, Mansi Vithlani, Werner Sieghart, Josef Kittler, Menelas Pangalos, Philip G Haydon, Douglas A Coulter, Stephen J Moss. Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Jan; 28(2):376-84. doi:
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Nature chemical biology.
2007 Dec; 3(12):795-804. doi:
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Biophysical journal.
2007 Oct; 93(8):2900-10. doi:
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Gastroenterology.
2007 Oct; 133(4):1229-39. doi:
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The Biochemical journal.
2007 Jul; 405(2):331-40. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2007 Feb; 292(2):G684-97. doi:
10.1152/ajpgi.00277.2006. [PMID: 17053160] - Edwin S L Chan, Hongwei Zhang, Patricia Fernandez, Sari D Edelman, Michael H Pillinger, Louis Ragolia, Thomas Palaia, Steven Carsons, Allison B Reiss. Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk.
Arthritis research & therapy.
2007; 9(1):R4. doi:
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The Journal of physiology.
2006 Dec; 577(Pt 2):479-95. doi:
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Investigative ophthalmology & visual science.
2006 Sep; 47(9):3989-4000. doi:
10.1167/iovs.06-0253. [PMID: 16936115] - Fanfan Zhou, Nicholas P Illsley, Guofeng You. Functional characterization of a human organic anion transporter hOAT4 in placental BeWo cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2006 Apr; 27(5):518-23. doi:
10.1016/j.ejps.2005.09.008. [PMID: 16257192] - Leslie A MacLaren, Aydin Guzeloglu, Frank Michel, William W Thatcher. Peroxisome proliferator-activated receptor (PPAR) expression in cultured bovine endometrial cells and response to omega-3 fatty acid, growth hormone and agonist stimulation in relation to series 2 prostaglandin production.
Domestic animal endocrinology.
2006 Mar; 30(3):155-69. doi:
10.1016/j.domaniend.2005.07.003. [PMID: 16154718] - Maria Paula Faillace, Jean Zwiller, George Di Scala, Ramon Bernabeu. Odor increases [3H]phorbol dibutyrate binding to protein kinase C in olfactory structures of rat brain. Effect of entorhinal cortex lesion.
Brain research.
2006 Jan; 1068(1):16-22. doi:
10.1016/j.brainres.2005.11.011. [PMID: 16386712] - Yuriy M Usachev, Anthony J Marsh, Tanner M Johanns, Michelle M Lemke, Stanley A Thayer. Activation of protein kinase C in sensory neurons accelerates Ca2+ uptake into the endoplasmic reticulum.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006 Jan; 26(1):311-8. doi:
10.1523/jneurosci.2920-05.2006. [PMID: 16399701] - Gülsüm Anderson, Jun Chen, Q Jane Wang. Individual C1 domains of PKD3 in phorbol ester-induced plasma membrane translocation of PKD3 in intact cells.
Cellular signalling.
2005 Nov; 17(11):1397-411. doi:
10.1016/j.cellsig.2005.02.007. [PMID: 15927450] - Robert V Stahelin, Jiyao Wang, Nichole R Blatner, John D Rafter, Diana Murray, Wonhwa Cho. The origin of C1A-C2 interdomain interactions in protein kinase Calpha.
The Journal of biological chemistry.
2005 Oct; 280(43):36452-63. doi:
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Traffic (Copenhagen, Denmark).
2005 Oct; 6(10):858-65. doi:
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British journal of pharmacology.
2005 Oct; 146(4):612-24. doi:
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Journal of immunology (Baltimore, Md. : 1950).
2005 Jul; 175(2):1239-47. doi:
10.4049/jimmunol.175.2.1239. [PMID: 16002728] - Fritz Wieser, Jean-Louis Vigne, Rene Wenzl, Johannes Huber, Robert N Taylor. Effects of phorbol dibutyrate on cell proliferation, apoptosis, and tumor necrosis factor-alpha expression in human endometrial adenocarcinoma cells.
Journal of the Society for Gynecologic Investigation.
2005 Jul; 12(5):370-5. doi:
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Cellular immunology.
2005 Jun; 235(2):136-44. doi:
10.1016/j.cellimm.2005.08.028. [PMID: 16226733] - Evgeny Kobrinsky, Donald E Mager, Sarah A Bentil, Shin-Ichi Murata, Darrell R Abernethy, Nikolai M Soldatov. Identification of plasma membrane macro- and microdomains from wavelet analysis of FRET microscopy.
Biophysical journal.
2005 May; 88(5):3625-34. doi:
10.1529/biophysj.104.054056. [PMID: 15722423] - Xian-hui He, Li-hui Xu, Yi Liu. Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain.
Acta pharmacologica Sinica.
2005 Apr; 26(4):462-8. doi:
10.1111/j.1745-7254.2005.00086.x. [PMID: 15780196] - Derek C Braun, Yeyu Cao, Shaomeng Wang, Susan H Garfield, Gang Min Hur, Peter M Blumberg. Role of phorbol ester localization in determining protein kinase C or RasGRP3 translocation: real-time analysis using fluorescent ligands and proteins.
Molecular cancer therapeutics.
2005 Jan; 4(1):141-50. doi:
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Journal of biomedical science.
2004 Nov; 11(6):764-72. doi:
10.1007/bf02254361. [PMID: 15591773] - Michael Schaefer, Harald Mischak, Susanne Schnell, Anne Griese, Roman Iakubov, Gabriele Riepenhausen, Christof Schöfl. Mechanisms of arginine-vasopressin-induced Ca2+ oscillations in beta-cells (HIT-T15): a role for oscillating protein kinase C.
Endocrinology.
2004 Oct; 145(10):4635-44. doi:
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Prostaglandins & other lipid mediators.
2004 Oct; 74(1-4):87-99. doi:
10.1016/j.prostaglandins.2004.07.004. [PMID: 15560118] - Joen R Sheu, Tsorng H Fong, Cheng M Liu, Ming Y Shen, Ta L Chen, Yi Chang, Meng S Lu, George Hsiao. Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies.
British journal of pharmacology.
2004 Sep; 143(1):193-201. doi:
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Journal of dairy science.
2004 Jul; 87(7):2032-41. doi:
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The Journal of pharmacology and experimental therapeutics.
2004 Jun; 309(3):951-8. doi:
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European journal of pharmacology.
2004 Mar; 488(1-3):51-9. doi:
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Pharmacology.
2004 Mar; 70(3):160-8. doi:
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Acta biochimica Polonica.
2004; 51(3):757-72. doi:
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Molecular pharmacology.
2003 Dec; 64(6):1342-8. doi:
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The Journal of biological chemistry.
2003 May; 278(20):18448-54. doi:
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Biochemical and biophysical research communications.
2003 Mar; 302(4):817-24. doi:
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Biochemistry.
2003 Mar; 42(9):2680-90. doi:
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The Journal of biological chemistry.
2002 Dec; 277(49):46871-6. doi:
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Prostaglandins & other lipid mediators.
2002 Sep; 70(1-2):79-90. doi:
10.1016/s0090-6980(02)00013-8. [PMID: 12428680] - P Gomes, P Soares-da-Silva. Dopamine-induced inhibition of Na+-K+-ATPase activity requires integrity of actin cytoskeleton in opossum kidney cells.
Acta physiologica Scandinavica.
2002 Jun; 175(2):93-101. doi:
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Veterinary microbiology.
2002 Apr; 86(1-2):157-63. doi:
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Cancer research.
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Molecular and cellular biology.
2002 Mar; 22(6):1714-22. doi:
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The Journal of biological chemistry.
2002 Jan; 277(1):645-55. doi:
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2002; 11(6):345-51. doi:
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Biochemical and biophysical research communications.
2001 Nov; 289(2):451-6. doi:
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2001 Oct; 276(41):37743-6. doi:
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American journal of physiology. Cell physiology.
2001 Sep; 281(3):C793-800. doi:
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The Journal of biological chemistry.
2001 Jul; 276(27):24743-50. doi:
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American journal of physiology. Endocrinology and metabolism.
2001 Jul; 281(1):E8-E15. doi:
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2001 Jul; 15(4):193-7. doi:
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The EMBO journal.
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American journal of physiology. Cell physiology.
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The Journal of biological chemistry.
2001 Apr; 276(16):13452-60. doi:
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American journal of physiology. Cell physiology.
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Biochemical and biophysical research communications.
2001 Mar; 282(2):621-8. doi:
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European journal of pharmacology.
2001 Jan; 411(1-2):61-66. doi:
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Experimental nephrology.
2001; 9(3):198-204. doi:
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2000 Dec; 275(49):38856-62. doi:
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Archives of physiology and biochemistry.
2000 Dec; 108(5):415-21. doi:
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European journal of pharmacology.
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Molecular pharmacology.
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The Biochemical journal.
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