Presqualene diphosphate (BioDeep_00000005204)

   

human metabolite Endogenous natural product


代谢物信息卡片


[({[(1S,2S,3S)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid

化学式: C30H52O7P2 (586.3188)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 8.34%

分子结构信息

SMILES: CC(=CCC/C(=C/CC/C(=C/[C@H]1[C@H](COP(=O)(O)OP(=O)(O)O)[C@@]1(C)CC/C=C(\C)/CCC=C(C)C)/C)/C)C
InChI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1

描述信息

Presqualene diphosphate is an intermediate in the biosynthesis of Terpenoid. It is a substrate for Farnesyl-diphosphate farnesyltransferase. [HMDB]. Presqualene diphosphate is found in many foods, some of which are soft-necked garlic, pomes, roman camomile, and white cabbage.
Presqualene diphosphate is an intermediate in the biosynthesis of Terpenoid. It is a substrate for Farnesyl-diphosphate farnesyltransferase.

同义名列表

10 个代谢物同义名

[({[(1S,2S,3S)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid; (1alpha,2beta(e),3beta(1E,5E))-Diphosphoric acid mono((2-(4,8-dimethyl-3,7-nonadienyl)-2-methyl-3-(2,6,10-trimethyl-1,5,9-undecatrienyl)cyclopropyl)methyl) ester; {(1r,2r,3r)-2-[(3e)-4,8-Dimethylnona-3,7-Dien-1-Yl]-2-Methyl-3-[(1e,5e)-2,6,10-Trimethylundeca-1,5,9-Trien-1-Yl]cyclopropyl}methyl Trihydrogen Diphosphate; [(1R,2R,3R)-2-[(e)-4,8-Dimethylnona-3,7-dienyl]-2-methyl-3-[(2E,6E)-2,6,10-trimethylundeca-1,5,9-trienyl]cyclopropan-1-yl]methyl diphosphoric acid; [(1S,2S,3S)-2-[(e)-4,8-Dimethylnona-3,7-dienyl]-2-methyl-3-[(2E,6E)-2,6,10-trimethylundeca-1,5,9-trienyl]cyclopropan-1-yl]methyl diphosphoric acid; [(1R,2R,3R)-2-[(e)-4,8-Dimethylnona-3,7-dienyl]-2-methyl-3-[(2E,6E)-2,6,10-trimethylundeca-1,5,9-trienyl]cyclopropan-1-yl]methyl diphosphate; [(1S,2S,3S)-2-[(e)-4,8-Dimethylnona-3,7-dienyl]-2-methyl-3-[(2E,6E)-2,6,10-trimethylundeca-1,5,9-trienyl]cyclopropan-1-yl]methyl diphosphate; Presqualene diphosphoric acid; Presqualene pyrophosphate; Presqualene diphosphate



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(1)

PlantCyc(0)

代谢反应

609 个相关的代谢反应过程信息。

Reactome(68)

BioCyc(2)

WikiPathways(2)

Plant Reactome(532)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(3)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 FNTA, INPP5J, ITPR3, MSMP, RPL18A
Endoplasmic reticulum membrane 6 FDFT1, HMGCR, IHH, ITPR3, PDP1, PLPP6
cytosol 4 FNTA, INPP5J, PRKCQ, RPL18A
nucleoplasm 1 ITPR3
Cell membrane 4 GPRC5A, IHH, LTB4R, TNF
Lipid-anchor 1 IHH
Multi-pass membrane protein 8 DUOX1, FDFT1, GPRC5A, HMGCR, ITPR3, LTB4R, PDP1, PLPP6
Golgi apparatus membrane 1 IHH
cell surface 2 DUOX1, TNF
dendritic shaft 1 INPP5J
Golgi membrane 2 IHH, INS
growth cone 1 INPP5J
neuronal cell body 2 ITPR3, TNF
plasma membrane 12 DUOX1, FNTA, GPRC5A, IHH, INPP5J, ITPR3, LTB, LTB4R, PDP1, PLPP6, PRKCQ, TNF
Membrane 8 DUOX1, FDFT1, HMGCR, ITPR3, LTB, PDP1, PLPP6, RPL18A
apical plasma membrane 1 DUOX1
brush border 1 ITPR3
extracellular exosome 1 GPRC5A
endoplasmic reticulum 4 DUOX1, FDFT1, HMGCR, ITPR3
extracellular space 5 IHH, INS, LTB, MSMP, TNF
mitochondrion 1 PDP1
intracellular membrane-bounded organelle 1 GPRC5A
Secreted 4 IHH, INS, MATN1, MSMP
extracellular region 4 IHH, INS, MATN1, TNF
mitochondrial matrix 1 PDP1
centriolar satellite 1 PRKCQ
nuclear membrane 2 PDP1, PLPP6
external side of plasma membrane 1 TNF
nucleolus 2 GPRC5A, ITPR3
apical part of cell 1 ITPR3
recycling endosome 1 TNF
Single-pass type II membrane protein 2 LTB, TNF
vesicle 1 GPRC5A
Apical cell membrane 1 DUOX1
Membrane raft 1 TNF
extracellular matrix 2 IHH, MATN1
sarcoplasmic reticulum 1 ITPR3
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 1 MATN1
Nucleus inner membrane 2 PDP1, PLPP6
nuclear inner membrane 2 PDP1, PLPP6
nuclear outer membrane 1 ITPR3
ruffle 1 INPP5J
receptor complex 2 GPRC5A, ITPR3
cell leading edge 1 DUOX1
microtubule associated complex 1 FNTA
phagocytic cup 1 TNF
Nucleus envelope 2 PDP1, PLPP6
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 GPRC5A
Peroxisome membrane 1 HMGCR
secretory granule lumen 1 INS
secretory granule membrane 1 ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
matrilin complex 1 MATN1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
ribonucleoprotein complex 1 RPL18A
platelet dense tubular network membrane 1 ITPR3
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
cytosolic ribosome 1 RPL18A
ribosome 1 RPL18A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
transport vesicle membrane 1 ITPR3
NADPH oxidase complex 1 DUOX1
cytosolic large ribosomal subunit 1 RPL18A
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
CAAX-protein geranylgeranyltransferase complex 1 FNTA
protein farnesyltransferase complex 1 FNTA
[Indian hedgehog protein N-product]: Cell membrane 1 IHH
[Indian hedgehog protein]: Endoplasmic reticulum membrane 1 IHH
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
pyruvate dehydrogenase (lipoamide) phosphatase complex 1 PDP1


文献列表

  • Troy Carlo, Nicos A Petasis, Bruce D Levy. Activation of polyisoprenyl diphosphate phosphatase 1 remodels cellular presqualene diphosphate. Biochemistry. 2009 Apr; 48(13):2997-3004. doi: 10.1021/bi8020636. [PMID: 19220020]
  • Sarah A Scott, Paige E Selvy, Jason R Buck, Hyekyung P Cho, Tracy L Criswell, Ashley L Thomas, Michelle D Armstrong, Carlos L Arteaga, Craig W Lindsley, H Alex Brown. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature chemical biology. 2009 Feb; 5(2):108-17. doi: 10.1038/nchembio.140. [PMID: 19136975]
  • Troy Carlo, Bruce D Levy. Chemical mediators and the resolution of airway inflammation. Allergology international : official journal of the Japanese Society of Allergology. 2008 Dec; 57(4):299-305. doi: 10.2332/allergolint.08-rai-0018. [PMID: 18946231]
  • Spyros Theofilopoulos, Athanasios Lykidis, George Leondaritis, Dimitra Mangoura. Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways. Biochimica et biophysica acta. 2008 Nov; 1781(11-12):731-42. doi: 10.1016/j.bbalip.2008.09.001. [PMID: 18930839]
  • B D Levy, C N Serhan. Polyisoprenyl phosphate signaling: topography in human neutrophils. Biochemical and biophysical research communications. 2000 Sep; 275(3):739-45. doi: 10.1006/bbrc.2000.3371. [PMID: 10973792]
  • B D Levy, V V Fokin, J M Clark, M J Wakelam, N A Petasis, C N Serhan. Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1999 May; 13(8):903-11. doi: 10.1096/fasebj.13.8.903. [PMID: 10224233]
  • B D Levy, N A Petasis, C N Serhan. Polyisoprenyl phosphates in intracellular signalling. Nature. 1997 Oct; 389(6654):985-90. doi: 10.1038/40180. [PMID: 9353124]
  • . . . . doi: . [PMID: 16464866]