myo-Inositol 1,3,4,5-tetrakisphosphate (BioDeep_00000004641)

 

Secondary id: BioDeep_00001868852

human metabolite Endogenous


代谢物信息卡片


{[(1S,2S,3S,4S,5R,6S)-2,4-dihydroxy-3,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid

化学式: C6H16O18P4 (499.9287)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 26.39%

分子结构信息

SMILES: C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)O)OP(=O)(O)O)O
InChI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2-,3-,4+,5-,6-/m0/s1

描述信息

myo-Inositol 1,3,4,5-tetrakisphosphate (CAS: 102850-29-3), also known as IP4, is a second messenger responsible for mediating Ca2+ entry through the plasma membrane and mobilizing intracellular Ca2+ by acting synergistically with inositol 1,4,5-trisphosphate (IP3). Inositol 1,4,5-trisphosphate 3-kinase (IP3K, EC 2.7.1.127) phosphorylates IP3 into IP4. Evidence shows that IP4 can activate a protein with ras- and rap-GAP activity and finally inactivate the G protein. This indicates that IP4 regulates Ca2+ influx in a GTP-dependent way, which potentially links the IP3 signalling pathway to GTP-regulated signalling mechanisms. IP4 is demonstrated to be a common regulator in Ca2+ homeostasis. IP4 can bind with a high affinity to several intracellular proteins: synaptotagmin (I and II), Gap1, Btk, and centaurin-alpha and may interact with synaptotagmin to inhibit synaptic transmission. IP4 also acts as a mediator in neuronal death in the ischemic hippocampus. IP4 production is not always associated with a modification in calcium concentration, and control of calcium mobilization is not the sole function proposed for IP4. IP4 defines an essential signalling pathway for T cell precursor responsiveness and development. In the thymus, IP4 is essential during the positive and negative selection of double-positive thymocytes, and in the control of thymocyte reactivity to antigens. IP4 is also a substrate for type I inositol-1,4,5-trisphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A, and skeletal muscle and kidney enriched inositol phosphatase (PMID: 15740635, 14517551).

同义名列表

28 个代谢物同义名

{[(1S,2S,3S,4S,5R,6S)-2,4-dihydroxy-3,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid; [(1S,2S,3S,4S,5R,6S)-2,4-dihydroxy-3,5,6-tris(phosphonooxy)cyclohexyl]oxyphosphonic acid; D-myo-inositol-1,3,4,5-tetrakis(dihydrogen phosphate), octasodium salt; 1D-myo-Inositol 1,3,4,5-tetrakis(dihydrogen phosphate); myo-Inositol, 1,3,4,5-tetrakis(dihydrogen phosphate); 1,3,4,5-Tetrakis(dihydrogen phosphate) myo-inositol; D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt); 1D-myo-Inositol 1,3,4,5-tetrakisphosphoric acid; D-Myo-inositol 1,3,4,5-tetrakisphosphoric acid; D-myo-Inositol 1,3,4,5-tetrakis(phosphate); 1D-myo-Inositol 1,3,4,5-tetrakisphosphate; Inositol 1,3,4,5-tetrakisphosphoric acid; myo-Inositol 1,3,4,5-tetrakis(phosphate); D-Myo-inositol 1,3,4,5-tetrakisphosphate; myo-Inositol-1,3,4,5-tetrakisphosphate; myo-Inositol 1,3,4,5-tetrakisphosphate; Inositol-(1,3,4,5)-tetrakisphosphate; Inositol 1,3,4,5-tetrakis(phosphate); myo-Inositol 1,3,4,5-tetraphosphate; Inositol-1,3,4,5-tetrakisphosphate; Inositol 1,3,4,5-tetrakisphosphate; Inositol-1,3,4,5-tetraphosphate; Inositol 1,3,4,5-tetraphosphate; Ins(1,3,4,5)P(4); Ins-1,3,4,5-P4; Ins(1,3,4,5)P4; SCHEMBL282194; IP4



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

36 个相关的代谢反应过程信息。

Reactome(21)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(14)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 BTK, CA1, INPP5D, ITPKB, ITPR3, PLEK, PRKX, SYT2
Peripheral membrane protein 2 BTK, INPP5D
Endoplasmic reticulum membrane 2 HSP90B1, ITPR3
Nucleus 6 BTK, HSP90B1, INPPL1, ITPKB, PLCZ1, PRKX
cytosol 11 BTK, CA1, HSP90B1, INPP5D, INPPL1, ITPKB, PLCZ1, PLEK, PRKCQ, RASA2, RASA3
nucleoplasm 3 ITPR3, PLCZ1, PRKX
Cell membrane 2 BTK, INPP5D
lamellipodium 1 INPPL1
ruffle membrane 1 PLEK
Multi-pass membrane protein 2 CACNA1I, ITPR3
Golgi apparatus 1 INPPL1
Golgi membrane 1 INS
lysosomal membrane 1 EGF
neuronal cell body 1 ITPR3
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 INPPL1
plasma membrane 10 BTK, CACNA1I, EGF, F2, INPP5D, ITPR3, KNG1, PLEK, PRKCQ, SYT2
synaptic vesicle membrane 1 SYT2
Membrane 8 CACNA1I, EGF, HSP90B1, INPP5D, INPPL1, ITPKB, ITPR3, PLEK
axon 1 SYT2
brush border 1 ITPR3
extracellular exosome 5 CA1, EGF, F2, HSP90B1, KNG1
endoplasmic reticulum 3 HSP90B1, ITPKB, ITPR3
extracellular space 4 EGF, F2, INS, KNG1
perinuclear region of cytoplasm 4 BTK, HSP90B1, PLCZ1, RASA2
protein-containing complex 1 HSP90B1
filopodium 1 INPPL1
pronucleus 1 PLCZ1
Secreted 2 F2, INS
extracellular region 6 EGF, F2, HSP90B1, INS, KNG1, PLEK
cytoplasmic side of plasma membrane 1 RASA3
Single-pass membrane protein 1 SYT2
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 SYT2
cytoplasmic vesicle 1 BTK
nucleolus 2 ITPR3, PLCZ1
midbody 1 HSP90B1
apical part of cell 1 ITPR3
Cell projection, lamellipodium 1 INPPL1
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 2 BTK, INPP5D
Cytoplasm, cytoskeleton 2 INPP5D, ITPKB
focal adhesion 1 HSP90B1
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 3 F2, HSP90B1, KNG1
nuclear speck 1 INPPL1
nuclear outer membrane 1 ITPR3
Cell projection, filopodium 1 INPPL1
receptor complex 1 ITPR3
cytoskeleton 2 INPP5D, ITPKB
Secreted, extracellular space 1 KNG1
spindle pole 1 INPPL1
blood microparticle 2 F2, KNG1
Cytoplasm, cytoskeleton, spindle pole 1 INPPL1
endosome lumen 1 INS
Melanosome 1 HSP90B1
Nucleus speckle 1 INPPL1
sperm plasma membrane 1 HSP90B1
basal plasma membrane 1 INPPL1
exocytic vesicle 1 SYT2
secretory granule lumen 1 INS
secretory granule membrane 1 ITPR3
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 4 F2, HSP90B1, INS, KNG1
platelet alpha granule lumen 2 EGF, KNG1
voltage-gated calcium channel complex 1 CACNA1I
dense core granule 1 SYT2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 2 EGF, SYT2
Sarcoplasmic reticulum lumen 1 HSP90B1
platelet dense tubular network membrane 1 ITPR3
Basal cell membrane 1 INPPL1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
endocytic vesicle lumen 1 HSP90B1
transport vesicle membrane 1 ITPR3
sperm head 1 PLCZ1
endoplasmic reticulum chaperone complex 1 HSP90B1
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 SYT2
chromaffin granule membrane 1 SYT2
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3


文献列表

  • Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B Shears, Ingo B Leibiger, Per-Olof Berggren, Christopher J Barker. Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling. Biomolecules. 2023 05; 13(6):. doi: 10.3390/biom13060885. [PMID: 37371464]
  • Ariane Scoumanne, Patricia Molina-Ortiz, Daniel Monteyne, David Perez-Morga, Christophe Erneux, Stéphane Schurmans. Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice. Advances in biological regulation. 2016 09; 62(?):1-10. doi: 10.1016/j.jbior.2016.03.001. [PMID: 27036498]
  • Yina H Huang, Karsten Sauer. Lipid signaling in T-cell development and function. Cold Spring Harbor perspectives in biology. 2010 Nov; 2(11):a002428. doi: 10.1101/cshperspect.a002428. [PMID: 20943760]
  • Karsten Sauer, Michael P Cooke. Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate. Nature reviews. Immunology. 2010 Apr; 10(4):257-71. doi: 10.1038/nri2745. [PMID: 20336153]
  • Anastasia Galvita, Dmitry Grachev, Tamara Azarashvili, Yulia Baburina, Olga Krestinina, Rolf Stricker, Georg Reiser. The brain-specific protein, p42(IP4) (ADAP 1) is localized in mitochondria and involved in regulation of mitochondrial Ca2+. Journal of neurochemistry. 2009 Jun; 109(6):1701-13. doi: 10.1111/j.1471-4159.2009.06089.x. [PMID: 19383085]
  • Andrew T Miller, Mark Sandberg, Yina H Huang, Michael Young, Susan Sutton, Karsten Sauer, Michael P Cooke. Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation. Nature immunology. 2007 May; 8(5):514-21. doi: 10.1038/ni1458. [PMID: 17417640]
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  • Sabine Kupzig, Delia Deaconescu, Dalila Bouyoucef, Simon A Walker, Qing Liu, Christian L Polte, Oliver Daumke, Toshimasa Ishizaki, Peter J Lockyer, Alfred Wittinghofer, Peter J Cullen. GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. The Journal of biological chemistry. 2006 Apr; 281(15):9891-900. doi: 10.1074/jbc.m512802200. [PMID: 16431904]
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  • Christine C Milburn, Maria Deak, Sharon M Kelly, Nick C Price, Dario R Alessi, Daan M F Van Aalten. Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. The Biochemical journal. 2003 Nov; 375(Pt 3):531-8. doi: 10.1042/bj20031229. [PMID: 12964941]
  • Hui-Jun Xia, Charles Brearley, Stephan Elge, Boaz Kaplan, Hillel Fromm, Bernd Mueller-Roeber. Arabidopsis inositol polyphosphate 6-/3-kinase is a nuclear protein that complements a yeast mutant lacking a functional ArgR-Mcm1 transcription complex. The Plant cell. 2003 Feb; 15(2):449-63. doi: 10.1105/tpc.006676. [PMID: 12566584]
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  • Laura Zonia, Sofia Cordeiro, Jaroslav Tupý, José A Feijó. Oscillatory chloride efflux at the pollen tube apex has a role in growth and cell volume regulation and is targeted by inositol 3,4,5,6-tetrakisphosphate. The Plant cell. 2002 Sep; 14(9):2233-49. doi: . [PMID: 12215517]
  • Fariba Sedehizade, Theo Hanck, Rolf Stricker, Angelika Horstmayer, Hans Gert Bernstein, Georg Reiser. Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells. Brain research. Molecular brain research. 2002 Feb; 99(1):1-11. doi: 10.1016/s0169-328x(01)00335-7. [PMID: 11869802]
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