myo-Inositol 1,3,4,5-tetrakisphosphate (BioDeep_00000004641)

 

Secondary id: BioDeep_00001868852

human metabolite Endogenous


代谢物信息卡片


{[(1S,2S,3S,4S,5R,6S)-2,4-dihydroxy-3,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid

化学式: C6H16O18P4 (499.92871560000003)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 58.33%

分子结构信息

SMILES: C1(C(C(C(C(C1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)O)OP(=O)(O)O)O
InChI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2-,3-,4+,5-,6-/m0/s1

描述信息

myo-Inositol 1,3,4,5-tetrakisphosphate (CAS: 102850-29-3), also known as IP4, is a second messenger responsible for mediating Ca2+ entry through the plasma membrane and mobilizing intracellular Ca2+ by acting synergistically with inositol 1,4,5-trisphosphate (IP3). Inositol 1,4,5-trisphosphate 3-kinase (IP3K, EC 2.7.1.127) phosphorylates IP3 into IP4. Evidence shows that IP4 can activate a protein with ras- and rap-GAP activity and finally inactivate the G protein. This indicates that IP4 regulates Ca2+ influx in a GTP-dependent way, which potentially links the IP3 signalling pathway to GTP-regulated signalling mechanisms. IP4 is demonstrated to be a common regulator in Ca2+ homeostasis. IP4 can bind with a high affinity to several intracellular proteins: synaptotagmin (I and II), Gap1, Btk, and centaurin-alpha and may interact with synaptotagmin to inhibit synaptic transmission. IP4 also acts as a mediator in neuronal death in the ischemic hippocampus. IP4 production is not always associated with a modification in calcium concentration, and control of calcium mobilization is not the sole function proposed for IP4. IP4 defines an essential signalling pathway for T cell precursor responsiveness and development. In the thymus, IP4 is essential during the positive and negative selection of double-positive thymocytes, and in the control of thymocyte reactivity to antigens. IP4 is also a substrate for type I inositol-1,4,5-trisphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A, and skeletal muscle and kidney enriched inositol phosphatase (PMID: 15740635, 14517551).

同义名列表

28 个代谢物同义名

{[(1S,2S,3S,4S,5R,6S)-2,4-dihydroxy-3,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid; [(1S,2S,3S,4S,5R,6S)-2,4-dihydroxy-3,5,6-tris(phosphonooxy)cyclohexyl]oxyphosphonic acid; D-myo-inositol-1,3,4,5-tetrakis(dihydrogen phosphate), octasodium salt; 1D-myo-Inositol 1,3,4,5-tetrakis(dihydrogen phosphate); myo-Inositol, 1,3,4,5-tetrakis(dihydrogen phosphate); 1,3,4,5-Tetrakis(dihydrogen phosphate) myo-inositol; D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt); 1D-myo-Inositol 1,3,4,5-tetrakisphosphoric acid; D-Myo-inositol 1,3,4,5-tetrakisphosphoric acid; D-myo-Inositol 1,3,4,5-tetrakis(phosphate); 1D-myo-Inositol 1,3,4,5-tetrakisphosphate; Inositol 1,3,4,5-tetrakisphosphoric acid; myo-Inositol 1,3,4,5-tetrakis(phosphate); D-Myo-inositol 1,3,4,5-tetrakisphosphate; myo-Inositol-1,3,4,5-tetrakisphosphate; myo-Inositol 1,3,4,5-tetrakisphosphate; Inositol-(1,3,4,5)-tetrakisphosphate; Inositol 1,3,4,5-tetrakis(phosphate); myo-Inositol 1,3,4,5-tetraphosphate; Inositol-1,3,4,5-tetrakisphosphate; Inositol 1,3,4,5-tetrakisphosphate; Inositol-1,3,4,5-tetraphosphate; Inositol 1,3,4,5-tetraphosphate; Ins(1,3,4,5)P(4); Ins-1,3,4,5-P4; Ins(1,3,4,5)P4; SCHEMBL282194; IP4



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

36 个相关的代谢反应过程信息。

Reactome(21)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(14)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B Shears, Ingo B Leibiger, Per-Olof Berggren, Christopher J Barker. Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling. Biomolecules. 2023 05; 13(6):. doi: 10.3390/biom13060885. [PMID: 37371464]
  • Ariane Scoumanne, Patricia Molina-Ortiz, Daniel Monteyne, David Perez-Morga, Christophe Erneux, Stéphane Schurmans. Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice. Advances in biological regulation. 2016 09; 62(?):1-10. doi: 10.1016/j.jbior.2016.03.001. [PMID: 27036498]
  • Yina H Huang, Karsten Sauer. Lipid signaling in T-cell development and function. Cold Spring Harbor perspectives in biology. 2010 Nov; 2(11):a002428. doi: 10.1101/cshperspect.a002428. [PMID: 20943760]
  • Karsten Sauer, Michael P Cooke. Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate. Nature reviews. Immunology. 2010 Apr; 10(4):257-71. doi: 10.1038/nri2745. [PMID: 20336153]
  • Anastasia Galvita, Dmitry Grachev, Tamara Azarashvili, Yulia Baburina, Olga Krestinina, Rolf Stricker, Georg Reiser. The brain-specific protein, p42(IP4) (ADAP 1) is localized in mitochondria and involved in regulation of mitochondrial Ca2+. Journal of neurochemistry. 2009 Jun; 109(6):1701-13. doi: 10.1111/j.1471-4159.2009.06089.x. [PMID: 19383085]
  • Andrew T Miller, Mark Sandberg, Yina H Huang, Michael Young, Susan Sutton, Karsten Sauer, Michael P Cooke. Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation. Nature immunology. 2007 May; 8(5):514-21. doi: 10.1038/ni1458. [PMID: 17417640]
  • Rolf Stricker, K Martin Chow, Daniela Walther, Theodor Hanck, Louis B Hersh, Georg Reiser. Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity. Journal of neurochemistry. 2006 Jul; 98(2):343-54. doi: 10.1111/j.1471-4159.2006.03869.x. [PMID: 16805830]
  • Sabine Kupzig, Delia Deaconescu, Dalila Bouyoucef, Simon A Walker, Qing Liu, Christian L Polte, Oliver Daumke, Toshimasa Ishizaki, Peter J Lockyer, Alfred Wittinghofer, Peter J Cullen. GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. The Journal of biological chemistry. 2006 Apr; 281(15):9891-900. doi: 10.1074/jbc.m512802200. [PMID: 16431904]
  • David Brough, Yirong Sim, Peter Thorn, Robin F Irvine. The structural integrity of the endoplasmic reticulum, and its possible regulation by inositol 1,3,4,5-tetrakisphosphate. Cell calcium. 2005 Aug; 38(2):153-9. doi: 10.1016/j.ceca.2005.05.002. [PMID: 16023721]
  • David Brough, Farzana Bhatti, Robin F Irvine. Mobility of proteins associated with the plasma membrane by interaction with inositol lipids. Journal of cell science. 2005 Jul; 118(Pt 14):3019-25. doi: 10.1242/jcs.02426. [PMID: 15985468]
  • G Reiser, F Striggow, C Hackmann, H Schwegler, D M Yilmazer-Hanke. Short-term down-regulation of the brain-specific, PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding, adapter protein, p42IP4/centaurin-alpha 1 in rat brain after acoustic and electric stimulation. Neurochemistry international. 2004 Jul; 45(1):89-93. doi: 10.1016/j.neuint.2003.12.003. [PMID: 15082226]
  • Theodor Hanck, Rolf Stricker, Fariba Sedehizade, Georg Reiser. Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins. Journal of neurochemistry. 2004 Jan; 88(2):326-36. doi: 10.1046/j.1471-4159.2003.02143.x. [PMID: 14690521]
  • Christine C Milburn, Maria Deak, Sharon M Kelly, Nick C Price, Dario R Alessi, Daan M F Van Aalten. Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. The Biochemical journal. 2003 Nov; 375(Pt 3):531-8. doi: 10.1042/bj20031229. [PMID: 12964941]
  • Hui-Jun Xia, Charles Brearley, Stephan Elge, Boaz Kaplan, Hillel Fromm, Bernd Mueller-Roeber. Arabidopsis inositol polyphosphate 6-/3-kinase is a nuclear protein that complements a yeast mutant lacking a functional ArgR-Mcm1 transcription complex. The Plant cell. 2003 Feb; 15(2):449-63. doi: 10.1105/tpc.006676. [PMID: 12566584]
  • Georg Reiser, Hans-Gert Bernstein. Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha. Neuroreport. 2002 Dec; 13(18):2417-9. doi: 10.1097/00001756-200212200-00008. [PMID: 12499840]
  • Laura Zonia, Sofia Cordeiro, Jaroslav Tupý, José A Feijó. Oscillatory chloride efflux at the pollen tube apex has a role in growth and cell volume regulation and is targeted by inositol 3,4,5,6-tetrakisphosphate. The Plant cell. 2002 Sep; 14(9):2233-49. doi: . [PMID: 12215517]
  • Fariba Sedehizade, Theo Hanck, Rolf Stricker, Angelika Horstmayer, Hans Gert Bernstein, Georg Reiser. Cellular expression and subcellular localization of the human Ins(1,3,4,5)P(4)-binding protein, p42(IP4), in human brain and in neuronal cells. Brain research. Molecular brain research. 2002 Feb; 99(1):1-11. doi: 10.1016/s0169-328x(01)00335-7. [PMID: 11869802]
  • Christina A Mitchell, Rajendra Gurung, Anne M Kong, Jennifer M Dyson, April Tan, Lisa M Ooms. Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair. IUBMB life. 2002 Jan; 53(1):25-36. doi: 10.1080/15216540210815. [PMID: 12018404]
  • T J McNulty, A J Letcher, A P Dawson, R F Irvine. Tissue distribution of GAP1(IP4BP) and GAP1(m): two inositol 1,3,4,5-tetrakisphosphate-binding proteins. Cellular signalling. 2001 Dec; 13(12):877-86. doi: 10.1016/s0898-6568(01)00197-8. [PMID: 11728827]
  • J K McAdara Berkowitz, S D Catz, J L Johnson, J M Ruedi, V Thon, B M Babior. JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. The Journal of biological chemistry. 2001 Jun; 276(22):18855-62. doi: 10.1074/jbc.m011167200. [PMID: 11278853]
  • F Hatzack, F Hübel, W Zhang, P E Hansen, S K Rasmussen. Inositol phosphates from barley low-phytate grain mutants analysed by metal-dye detection HPLC and NMR. The Biochemical journal. 2001 Mar; 354(Pt 2):473-80. doi: 10.1042/0264-6021:3540473. [PMID: 11171128]
  • G E Cozier, P J Lockyer, J S Reynolds, S Kupzig, J R Bottomley, T H Millard, G Banting, P J Cullen. GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association. The Journal of biological chemistry. 2000 Sep; 275(36):28261-8. doi: 10.1074/jbc.m000469200. [PMID: 10869341]
  • B Mehrotra, D G Myszka, G D Prestwich. Binding kinetics and ligand specificity for the interactions of the C2B domain of synaptogmin II with inositol polyphosphates and phosphoinositides. Biochemistry. 2000 Aug; 39(32):9679-86. doi: 10.1021/bi000487o. [PMID: 10933784]
  • A L Hsu, T T Ching, G Sen, D S Wang, S Bondada, K S Authi, C S Chen. Novel function of phosphoinositide 3-kinase in T cell Ca2+ signaling. A phosphatidylinositol 3,4,5-trisphosphate-mediated Ca2+ entry mechanism. The Journal of biological chemistry. 2000 May; 275(21):16242-50. doi: 10.1074/jbc.m002077200. [PMID: 10748064]
  • R Stricker, S Adelt, G Vogel, G Reiser. Translocation between membranes and cytosol of p42IP4, a specific inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4, 5-trisphosphate-receptor protein from brain, is induced by inositol 1,3,4,5-tetrakisphosphate and regulated by a membrane-associated 5-phosphatase. European journal of biochemistry. 1999 Oct; 265(2):815-24. doi: 10.1046/j.1432-1327.1999.00795.x. [PMID: 10504414]
  • K Venkateswarlu, P J Cullen. Molecular cloning and functional characterization of a human homologue of centaurin-alpha. Biochemical and biophysical research communications. 1999 Aug; 262(1):237-44. doi: 10.1006/bbrc.1999.1065. [PMID: 10448098]
  • K Hirose, S Kadowaki, M Tanabe, H Takeshima, M Iino. Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns. Science (New York, N.Y.). 1999 May; 284(5419):1527-30. doi: 10.1126/science.284.5419.1527. [PMID: 10348740]
  • E Baraldi, K Djinovic Carugo, M Hyvönen, P L Surdo, A M Riley, B V Potter, R O'Brien, J E Ladbury, M Saraste. Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. Structure (London, England : 1993). 1999 Apr; 7(4):449-60. doi: 10.1016/s0969-2126(99)80057-4. [PMID: 10196129]
  • T Hanck, R Stricker, U M Krishna, J R Falck, Y T Chang, S K Chung, G Reiser. Recombinant p42IP4, a brain-specific 42-kDa high-affinity Ins(1,3,4,5)P4 receptor protein, specifically interacts with lipid membranes containing Ptd-Ins(3,4,5)P3. European journal of biochemistry. 1999 Apr; 261(2):577-84. doi: 10.1046/j.1432-1327.1999.00326.x. [PMID: 10215872]
  • P J Lockyer, S Vanlingen, J S Reynolds, T J McNulty, R F Irvine, J B Parys, P J Cullen. Tissue-specific expression and endogenous subcellular distribution of the inositol 1,3,4,5-tetrakisphosphate-binding proteins GAP1(IP4BP) and GAP1(m). Biochemical and biophysical research communications. 1999 Feb; 255(2):421-6. doi: 10.1006/bbrc.1999.0217. [PMID: 10049724]
  • J M Kavran, D E Klein, A Lee, M Falasca, S J Isakoff, E Y Skolnik, M A Lemmon. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. The Journal of biological chemistry. 1998 Nov; 273(46):30497-508. doi: 10.1074/jbc.273.46.30497. [PMID: 9804818]
  • X Pesesse, C Moreau, A L Drayer, R Woscholski, P Parker, C Erneux. The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity. FEBS letters. 1998 Oct; 437(3):301-3. doi: 10.1016/s0014-5793(98)01255-1. [PMID: 9824312]
  • K Venkateswarlu, F Gunn-Moore, P B Oatey, J M Tavaré, P J Cullen. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain. The Biochemical journal. 1998 Oct; 335 ( Pt 1)(?):139-46. doi: 10.1042/bj3350139. [PMID: 9742223]
  • M Aggensteiner, R Stricker, G Reiser. Identification of rat brain p42(IP4), a high-affinity inositol(1,3,4, 5)tetrakisphosphate/phosphatidylinositol(3,4,5)trisphosphate binding protein. Biochimica et biophysica acta. 1998 Sep; 1387(1-2):117-28. doi: 10.1016/s0167-4838(98)00113-7. [PMID: 9748531]
  • K Venkateswarlu, P B Oatey, J M Tavaré, P J Cullen. Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase. Current biology : CB. 1998 Apr; 8(8):463-6. doi: 10.1016/s0960-9822(98)70181-2. [PMID: 9550703]
  • E Brailoiu, A Margineanu, C P Toma, C M Filipeanu, V Rusu, D D Branisteanu. D-myo-inositol derivatives alter liposomal membrane fluidity. Biochemistry and molecular biology international. 1998 Jan; 44(1):195-201. doi: 10.1080/15216549800201212. [PMID: 9503163]
  • P J Lockyer, J R Bottomley, J S Reynolds, T J McNulty, K Venkateswarlu, B V Potter, C E Dempsey, P J Cullen. Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting. Current biology : CB. 1997 Dec; 7(12):1007-10. doi: 10.1016/s0960-9822(06)00423-4. [PMID: 9382842]
  • J I Kourie, P S Foster, A F Dulhunty. Inositol polyphosphates modify the kinetics of a small chloride channel in skeletal muscle sarcoplasmic reticulum. The Journal of membrane biology. 1997 May; 157(2):147-58. doi: 10.1007/s002329900224. [PMID: 9151656]
  • W J Van Marrewijk, A T Van den Broek, M L Gielbert, D J Van der Horst. Insect adipokinetic hormone stimulates inositol phosphate metabolism: roles for both Ins(1,4,5)P3 and Ins(1,3,4,5)P4 in signal transduction?. Molecular and cellular endocrinology. 1996 Sep; 122(2):141-50. doi: 10.1016/0303-7207(96)03877-4. [PMID: 8902844]
  • E Brailoiu, C Beschea, C Brailoiu, A Costuleanu, C M Filipeanu, M Costuleanu, B Fallgren, D D Branisteanu. TLC characterization of small unilamellar liposomes containing D-myo-inositol derivatives. Biomedical chromatography : BMC. 1996 Sep; 10(5):233-6. doi: 10.1002/(sici)1099-0801(199609)10:5<233::aid-bmc594>3.0.co;2-5. [PMID: 8879530]
  • G S Bird, J W Putney. Effect of inositol 1,3,4,5-tetrakisphosphate on inositol trisphosphate-activated Ca2+ signaling in mouse lacrimal acinar cells. The Journal of biological chemistry. 1996 Mar; 271(12):6766-70. doi: 10.1074/jbc.271.12.6766. [PMID: 8636098]
  • R Stricker, E Westerberg, G Reiser. Binding sites for alpha-trinositol (inositol 1,2,6-trisphosphate) in porcine tissues; comparison with Ins(1,4,5)P3 and Ins(1,3,4,5)P4-binding sites. British journal of pharmacology. 1996 Mar; 117(5):919-25. doi: 10.1111/j.1476-5381.1996.tb15281.x. [PMID: 8851511]
  • E Brailoiu, G Huhurez, S Slatineanu, C M Filipeanu, M Costuleanu, D D Branisteanu. TLC characterization of liposomes containing D-myo-inositol derivatives. Biomedical chromatography : BMC. 1995 Jul; 9(4):175-8. doi: 10.1002/bmc.1130090405. [PMID: 8520206]
  • L Leino, H Tuominen, K Lehtola, K O Akerman, K Punnonen. Biphasic formation of inositol phosphates in opsonized zymosan-stimulated human neutrophils. Cellular signalling. 1995 May; 7(4):397-402. doi: 10.1016/0898-6568(94)00094-r. [PMID: 8527308]
  • M Mayrleitner, R Schäfer, S Fleischer. IP3 receptor purified from liver plasma membrane is an (1,4,5)IP3 activated and (1,3,4,5)IP4 inhibited calcium permeable ion channel. Cell calcium. 1995 Feb; 17(2):141-53. doi: 10.1016/0143-4160(95)90083-7. [PMID: 7736563]
  • A Craxton, N Ali, S B Shears. Comparison of the activities of a multiple inositol polyphosphate phosphatase obtained from several sources: a search for heterogeneity in this enzyme. The Biochemical journal. 1995 Jan; 305 ( Pt 2)(?):491-8. doi: 10.1042/bj3050491. [PMID: 7832765]
  • A Garlind, R F Cowburn, C J Fowler. Characteristics of [3H]inositol(1,3,4,5)tetrakisphosphate recognition sites in human cerebellar membranes. Journal of neural transmission. General section. 1995; 100(2):101-9. doi: 10.1007/bf01271533. [PMID: 8962680]
  • P Köppler, M Mersel, A N Malviya. Subcellular localization of specific inositol 1,3,4,5-tetrakis([3H]phosphate) binding sites in rat liver membrane fractions: a comparative evaluation of pH sensitivity and binding characteristics. Biochemistry. 1994 Dec; 33(49):14707-13. doi: 10.1021/bi00253a008. [PMID: 7993899]
  • D A Fadool, B W Ache. Inositol 1,3,4,5-tetrakisphosphate-gated channels interact with inositol 1,4,5-trisphosphate-gated channels in olfactory receptor neurons. Proceedings of the National Academy of Sciences of the United States of America. 1994 Sep; 91(20):9471-5. doi: 10.1073/pnas.91.20.9471. [PMID: 7937791]
  • S G Ward, D Lampe, C Liu, B V Potter, J Westwick. Calcium release activity and metabolism of inositol 1,4,5-trisphosphate in T cells. Modulation by novel inositol 1,4,5-trisphosphate 5-phosphatase inhibitors. European journal of biochemistry. 1994 Jun; 222(2):515-23. doi: 10.1111/j.1432-1033.1994.tb18893.x. [PMID: 8020489]
  • P J Cullen, Y Patel, V V Kakkar, R F Irvine, K S Authi. Specific binding sites for inositol 1,3,4,5-tetrakisphosphate are located predominantly in the plasma membranes of human platelets. The Biochemical journal. 1994 Mar; 298 Pt 3(?):739-42. doi: 10.1042/bj2980739. [PMID: 8141791]
  • J W Putney, G S Bird. The inositol phosphate-calcium signalling system in lacrimal gland cells. Advances in experimental medicine and biology. 1994; 350(?):115-9. doi: 10.1007/978-1-4615-2417-5_20. [PMID: 8030462]
  • P Koppler, N Matter, A N Malviya. Evidence for stereospecific inositol 1,3,4,5-[3H]tetrakisphosphate binding sites on rat liver nuclei. Delineating inositol 1,3,4,5-tetrakisphosphate interaction in nuclear calcium signaling process. The Journal of biological chemistry. 1993 Dec; 268(35):26248-52. doi: NULL. [PMID: 8253746]
  • M L Contreras. Nerve growth factor stimulates the production of inositol 1,3,4- and 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in PC12 cells. Journal of neurochemistry. 1993 Sep; 61(3):1035-42. doi: 10.1111/j.1471-4159.1993.tb03617.x. [PMID: 8360670]
  • K Enomoto, K Furuya, S Yamagishi, T Maeno. Proliferation-associated increase in sensitivity of mammary epithelial cells to inositol-1,4,5-trisphosphate. Cell biochemistry and function. 1993 Mar; 11(1):55-62. doi: 10.1002/cbf.290110107. [PMID: 8453737]
  • A H Guse, E Roth, F Emmrich. D-myo-inositol 1,3,4,5-tetrakisphosphate releases Ca2+ from crude microsomes and enriched vesicular plasma membranes, but not from intracellular stores of permeabilized T-lymphocytes and monocytes. The Biochemical journal. 1992 Dec; 288 ( Pt 2)(?):489-95. doi: 10.1042/bj2880489. [PMID: 1463453]
  • C L Fraser, P Sarnacki. Regulation of plasma membrane-bound Ca(2+)-ATPase pump by inositol phosphates in rat brain. The American journal of physiology. 1992 Mar; 262(3 Pt 2):F411-6. doi: 10.1152/ajprenal.1992.262.3.f411. [PMID: 1532692]
  • C H Lee, J F Dixon, M Reichman, C Moummi, G Los, L E Hokin. Li+ increases accumulation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in cholinergically stimulated brain cortex slices in guinea pig, mouse and rat. The increases require inositol supplementation in mouse and rat but not in guinea pig. The Biochemical journal. 1992 Mar; 282 ( Pt 2)(?):377-85. doi: 10.1042/bj2820377. [PMID: 1546953]
  • J Scholz, N Roewer, U Rum, W Schmitz, H Scholz, J Schulte am Esch. Possible involvement of inositol-lipid metabolism in malignant hyperthermia. British journal of anaesthesia. 1991 Jun; 66(6):692-6. doi: 10.1093/bja/66.6.692. [PMID: 2064884]
  • J Ng, J Gustavsson, M Jondal, T Andersson. Regulation of calcium influx across the plasma membrane of the human T-leukemic cell line, JURKAT: dependence on a rise in cytosolic free calcium can be dissociated from formation of inositol phosphates. Biochimica et biophysica acta. 1990 Jun; 1053(1):97-105. doi: 10.1016/0167-4889(90)90031-8. [PMID: 2163689]
  • M E Hodgson, S B Shears. Rat liver contains a potent endogenous inhibitor of inositol 1,3,4,5-tetrakisphosphate 3-phosphatase. The Biochemical journal. 1990 May; 267(3):831-4. doi: 10.1042/bj2670831. [PMID: 2160239]
  • S B Shears. Kinetic consequences of the inhibition by ATP of the metabolism of inositol (1,4,5) trisphosphate and inositol (1,3,4,5) tetrakisphosphate in liver. Different effects upon the 3- and 5-phosphatases. Cellular signalling. 1990; 2(2):191-5. doi: 10.1016/0898-6568(90)90023-4. [PMID: 2169288]
  • S K Joseph, J R Williamson. Inositol polyphosphates and intracellular calcium release. Archives of biochemistry and biophysics. 1989 Aug; 273(1):1-15. doi: 10.1016/0003-9861(89)90156-2. [PMID: 2667466]
  • H Banfić, S Kukolja. Plasma from uninephrectomized rats stimulates production of inositol trisphosphates and inositol tetrakisphosphate in renal cortical slices. The Biochemical journal. 1988 Oct; 255(2):671-6. doi: NULL. [PMID: 2849423]
  • J R Cunha-Melo, N M Dean, J D Moyer, K Maeyama, M A Beaven. The kinetics of phosphoinositide hydrolysis in rat basophilic leukemia (RBL-2H3) cells varies with the type of IgE receptor cross-linking agent used. The Journal of biological chemistry. 1987 Aug; 262(24):11455-63. doi: . [PMID: 3040703]
  • S B Shears, J B Parry, E K Tang, R F Irvine, R H Michell, C J Kirk. Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate. The Biochemical journal. 1987 Aug; 246(1):139-47. doi: 10.1042/bj2460139. [PMID: 2823793]
  • Y Zilberman, L R Howe, J P Moore, T R Hesketh, J C Metcalfe. Calcium regulates inositol 1,3,4,5-tetrakisphosphate production in lysed thymocytes and in intact cells stimulated with concanavalin A. The EMBO journal. 1987 Apr; 6(4):957-62. doi: 10.1002/j.1460-2075.1987.tb04845.x. [PMID: 3297676]
  • R F Irvine, R M Moor. Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+. The Biochemical journal. 1986 Dec; 240(3):917-20. doi: 10.1042/bj2400917. [PMID: 3827881]
  • P T Hawkins, L Stephens, C P Downes. Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate. The Biochemical journal. 1986 Sep; 238(2):507-16. doi: 10.1042/bj2380507. [PMID: 3026354]
  • C A Hansen, S Mah, J R Williamson. Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver. The Journal of biological chemistry. 1986 Jun; 261(18):8100-3. doi: . [PMID: 3487541]
  • Kh Goranov, V Ivanov. [Comparative study of the optimum pH value of serum alkaline phosphatase in various species of farm animals]. Veterinarno-meditsinski nauki. 1975; 12(6):89-93. doi: NULL. [PMID: 5802]
  • . . . . doi: . [PMID: 10983984]
  • . . . . doi: . [PMID: 9430698]
  • . . . . doi: . [PMID: 10866302]