Nepodin (BioDeep_00000000424)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethan-1-one

化学式: C13H12O3 (216.0786402)
中文名称: 1-(1,8-二羟基-3-甲基萘-2-基)乙酮, 羊蹄素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 33%

分子结构信息

SMILES: CC(=O)c1c(C)cc2cccc(O)c2c1O
InChI: InChI=1S/C13H12O3/c1-7-6-9-4-3-5-10(15)12(9)13(16)11(7)8(2)14/h3-6,15-16H,1-2H3

描述信息

Nepodin is a member of naphthols.
Nepodin is a natural product found in Rumex dentatus, Rumex alpinus, and other organisms with data available.
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

同义名列表

17 个代谢物同义名

1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethan-1-one; Ethanone, 1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)-; 1-(1,8-Dihydroxy-3-methyl-naphthalen-2-yl)-ethanone; 1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)-ethanone; 1-(1,8-dihydroxy-3-methyl-naphthalen-2-yl)ethanone; 1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethanone; 1-(1,8-Dihydroxy-3-methyl-2-naphthalenyl)ethanone; 1-(1,8-dihydroxy-3-methyl-2-naphthyl)ethanone; 2-Acetyl-1,8-dihydroxy-3-methylnaphthalene; 2-ACETONAPHTHONE, 1,8-DIHYDROXY-3-METHYL-; UNII-XST9SRR6X4; dianellidin; XST9SRR6X4; AC1L2PGU; MUSIZINE; Nepodin; Musizin



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

66 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jin-Hyung Lee, Yong-Guy Kim, Sagar Kiran Khadke, Aki Yamano, Akio Watanabe, Jintae Lee. Inhibition of Biofilm Formation by Candida albicans and Polymicrobial Microorganisms by Nepodin via Hyphal-Growth Suppression. ACS infectious diseases. 2019 07; 5(7):1177-1187. doi: 10.1021/acsinfecdis.9b00033. [PMID: 31055910]
  • Motoyasu Minami, Takako Mori, Takayuki Yonezawa, Yukiko Saito, Toshiaki Teruya, Je-Tae Woo. Evaluation of raw nepodin extraction from Rumex japonicus and R. obtusifolius and their DNA polymorphisms. Journal of natural medicines. 2018 Jan; 72(1):369-374. doi: 10.1007/s11418-017-1143-0. [PMID: 29063361]
  • Byung Geun Ha, Takayuki Yonezawa, Myoung Jin Son, Je Tae Woo, Shinsuke Ohba, Ung-Il Chung, Kazumi Yagasaki. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. BioFactors (Oxford, England). 2014 Jul; 40(4):436-47. doi: 10.1002/biof.1165. [PMID: 24756979]
  • Keyong Ho Lee, Ki-Hyeong Rhee. Antimalarial activity of nepodin isolated from Rumex crispus. Archives of pharmacal research. 2013 Apr; 36(4):430-5. doi: 10.1007/s12272-013-0055-0. [PMID: 23440579]
  • Mi-Young Yoon, Nam Hee Choi, Byung Sun Min, Gyung Ja Choi, Yong Ho Choi, Kyoung Soo Jang, Seong-Sook Han, Byeongjin Cha, Jin-Cheol Kim. Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii. Journal of agricultural and food chemistry. 2011 Nov; 59(22):12210-6. doi: 10.1021/jf2039185. [PMID: 21992072]