acetohexamide (BioDeep_00000413078)

Main id: BioDeep_00000006351

 


代谢物信息卡片


acetohexamide

化学式: C15H20N2O4S (324.1144)
中文名称: 乙酰己酰胺
谱图信息: 最多检出来源 Homo sapiens(urine) 27.78%

分子结构信息

SMILES: CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1
InChI: InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

描述信息

A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BB - Sulfonylureas
C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C97936 - Sulfonylurea Antidiabetic Agent
D007004 - Hypoglycemic Agents
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4168; ORIGINAL_PRECURSOR_SCAN_NO 4165
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4170; ORIGINAL_PRECURSOR_SCAN_NO 4165
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4125; ORIGINAL_PRECURSOR_SCAN_NO 4121
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4143; ORIGINAL_PRECURSOR_SCAN_NO 4140
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4151; ORIGINAL_PRECURSOR_SCAN_NO 4150
ORIGINAL_PRECURSOR_SCAN_NO 4163; CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4165
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4165; ORIGINAL_PRECURSOR_SCAN_NO 4163
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8394; ORIGINAL_PRECURSOR_SCAN_NO 8389
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8413; ORIGINAL_PRECURSOR_SCAN_NO 8409
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8458; ORIGINAL_PRECURSOR_SCAN_NO 8454
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8489; ORIGINAL_PRECURSOR_SCAN_NO 8485
CONFIDENCE standard compound; INTERNAL_ID 894; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8471; ORIGINAL_PRECURSOR_SCAN_NO 8468

同义名列表

2 个代谢物同义名

acetohexamide; Acetohexamide



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AHR, AKR1C3, AKR1C4, ALB, CBR1, IFI44, IFI44L, MX1, MYL2, OAS1
Peripheral membrane protein 1 MX1
Endoplasmic reticulum membrane 4 HSD11B1, IFI6, MX1, RSAD2
Nucleus 5 AHR, AKR1C3, ALB, MX1, OAS1
cytosol 12 AHR, AKR1A1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALB, CBR1, MX1, MYL2, OAS1, PXN
mitochondrial membrane 1 IFI6
centrosome 1 ALB
nucleoplasm 2 AHR, OAS1
lamellipodium 1 PXN
Multi-pass membrane protein 1 IFI6
Synapse 1 AKR1A1
cell cortex 1 PXN
Golgi apparatus 2 ALB, RSAD2
Golgi membrane 1 INS
mitochondrial inner membrane 2 IFI6, RSAD2
Cytoplasm, cytosol 4 AKR1A1, AKR1C1, AKR1C2, AKR1C4
plasma membrane 3 IFI6, IFNLR1, PXN
Membrane 5 HSD11B1, IFI6, IFNLR1, MX1, OAS1
apical plasma membrane 1 AKR1A1
extracellular exosome 6 AKR1A1, AKR1C1, AKR1C3, AKR1C4, ALB, CBR1
endoplasmic reticulum 3 ALB, OAS1, RSAD2
extracellular space 3 AKR1A1, ALB, INS
perinuclear region of cytoplasm 1 MX1
mitochondrion 3 IFI6, OAS1, RSAD2
protein-containing complex 2 AHR, ALB
intracellular membrane-bounded organelle 1 HSD11B1
Single-pass type I membrane protein 1 IFNLR1
Secreted 4 ALB, DHRS11, INS, OAS1
extracellular region 4 ALB, DHRS11, INS, OAS1
mitochondrial outer membrane 1 RSAD2
anchoring junction 1 ALB
transcription regulator complex 1 AHR
nuclear membrane 1 MX1
Extracellular vesicle 1 CBR1
cell-cell junction 1 PXN
Single-pass type II membrane protein 1 HSD11B1
Apical cell membrane 1 AKR1A1
Cytoplasm, perinuclear region 1 MX1
Mitochondrion inner membrane 1 IFI6
Cell junction, focal adhesion 1 PXN
Cytoplasm, cytoskeleton 1 PXN
focal adhesion 1 PXN
microtubule 1 MX1
myofibril 1 MYL2
sarcomere 1 MYL2
ciliary basal body 1 ALB
chromatin 1 AHR
microtubule associated complex 1 PXN
cytoskeleton 2 MYL2, PXN
centriole 1 ALB
spindle pole 1 ALB
Cytoplasm, cell cortex 1 PXN
blood microparticle 1 ALB
fibrillar center 1 RSAD2
endosome lumen 1 INS
Lipid droplet 1 RSAD2
aryl hydrocarbon receptor complex 1 AHR
myosin complex 1 MYL2
stress fiber 1 PXN
Microsome 1 OAS1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 2]: Cytoplasm 1 MX1
A band 1 MYL2
ribosome 1 OAS1
cardiac myofibril 1 MYL2
Cytoplasm, myofibril, sarcomere, A band 1 MYL2
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1


文献列表

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  • Agnieszka Szkudlarek, Michał Wilk, Małgorzata Maciążek-Jurczyk. In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid. Molecules (Basel, Switzerland). 2020 May; 25(10):. doi: 10.3390/molecules25102340. [PMID: 32429512]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions. 2019 May; 305(?):12-20. doi: 10.1016/j.cbi.2019.03.026. [PMID: 30926317]
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