Vitamin K (BioDeep_00000004129)

 

Secondary id: BioDeep_00000017491

PANOMIX_OTCML-2023 natural product BioNovoGene_Lab2019


代谢物信息卡片


2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione

化学式: C31H46O2 (450.3498)
中文名称: 维生素K, 维他命K, 维生素K1, 维生素 K1
谱图信息: 最多检出来源 Viridiplantae(plant) 1.24%

分子结构信息

SMILES: CC(=CCC1=C(C)C(=O)c2ccccc2C1=O)CCCC(C)CCCC(C)CCCC(C)C
InChI: InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+

描述信息

D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
D050299 - Fibrin Modulating Agents > D000933 - Antifibrinolytic Agents
D018977 - Micronutrients > D014815 - Vitamins
Widely distributed in green leaves and vegetables, especies cabbage and spinach. Infant formula fortifier. Phytomenadione is found in many foods, some of which are swiss chard, fruit salad, milk (cow), and common buckwheat.
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

同义名列表

10 个代谢物同义名

Vitamin K; Phytomenadione; 2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione; 2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione; 2-Methyl-3-phytyl-1,4-naphthoquinone; Phylloquinone; Phytonadione; Vitamin K1; Phylloquinone; Vitamin K



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

10 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(6)

  • vitamin K-epoxide cycle: H+ + H2O + a [protein] 4-carboxy-L-glutamate + vitamin K 2,3-epoxide ⟶ CO2 + O2 + a [protein]-α-L-glutamate + phylloquinol
  • vitamin K-epoxide cycle: a reduced thioredoxin + phylloquinone ⟶ an oxidized thioredoxin + phylloquinol
  • menaquinol-4 biosynthesis II: H+ + NADH + menadione ⟶ NAD+ + menadiol
  • menaquinol-4 biosynthesis II: H2O + phylloquinone ⟶ menadione + phytol
  • vitamin K degradation: O2 + a reduced [NADPH-hemoprotein reductase] + phylloquinone ⟶ ω-hydroxyphylloquinone + H2O + an oxidized [NADPH-hemoprotein reductase]
  • vitamin K degradation: O2 + a reduced [NADPH-hemoprotein reductase] + phylloquinone ⟶ ω-hydroxyphylloquinone + H2O + an oxidized [NADPH-hemoprotein reductase]

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(4)

  • Vitamin K Metabolism: Carbon dioxide + Oxygen + Peptidyl-4-carboxyglutamate + Phylloquinol ⟶ Peptidyl-glutamate + Vitamin K1 2,3-epoxide + Water
  • Vitamin K Metabolism: Carbon dioxide + Oxygen + Reduced Vitamin K (phylloquinone) + Unknown ⟶ Unknown + Vitamin K1 2,3-epoxide + Water
  • Vitamin K Metabolism: Oxidized dithiothreitol + Vitamin K1 ⟶ 1,4-Dithiothreitol + Vitamin K1 2,3-epoxide
  • Vitamin K Metabolism: Oxidized dithiothreitol + Vitamin K1 ⟶ 1,4-Dithiothreitol + Vitamin K1 2,3-epoxide

PharmGKB(0)

25 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 APOE, CASP3, CYP2C9, CYP3A4, CYP4F2, GLA, MERTK, NQO1
Peripheral membrane protein 2 CYP4F2, HSD17B6
Endoplasmic reticulum membrane 6 CYP2C9, CYP3A4, CYP4F2, GLA, PROS1, TYRO3
Nucleus 4 APOE, CASP3, NQO1, TYRO3
cytosol 2 CASP3, NQO1
dendrite 2 APOE, NQO1
nucleoplasm 1 CASP3
Cell membrane 3 MERTK, P2RY12, TYRO3
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 P2RY12
Synapse 1 NQO1
cell surface 2 P2RY12, TYRO3
glutamatergic synapse 2 APOE, CASP3
Golgi apparatus 2 APOE, GLA
Golgi membrane 1 PROS1
neuronal cell body 3 APOE, CASP3, NQO1
Cytoplasm, cytosol 1 NQO1
Lysosome 1 GLA
plasma membrane 11 APOE, CYP2C9, F2, F7, F8, F9, MERTK, P2RY12, PROS1, TNFRSF11B, TYRO3
Membrane 9 APOE, CYP3A4, CYP4F2, F8, GLA, MERTK, NQO1, P2RY12, TYRO3
apical plasma membrane 1 CYP4F2
extracellular exosome 7 APOE, F2, F9, GLA, PROS1, TTR, VWF
Lumenal side 1 HSD17B6
endoplasmic reticulum 4 APOE, HSD17B6, PROS1, VWF
extracellular space 11 APOE, F2, F7, F8, F9, IL6, MERTK, PROS1, TNFRSF11B, TTR, VWF
lysosomal lumen 1 GLA
intracellular membrane-bounded organelle 4 CYP2C9, CYP3A4, CYP4F2, HSD17B6
Microsome membrane 4 CYP2C9, CYP3A4, CYP4F2, HSD17B6
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 MERTK, TYRO3
Secreted 9 APOE, F2, F7, F9, IL6, PROS1, TNFRSF11B, TTR, VWF
extracellular region 11 APOE, F2, F7, F8, F9, GLA, IL6, PROS1, TNFRSF11B, TTR, VWF
photoreceptor outer segment 1 MERTK
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 2 APOE, VWF
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
Early endosome 1 APOE
COPII-coated ER to Golgi transport vesicle 1 F8
vesicle 1 F7
extracellular matrix 3 APOE, TNFRSF11B, VWF
collagen-containing extracellular matrix 5 APOE, F2, F7, F9, VWF
receptor complex 3 MERTK, TNFRSF11B, TYRO3
Secreted, extracellular space 1 APOE
blood microparticle 3 APOE, F2, PROS1
nuclear envelope 1 TYRO3
Melanosome 1 APOE
platelet alpha granule 1 VWF
Golgi lumen 5 F2, F7, F8, F9, PROS1
endoplasmic reticulum lumen 6 APOE, F2, F7, F8, F9, IL6
platelet alpha granule lumen 3 F8, PROS1, VWF
azurophil granule lumen 2 GLA, TTR
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 F8, GLA
clathrin-coated endocytic vesicle membrane 1 APOE
endoplasmic reticulum-Golgi intermediate compartment 1 GLA
synaptic cleft 1 APOE
death-inducing signaling complex 1 CASP3
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
Weibel-Palade body 1 VWF
interleukin-6 receptor complex 1 IL6
serine-type peptidase complex 1 F7
cell body membrane 1 P2RY12
cell projection membrane 1 P2RY12


文献列表

  • HaoLiang Zhang, Shiqin Chen, QianYuan Zhu, ZongShan Li, Tian Lv, Chengjiang Liu. Mechanical Thrombectomy in Anticoagulated Patients With Acute Ischemic Stroke: A Meta-Analysis. The neurologist. 2024 May; 29(3):194-203. doi: 10.1097/nrl.0000000000000542. [PMID: 38019090]
  • Vasiliki Adamopoulou, Argyro Bekatorou, Vasilios Brinias, Panagiota Michalopoulou, Charalampos Dimopoulos, John Zafeiropoulos, Theano Petsi, Athanasios A Koutinas. Optimization of bacterial cellulose production by Komagataeibacter sucrofermentans in synthetic media and agrifood side streams supplemented with organic acids and vitamins. Bioresource technology. 2024 Apr; 398(?):130511. doi: 10.1016/j.biortech.2024.130511. [PMID: 38437963]
  • Diana Moldovan, Crina Rusu, Alina Potra, Dacian Tirinescu, Maria Ticala, Ina Kacso. Food to Prevent Vascular Calcification in Chronic Kidney Disease. Nutrients. 2024 Feb; 16(5):. doi: 10.3390/nu16050617. [PMID: 38474744]
  • Natália Gonçalves Silva, Marco Preto, Vitor Vasconcelos, Ralph Urbatzka. Reduction of neutral lipid reservoirs, bioconversion and untargeted metabolomics reveal distinct roles for vitamin K isoforms on lipid metabolism. Food & function. 2024 Feb; 15(4):2170-2180. doi: 10.1039/d3fo02915h. [PMID: 38312068]
  • Qiu-Yan Zhao, Qiu Li, Minoo Hasan Rashedi, Mohammadhassan Sohouli, Pejman Rohani, Periyannan Velu. The effect of vitamin K supplementation on cardiovascular risk factors: a systematic review and meta-analysis. Journal of nutritional science. 2024; 13(?):e3. doi: 10.1017/jns.2023.106. [PMID: 38282652]
  • Lenka Vlasatikova, Michal Zeman, Magdalena Crhanova, Jitka Matiasovicova, Daniela Karasova, Marcela Faldynova, Hana Prikrylova, Alena Sebkova, Ivan Rychlik. Colonization of chickens with competitive exclusion products results in extensive differences in metabolite composition in cecal digesta. Poultry science. 2024 Jan; 103(1):103217. doi: 10.1016/j.psj.2023.103217. [PMID: 37980752]
  • Ateequr Rehman, Van Pham, Nicole Seifert, Nathalie Richard, Wilbert Sybesma, Robert E Steinert. The Polyunsaturated Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid, and Vitamin K1 Modulate the Gut Microbiome: A Study Using an In Vitro Shime Model. Journal of dietary supplements. 2024; 21(2):135-153. doi: 10.1080/19390211.2023.2198007. [PMID: 37078491]
  • Roseani da Silva Andrade, Fabíola Isabel Suano de Souza, Carolina Sanchez Aranda, Marcia Carvalho Mallozi, Ariel Cordeiro Ferreira, Talita Lemos Neves Barreto, Fernando Luiz Affonso Fonseca, Roseli Oselka Saccardo Sarni, Dirceu Solé. Antioxidant defense of children and adolescents with atopic dermatitis: Association with disease severity. Allergologia et immunopathologia. 2024; 52(1):65-70. doi: 10.15586/aei.v52i1.933. [PMID: 38186195]
  • Anqi Chen, Jialu Li, Nianxuan Shen, Haifeng Huang, Qinglei Hang. Vitamin K: New insights related to senescence and cancer metastasis. Biochimica et biophysica acta. Reviews on cancer. 2023 Dec; 1879(2):189057. doi: 10.1016/j.bbcan.2023.189057. [PMID: 38158025]
  • Camelia Munteanu, Betty Schwartz. B Vitamins, Glucoronolactone and the Immune System: Bioavailability, Doses and Efficiency. Nutrients. 2023 Dec; 16(1):. doi: 10.3390/nu16010024. [PMID: 38201854]
  • Éva Szabó, Ildikó Csölle, Regina Felső, Daniela Kuellenberg de Gaudry, Patrick Nyamemba Nyakundi, Kazahyet Ibrahim, Maria-Inti Metzendorf, Tamás Ferenci, Szimonetta Lohner. Benefits and Harms of Edible Vegetable Oils and Fats Fortified with Vitamins A and D as a Public Health Intervention in the General Population: A Systematic Review of Interventions. Nutrients. 2023 Dec; 15(24):. doi: 10.3390/nu15245135. [PMID: 38140394]
  • Amani M Ali, Maggie M Abbassi, Nirmeen A Sabry, May Fawzi, Shrook Mousa. The effect of vitamin K4 supplementation on insulin resistance in individuals with type 2 diabetes: a double-blind randomised placebo-controlled clinical trial. European journal of nutrition. 2023 Dec; 62(8):3241-3249. doi: 10.1007/s00394-023-03215-8. [PMID: 37552330]
  • Dries S Martens, De-Wei An, Yu-Ling Yu, Babangida S Chori, Congrong Wang, Ana Inês Silva, Fang-Fei Wei, Chen Liu, Katarzyna Stolarz-Skrzypek, Marek Rajzer, Agnieszka Latosinska, Harald Mischak, Jan A Staessen, Tim S Nawrot. Association of Air Pollution with a Urinary Biomarker of Biological Aging and Effect Modification by Vitamin K in the FLEMENGHO Prospective Population Study. Environmental health perspectives. 2023 Dec; 131(12):127011. doi: 10.1289/ehp13414. [PMID: 38078706]
  • Jiameng Liu, Luqi Qin, Jiahuan Zheng, Litao Tong, Wei Lu, Cong Lu, Jing Sun, Bei Fan, Fengzhong Wang. Research Progress on the Relationship between Vitamins and Diabetes: Systematic Review. International journal of molecular sciences. 2023 Nov; 24(22):. doi: 10.3390/ijms242216371. [PMID: 38003557]
  • Karina A Pedroza-García, Gabriela Careaga-Cárdenas, Carmen Díaz-Galindo, J Luis Quintanar, Irma Hernández-Jasso, Ricardo E Ramírez-Orozco. Bioactive role of vitamins as a key modulator of oxidative stress, cellular damage and comorbidities associated with spinal cord injury (SCI). Nutritional neuroscience. 2023 Nov; 26(11):1120-1137. doi: 10.1080/1028415x.2022.2133842. [PMID: 36537581]
  • María Ciudad-Mulero, Laura Domínguez, Patricia Morales, Virginia Fernández-Ruiz, Montaña Cámara. A Review of Foods of Plant Origin as Sources of Vitamins with Proven Activity in Oxidative Stress Prevention according to EFSA Scientific Evidence. Molecules (Basel, Switzerland). 2023 Oct; 28(21):. doi: 10.3390/molecules28217269. [PMID: 37959689]
  • Alexandru Vasile Rusu, Monica Trif, João Miguel Rocha. Microbial Secondary Metabolites via Fermentation Approaches for Dietary Supplementation Formulations. Molecules (Basel, Switzerland). 2023 Aug; 28(16):. doi: 10.3390/molecules28166020. [PMID: 37630272]
  • Toshitaka Nakamura, Clara Hipp, André Santos Dias Mourão, Jan Borggräfe, Maceler Aldrovandi, Bernhard Henkelmann, Jonas Wanninger, Eikan Mishima, Elena Lytton, David Emler, Bettina Proneth, Michael Sattler, Marcus Conrad. Phase separation of FSP1 promotes ferroptosis. Nature. 2023 Jul; 619(7969):371-377. doi: 10.1038/s41586-023-06255-6. [PMID: 37380771]
  • Zhaofang Li, Yajing Li, Yijing Hou, Yahui Fan, Hong Jiang, Baoyu Li, Hailu Zhu, Yaning Liu, Lei Zhang, Jie Zhang, Min Wu, Tianyou Ma, Tong Zhao, Le Ma. Association of Plasma Vitamins and Carotenoids, DNA Methylation of LCAT, and Risk of Age-Related Macular Degeneration. Nutrients. 2023 Jun; 15(13):. doi: 10.3390/nu15132985. [PMID: 37447314]
  • Eikan Mishima, Adam Wahida, Tobias Seibt, Marcus Conrad. Diverse biological functions of vitamin K: from coagulation to ferroptosis. Nature metabolism. 2023 Jun; ?(?):. doi: 10.1038/s42255-023-00821-y. [PMID: 37337123]
  • Clement G Yedjou, Jameka Grigsby, Ariane Mbemi, Daryllynn Nelson, Bryan Mildort, Lekan Latinwo, Paul B Tchounwou. The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24109085. [PMID: 37240430]
  • Khushnuma Saleem, Tariq Aziz, Ayaz Ali Khan, Ali Muhammad, Shafiq Ur Rahman, Metab Alharbi, Abdulrahman Alshammari, Abdullah F Alasmari. Evaluating the in-vivo effects of olive oil, soya bean oil, and vitamins against oxidized ghee toxicity. Acta biochimica Polonica. 2023 May; 70(2):305-312. doi: 10.18388/abp.2020_6549. [PMID: 37163731]
  • Oladapo F Fagbohun, Caroline R Gillies, Kieran P J Murphy, H P Vasantha Rupasinghe. Role of Antioxidant Vitamins and Other Micronutrients on Regulations of Specific Genes and Signaling Pathways in the Prevention and Treatment of Cancer. International journal of molecular sciences. 2023 Mar; 24(7):. doi: 10.3390/ijms24076092. [PMID: 37047063]
  • Alireza Ekhlasian, Ebrahim Eftekhar, Sajedeh Daei, Roghayeh Abbasalipourkabir, Alireza Nourian, Nasrin Ziamajidi. The antioxidant and anti-apoptotic properties of vitamins A, C and E in heart tissue of rats exposed to zinc oxide nanoparticles. Molecular biology reports. 2023 Mar; 50(3):2357-2365. doi: 10.1007/s11033-022-08103-8. [PMID: 36580195]
  • Saša Đurović, Darko Micić, Saša Šorgić, Saša Popov, Uroš Gašić, Tomislav Tosti, Marija Kostić, Yulia A Smyatskaya, Stevan Blagojević, Zoran Zeković. Recovery of Polyphenolic Compounds and Vitamins from the Stinging Nettle Leaves: Thermal and Behavior and Biological Activity of Obtained Extracts. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052278. [PMID: 36903524]
  • Jiayue Xia, Junhui Yu, Hai Xu, Yuhao Zhou, Hui Li, Shiyu Yin, Dengfeng Xu, Yuanyuan Wang, Hui Xia, Wang Liao, Shaokang Wang, Guiju Sun. Comparative effects of vitamin and mineral supplements in the management of type 2 diabetes in primary care: A systematic review and network meta-analysis of randomized controlled trials. Pharmacological research. 2023 Feb; 188(?):106647. doi: 10.1016/j.phrs.2023.106647. [PMID: 36638933]
  • Cristiane Hermes Sales, Mariane de Mello Fontanelli, Marcelo Macedo Rogero, Flávia Mori Sarti, Regina Mara Fisberg. Dietary inadequacies overestimate the blood deficiencies of magnesium, zinc, and vitamins A, C, E, and D among residents of Sao Paulo. Clinical nutrition ESPEN. 2023 02; 53(?):196-205. doi: 10.1016/j.clnesp.2022.12.015. [PMID: 36657914]
  • Sergio Moreno-Nombela, Javier Romero-Parra, Francisco Javier Ruiz-Ojeda, Patricio Solis-Urra, Aiman Tariq Baig, Julio Plaza-Diaz. Genome Editing and Protein Energy Malnutrition. Advances in experimental medicine and biology. 2023; 1396(?):215-232. doi: 10.1007/978-981-19-5642-3_15. [PMID: 36454470]
  • Chunli Fan, Tingting Feng, Xingwei Wang, Shuqin Xia, Caleb John Swing. Liposomes for encapsulation of liposoluble vitamins (A, D, E and K): Comparation of loading ability, storage stability and bilayer dynamics. Food research international (Ottawa, Ont.). 2023 01; 163(?):112264. doi: 10.1016/j.foodres.2022.112264. [PMID: 36596175]
  • Guicun Yang, Nianrong Wang, Hao Liu, Lina Si, Yan Zhao. The association between umbilical cord blood fat-soluble vitamin concentrations and infant birth weight. Frontiers in endocrinology. 2023; 14(?):1048615. doi: 10.3389/fendo.2023.1048615. [PMID: 37810886]
  • Wei-Li Kong, Xin-Rong Lu, Lin-Lin Hou, Xiu-Fa Sun, Gui-Qin Sun, Li Chen. [Vitamins and Immune System Health]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2023 Jan; 54(1):7-13. doi: 10.12182/20230160107. [PMID: 36647636]
  • Muhammad Zahoor Khan, Bingjian Huang, Xiyan Kou, Yinghui Chen, Huili Liang, Qudrat Ullah, Ibrar Muhammad Khan, Adnan Khan, Wenqiong Chai, Changfa Wang. Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis. Frontiers in immunology. 2023; 14(?):1290044. doi: 10.3389/fimmu.2023.1290044. [PMID: 38259482]
  • Tommaso Cai, Luca Gallelli, Erika Cione, Paolo Verze, Alessandro Palmieri, Vincenzo Mirone, Gernot Bonkat, Florian M Wagenlehner, Truls E Bjerklund Johansen. The efficacy and tolerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study. Minerva urology and nephrology. 2022 Dec; 74(6):780-788. doi: 10.23736/s2724-6051.21.04141-2. [PMID: 33781014]
  • Huaying Song, Zhufeng Cong, Changlin Wang, Mengyuan He, Congying Liu, Peng Gao. Research progress on Walnut oil: Bioactive compounds, health benefits, extraction methods, and medicinal uses. Journal of food biochemistry. 2022 12; 46(12):e14504. doi: 10.1111/jfbc.14504. [PMID: 36369998]
  • Birgitta Ryback, Miriam Bortfeld-Miller, Julia A Vorholt. Metabolic adaptation to vitamin auxotrophy by leaf-associated bacteria. The ISME journal. 2022 12; 16(12):2712-2724. doi: 10.1038/s41396-022-01303-x. [PMID: 35987782]
  • Toshinobu Hondo, Chihiro Ota, Yumi Miyake, Hiroshi Furutani, Michisato Toyoda. Microscale supercritical fluid extraction combined with supercritical fluid chromatography and proton-transfer-reaction ionization time-of-flight mass spectrometry for a magnitude lower limit of quantitation of lipophilic compounds. Journal of chromatography. A. 2022 Oct; 1682(?):463495. doi: 10.1016/j.chroma.2022.463495. [PMID: 36126560]
  • Tal Hirschhorn, Brent R Stockwell. Vitamin K: A new guardian against ferroptosis. Molecular cell. 2022 10; 82(20):3760-3762. doi: 10.1016/j.molcel.2022.10.001. [PMID: 36270246]
  • Xinyang Li, Yingyi Mao, Shuang Liu, Jin Wang, Xiang Li, Yanrong Zhao, David R Hill, Shuo Wang. Vitamins, Vegetables and Metal Elements Are Positively Associated with Breast Milk Oligosaccharide Composition among Mothers in Tianjin, China. Nutrients. 2022 Oct; 14(19):. doi: 10.3390/nu14194131. [PMID: 36235783]
  • Melanie P Muller, James H Morrissey, Emad Tajkhorshid. Molecular View into Preferential Binding of the Factor VII Gla Domain to Phosphatidic Acid. Biochemistry. 2022 08; 61(16):1694-1703. doi: 10.1021/acs.biochem.2c00266. [PMID: 35853076]
  • Vincenzo Russo, Roberta Bottino, Antonello D'Andrea, Angelo Silverio, Marco Di Maio, Paolo Golino, Gerardo Nigro, Orazio Valsecchi, Emilio Attena, Mario Enrico Canonico, Gennaro Galasso, Guido Parodi, Fernando Scudiero. Chronic Oral Anticoagulation and Clinical Outcome in Hospitalized COVID-19 Patients. Cardiovascular drugs and therapy. 2022 Aug; 36(4):705-712. doi: 10.1007/s10557-021-07194-y. [PMID: 33988835]
  • Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-Ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, Bettina Proneth, Derek A Pratt, Marcus Conrad. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature. 2022 08; 608(7924):778-783. doi: 10.1038/s41586-022-05022-3. [PMID: 35922516]
  • Shaughn Nalezinski. Methods to Correct Drug-Induced Coagulopathy in Bleeding Emergencies: A Comparative Review. Laboratory medicine. 2022 Jul; 53(4):336-343. doi: 10.1093/labmed/lmab115. [PMID: 35073576]
  • Lin Li, Min Dai, Yingying Fu. Non-vitamin K antagonist oral anticoagulants (NOACs) in preventing thromboembolism in atrial fibrillation patients with moderate to severe mitral stenosis: Results from a pilot trial. International journal of cardiology. 2022 07; 358(?):58. doi: 10.1016/j.ijcard.2022.04.029. [PMID: 35417739]
  • Sajidah Alkhameys, Ravina Barrett. Impact of the COVID-19 pandemic on England's national prescriptions of oral vitamin K antagonist (VKA) and direct-acting oral anticoagulants (DOACs): an interrupted time series analysis (January 2019-February 2021). Current medical research and opinion. 2022 Jul; 38(7):1081-1092. doi: 10.1080/03007995.2022.2078100. [PMID: 35582854]
  • Bodil Roth, Ewa Larsson, Bodil Ohlsson. Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome. Journal of gastroenterology and hepatology. 2022 Jul; 37(7):1253-1262. doi: 10.1111/jgh.15830. [PMID: 35304769]
  • Nicole E Lock, Alexandra A Sawyer, Linda Wise, Jatinder Bhatia, Brian K Stansfield. Vitamin K and ECMO for neonatal hypoxic respiratory failure. Perfusion. 2022 07; 37(5):484-492. doi: 10.1177/02676591211003870. [PMID: 33761796]
  • Takahiro Sakai, Hirohiko Motoki, Aya Fuchida, Takahiro Takeuchi, Kyuhachi Otagiri, Masafumi Kanai, Kazuhiro Kimura, Masatoshi Minamisawa, Koji Yoshie, Tatsuya Saigusa, Soichiro Ebisawa, Ayako Okada, Hiroshi Kitabayashi, Koichiro Kuwahara. Comparison of prognostic impact of anticoagulants in heart failure patients with atrial fibrillation and renal dysfunction: direct oral anticoagulants versus vitamin K antagonists. Heart and vessels. 2022 Jul; 37(7):1232-1241. doi: 10.1007/s00380-022-02027-w. [PMID: 35064298]
  • Karin Willeit, Peter Santer, Lena Tschiderer, Raimund Pechlaner, Cees Vermeer, Johann Willeit, Stefan Kiechl. Association of desphospho-uncarboxylated matrix gla protein with incident cardiovascular disease and all-cause mortality: Results from the prospective Bruneck Study. Atherosclerosis. 2022 07; 353(?):20-27. doi: 10.1016/j.atherosclerosis.2022.06.1017. [PMID: 35764030]
  • David Card, Ella Freke, Dominic Harrington. Characterization and traceability of two generations of standard reference material for the measurement of vitamin K1 (phylloquinone) at endogenous concentrations in human plasma and serum. Biomedical chromatography : BMC. 2022 Jul; 36(7):e5378. doi: 10.1002/bmc.5378. [PMID: 35368089]
  • Andreas Meinitzer, Dietmar Enko, Sieglinde Zelzer, Florian Prüller, Nerea Alonso, Eva Fritz-Petrin, Markus Herrmann. Development of a liquid chromatography mass spectrometry method for the determination of vitamin K1, menaquinone-4, menaquinone-7 and vitamin K1-2,3 epoxide in serum of individuals without vitamin K supplements. Clinical chemistry and laboratory medicine. 2022 06; 60(7):1011-1019. doi: 10.1515/cclm-2022-0192. [PMID: 35427444]
  • Daan Kremer, Dion Groothof, Charlotte A Keyzer, Coby Eelderink, Tim J Knobbe, Adrian Post, Marco van Londen, Michele F Eisenga, TransplantLines Investigators, Leon J Schurgers, Stefan P Berger, Martin H de Borst, Stephan J L Bakker. Reply to Janssen et al. Comment on 'Kremer et al. Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies. Nutrients 2021, 13, 3069'. Nutrients. 2022 Jun; 14(12):. doi: 10.3390/nu14122440. [PMID: 35745170]
  • Rob Janssen, Jona Walk, Cees Vermeer. Comment on Kremer et al. Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies. Nutrients 2021, 13, 3069. Nutrients. 2022 Jun; 14(12):. doi: 10.3390/nu14122439. [PMID: 35745169]
  • Cheng Xu, Yang Cunqing, Gu Chun, Wu Min, Li Jun, Hou Xueyun, Fei Jiaxin, Sun Li, An Cheng, Liu Guijian, Shi Fengxiang, Pang Bo. The relationship between serum vitamin K concentration and coronary artery calcification in middle-aged and elderly people. Clinica chimica acta; international journal of clinical chemistry. 2022 Jun; 531(?):325-330. doi: 10.1016/j.cca.2022.04.1001. [PMID: 35504322]
  • Radwa El Borolossy, Mohamed Samy El-Farsy. The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. A randomized controlled trial. European journal of clinical nutrition. 2022 Jun; 76(6):848-854. doi: 10.1038/s41430-021-01050-w. [PMID: 34845313]
  • Federica Bellone, Maria Cinquegrani, Ramona Nicotera, Nazareno Carullo, Alessandro Casarella, Pierangela Presta, Michele Andreucci, Giovanni Squadrito, Giuseppe Mandraffino, Marcello Prunestì, Cristina Vocca, Giovambattista De Sarro, Davide Bolignano, Giuseppe Coppolino. Role of Vitamin K in Chronic Kidney Disease: A Focus on Bone and Cardiovascular Health. International journal of molecular sciences. 2022 May; 23(9):. doi: 10.3390/ijms23095282. [PMID: 35563672]
  • Habib Yarizadeh, Leila Setayesh, Nazanin Majidi, Niloufar Rasaei, Sanaz Mehranfar, Reyhane Ebrahimi, Krista Casazzza, Khadijeh Mirzaei. Nutrient patterns and their relation to obesity and metabolic syndrome in Iranian overweight and obese adult women. Eating and weight disorders : EWD. 2022 May; 27(4):1327-1337. doi: 10.1007/s40519-021-01268-4. [PMID: 34273097]
  • Aaron J Riviere, Kristen S Smith, Megan N Schaberg, Michael W Greene, Andrew D Frugé. Plasma and fecal zonulin are not altered by a high green leafy vegetable dietary intervention: secondary analysis of a randomized control crossover trial. BMC gastroenterology. 2022 Apr; 22(1):184. doi: 10.1186/s12876-022-02248-3. [PMID: 35413837]
  • Nicoleta Cazacu, Claudia G Chilom, Melinda David, Monica Florescu. Conformational Changes in the BSA-LT4 Complex Induced by the Presence of Vitamins: Spectroscopic Approach and Molecular Docking. International journal of molecular sciences. 2022 Apr; 23(8):. doi: 10.3390/ijms23084215. [PMID: 35457032]
  • Uwe Zeymer, Hendrik Bonnemeier, Christoph Wanner. [Safety and effectiveness of oral anticoagulation in patients with atrial fibrillation and renal insufficiency - a real-world perspective]. Deutsche medizinische Wochenschrift (1946). 2022 Apr; 147(10):617-624. doi: 10.1055/a-1792-7094. [PMID: 35545071]
  • Jessie L Ellis, Xueyan Fu, J Philip Karl, Christopher J Hernandez, Joel B Mason, Russell A DeBose-Boyd, Sarah L Booth. Multiple Dietary Vitamin K Forms Are Converted to Tissue Menaquinone-4 in Mice. The Journal of nutrition. 2022 04; 152(4):981-993. doi: 10.1093/jn/nxab332. [PMID: 34550377]
  • Scott E Janus, Jared C Durieux, Jamal Hajjari, Herman Carneiro, Grace A McComsey. Inflammation-mediated vitamin K and vitamin D effects on vascular calcifications in people with HIV on active antiretroviral therapy. AIDS (London, England). 2022 04; 36(5):647-655. doi: 10.1097/qad.0000000000003149. [PMID: 34907958]
  • Sara Mancell, Maeisha Islam, Anil Dhawan, Kevin Whelan. Fat-soluble vitamin assessment, deficiency and supplementation in infants with cholestasis. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. 2022 04; 35(2):273-279. doi: 10.1111/jhn.12957. [PMID: 34679231]
  • Aegida Neradova, Grzegorz Wasilewski, Selene Prisco, Peter Leenders, Marjolein Caron, Tim Welting, Bert van Rietbergen, Rafael Kramann, Jürgen Floege, Marc G Vervloet, Leon J Schurgers. Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2022 03; 37(4):652-662. doi: 10.1093/ndt/gfab314. [PMID: 34718756]
  • Luisa Süfling, Daniel Greinert, Matthias Girndt. Risk of overanticoagulation during acute kidney injury in patients treated with vitamin K antagonists. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2022 03; 37(4):681-686. doi: 10.1093/ndt/gfab008. [PMID: 33459792]
  • Přemysl Mladěnka, Kateřina Macáková, Lenka Kujovská Krčmová, Lenka Javorská, Kristýna Mrštná, Alejandro Carazo, Michele Protti, Fernando Remião, Lucie Nováková. Vitamin K - sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity. Nutrition reviews. 2022 03; 80(4):677-698. doi: 10.1093/nutrit/nuab061. [PMID: 34472618]
  • M Kyla Shea, Kathryn Barger, Sarah L Booth, Jifan Wang, Harold I Feldman, Raymond R Townsend, Jing Chen, John Flack, Jiang He, Bernard G Jaar, Mayank Kansal, Sylvia E Rosas, Daniel E Weiner. Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the Chronic Renal Insufficiency Cohort. The American journal of clinical nutrition. 2022 03; 115(3):941-948. doi: 10.1093/ajcn/nqab375. [PMID: 34788785]
  • Chantal Visser, Joseph S Biedermann, Melchior C Nierman, Felix J M van der Meer, Anouk J W Gulpen, Yvonne C F Moors, Suzanne C Cannegieter, Willem M Lijfering, Marieke J H A Kruip. The Immediate Effect of COVID-19 Vaccination on Anticoagulation Control in Patients Using Vitamin K Antagonists. Thrombosis and haemostasis. 2022 Mar; 122(3):377-385. doi: 10.1055/s-0042-1742628. [PMID: 35245945]
  • Alessandro Squizzato, Daniela Poli, Doris Barcellona, Antonio Ciampa, Elvira Grandone, Cesare Manotti, Marco Moia, Vincenzo Toschi, Alberto Tosetto, Sophie Testa. Management of DOAC in Patients Undergoing Planned Surgery or Invasive Procedure: Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA) Position Paper. Thrombosis and haemostasis. 2022 Mar; 122(3):329-335. doi: 10.1055/a-1715-5960. [PMID: 34875702]
  • Stefanos Roumeliotis, Anila Duni, Vasilios Vaios, Athanasios Kitsos, Vassilios Liakopoulos, Evangelia Dounousi. Vitamin K Supplementation for Prevention of Vascular Calcification in Chronic Kidney Disease Patients: Are We There Yet?. Nutrients. 2022 Feb; 14(5):. doi: 10.3390/nu14050925. [PMID: 35267901]
  • Rama Vaidya, Ashok D B Vaidya, Jayesh Sheth, Shashank Jadhav, Umakant Mahale, Dilip Mehta, Janusz Popko, Vladimir Badmaev, Sidney J Stohs. Vitamin K Insufficiency in the Indian Population: Pilot Observational Epidemiology Study. JMIR public health and surveillance. 2022 02; 8(2):e31941. doi: 10.2196/31941. [PMID: 35113033]
  • Lucía Camacho-Barcia, Jesús García-Gavilán, Miguel Ángel Martínez-González, Fernando Fernández-Aranda, Serena Galié, Dolores Corella, Aida Cuenca-Royo, Dora Romaguera, Jesús Vioque, Ángel M Alonso-Gómez, Julia Wärnberg, J Alfredo Martínez, Luís Serra-Majem, Ramón Estruch, M Rosa Bernal-López, José Lapetra, Xavier Pintó, Josep A Tur, Antonio Garcia-Rios, Aurora Bueno-Cavanillas, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín-Sánchez, Josep Vidal, Clotilde Vázquez, Emilio Ros, Miguel Ruiz Canela, Jose V Sorlí, Rafael de la Torre, Jadwiga Konieczna, Alejandro Oncina-Cánovas, Lucas Tojal-Sierra, Jessica Pérez-López, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Cristina Bouzas, Cristina Razquin, Raúl Martínez-Lacruz, Olga Castañer, Aina M Yañez, Rafael Valls-Enguix, Maria Concepción Belló-Mora, Javier Basterra-Gortari, Josep Basora, Jordi Salas-Salvadó, Mònica Bulló. Vitamin K dietary intake is associated with cognitive function in an older adult Mediterranean population. Age and ageing. 2022 02; 51(2):. doi: 10.1093/ageing/afab246. [PMID: 35180284]
  • A Roffé, A Guedon, E Lallmahomed. [Actual use of direct oral anticoagulants in venous thromboembolic disease]. La Revue de medecine interne. 2022 Feb; 43(2):82-88. doi: 10.1016/j.revmed.2021.06.005. [PMID: 34176700]
  • Nadine Kaesler, Felix Schreibing, Thimoteus Speer, Sofia de la Puente-Secades, Nikolas Rapp, Christiane Drechsler, Nazanin Kabgani, Christoph Kuppe, Peter Boor, Vera Jankowski, Leon Schurgers, Rafael Kramann, Jürgen Floege. Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease. Kidney international. 2022 02; 101(2):338-348. doi: 10.1016/j.kint.2021.10.029. [PMID: 34774554]
  • Jennifer S Lees, Patrick B Mark. Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency. Kidney international. 2022 02; 101(2):216-219. doi: 10.1016/j.kint.2021.11.022. [PMID: 35065688]
  • Jeremiah P Tao, Vinay K Aakalu, Suzanne K Freitag, Rachel K Sobel, Jill A Foster, Edward J Wladis, Timothy J McCulley, Michael T Yen. Homeopathic Agents or Vitamins in Reducing Ecchymosis after Oculofacial Surgery: A Report by the American Academy of Ophthalmology. Ophthalmology. 2022 02; 129(2):220-226. doi: 10.1016/j.ophtha.2021.05.018. [PMID: 34176651]
  • Maria Fusaro, Francesco Tondolo, Lorenzo Gasperoni, Giovanni Tripepi, Mario Plebani, Martina Zaninotto, Thomas L Nickolas, Markus Ketteler, Andrea Aghi, Cristina Politi, Gaetano La Manna, Maria Luisa Brandi, Serge Ferrari, Maurizio Gallieni, Maria Cristina Mereu, Giuseppe Cianciolo. The Role of Vitamin K in CKD-MBD. Current osteoporosis reports. 2022 02; 20(1):65-77. doi: 10.1007/s11914-022-00716-z. [PMID: 35132525]
  • Sylwester Rogula, Aleksandra Gąsecka, Tomasz Mazurek, Eliano Pio Navarese, Łukasz Szarpak, Krzysztof J Filipiak. Safety and Efficacy of DOACs in Patients with Advanced and End-Stage Renal Disease. International journal of environmental research and public health. 2022 01; 19(3):. doi: 10.3390/ijerph19031436. [PMID: 35162472]
  • Marcel Hrubša, Tomáš Siatka, Iveta Nejmanová, Marie Vopršalová, Lenka Kujovská Krčmová, Kateřina Matoušová, Lenka Javorská, Kateřina Macáková, Laura Mercolini, Fernando Remião, Marek Máťuš, Přemysl Mladěnka, On Behalf Of The Oemonom. Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5. Nutrients. 2022 Jan; 14(3):. doi: 10.3390/nu14030484. [PMID: 35276844]
  • Anna Stępień, Małgorzata Koziarska-Rościszewska, Jacek Rysz, Mariusz Stępień. Biological Role of Vitamin K-With Particular Emphasis on Cardiovascular and Renal Aspects. Nutrients. 2022 Jan; 14(2):. doi: 10.3390/nu14020262. [PMID: 35057443]
  • Jennifer S Lees, Patrick B Mark. Vitamin K supplementation and vascular health after kidney transplantation: Authors' response. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2022 01; 22(1):320-321. doi: 10.1111/ajt.16769. [PMID: 34291553]
  • C A Te Velde-Keyzer, M H de Borst. Vitamin K supplementation and vascular health after kidney transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2022 01; 22(1):318-319. doi: 10.1111/ajt.16741. [PMID: 34212488]
  • Stefanos Roumeliotis, Vassilios Liakopoulos, Leon J Schurgers. Vitamin K Supplementation in Chronic Kidney Disease Patients: Where is the Evidence?. Current vascular pharmacology. 2022; 20(2):121-126. doi: 10.2174/1570161120666220209145341. [PMID: 35139790]
  • Shin-Yi Lin, Ching-Hua Kuo, Tao-Min Huang, Yu-Fong Peng, Chih-Fen Huang, Sung-Chun Tang, Jiann-Shing Jeng. Impact of different renal function equations on direct oral anticoagulant concentrations. Scientific reports. 2021 12; 11(1):23833. doi: 10.1038/s41598-021-03318-4. [PMID: 34903821]
  • Markus Ketteler, Moritz Schanz, Severin Schricker. Vitamin K: should we supplement to protect the kidneys and the heart?. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2021 12; 36(12):2196-2198. doi: 10.1093/ndt/gfz291. [PMID: 31943083]
  • Dion Groothof, Adrian Post, Camilo G Sotomayor, Charlotte A Keyzer, Jose L Flores-Guerero, Eelko Hak, Jens H J Bos, Leon J Schurgers, Gerjan J Navis, Reinold O B Gans, Coby Eelderink, Martin H de Borst, Stephan J L Bakker, Ineke J Riphagen. Functional vitamin K status and risk of incident chronic kidney disease and microalbuminuria: a prospective general population-based cohort study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2021 12; 36(12):2290-2299. doi: 10.1093/ndt/gfaa304. [PMID: 33313895]
  • Kais Mnafgui, Emna Khdhiri, Lakhdar Ghazouani, Marwa Ncir, Zouhaier Zaafouri, Noureddine Allouche, Abdelfattah Elfeki, Houcine Ammar, Souhir Abid, Raouf Hajji. Anti-embolic and anti-oxidative effects of a novel (E)-4-amino-N'-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide against isoproterenol and vitamin-K induced ischemic stroke. Archives of physiology and biochemistry. 2021 Dec; 127(6):527-540. doi: 10.1080/13813455.2019.1657900. [PMID: 31469295]
  • Maria Fusaro, Giuseppe Cianciolo, Giovanni Tripepi, Mario Plebani, Andrea Aghi, Cristina Politi, Martina Zaninotto, Thomas L Nickolas, Serge Ferrari, Markus Ketteler, Gaetano La Manna, Lorenzo Gasperoni, Piergiorgio Messa, Maura Ravera, Maurizio Gallieni, Laura Cosmai, Francesco Locatelli, Giorgio Iervasi, Roberto Vettor, Maria Cristina Mereu, Stefania Sella, Gaetano Arcidiacono, Sandro Giannini. Oral Calcitriol Use, Vertebral Fractures, and Vitamin K in Hemodialysis Patients: A Cross-Sectional Study. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021 12; 36(12):2361-2370. doi: 10.1002/jbmr.4440. [PMID: 34622481]
  • Marion Moine, Marc Vasse, Sarah Jegaden, Olfa Boufares, Elodie Besson, Svetlana Dodille, Joelle Jerome, Brigitte Bonan, Valérie Ducasse. [VKA overdose in Covid-19 infected patients]. Geriatrie et psychologie neuropsychiatrie du vieillissement. 2021 Dec; 19(4):392-400. doi: 10.1684/pnv.2021.0972. [PMID: 34821558]
  • Kabelo Mokgalaboni, Bongani B Nkambule, Yonela Ntamo, Khanyisani Ziqubu, Tawanda M Nyambuya, Sithandiwe E Mazibuko-Mbeje, Kwazikwakhe B Gabuza, Nireshni Chellan, Ilenia Cirilli, Luca Tiano, Phiwayinkosi V Dludla. Vitamin K: A vital micronutrient with the cardioprotective potential against diabetes-associated complications. Life sciences. 2021 Dec; 286(?):120068. doi: 10.1016/j.lfs.2021.120068. [PMID: 34688697]
  • David Martín Enguix, Juan Carlos Aguirre Rodríguez, Abraham Hidalgo Rodríguez. Mortality in a cohort of primary care patients treated with vitamin K antagonist anticoagulants. Medicina clinica. 2021 Nov; 157(9):427-433. doi: 10.1016/j.medcli.2020.07.037. [PMID: 33509604]
  • Sofie Hertz Rønn, Torben Harsløf, Steen Bønløkke Pedersen, Bente Lomholt Langdahl. Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial. European journal of clinical nutrition. 2021 11; 75(11):1661-1667. doi: 10.1038/s41430-021-00884-8. [PMID: 33664429]
  • Truman J Milling, Majed A Refaai, Neil Sengupta. Anticoagulant Reversal in Gastrointestinal Bleeding: Review of Treatment Guidelines. Digestive diseases and sciences. 2021 11; 66(11):3698-3714. doi: 10.1007/s10620-020-06728-y. [PMID: 33403486]
  • A G Buenen, Marijn Sinkeldam, Martje L Maas, Martha Verdonschot, Peter C Wever. Prior use of anticoagulation is associated with a better survival in COVID-19. Journal of thrombosis and thrombolysis. 2021 Nov; 52(4):1207-1211. doi: 10.1007/s11239-021-02486-4. [PMID: 34061283]
  • Nadine Kaesler, Leon J Schurgers, Jürgen Floege. Vitamin K and cardiovascular complications in chronic kidney disease patients. Kidney international. 2021 11; 100(5):1023-1036. doi: 10.1016/j.kint.2021.06.037. [PMID: 34310988]
  • Joline W J Beulens, Elisa Dal Canto, Coen D A Stehouwer, Roger J M W Rennenberg, Petra J M Elders, Adriana Johanne van Ballegooijen. High vitamin K status is prospectively associated with decreased left ventricular mass in women: the Hoorn Study. Nutrition journal. 2021 10; 20(1):85. doi: 10.1186/s12937-021-00742-0. [PMID: 34666769]
  • Liyou Hu, Jindou Ji, Dong Li, Jing Meng, Bo Yu. The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials. Journal of orthopaedic surgery and research. 2021 Oct; 16(1):592. doi: 10.1186/s13018-021-02728-4. [PMID: 34649591]
  • Maria Fusaro, Giovanni Tripepi, Mario Plebani, Cristina Politi, Andrea Aghi, Fulvia Taddei, Enrico Schileo, Martina Zaninotto, Gaetano La Manna, Giuseppe Cianciolo, Maurizio Gallieni, Laura Cosmai, Piergiorgio Messa, Maura Ravera, Thomas L Nickolas, Serge Ferrari, Markus Ketteler, Giorgio Iervasi, Maria Cristina Mereu, Roberto Vettor, Sandro Giannini, Lorenzo Gasperoni, Stefania Sella, Maria Luisa Brandi, Luisella Cianferotti, Raffaele De Caterina. The Vessels-Bone Axis: Iliac Artery Calcifications, Vertebral Fractures and Vitamin K from VIKI Study. Nutrients. 2021 Oct; 13(10):. doi: 10.3390/nu13103567. [PMID: 34684568]
  • Jan Steffel, Hein Heidbüchel. Dose adjustment based on the plasma level measurement used anti-FXa chromogenic assay on the use of non-vitamin K antagonist oral anticoagulants (NOACs) improved the overall benefit of NOACs dosing in patients with atrial fibrillation: Authors' reply. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2021 10; 23(10):1686-1687. doi: 10.1093/europace/euab220. [PMID: 34549781]
  • Michihiro Suwa, Isao Morii, Masaya Kino. Dose adjustment based on the plasma level measurement used anti-FXa chromogenic assay on the use of non-vitamin K antagonist oral anticoagulants (NOACs) improved the overall benefit of NOACs dosing in patients with atrial fibrillation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2021 10; 23(10):1686. doi: 10.1093/europace/euab219. [PMID: 34549782]