Naloxone (BioDeep_00000411060)

Main id: BioDeep_00000002559

 

natural product


代谢物信息卡片


Naloxone

化学式: C19H21NO4 (327.1471)
中文名称: 纳洛酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O
InChI: InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1

描述信息

A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.
A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AH - Peripheral opioid receptor antagonists
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
C78272 - Agent Affecting Nervous System > C681 - Opiate Antagonist

同义名列表

2 个代谢物同义名

Naloxone; Naloxone



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CA1, CNR1, POMC, PRL, TLR4
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 1 DRD1
Nucleus 3 DRD1, FOS, PRL
cytosol 3 CA1, FOS, SST
dendrite 4 DRD2, OPRM1, PDYN, PNOC
nucleoplasm 2 FOS, PRL
RNA polymerase II transcription regulator complex 2 FOS, PRL
Cell membrane 7 ADRB3, CNR1, DRD1, DRD2, GPRC5A, OPRM1, TLR4
Cell projection, axon 2 CNR1, OPRM1
Multi-pass membrane protein 7 ADRB3, CACNA1I, CNR1, DRD1, DRD2, GPRC5A, OPRM1
Golgi apparatus membrane 1 DRD2
Synapse 5 CRH, DRD2, OPRM1, PDYN, PNOC
cell surface 1 TLR4
glutamatergic synapse 3 CNR1, DRD1, DRD2
Golgi apparatus 2 NPY, OPRM1
Golgi membrane 2 DRD2, INS
growth cone 1 CNR1
neuronal cell body 3 PDYN, PNOC, SST
presynaptic membrane 3 CNR1, DRD1, DRD2
Presynapse 1 CNR1
acrosomal vesicle 1 DRD2
endosome 1 OPRM1
plasma membrane 12 ADRB3, CACNA1I, CNR1, DRD1, DRD2, GCG, GPRC5A, KNG1, OPRM1, PDYN, PNOC, TLR4
synaptic vesicle membrane 1 DRD2
Membrane 3 CACNA1I, OPRM1, TLR4
axon 3 CNR1, DRD2, OPRM1
extracellular exosome 3 CA1, GPRC5A, KNG1
endoplasmic reticulum 2 FOS, OPRM1
extracellular space 8 CRH, GCG, INS, KNG1, NPY, POMC, PRL, SST
perinuclear region of cytoplasm 1 TLR4
intracellular membrane-bounded organelle 1 GPRC5A
Single-pass type I membrane protein 1 TLR4
Secreted 9 CRH, GCG, INS, NPY, PDYN, PNOC, POMC, PRL, SST
extracellular region 10 CRH, GCG, INS, KNG1, NPY, PDYN, PNOC, POMC, PRL, SST
Mitochondrion outer membrane 1 CNR1
mitochondrial outer membrane 1 CNR1
hippocampal mossy fiber to CA3 synapse 1 PDYN
ciliary membrane 2 DRD1, DRD2
external side of plasma membrane 1 TLR4
varicosity 1 CRH
actin cytoskeleton 1 CNR1
dendritic spine 2 DRD1, DRD2
neuronal dense core vesicle lumen 1 CRH
perikaryon 3 CRH, DRD2, OPRM1
nucleolus 1 GPRC5A
Early endosome 1 TLR4
vesicle 1 GPRC5A
postsynaptic membrane 2 DRD1, DRD2
Membrane raft 1 CNR1
GABA-ergic synapse 5 CNR1, DRD1, DRD2, NPY, SST
Cell projection, dendritic spine 1 DRD1
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 POMC
lateral plasma membrane 1 DRD2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 ADRB3, GPRC5A, TLR4
neuron projection 1 OPRM1
cilium 2 DRD1, DRD2
chromatin 2 FOS, PRL
phagocytic cup 1 TLR4
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
non-motile cilium 2 DRD1, DRD2
sperm flagellum 1 DRD2
endosome lumen 2 INS, PRL
Cytoplasmic vesicle membrane 1 GPRC5A
Cell projection, dendrite 2 DRD1, OPRM1
synaptic membrane 1 PNOC
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 3 GCG, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 GCG, INS, KNG1
nuclear matrix 1 FOS
platelet alpha granule lumen 1 KNG1
axon terminus 3 DRD2, PDYN, PNOC
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 3 NPY, PDYN, SST
protein-DNA complex 1 FOS
dopaminergic synapse 1 DRD2
Cell projection, cilium membrane 1 DRD1
transcription factor AP-1 complex 1 FOS
[Glucagon-like peptide 1]: Secreted 1 GCG
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
G protein-coupled receptor complex 2 DRD1, DRD2
[Isoform 12]: Cytoplasm 1 OPRM1


文献列表

  • Minghong Li, Zilei Tang, Liuyan Yu, Yingming Li, Wenyu Ma, Jincun Li, Gang Li, Lei Xiong, Na Lei, Peixin Guo, Yuhuan Xie. The arousal effect of An-Gong-Niu-Huang-Wan on alcoholic-induced coma rats: A research based on EEG. Journal of ethnopharmacology. 2024 Jun; 328(?):117974. doi: 10.1016/j.jep.2024.117974. [PMID: 38467317]
  • Xiangzhen Min, Yan Ma, Yufang Leng, Xiaoxi Li, Jianmin Zhang, Shoucai Xu, Xiuqin Wang, Renjun Lv, Jie Guo, Huaixin Xing. Effects of perioperative low-dose naloxone on the immune system in patients undergoing laparoscopic-assisted total gastrectomy: a randomized controlled trial. BMC anesthesiology. 2024 May; 24(1):172. doi: 10.1186/s12871-024-02524-7. [PMID: 38720250]
  • Ben A Chindo, Melanie-Jayne R Howes, Sawsan Abuhamdah, Danjuma Mallam, Timothy Micah, Rosemary I Awotula, Robin Battison, Paul L Chazot. Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models. Journal of ethnopharmacology. 2024 Mar; 321(?):117500. doi: 10.1016/j.jep.2023.117500. [PMID: 38030022]
  • M Oqal, E Qnais, A Alqudah, O Gammoh. Analgesic effect of the flavonoid herbacetin in nociception animal models. European review for medical and pharmacological sciences. 2023 Dec; 27(23):11236-11248. doi: 10.26355/eurrev_202312_34563. [PMID: 38095373]
  • Gowhar Ali, Nazar Ul Islam, Muhammad Qaim, Rahim Ullah, Muhammad Saeed Jan, Khadija Shabbiri, Muhammad Shafique, Muhammad Ayaz. 2-Hydroxybenzohydrazide as a novel potential candidate against nociception, inflammation, and pyrexia: in vitro, in vivo, and computational approaches. Inflammopharmacology. 2023 Oct; ?(?):. doi: 10.1007/s10787-023-01356-0. [PMID: 37864684]
  • Shahrzad Molavinia, Mehrad Nikravesh, Marzieh Pashmforoosh, Hossein Rajabi Vardanjani, Mohammad Javad Khodayar. Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation. Neurochemical research. 2023 Oct; ?(?):. doi: 10.1007/s11064-023-04043-2. [PMID: 37864024]
  • Adriana Jesus Souza, Francisco S Guimarães, Felipe V Gomes. Cannabidiol attenuates the expression of conditioned place aversion induced by naloxone-precipitated morphine withdrawal through the activation of 5-HT1A receptors. Behavioural brain research. 2023 May; 450(?):114504. doi: 10.1016/j.bbr.2023.114504. [PMID: 37209879]
  • David Peran, Michael Stern, Petr Cernohorsky, Roman Sykora, Stanislav Popela, Frantisek Duska. Mitragyna speciosa (Kratom) poisoning: Findings from ten cases. Toxicon : official journal of the International Society on Toxinology. 2023 Feb; 225(?):107054. doi: 10.1016/j.toxicon.2023.107054. [PMID: 36801215]
  • Geun Joo Choi, Hyun Kang, Oh Haeng Lee, Ji Wung Kwon. Effect of Immature Rubus occidentalis on Postoperative Pain in a Rat Model. Medicina (Kaunas, Lithuania). 2023 Jan; 59(2):. doi: 10.3390/medicina59020264. [PMID: 36837466]
  • Rodrigo Vargas-Ruiz, Rosa Mariana Montiel-Ruiz, Alejandro Zamilpa, Manases Gonzalez-Cortazar, Maribel Lucila Herrera-Ruiz, Jaqueline Molina-Cabrera, María Cruz Juárez-Aragón, Francisco Javier Flores-Murrieta. Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception. Journal of ethnopharmacology. 2023 Jan; 300(?):115756. doi: 10.1016/j.jep.2022.115756. [PMID: 36170958]
  • Zahra Rahimian, SeyedHassan Sadrian, Mina Shahisavandi, Hadi Aligholi, Mohammad M Zarshenas, Alireza Abyar, Zahra Zeraatpisheh, Ali A Asadi-Pooya. Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia. BioMed research international. 2023; 2023(?):4121998. doi: 10.1155/2023/4121998. [PMID: 38089644]
  • Andreza Larissa do Nascimento, Joyce Bezerra Guedes, Wêndeo Kennedy Costa, Bruno Oliveira de Veras, Júlio César Ribeiro de Oliveira Farias de Aguiar, Daniela Maria do Amaral Ferraz Navarro, Maria Tereza Dos Santos Correia, Thiago Henrique Napoleão, Alisson Macário de Oliveira, Márcia Vanusa da Silva. Essential oil from the leaves of Eugenia pohliana DC. (Myrtaceae) alleviate nociception and acute inflammation in mice. Inflammopharmacology. 2022 Dec; 30(6):2273-2284. doi: 10.1007/s10787-022-01067-y. [PMID: 36094726]
  • Yi Zhou, Xihua Lu, Yunfei Zhang, Changsheng Li, Yu Bai, Zhen Zhang. Investigation of the effects of opioids on microglial nitrite and nitric oxide synthase (iNOS) production and phagocytosis during inflammation. Combinatorial chemistry & high throughput screening. 2022 Nov; ?(?):. doi: 10.2174/1386207326666221111093915. [PMID: 36372918]
  • Glenda Laíssa Oliveira de Melo Candeia, Wêndeo Kennedy Costa, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Magda Rhayanny Assunção Ferreira, Luiz Alberto Lira Soares. Anti-inflammatory, antinociceptive effects and involvement of opioid receptors in the antinociceptive activity of Eugenia uniflora leaves obtained with water, ethanol, and propylene glycol mixture. Journal of ethnopharmacology. 2022 Oct; 296(?):115508. doi: 10.1016/j.jep.2022.115508. [PMID: 35779820]
  • Yingfu Jiao, Fugui Li, Mo Chen, Zhijian He, Zhangxiang Huang, Weifeng Yu, Kangjie Xie. Pre-treatment with morphine prevents lipopolysaccharide-induced acute respiratory distress syndrome in rats via activation of opioid receptors. Experimental cell research. 2022 09; 418(1):113224. doi: 10.1016/j.yexcr.2022.113224. [PMID: 35643178]
  • David Dadiomov, Maria Bolshakova, Melania Mikhaeilyan, Rebecca Trotzky-Sirr. Buprenorphine and naloxone access in pharmacies within high overdose areas of Los Angeles during the COVID-19 pandemic. Harm reduction journal. 2022 Jun; 19(1):69. doi: 10.1186/s12954-022-00651-3. [PMID: 35768817]
  • Leila Mohammadzadeh, Amir Mohammad Alizadeh, Mohammad Sadegh Feiz, Shole Jamali, Mohaddeseh Abedi, Hamid Latifi, Abbas Haghparast. Acute morphine administration, morphine dependence, and naloxone-induced withdrawal syndrome affect the resting-state functional connectivity and Local Field Potentials of the rat prefrontal cortex. Behavioural brain research. 2022 06; 427(?):113859. doi: 10.1016/j.bbr.2022.113859. [PMID: 35337941]
  • Chayanin Kiratipaiboon, Peththa Wadu Dasuni Wasana, Hasriadi, Suchada Sukrong, Nijsiri Ruangrungsri, Pasarapa Towiwat. Herbal root extracts in Ben-Cha-Moon-Yai remedy attenuated pain-like behaviors and inflammation through the opioid and prostaglandin systems. Journal of ethnopharmacology. 2022 May; 290(?):115088. doi: 10.1016/j.jep.2022.115088. [PMID: 35149131]
  • Randa Abdelal, A Raja Banerjee, Suzanne Carlberg-Racich, Neyla Darwaza, Diane Ito, Jessica Shoaff, Josh Epstein. Real-world study of multiple naloxone administration for opioid overdose reversal among bystanders. Harm reduction journal. 2022 05; 19(1):49. doi: 10.1186/s12954-022-00627-3. [PMID: 35596213]
  • M Duska, D Goodman. Implementation of a Prenatal Naloxone Distribution Program to Decrease Maternal Mortality from Opioid Overdose. Maternal and child health journal. 2022 May; 26(5):985-993. doi: 10.1007/s10995-021-03307-z. [PMID: 35029805]
  • Phil Skolnick. Treatment of overdose in the synthetic opioid era. Pharmacology & therapeutics. 2022 05; 233(?):108019. doi: 10.1016/j.pharmthera.2021.108019. [PMID: 34637841]
  • Carly A Baehr, Mariah M Wu, Sujata G Pandit, Jose Arias-Umana, David AuCoin, Marco Pravetoni. Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity. The Journal of pharmacology and experimental therapeutics. 2022 05; 381(2):129-136. doi: 10.1124/jpet.121.001048. [PMID: 35153198]
  • Katherine L Potaka, Rebecca Freeman, Danny Soo, Nam-Anh Nguyen, Tin Fei Sim, Joanna C Moullin. Retrospective analysis of patterns of opioid overdose and interventions delivered at a tertiary hospital emergency department: impact of COVID-19. BMC emergency medicine. 2022 04; 22(1):62. doi: 10.1186/s12873-022-00604-w. [PMID: 35397487]
  • Aaron Dora-Laskey, Joan Kellenberg, Chin Hwa Dahlem, Elizabeth English, Monica Gonzalez Walker, Chad M Brummett, Keith E Kocher. Piloting a statewide emergency department take-home naloxone program: Improving the quality of care for patients at risk of opioid overdose. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2022 04; 29(4):442-455. doi: 10.1111/acem.14435. [PMID: 34962682]
  • Piyusha P Pagare, Mengchu Li, Yi Zheng, Abhishek S Kulkarni, Samuel Obeng, Boshi Huang, Christian Ruiz, James C Gillespie, Rolando E Mendez, David L Stevens, Justin L Poklis, Matthew S Halquist, William L Dewey, Dana E Selley, Yan Zhang. Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists. Journal of medicinal chemistry. 2022 03; 65(6):5095-5112. doi: 10.1021/acs.jmedchem.2c00087. [PMID: 35255685]
  • Kai Yue, Jonathan L Katz, Xiji Shu. Physiological dependence to mitragynine indicated by a rapid cross-dependence procedure with heroin-dependent mice. Psychopharmacology. 2022 Mar; 239(3):897-908. doi: 10.1007/s00213-022-06080-1. [PMID: 35107609]
  • Laura J Cremer, Amy Board, Gery P Guy, Lyna Schieber, Alice Asher, Erin M Parker. Trends in pharmacy-based dispensing of buprenorphine, extended-release naltrexone, and naloxone during the COVID-19 pandemic by age and sex - United States, March 2019 - December 2020. Drug and alcohol dependence. 2022 03; 232(?):109192. doi: 10.1016/j.drugalcdep.2021.109192. [PMID: 35065513]
  • Tara Gomes, Tonya J Campbell, Sophie A Kitchen, Ria Garg, Nikki Bozinoff, Siyu Men, Mina Tadrous, Charlotte Munro, Tony Antoniou, Dan Werb, Jennifer Wyman. Association Between Increased Dispensing of Opioid Agonist Therapy Take-Home Doses and Opioid Overdose and Treatment Interruption and Discontinuation. JAMA. 2022 03; 327(9):846-855. doi: 10.1001/jama.2022.1271. [PMID: 35230394]
  • Akshat Khare, Arsh Sidana, Ammar Mohemmed, Denisha Markelle Allicock, Anna Waterstone, Matthew Aaron Zimmer, Dora Il'yasova. Acceleration of opioid-related EMS runs in the spring of 2020: The National Emergency Medical Services Information System data for 2018-2020. Drug and alcohol dependence. 2022 Mar; 232(?):109271. doi: 10.1016/j.drugalcdep.2022.109271. [PMID: 35051696]
  • Mohammad-Ali Sobhanifar, Roghayeh Rashidi, Arezoo Rajabian, Fatemeh Forouzanfar, Maede Hasanpour, Mehrdad Iranshahi, Hassan Rakhshandeh, Azar Hosseini. The possible mechanism of Datura stramonium on pentobarbital-induced sleep in mice. The International journal of neuroscience. 2022 Feb; ?(?):1-9. doi: 10.1080/00207454.2021.1998045. [PMID: 35213269]
  • Sacha Uljon. An Adulterated Urine Buprenorphine Specimen. The primary care companion for CNS disorders. 2022 Feb; 24(2):. doi: 10.4088/pcc.21cr03007. [PMID: 35213940]
  • Elizabeth Dogherty, Carlin Patterson, Marilou Gagnon, Scott Harrison, Jocelyn Chase, Jill Boerstler, Jennifer Gibson, Sam Gill, Seonaid Nolan, Andy Ryan. Implementation of a nurse-led overdose prevention site in a hospital setting: lessons learned from St. Paul's Hospital, Vancouver, Canada. Harm reduction journal. 2022 02; 19(1):13. doi: 10.1186/s12954-022-00596-7. [PMID: 35120536]
  • Mark G Papich, Roger J Narayan. Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection. Drug delivery and translational research. 2022 02; 12(2):376-383. doi: 10.1007/s13346-021-01096-0. [PMID: 34817831]
  • Piotr Niezgoda, Malwina A Barańska, Joanna Sikora, Przemysław Sobczak, Katarzyna Buszko, Adam Sikora, Michał P Marszałł, Eliano P Navarese, Bernd Jilma, Jacek Kubica. Oral NAloxone to overcome the moRphine effect in acute COronary syndrome patients treated with TICagrelor - NARCOTIC trial. Cardiology journal. 2022; 29(3):432-440. doi: 10.5603/cj.a2020.0040. [PMID: 32207836]
  • Claudia C Tussey, Margaret D Reyes, Rosalinda B Thomas, Charlotte T Boyd, John G Spangler, Julienne K Kirk. Utility of the group medical visit model for medication-assisted therapy. Journal of opioid management. 2022 Jan; 18(1):69-74. doi: 10.5055/jom.2022.0696. [PMID: 35238015]
  • Christine Ramdin, Marshall Guo, Scott Fabricant, Cynthia Santos, Lewis Nelson. The Impact of a Peer-Navigator Program on Naloxone Distribution and Buprenorphine Utilization in the Emergency Department. Substance use & misuse. 2022; 57(4):581-587. doi: 10.1080/10826084.2021.2023187. [PMID: 34970942]
  • Traci C Green, Jeffrey Bratberg, Adriane N Irwin, Jesse Boggis, Mary Gray, Gillian Leichtling, Derek Bolivar, Anthony Floyd, Zain Al-Jammali, Jenny Arnold, Ryan Hansen, Daniel Hartung. Study protocol for the Respond to Prevent Study: a multi-state randomized controlled trial to improve provision of naloxone, buprenorphine and nonprescription syringes in community pharmacies. Substance abuse. 2022; 43(1):901-905. doi: 10.1080/08897077.2021.2010162. [PMID: 35213293]
  • Albert J Burgess-Hull, Kirsten E Smith, Leigh V Panlilio, Destiny Schriefer, Kenzie L Preston, Aliese Alter, Christopher Yeager, Timothy Chizmar, Ted Delbridge, Kenan Zamore, Jeff Beeson, David H Epstein. Nonfatal opioid overdoses before and after Covid-19: Regional variation in rates of change. PloS one. 2022; 17(3):e0263893. doi: 10.1371/journal.pone.0263893. [PMID: 35263326]
  • Terence M Hughes, Alexander Kalicki, Zina Huxley-Reicher, Wilma Toribio, Don L Samuels, Jeffrey J Weiss, Michael Herscher, Linda Wang. A medical student-led model for telephone-based opioid overdose education and naloxone distribution during the COVID-19 pandemic. Substance abuse. 2022; 43(1):988-992. doi: 10.1080/08897077.2022.2060426. [PMID: 35435812]
  • Matthew S Ellis, Zachary A Kasper, Theodore J Cicero. Polysubstance use trends and variability among individuals with opioid use disorder in rural versus urban settings. Preventive medicine. 2021 11; 152(Pt 2):106729. doi: 10.1016/j.ypmed.2021.106729. [PMID: 34293380]
  • Illa S Johari, Norsyifa Harun, Zarif M Sofian, Mohammed Shoaib. Pentylenetetrazol-like stimulus is not produced following naloxone-precipitated mitragynine withdrawal in rats. Psychopharmacology. 2021 Nov; 238(11):3183-3191. doi: 10.1007/s00213-021-05934-4. [PMID: 34333672]
  • Manuel P Pereira, Claudia Zeidler, Sonja Ständer. Improvement of Chronic Kidney Disease-Associated Pruritus After Treatment With Intravenous Naloxone. JAMA dermatology. 2021 11; 157(11):1380-1381. doi: 10.1001/jamadermatol.2021.3829. [PMID: 34586358]
  • Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Masoumeh Askari, Alireza Amirabadizadeh, Mohsen Foadoddini, Omid Mehrpour. Effects of naloxone and diazepam on blood glucose levels in tramadol overdose using generalized estimating equation (GEE) model; (an experimental study). BMC endocrine disorders. 2021 Sep; 21(1):180. doi: 10.1186/s12902-021-00847-x. [PMID: 34488743]
  • Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter. Prostaglandins, leukotrienes, and essential fatty acids. 2021 09; 172(?):102323. doi: 10.1016/j.plefa.2021.102323. [PMID: 34392133]
  • Claudia Mariottini, Merja Gergov, Ilkka Ojanperä. Determination of buprenorphine, norbuprenorphine, naloxone, and their glucuronides in urine by liquid chromatography-tandem mass spectrometry. Drug testing and analysis. 2021 Sep; 13(9):1658-1667. doi: 10.1002/dta.3104. [PMID: 34047070]
  • Michael Levine, Frank Lovecchio. New Designer Drugs. Emergency medicine clinics of North America. 2021 Aug; 39(3):677-687. doi: 10.1016/j.emc.2021.04.013. [PMID: 34215409]
  • Rachel French, Jamie Favaro, Shoshana V Aronowitz. A free mailed naloxone program in Philadelphia amidst the COVID-19 pandemic. The International journal on drug policy. 2021 08; 94(?):103199. doi: 10.1016/j.drugpo.2021.103199. [PMID: 33765515]
  • Elizabeth M Oliva, John Richardson, Michael A Harvey, Pamela Bellino. Saving Lives: The Veterans Health Administration (VHA) Rapid Naloxone Initiative. Joint Commission journal on quality and patient safety. 2021 08; 47(8):469-480. doi: 10.1016/j.jcjq.2021.06.004. [PMID: 34330409]
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