pyrantel (BioDeep_00000409336)
Main id: BioDeep_00000002993
代谢物信息卡片
pyrantel
化学式: C11H14N2S (206.0878)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(general) 30.3%
分子结构信息
SMILES: CN1CCCN=C1/C=C/c1cccs1
InChI: InChI=1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+
描述信息
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02C - Antinematodal agents > P02CC - Tetrahydropyrimidine derivatives
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; YSAUAVHXTIETRK-AATRIKPKSA-N_STSL_0148_Pyrantel_0031fmol_180418_S2_LC02_MS02_13; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
同义名列表
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:94685
- ChEBI: CHEBI:8654
- KEGG: C07409
- KEGGdrug: D08451
- PubChem: 708857
- DrugBank: DB11156
- ChEMBL: CHEMBL1626223
- MeSH: Pyrantel
- CAS: 15686-83-6
- CAS: 5686-02-2
- MoNA: MoNA010166
- MoNA: MoNA010165
- MoNA: MoNA010164
- MoNA: MoNA010163
- MoNA: MoNA010162
- MoNA: MoNA010161
- PubChem: 9613
- NIKKAJI: J15.629I
- RefMet: Pyrantel
- KNApSAcK: 8654
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pablo D Jimenez Castro, Abhinaya Venkatesan, Elizabeth Redman, Rebecca Chen, Abigail Malatesta, Hannah Huff, Daniel A Zuluaga Salazar, Russell Avramenko, John S Gilleard, Ray M Kaplan. Multiple drug resistance in hookworms infecting greyhound dogs in the USA.
International journal for parasitology. Drugs and drug resistance.
2021 12; 17(?):107-117. doi:
10.1016/j.ijpddr.2021.08.005. [PMID: 34492564] - Evelina Dauparaitė, Tomas Kupčinskas, Georg von Samson-Himmelstjerna, Saulius Petkevičius. Anthelmintic resistance of horse strongyle nematodes to ivermectin and pyrantel in Lithuania.
Acta veterinaria Scandinavica.
2021 Jan; 63(1):5. doi:
10.1186/s13028-021-00569-z. [PMID: 33494770] - Csilla Becskei, Kristina Kryda, Daphne Fias, Stacey L Follis, Magda Wozniakiewicz, Sean P Mahabir, Robert Farkas. Field efficacy and safety of a novel oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against naturally acquired gastrointestinal nematode infections in dogs presented as veterinary patients in Europe and the USA.
Parasites & vectors.
2020 Mar; 13(1):70. doi:
10.1186/s13071-020-3947-0. [PMID: 32113470] - Kristina Kryda, Sean P Mahabir, Tammy Inskeep, Jady Rugg. Safety and efficacy of a novel oral chewable combination tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against natural flea infestations in client-owned dogs in the USA.
Parasites & vectors.
2020 Mar; 13(1):98. doi:
10.1186/s13071-020-3952-3. [PMID: 32113472] - Pablo D Jimenez Castro, Sue B Howell, John J Schaefer, Russell W Avramenko, John S Gilleard, Ray M Kaplan. Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?.
Parasites & vectors.
2019 Dec; 12(1):576. doi:
10.1186/s13071-019-3828-6. [PMID: 31818311] - Jeba Jesudoss Chelladurai, Tsegabirhan Kifleyohannes, Janelle Scott, Matthew T Brewer. Praziquantel Resistance in the Zoonotic Cestode Dipylidium caninum.
The American journal of tropical medicine and hygiene.
2018 11; 99(5):1201-1205. doi:
10.4269/ajtmh.18-0533. [PMID: 30226153] - Alexandra Blanchard, Fabrice Guégnard, Claude L Charvet, Anna Crisford, Elise Courtot, Christine Sauvé, Abdallah Harmache, Thomas Duguet, Vincent O'Connor, Philippe Castagnone-Sereno, Barbara Reaves, Adrian J Wolstenholme, Robin N Beech, Lindy Holden-Dye, Cedric Neveu. Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species.
PLoS pathogens.
2018 05; 14(5):e1006996. doi:
10.1371/journal.ppat.1006996. [PMID: 29719008] - Tim van der Weijde, Claire L Alvim Kamei, Edouard I Severing, Andres F Torres, Leonardo D Gomez, Oene Dolstra, Chris A Maliepaard, Simon J McQueen-Mason, Richard G F Visser, Luisa M Trindade. Genetic complexity of miscanthus cell wall composition and biomass quality for biofuels.
BMC genomics.
2017 05; 18(1):406. doi:
10.1186/s12864-017-3802-7. [PMID: 28545405] - Stephanie Schneider, Kurt Pfister, Anne M Becher, Miriam C Scheuerle. Strongyle infections and parasitic control strategies in German horses - a risk assessment.
BMC veterinary research.
2014 Nov; 10(?):262. doi:
10.1186/s12917-014-0262-z. [PMID: 25387542] - S K Armstrong, R G Woodgate, S Gough, J Heller, N C Sangster, K J Hughes. The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia.
Veterinary parasitology.
2014 Oct; 205(3-4):575-80. doi:
10.1016/j.vetpar.2014.08.028. [PMID: 25224788] - Cengiz Gokbulut, Dilek Aksit, Giorgio Smaldone, Ugo Mariani, Vincenzo Veneziano. Plasma pharmacokinetics, faecal excretion and efficacy of pyrantel pamoate paste and granule formulations following per os administration in donkeys naturally infected with intestinal strongylidae.
Veterinary parasitology.
2014 Sep; 205(1-2):186-92. doi:
10.1016/j.vetpar.2014.06.026. [PMID: 25015542] - M K Nielsen, A N Vidyashankar, B M Hanlon, G Diao, S L Petersen, R M Kaplan. Hierarchical model for evaluating pyrantel efficacy against strongyle parasites in horses.
Veterinary parasitology.
2013 Nov; 197(3-4):614-22. doi:
10.1016/j.vetpar.2013.04.036. [PMID: 23680542] - Ricardo J Canever, Pollyana R C Braga, Albert Boeckh, Marcelly Grycajuck, Daniele Bier, Marcelo B Molento. Lack of Cyathostomin sp. reduction after anthelmintic treatment in horses in Brazil.
Veterinary parasitology.
2013 May; 194(1):35-9. doi:
10.1016/j.vetpar.2012.12.020. [PMID: 23318166] - Piyanan Taweethavonsawat, Sudchit Chungpivat, Supoj Watanapongchati, Rebecca J Traub, Roland Schaper. Comparative efficacy of a spot-on formulation containing emodepside and praziquantel (Profender ®, Bayer) and praziquantel and pyrantel oral tablets (Drontal ® for Cats) against experimental Ancylostoma ceylanicum infections in cats.
Veterinary parasitology.
2013 Jan; 191(1-2):172-6. doi:
10.1016/j.vetpar.2012.08.024. [PMID: 23026558] - Anu Näreaho, Jutta Puomio, Kaisa Saarinen, Pikka Jokelainen, Tiina Juselius, Antti Sukura. Feline intestinal parasites in Finland: prevalence, risk factors and anthelmintic treatment practices.
Journal of feline medicine and surgery.
2012 Jun; 14(6):378-83. doi:
10.1177/1098612x12439257. [PMID: 22328587] - K Schmid, N Rohdich, E Zschiesche, D J Kok, M J Allan. Efficacy, safety and palatability of a new broad-spectrum anthelmintic formulation in dogs.
The Veterinary record.
2010 Oct; 167(17):647-51. doi:
10.1136/vr.c4661. [PMID: 21257464] - Piyanan Taweethavonsawat, Sudchit Chungpivat, Pakkawan Satranarakun, Rebecca J Traub, Roland Schaper. Efficacy of a combination product containing pyrantel, febantel and praziquantel (Drontal Plus Flavour, Bayer Animal Health) against experimental infection with the hookworm Ancylostoma ceylanicum in dogs.
Parasitology research.
2010 Jan; 106(2):533-7. doi:
10.1007/s00436-009-1665-9. [PMID: 19911198] - Steven R Kopp, Glen T Coleman, James S McCarthy, Andrew C Kotze. Application of in vitro anthelmintic sensitivity assays to canine parasitology: detecting resistance to pyrantel in Ancylostoma caninum.
Veterinary parasitology.
2008 Apr; 152(3-4):284-93. doi:
10.1016/j.vetpar.2007.12.020. [PMID: 18242867] - K Lindgren, O Ljungvall, O Nilsson, B-L Ljungström, C Lindahl, J Höglund. Parascaris equorum in foals and in their environment on a Swedish stud farm, with notes on treatment failure of ivermectin.
Veterinary parasitology.
2008 Feb; 151(2-4):337-43. doi:
10.1016/j.vetpar.2007.10.014. [PMID: 18077096] - E Grandemange, E Claerebout, C Genchi, M Franc. Field evaluation of the efficacy and the safety of a combination of oxantel/pyrantel/praziquantel in the treatment of naturally acquired gastrointestinal nematode and/or cestode infestations in dogs in Europe.
Veterinary parasitology.
2007 Apr; 145(1-2):94-9. doi:
10.1016/j.vetpar.2006.11.013. [PMID: 17184919] - Steven R Kopp, Andrew C Kotze, James S McCarthy, Glen T Coleman. High-level pyrantel resistance in the hookworm Ancylostoma caninum.
Veterinary parasitology.
2007 Feb; 143(3-4):299-304. doi:
10.1016/j.vetpar.2006.08.036. [PMID: 17011128] - K C Comer, M H Hillyer, G C Coles. Anthelmintic use and resistance on thoroughbred training yards in the UK.
The Veterinary record.
2006 Apr; 158(17):596-8. doi:
10.1136/vr.158.17.596. [PMID: 16648441] - Andrea V Scorza, Steven V Radecki, Michael R Lappin. Efficacy of a combination of febantel, pyrantel, and praziquantel for the treatment of kittens experimentally infected with Giardia species.
Journal of feline medicine and surgery.
2006 Feb; 8(1):7-13. doi:
10.1016/j.jfms.2005.04.004. [PMID: 16011902] - E-M King, H T Kim, N T Dang, E Michael, L Drake, C Needham, R Haque, D A P Bundy, J P Webster. Immuno-epidemiology of Ascaris lumbricoides infection in a high transmission community: antibody responses and their impact on current and future infection intensity.
Parasite immunology.
2005 Mar; 27(3):89-96. doi:
10.1111/j.1365-3024.2005.00753.x. [PMID: 15882235] - W Peng, X Zhou, R B Gasser. Ascaris egg profiles in human faeces: biological and epidemiological implications.
Parasitology.
2003 Sep; 127(Pt 3):283-90. doi:
10.1017/s0031182003003615. [PMID: 12964831] - D Little, J R Flowers, B H Hammerberg, S Y Gardner. Management of drug-resistant cyathostominosis on a breeding farm in central North Carolina.
Equine veterinary journal.
2003 May; 35(3):246-51. doi:
10.2746/042516403776148264. [PMID: 12755426] - Ray M Kaplan. Anthelmintic resistance in nematodes of horses.
Veterinary research.
2002 Sep; 33(5):491-507. doi:
10.1051/vetres:2002035. [PMID: 12387486] - Jennifer Keiser, Eliézer K N'Goran, Mahamadou Traoré, Kouassi L Lohourignon, Burton H Singer, Christian Lengeler, Marcel Tanner, Jürg Utzinger. Polyparasitism with Schistosoma mansoni, geohelminths, and intestinal protozoa in rural Côte d'Ivoire.
The Journal of parasitology.
2002 Jun; 88(3):461-6. doi:
10.1645/0022-3395(2002)088[0461:pwsmga]2.0.co;2. [PMID: 12099412] - Patricia A Payne, Robert K Ridley, Michael W Dryden, Christine Bathgate, George A Milliken, Patricia W Stewart. Efficacy of a combination febantel-praziquantel-pyrantel product, with or without vaccination with a commercial Giardia vaccine, for treatment of dogs with naturally occurring giardiasis.
Journal of the American Veterinary Medical Association.
2002 Feb; 220(3):330-3. doi:
10.2460/javma.2002.220.330. [PMID: 11829263] - S Gerwert, K Failing, C Bauer. Prevalence of levamisole and benzimidazole resistance in oesophagostomum populations of pig-breeding farms in North Rhine-Westphalia, Germany.
Parasitology research.
2002 Jan; 88(1):63-8. doi:
10.1007/s004360100507. [PMID: 11822739] - A Ishih, M Yanoh, C Ikeya, A Ban, M Terada. Effects of anthelmintics on the development of eggs of Angiostrongylus costaricensis in vitro.
Journal of helminthology.
2001 Dec; 75(4):351-4. doi:
10.1017/s0022149x01000531. [PMID: 11818052] - M Várady, A Königová, J Corba. Benzimidazole resistance in equine cyathostomes in Slovakia.
Veterinary parasitology.
2000 Dec; 94(1-2):67-74. doi:
10.1016/s0304-4017(00)00366-6. [PMID: 11078945] - A Hall, C Holland. Geographical variation in Ascaris lumbricoides fecundity and its implications for helminth control.
Parasitology today (Personal ed.).
2000 Dec; 16(12):540-4. doi:
10.1016/s0169-4758(00)01779-8. [PMID: 11121853] - D R Hennessy, J Praslicka, H Bjørn. The disposition of pyrantel in the gastrointestinal tract and effect of digesta flow rate on the kinetic behaviour of pyrantel in the pig.
Veterinary parasitology.
2000 Oct; 92(4):277-85. doi:
10.1016/s0304-4017(00)00327-7. [PMID: 10996739] - L Changhua, Z Xiaorong, Q Dongchuan, X Shuhua, P J Hotez, Z Defu, Z Hulian, L Mingden, R Hainan, Z Bing, X Haichou, J Hawdon, F Zheng. Epidemiology of human hookworm infections among adult villagers in Hejiang and Santai Counties, Sichuan Province, China.
Acta tropica.
1999 Oct; 73(3):243-9. doi:
10.1016/s0001-706x(99)00035-2. [PMID: 10546842] - J Craven, H Bjørn, E H Barnes, S A Henriksen, P Nansen. A comparison of in vitro tests and a faecal egg count reduction test in detecting anthelmintic resistance in horse strongyles.
Veterinary parasitology.
1999 Aug; 85(1):49-59. doi:
10.1016/s0304-4017(99)00113-2. [PMID: 10447192] - M Sacko, D De Clercq, J M Behnke, F S Gilbert, P Dorny, J Vercruysse. Comparison of the efficacy of mebendazole, albendazole and pyrantel in treatment of human hookworm infections in the southern region of Mali, West Africa.
Transactions of the Royal Society of Tropical Medicine and Hygiene.
1999 Mar; 93(2):195-203. doi:
10.1016/s0035-9203(99)90306-1. [PMID: 10450449] - J E Forrester, J C Bailar, S A Esrey, M V José, B T Castillejos, G Ocampo. Randomised trial of albendazole and pyrantel in symptomless trichuriasis in children.
Lancet (London, England).
1998 Oct; 352(9134):1103-8. doi:
10.1016/s0140-6736(97)08325-6. [PMID: 9798586] - C M Monahan, M R Chapman, H W Taylor, D D French, T R Klei. Foals raised on pasture with or without daily pyrantel tartrate feed additive: comparison of parasite burdens and host responses following experimental challenge with large and small strongyle larvae.
Veterinary parasitology.
1997 Dec; 73(3-4):277-89. doi:
10.1016/s0304-4017(97)00096-4. [PMID: 9477514] - A Dangolla, H Bjørn, P Willeberg, E H Barnes. Faecal egg count reduction percentage calculations to detect anthelmintic resistance in Oesophagostomum spp. in pigs.
Veterinary parasitology.
1997 Jan; 68(1-2):127-42. doi:
10.1016/s0304-4017(96)01029-1. [PMID: 9066059] - J H Boersema, M Eysker, J Maas, W M van der Aar. Comparison of the reappearance of strongyle eggs on foals, yearlings and adult horses after treatment with ivermectin or pyrantel.
The veterinary quarterly.
1996 Mar; 18(1):7-9. doi:
10.1080/01652176.1996.9694602. [PMID: 8833604] - A A Fasanmade, A O Akanni, A A Olaniyi, A A Fasanmade, F Tayo. Bioequivalence of pyrantel pamoate dosage forms in healthy human subjects.
Biopharmaceutics & drug disposition.
1994 Aug; 15(6):527-34. doi:
10.1002/bdd.2510150610. [PMID: 7993990] - D D French, M R Chapman, T R Klei. Effects of treatment with ivermectin for five years on the prevalence of Anoplocephala perfoliata in three Louisiana pony herds.
The Veterinary record.
1994 Jul; 135(3):63-5. doi:
10.1136/vr.135.3.63. [PMID: 7975087] - J M Parry, M A Fisher, W T Grimshaw, D E Jacobs. Anthelmintic dosing intervals for horses: comparison of three chemical groups.
The Veterinary record.
1993 Oct; 133(14):346-7. doi:
10.1136/vr.133.14.346. [PMID: 8236679] - J L Duncan, S Love. Preliminary observations on an alternative strategy for the control of horse strongyles.
Equine veterinary journal.
1991 May; 23(3):226-8. doi:
10.1111/j.2042-3306.1991.tb02762.x. [PMID: 1909236] - M Eysker, J H Boersema, F N Kooyman. Effect of early season ivermectin and pyrantel treatments on strongylid infections in young Shetland ponies in The Netherlands.
Veterinary parasitology.
1991 Jan; 38(1):33-9. doi:
10.1016/0304-4017(91)90005-g. [PMID: 2024428] - A I King, S Love, J L Duncan. Field investigation of anthelmintic resistance of small strongyles in horses.
The Veterinary record.
1990 Sep; 127(9):232-3. doi:
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Veterinary parasitology.
1990 Aug; 37(1):21-30. doi:
10.1016/0304-4017(90)90022-4. [PMID: 2146796] - J Nahmias, R Kennet, R Goldsmith, Z Greenberg. Evaluation of albendazole, pyrantel, bephenium, pyrantel-praziquantel and pyrantel-bephenium for single-dose mass treatment of necatoriasis.
Annals of tropical medicine and parasitology.
1989 Dec; 83(6):625-9. doi:
10.1080/00034983.1989.11812397. [PMID: 2619378] - G G Lumsden, R Quan-Taylor, S M Smith, I M Washbrooke. Field efficacy of ivermectin, fenbendazole and pyrantel embonate paste anthelmintics in horses.
The Veterinary record.
1989 Nov; 125(20):497-9. doi:
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Parasitology.
1988 Jun; 96 ( Pt 3)(?):565-77. doi:
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Parasitology.
1988 Feb; 96 ( Pt 1)(?):171-84. doi:
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The Journal of parasitology.
1987 Aug; 73(4):843-4. doi:
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Veterinary parasitology.
1987 May; 24(3-4):229-39. doi:
10.1016/0304-4017(87)90044-6. [PMID: 2956755] - H J Bürger, C Bauer. Efficacy of four anthelmintics against benzimidazole-resistant cyathostomes of horses.
The Veterinary record.
1987 Mar; 120(13):293-6. doi:
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Journal of veterinary pharmacology and therapeutics.
1987 Mar; 10(1):23-9. doi:
10.1111/j.1365-2885.1987.tb00072.x. [PMID: 3586119] - D B Elkins, M Haswell-Elkins, R M Anderson. The epidemiology and control of intestinal helminths in the Pulicat Lake region of Southern India. I. Study design and pre- and post-treatment observations on Ascaris lumbricoides infection.
Transactions of the Royal Society of Tropical Medicine and Hygiene.
1986; 80(5):774-92. doi:
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The Veterinary record.
1985 Dec; 117(23):613-4. doi:
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Bangladesh Medical Research Council bulletin.
1985 Dec; 11(2):44-50. doi:
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Equine veterinary journal.
1985 May; 17(3):202-7. doi:
10.1111/j.2042-3306.1985.tb02470.x. [PMID: 3841055] - R E Pust, C W Binns, D W Weinhold, J R Martin. Palm oil and pyrantel as child nutrition mass interventions in Papua New Guinea.
Tropical and geographical medicine.
1985 Mar; 37(1):1-10. doi:
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Salud publica de Mexico.
1985 Mar; 27(2):149-54. doi:
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Zeitschrift fur Lebensmittel-Untersuchung und -Forschung.
1983; 177(2):117-20. doi:
10.1007/bf01043076. [PMID: 6637092] - B D Cabrera, E V Valdez, T G Go. Clinical trials of broad spectrum anthelmintics against soil-transmitted helminthiasis.
The Southeast Asian journal of tropical medicine and public health.
1980 Dec; 11(4):502-6. doi:
NULL. [PMID: 7221692] - H M Clayton, J L Duncan, G A Gilbert. Equine parasite control using pyrantel embonate.
The Veterinary record.
1979 Oct; 105(17):389-91. doi:
10.1136/vr.105.17.389. [PMID: 552733] - S K Figdor, M S von Wittenau, M J Lynch. Banminth and a common fragment assay.
Journal - Association of Official Analytical Chemists.
1978 Sep; 61(5):1228-31. doi:
NULL. [PMID: 721736] - J K Lim. Anthelminthic effect of oxantel and oxantel-pyrantel in intestinal nematode infections.
Drugs.
1978; 15 Suppl 1(?):99-103. doi:
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