nicardipine (BioDeep_00000408959)
Main id: BioDeep_00000002100
代谢物信息卡片
nicardipine
化学式: C26H29N3O6 (479.20562540000003)
中文名称: 尼卡地平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c(c1)(N(=O)=O)cccc1C(C(C(=O)OC)=2)C(C(=O)OCCN(C)Cc(c3)cccc3)=C(NC2C)C
InChI: InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
描述信息
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
2 个代谢物同义名
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:180905
- ChEBI: CHEBI:7550
- KEGG: C07264
- KEGGdrug: D08270
- PubChem: 4474
- DrugBank: DB00622
- ChEMBL: CHEMBL3302409
- ChEMBL: CHEMBL1484
- MeSH: Nicardipine
- CAS: 106664-28-2
- CAS: 55985-32-5
- MoNA: MoNA037449
- MoNA: MoNA032943
- MoNA: MoNA032941
- MoNA: MoNA032942
- MoNA: WA002569
- MoNA: WA002568
- MoNA: WA002567
- MoNA: WA002566
- MoNA: WA002565
- MoNA: WA002564
- MoNA: WA002563
- PubChem: 9473
- NIKKAJI: J11.098A
- KNApSAcK: 7550
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ting Wang, Ruoan Jiang, Yingsha Yao, Ting Xu, Na Li. Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review.
Hypertension in pregnancy.
2024 Dec; 43(1):2329068. doi:
10.1080/10641955.2024.2329068. [PMID: 38488570] - Chen Wang, Xiaoli Zhao, Yunyun Chen, Jianhua Xia, Xixue Zhang, Tingting Wang. Optimizing nicardipine dosage for effective control of pituitrin-induced hypertension in laparoscopic myomectomy undergoing total intravenous anesthesia.
BMC anesthesiology.
2024 Apr; 24(1):155. doi:
10.1186/s12871-024-02521-w. [PMID: 38654209] - Sara Saldana, James Breslin, Jennifer Hanify, Theodore Heierman, Kristina Larizadeh, Michael Sanchez, William Phipps. Comparison of Clevidipine and Nicardipine for Acute Blood Pressure Reduction in Hemorrhagic Stroke.
Neurocritical care.
2022 06; 36(3):983-992. doi:
10.1007/s12028-021-01407-w. [PMID: 34904214] - Bhuvanenthiran Mutharani, Hsieh-Chih Tsai, Juin-Yih Lai, Shen-Ming Chen. Protein-assisted biomimetic synthesis of nanoscale gadolinium-integrated polypyrrole for synergetic and ultrasensitive electrochemical assays of nicardipine in biological samples.
Analytica chimica acta.
2022 Mar; 1199(?):339567. doi:
10.1016/j.aca.2022.339567. [PMID: 35227379] - Mayumi Fukuda-Doi, Haruko Yamamoto, Masatoshi Koga, Yohei Doi, Adnan I Qureshi, Sohei Yoshimura, Kaori Miwa, Akiko Ishigami, Masayuki Shiozawa, Katsuhiro Omae, Masafumi Ihara, Kazunori Toyoda. Impact of Renal Impairment on Intensive Blood-Pressure-Lowering Therapy and Outcomes in Intracerebral Hemorrhage: Results From ATACH-2.
Neurology.
2021 08; 97(9):e913-e921. doi:
10.1212/wnl.0000000000012442. [PMID: 34210824] - Q Chen, Z Jiang, J Zhang, L Cao, Z Chen. Arecoline hydrobromide enhances jejunum smooth muscle contractility via voltage-dependent potassium channels in W/Wv mice.
Physiological research.
2021 07; 70(3):437-446. doi:
10.33549/physiolres.934557. [PMID: 33982580] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Noelle Breslin, Caitlin Baptiste, Russell Miller, Karin Fuchs, Dena Goffman, Cynthia Gyamfi-Bannerman, Mary D'Alton. Coronavirus disease 2019 in pregnancy: early lessons.
American journal of obstetrics & gynecology MFM.
2020 05; 2(2):100111. doi:
10.1016/j.ajogmf.2020.100111. [PMID: 32518902] - Jelena Ristic, Marko Folic, Katarina Radonjic, Milenko I Rosic, Sergey Bolevich, Omarov Israpil Alisultanovich, Nevena Draginic, Marijana Andjic, Jovana Jeremic, Isidora Milosavljevic, Vladimir Zivkovic, Vladimir Jakovljevic. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats.
Oxidative medicine and cellular longevity.
2020; 2020(?):6361703. doi:
10.1155/2020/6361703. [PMID: 32104536] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Stephen Boulton, Rajeevan Selvaratnam, Rashik Ahmed, Katherine Van, Xiaodong Cheng, Giuseppe Melacini. Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators.
Journal of medicinal chemistry.
2019 05; 62(10):5063-5079. doi:
10.1021/acs.jmedchem.9b00258. [PMID: 31074269] - Seth J Lichtenstein, Michael J Herring, Pravir V Baxi, Richard I Abrams, Stephen M Korbet. Without Warning: Scleroderma Renal Crisis.
The American journal of medicine.
2019 02; 132(2):175-178. doi:
10.1016/j.amjmed.2018.09.024. [PMID: 30290189] - Zachary Rosenfeldt, Katelyn Conklen, Breck Jones, Don Ferrill, Maithili Deshpande, Fazeel M Siddiqui. Comparison of Nicardipine with Clevidipine in the Management of Hypertension in Acute Cerebrovascular Diseases.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2018 Aug; 27(8):2067-2073. doi:
10.1016/j.jstrokecerebrovasdis.2018.03.001. [PMID: 29627171] - Elena-Mihaela Cordeanu, Sébastien Gaertner, Alix Faller, Corina Mirea, Jean-Marc Lessinger, Veronique Kemmel, Dominique Stephan. Rifampicin reverses nicardipine effect inducing uncontrolled essential hypertension.
Fundamental & clinical pharmacology.
2017 Oct; 31(5):587-589. doi:
10.1111/fcp.12292. [PMID: 28407303] - Cholhee Park, Ji Young Kim, Chanmi Kim, Chul Ho Chang. Nicardipine Effects on Renal Function During Spine Surgery.
Clinical spine surgery.
2017 Aug; 30(7):E954-E958. doi:
10.1097/bsd.0000000000000394. [PMID: 27231835] - Joji Inamasu, Shunsuke Nakae, Kazuhide Adachi, Yuichi Hirose. Angiotensin II receptor blockers following intravenous nicardipine administration to lower blood pressure in patients with hypertensive intracerebral hemorrhage: a prospective randomized study.
Blood pressure monitoring.
2017 Feb; 22(1):34-39. doi:
10.1097/mbp.0000000000000225. [PMID: 27824680] - Rituparna Mittra, Megan Pavy, Nanditha Subramanian, Anthony M George, Megan L O'Mara, Ian D Kerr, Richard Callaghan. Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein.
Biochemical pharmacology.
2017 Jan; 123(?):19-28. doi:
10.1016/j.bcp.2016.10.002. [PMID: 27729218] - Hiroko Negishi, Sari Sugahama, Ayaka Kawakamia, Junna Kondo, Yuriko Nishigaki, Masato Yoshikawa, Taketeru Ueyama, Katsumi Ikeda. Effect of Angelica acutiloba Extract on Blood flow Regulation in Stroke-prone Spontaneously Hypertensive Rats.
Natural product communications.
2016 Oct; 11(10):1497-1498. doi:
". [PMID: 30549606] - Christopher W Mastropietro, Diego Arango Uribe. Nicardipine for Hypertension Following Aortic Coarctectomy or Superior Cavopulmonary Anastomosis.
World journal for pediatric & congenital heart surgery.
2016 Jan; 7(1):32-5. doi:
10.1177/2150135115608815. [PMID: 26714991] - Filip Zmuda, Gaurav Malviya, Adele Blair, Marie Boyd, Anthony J Chalmers, Andrew Sutherland, Sally L Pimlott. Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo.
Journal of medicinal chemistry.
2015 Nov; 58(21):8683-93. doi:
10.1021/acs.jmedchem.5b01324. [PMID: 26469301] - Kamsiah Jaarin, Wai Dic Foong, Min Hui Yeoh, Zaman Yusoff Nik Kamarul, Haji Mohd Saad Qodriyah, Abdullah Azman, Japar Sidik Fadhlullah Zuhair, Abdul Hamid Juliana, Yusof Kamisah. Mechanisms of the antihypertensive effects of Nigella sativa oil in L-NAME-induced hypertensive rats.
Clinics (Sao Paulo, Brazil).
2015 Nov; 70(11):751-7. doi:
10.6061/clinics/2015(11)07. [PMID: 26602523] - Changwoo Kang, Dong Hoon Kim, Seong Chun Kim, Soo Hoon Lee, Jin Hee Jeong, Tae-Sin Kang, Il-Woo Shin, Rock Bum Kim, Dong Hoon Lee. The effects of intravenous lipid emulsion on prolongation of survival in a rat model of calcium channel blocker toxicity.
Clinical toxicology (Philadelphia, Pa.).
2015 Jul; 53(6):540-4. doi:
10.3109/15563650.2015.1045979. [PMID: 25984591] - Joji Inamasu, Motoki Oheda, Takuro Hayashi, Yoko Kato, Yuichi Hirose. Are admission systolic blood pressures predictive of outcomes in patients with spontaneous intracerebral haemorrhage after aggressive blood pressure management?.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine.
2015 Jun; 22(3):170-5. doi:
10.1097/mej.0000000000000128. [PMID: 24557148] - Amanda L Hurst, Natalie Clark, Todd C Carpenter, Shikha S Sundaram, Pamela D Reiter. Supra-therapeutic tacrolimus concentrations associated with concomitant nicardipine in pediatric liver transplant recipients.
Pediatric transplantation.
2015 Jun; 19(4):E83-7. doi:
10.1111/petr.12470. [PMID: 25850753] - Yufeng Wu, Ruirui Si, Hong Tang, Zhen He, Hui Zhu, Lili Wang, Yingchao Fan, Suhua Xia, Zelai He, Qiming Wang. Cholesterol reduces the sensitivity to platinum-based chemotherapy via upregulating ABCG2 in lung adenocarcinoma.
Biochemical and biophysical research communications.
2015 Feb; 457(4):614-20. doi:
10.1016/j.bbrc.2015.01.035. [PMID: 25603057] - Takeshi Ogura, Ririko Takeda, Hidetoshi Ooigawa, Hiroyuki Nakajima, Hiroki Kurita. Effects of diltiazem on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage.
Acta neurochirurgica. Supplement.
2015; 120(?):47-50. doi:
10.1007/978-3-319-04981-6_8. [PMID: 25366598] - Mouna B Sassi, Emna Gaies, Issam Salouage, Sameh Trabelsi, Mohamed Lakhal, Anis Klouz. Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report.
Current drug safety.
2015; 10(3):254-6. doi:
10.2174/1574886310666150512105459. [PMID: 25968921] - Serafin Farias, W Frank Peacock, Michael Gonzalez, Phillip D Levy. Impact of initial blood pressure on antihypertensive response in patients with acute hypertension.
The American journal of emergency medicine.
2014 Aug; 32(8):833-6. doi:
10.1016/j.ajem.2014.03.021. [PMID: 24857251] - André Mateus, Pär Matsson, Per Artursson. A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Journal of medicinal chemistry.
2014 Apr; 57(7):3005-10. doi:
10.1021/jm401963n. [PMID: 24601604] - Hyub Huh, Na Young Kim, Seol Ju Park, Jang Eun Cho. Effect of nicardipine on renal function following robot-assisted laparoscopic radical prostatectomy in patients with pre-existing renal insufficiency.
The Journal of international medical research.
2014 Apr; 42(2):427-35. doi:
10.1177/0300060513510435. [PMID: 24570078] - Hideyoshi Matsumura, Kenjiro Takagi, Hiroyuki Seki, Yoshihisa Ono, Shunichiro Ichinose, Hiroko Masuko, Mayumi Fukatsu, Aiji Miyashita, Ayako Mera. Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia.
Hypertension in pregnancy.
2014 Feb; 33(1):93-101. doi:
10.3109/10641955.2013.846367. [PMID: 24131296] - Ji Eun Kim, Jong Seok Lee, Mi Kyeong Kim, Seung Hyun Kim, Ji Young Kim. Nicardipine infusion for hypotensive anesthesia during orthognathic surgery has protective effect on renal function.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
2014 Jan; 72(1):41-6. doi:
10.1016/j.joms.2013.08.011. [PMID: 24071376] - Sergey Shityakov, Carola Förster. Pharmacokinetic delivery and metabolizing rate of nicardipine incorporated in hydrophilic and hydrophobic cyclodextrins using two-compartment mathematical model.
TheScientificWorldJournal.
2013; 2013(?):131358. doi:
10.1155/2013/131358. [PMID: 24391458] - Chung-Ren Jan, Horng-Ren Lo, Chung-Yi Chen, Soong-Yu Kuo. Effect of allyl sulfides from garlic essential oil on intracellular ca2+ levels in renal tubular cells.
Journal of natural products.
2012 Dec; 75(12):2101-7. doi:
10.1021/np3005248. [PMID: 23163425] - Hasan K Siddiqi, Hui-yu Yang, Amanda M Laird, Amy C Fox, Gerard M Doherty, Barbra S Miller, Paul G Gauger. Utility of oral nicardipine and magnesium sulfate infusion during preparation and resection of pheochromocytomas.
Surgery.
2012 Dec; 152(6):1027-36. doi:
10.1016/j.surg.2012.08.023. [PMID: 23158177] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Adnan I Qureshi, Yuko Y Palesch, Renee Martin, Jill Novitzke, Salvador Cruz Flores, Asad Ehtisham, Joshua N Goldstein, Jawad F Kirmani, Haitham M Hussein, M Fareed K Suri, Nauman Tariq. Systolic blood pressure reduction and risk of acute renal injury in patients with intracerebral hemorrhage.
The American journal of medicine.
2012 Jul; 125(7):718.e1-6. doi:
10.1016/j.amjmed.2011.09.031. [PMID: 22560810] - Douglas J Cook, Sabrina Kan, Jinglu Ai, Hidetoshi Kasuya, R Loch Macdonald. Cisternal sustained release dihydropyridines for subarachnoid hemorrhage.
Current neurovascular research.
2012 May; 9(2):139-48. doi:
10.2174/156720212800410894. [PMID: 22475399] - David K Hooper, Tsuyoshi Fukuda, Rhonda Gardiner, Barbara Logan, Ashwini Roy-Chaudhury, Cassie L Kirby, Alexander A Vinks, Jens Goebel. Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation.
Transplantation.
2012 Apr; 93(8):806-12. doi:
10.1097/tp.0b013e318247a6c7. [PMID: 22491658] - Adnan I Qureshi, Yuko Y Palesch, Renee Martin, Jill Novitzke, Salvador Cruz-Flores, Asad Ehtisham, Mustapha A Ezzeddine, Joshua N Goldstein, Jawad F Kirmani, Haitham M Hussein, M Fareed K Suri, Nauman Tariq, Yuan Liu. Association of serum glucose concentrations during acute hospitalization with hematoma expansion, perihematomal edema, and three month outcome among patients with intracerebral hemorrhage.
Neurocritical care.
2011 Dec; 15(3):428-35. doi:
10.1007/s12028-011-9541-8. [PMID: 21573860] - Ruth E Curran, Christopher R J Claxton, Laura Hutchison, Paul J Harradine, Iain J Martin, Peter Littlewood. Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Mar; 39(3):551-7. doi:
10.1124/dmd.110.036988. [PMID: 21098647] - David K Hooper, Adam C Carle, Joseph Schuchter, Jens Goebel. Interaction between tacrolimus and intravenous nicardipine in the treatment of post-kidney transplant hypertension at pediatric hospitals.
Pediatric transplantation.
2011 Feb; 15(1):88-95. doi:
10.1111/j.1399-3046.2010.01417.x. [PMID: 21159108] - You Komagiri, Kazuyoshi Nakamura, Manabu Kubokawa. A nicardipine-sensitive Ca2+ entry contributes to the hypotonicity-induced increase in [Ca2+]i of principal cells in rat cortical collecting duct.
Cell calcium.
2011 Jan; 49(1):35-42. doi:
10.1016/j.ceca.2010.11.006. [PMID: 21146213] - Joong-W Chung, Si H Yang, Jun-S Choi. Effects of lovastatin on the pharmacokinetics of nicardipine in rats.
Biopharmaceutics & drug disposition.
2010 Oct; 31(7):436-41. doi:
10.1002/bdd.721. [PMID: 20824619] - Yoshitaka Hasegawa, Shuichi Kishimoto, Naoki Shibatani, Nobuo Inotsume, Yoshikazu Takeuchi, Shoji Fukushima. Effects of insulin on CYP3A activity and nicardipine disposition in streptozotocin-induced diabetic rats.
The Journal of pharmacy and pharmacology.
2010 Jul; 62(7):883-9. doi:
10.1211/jpp.62.05.0009. [PMID: 20636876] - Thi Diem Thuy Hoang, Vo Quoc Bao, Vu Hiep Phat. Massive polyuria after kidney transplantation.
Pediatric nephrology (Berlin, Germany).
2010 Feb; 25(2):383-4. doi:
10.1007/s00467-009-1344-1. [PMID: 19885682] - Jun-Shik Choi, Jin-Pil Burm. Effects of oral epigallocatechin gallate on the pharmacokinetics of nicardipine in rats.
Archives of pharmacal research.
2009 Dec; 32(12):1721-5. doi:
10.1007/s12272-009-2209-7. [PMID: 20162400] - Xiaofan Sui, Jin Sun, Haiyan Li, Yongjun Wang, Jianfang Liu, Xiaohong Liu, Wenping Zhang, Lijiang Chen, Zhonggui He. Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
European journal of medicinal chemistry.
2009 Nov; 44(11):4455-60. doi:
10.1016/j.ejmech.2009.06.004. [PMID: 19586686] - Ching-Hsein Chen, Shu-Jem Su, Kee-Lung Chang, Mei-Wen Huang, Soong-Yu Kuo. The garlic ingredient diallyl sulfide induces Ca(2+) mobilization in Madin-Darby canine kidney cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Sep; 47(9):2344-50. doi:
10.1016/j.fct.2009.06.028. [PMID: 19555733] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Changqing Yu, Zhiwei Yang, Hongmei Ren, Yie Zhang, Yu Han, Duofen He, Quansheng Lu, Xiaoyan Wang, Xukai Wang, Chengming Yang, Laureano D Asico, Ulrich Hopfer, Gilbert M Eisner, Pedro A Jose, Chunyu Zeng. D3 dopamine receptor regulation of ETB receptors in renal proximal tubule cells from WKY and SHRs.
American journal of hypertension.
2009 Aug; 22(8):877-83. doi:
10.1038/ajh.2009.80. [PMID: 19390510] - Makoto Tsunoda, Masanori Yamagishi, Kazuhiro Imai, Teruyuki Yanagisawa. Study of the acute cardiovascular effects of several antihypertensive agents with the measurement of plasma catecholamines in mice.
Analytical and bioanalytical chemistry.
2009 Jun; 394(4):947-52. doi:
10.1007/s00216-009-2685-0. [PMID: 19234691] - Anil Patel, Harsh Patel, Anush Patel. Thrombotic thrombocytopenic purpura: the masquerader.
Southern medical journal.
2009 May; 102(5):504-9. doi:
10.1097/smj.0b013e31819f330e. [PMID: 19373147] - Jang Eun Cho, Jae Kwang Shim, Jae Hyun Chang, Young Jun Oh, Hae Keum Kil, Koon Ho Rha, Young Lan Kwak. Effect of nicardipine on renal function after robot-assisted laparoscopic radical prostatectomy.
Urology.
2009 May; 73(5):1056-60. doi:
10.1016/j.urology.2008.08.490. [PMID: 19394503] - Edwin E Daniel, Tahereh Eteraf, Bettina Sommer, Woo Jung Cho, Ahmed Elyazbi. The role of caveolae and caveolin 1 in calcium handling in pacing and contraction of mouse intestine.
Journal of cellular and molecular medicine.
2009 Feb; 13(2):352-64. doi:
10.1111/j.1582-4934.2008.00667.x. [PMID: 19166483] - Xiaoyi Wei, Gengliang Yang, Li Qi, Yi Chen. Determination of nicardipine and amlodipine in human plasma using on-line solid-phase extraction with a monolithic weak cation-exchange column.
Talanta.
2009 Jan; 77(3):1197-202. doi:
10.1016/j.talanta.2008.08.034. [PMID: 19064112] - Muhammad Chaudhry, Abrar Maqsood, Samer Diab-Agha, Joshua Rosenberg. Nicardipine-induced acute hepatitis in an intensive care unit patient.
American journal of therapeutics.
2009 Jan; 16(1):71-3. doi:
10.1097/mjt.0b013e31817fde68. [PMID: 19092642] - Naoe Yamane, Tomonori Takami, Zenzaburo Tozuka, Yuichi Sugiyama, Akira Yamazaki, Yuji Kumagai. Microdose clinical trial: quantitative determination of nicardipine and prediction of metabolites in human plasma.
Drug metabolism and pharmacokinetics.
2009; 24(4):389-403. doi:
10.2133/dmpk.24.389. [PMID: 19745565] - Yutaka Ikeno, So-hyun Cheon, Naoko Konno, Ayako Nakamura, Katsuhiko Kitamoto, Manabu Arioka. Lysophosphatidylcholine protects cerebellar granule neurons from apoptotic cell death.
Journal of neuroscience research.
2009 Jan; 87(1):190-9. doi:
10.1002/jnr.21821. [PMID: 18711725] - Jun-Shik Choi, Byung-Chul Choi, Keon Wook Kang. Effect of resveratrol on the pharmacokinetics of oral and intravenous nicardipine in rats: possible role of P-glycoprotein inhibition by resveratrol.
Die Pharmazie.
2009 Jan; 64(1):49-52. doi:
. [PMID: 19216231] - Eun Joo Roh, Jason M Keller, Zoltan Olah, Michael J Iadarola, Kenneth A Jacobson. Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1).
Bioorganic & medicinal chemistry.
2008 Oct; 16(20):9349-58. doi:
10.1016/j.bmc.2008.08.048. [PMID: 18809334] - Jun-Shik Choi, Young-Youp Koh, Joong-Hwa Chung, Dong-Hyun Choi, Hyo-Kyung Han. Reduced prehepatic extraction of nicardipine in the presence of pioglitazone in rats.
The Journal of pharmacy and pharmacology.
2008 Oct; 60(10):1403-7. doi:
10.1211/jpp/60.10.0017. [PMID: 18812034] - Hiroshi Fukagawa, Mitsuko Hashiguchi, Yuko Ayabe, Taiki Ando, Kumi Nakamura. [Anesthetic management of undiagnosed pheochromocytoma: a case report].
Masui. The Japanese journal of anesthesiology.
2008 Oct; 57(10):1241-4. doi:
NULL. [PMID: 18975540] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Yong-Ji Piao, Jun-Shik Choi. Effects of morin on the pharmacokinetics of nicardipine after oral and intravenous administration of nicardipine in rats.
The Journal of pharmacy and pharmacology.
2008 May; 60(5):625-9. doi:
10.1211/jpp.60.5.0008. [PMID: 18416939] - Chung-Yi Chen, Ching-Hsein Chen, Chiu-Hu Kung, Shih-Hsing Kuo, Soong-Yu Kuo. [6]-gingerol induces Ca2+ mobilization in Madin-Darby canine kidney cells.
Journal of natural products.
2008 Jan; 71(1):137-40. doi:
10.1021/np070279y. [PMID: 18181576] - Toru Iizuka, Seiji Nagumo, Hideomi Yotsumoto, Hiroyoshi Moriyama, Masahiro Nagai. Vasorelaxant effects of Acer nikoense extract and isolated coumarinolignans on rat aortic rings.
Biological & pharmaceutical bulletin.
2007 Jun; 30(6):1164-6. doi:
10.1248/bpb.30.1164. [PMID: 17541175] - Meiling Qi, Peng Wang, Xin Jin. Liquid chromatography-mass spectrometry method for the determination of nicardipine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jan; 830(1):81-5. doi:
10.1016/j.jchromb.2005.10.035. [PMID: 16280265] - Hideyuki Okano, Chiyoji Ohkubo. Elevated plasma nitric oxide metabolites in hypertension: synergistic vasodepressor effects of a static magnetic field and nicardipine in spontaneously hypertensive rats.
Clinical hemorheology and microcirculation.
2006; 34(1-2):303-8. doi:
NULL. [PMID: 16543650] - Jason M Hoover, Alan D Kaye, Ikhlass N Ibrahim, Aaron M Fields, Todd A Richards. Analysis of responses to kava kava in the feline pulmonary vascular bed.
Journal of medicinal food.
2006; 9(1):62-71. doi:
10.1089/jmf.2006.9.62. [PMID: 16579730] - Kazuhiko Hanada, Rie Ogawa, Kishin Son, Yuuki Sasaki, Akashi Kikkawa, Shiho Ichihara, Hiroyasu Ogata. Effects of indoxylsulfate on the in vitro hepatic metabolism of various compounds using human liver microsomes and hepatocytes.
Nephron. Physiology.
2006; 103(4):p179-86. doi:
10.1159/000092919. [PMID: 16645322] - Dorota Kowalczuk, Maria Bozena Wawrzycka, Agnieszka Haratym Maj. Determination of nifedipine in serum of women in preterm labor by high-performance liquid chromatography with diode array detection.
Journal of AOAC International.
2006 Jan; 89(1):71-7. doi:
10.1093/jaoac/89.1.71. [PMID: 16512231] - Toru Iizuka, Hiroyoshi Moriyama, Masahiro Nagai. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri.
Biological & pharmaceutical bulletin.
2006 Jan; 29(1):177-9. doi:
10.1248/bpb.29.177. [PMID: 16394535] - Hideyuki Okano, Chiyoji Ohkubo. Exposure to a moderate intensity static magnetic field enhances the hypotensive effect of a calcium channel blocker in spontaneously hypertensive rats.
Bioelectromagnetics.
2005 Dec; 26(8):611-23. doi:
10.1002/bem.20144. [PMID: 16189831] - Yutaka Ikeno, Naoko Konno, So-hyun Cheon, Angelo Bolchi, Simone Ottonello, Katsuhiko Kitamoto, Manabu Arioka. Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.
The Journal of biological chemistry.
2005 Jul; 280(30):28044-52. doi:
10.1074/jbc.m503343200. [PMID: 15927955] - Mee-Ra Rhyu, Jung-Hyun Kim, Eun-Young Kim. Radix angelica elicits both nitric oxide-dependent and calcium influx-mediated relaxation in rat aorta.
Journal of cardiovascular pharmacology.
2005 Jul; 46(1):99-104. doi:
10.1097/01.fjc.0000164092.88821.49. [PMID: 15965361] - Pascale Dewachter, Valérie Jouan-Hureaux, Patricia Franck, Patrick Menu, Nicole de Talancé, Faiez Zannad, Marie-Claire Laxenaire, Dan Longrois, Paul Michel Mertes. Anaphylactic shock: a form of distributive shock without inhibition of oxygen consumption.
Anesthesiology.
2005 Jul; 103(1):40-9. doi:
10.1097/00000542-200507000-00010. [PMID: 15983455] - Szabolcs Modok, Catherine Heyward, Richard Callaghan. P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment.
Journal of lipid research.
2004 Oct; 45(10):1910-8. doi:
10.1194/jlr.m400220-jlr200. [PMID: 15258203] - Giuseppe Ermondi, Miriam Lorenti, Giulia Caron. Contribution of ionization and lipophilicity to drug binding to albumin: a preliminary step toward biodistribution prediction.
Journal of medicinal chemistry.
2004 Jul; 47(16):3949-61. doi:
10.1021/jm040760a. [PMID: 15267234] - N A Belyavskaya. Changes in calcium signalling, gravitropism, and statocyte ultrastructure in pea roots induced by calcium channel blockers.
Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology.
2004 Jul; 11(2):P209-10. doi:
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Clinical and experimental hypertension (New York, N.Y. : 1993).
2004 May; 26(4):375-86. doi:
10.1081/ceh-120034141. [PMID: 15195691] - Pekka Suomalainen, Christoffer Johans, Tim Söderlund, Paavo K J Kinnunen. Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Journal of medicinal chemistry.
2004 Mar; 47(7):1783-8. doi:
10.1021/jm0309001. [PMID: 15027870] - Shogo Suzuki, Tomoko Nishimaki-Mogami, Norimasa Tamehiro, Kazuhide Inoue, Reijiro Arakawa, Sumiko Abe-Dohmae, Arowu R Tanaka, Kazumitsu Ueda, Shinji Yokoyama. Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism.
Arteriosclerosis, thrombosis, and vascular biology.
2004 Mar; 24(3):519-25. doi:
10.1161/01.atv.0000117178.94087.ba. [PMID: 14726413] - Yutaka Oda, Tomoharu Funao, Katsuaki Tanaka, Akira Asada. Vasodilation increases the threshold for bupivacaine-induced convulsions in rats.
Anesthesia and analgesia.
2004 Mar; 98(3):677-82, table of contents. doi:
10.1213/01.ane.0000101984.50597.e9. [PMID: 14980918] - H J Yang, J G Kim, Y S Lim, E Ryoo, S Y Hyun, G Lee. Nicardipine versus nitroprusside infusion as antihypertensive therapy in hypertensive emergencies.
The Journal of international medical research.
2004 Mar; 32(2):118-23. doi:
10.1177/147323000403200203. [PMID: 15080014] - Jason M Hoover, Alan D Kaye, Ikhlass N Ibrahim, Aaron M Fields, Todd A Richards. Analysis of responses to St. John's Wort in the feline pulmonary vascular bed.
Journal of herbal pharmacotherapy.
2004; 4(3):47-62. doi:
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Clinical pharmacokinetics.
2004; 43(13):833-44. doi:
10.2165/00003088-200443130-00001. [PMID: 15509182] - S Kazmi, S S Sidhu, T J Donohoe, M Wickham, M N Jones, D G Thompson, R M Case, R S P Benson. Calcium mobilisation and CCK secretion induced by modified fatty acids and latex microspheres reveal dual receptor mechanisms for lipid stimulation of STC-1 cells.
The Journal of physiology.
2003 Dec; 553(Pt 3):759-73. doi:
10.1113/jphysiol.2003.051680. [PMID: 14555726] - Yoko Kubota, Kyoko Kobayashi, Naoka Tanaka, Kazuki Nakamura, Masaru Kunitomo, Keizo Umegaki, Kazumasa Shinozuka. Interaction of Ginkgo biloba extract (GBE) with hypotensive agent, nicardipine, in rats.
In vivo (Athens, Greece).
2003 Sep; 17(5):409-12. doi:
NULL. [PMID: 14598602] - Noriyuki Hatano, Susumu Ohya, Katsuhiko Muraki, Wayne Giles, Yuji Imaizumi. Dihydropyridine Ca2+ channel antagonists and agonists block Kv4.2, Kv4.3 and Kv1.4 K+ channels expressed in HEK293 cells.
British journal of pharmacology.
2003 Jun; 139(3):533-44. doi:
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The Annals of pharmacotherapy.
2003 May; 37(5):667-70. doi:
10.1345/aph.1c366. [PMID: 12708943] - Y S R Krishnaiah, V Satyanarayana, P Bhaskar. Influence of menthol and pressure-sensitive adhesives on the in vivo performance of membrane-moderated transdermal therapeutic system of nicardipine hydrochloride in human volunteers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2003 May; 55(3):329-37. doi:
10.1016/s0939-6411(03)00027-4. [PMID: 12754008] - Y S R Krishnaiah, V Satyanarayana, P Bhaskar. Formulation and in vivo evaluation of membrane-moderated transdermal therapeutic systems of nicardipine hydrochloride using carvone as a penetration enhancer.
Drug delivery.
2003 Apr; 10(2):101-9. doi:
10.1080/713840367. [PMID: 12746056] - Catarina Marques Fernandes, Pedro Ramos, Amílcar Celta Falcão, Francisco José Baptista Veiga. Hydrophilic and hydrophobic cyclodextrins in a new sustained release oral formulation of nicardipine: in vitro evaluation and bioavailability studies in rabbits.
Journal of controlled release : official journal of the Controlled Release Society.
2003 Feb; 88(1):127-34. doi:
10.1016/s0168-3659(02)00465-0. [PMID: 12586510] - N M Moursy, N N Afifi, D M Ghorab, Y El-Saharty. Formulation and evaluation of sustained release floating capsules of nicardipine hydrochloride.
Die Pharmazie.
2003 Jan; 58(1):38-43. doi:
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Journal of cardiovascular pharmacology.
2003 Jan; 41(1):40-8. doi:
10.1097/00005344-200301000-00006. [PMID: 12500020] - Catarina Marques Fernandes, Francisco José Baptista Veiga. A simple method for nicardipine hydrochloride quantification in plasma using solid-phase extraction and reversed-phase high-performance liquid chromatography.
Biomedical chromatography : BMC.
2003 Jan; 17(1):33-8. doi:
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International journal of pharmaceutics.
2002 Oct; 247(1-2):91-102. doi:
10.1016/s0378-5173(02)00401-5. [PMID: 12429488] - Nobuo Hokama, Norio Hobara, Masayuki Sakai, Hiromasa Kameya, Susumu Ohshiro, Matao Sakanashi. Influence of nicardipine and nifedipine on plasma carvedilol disposition after oral administration in rats.
The Journal of pharmacy and pharmacology.
2002 Jun; 54(6):821-5. doi:
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