Albendazole sulfone (BioDeep_00000408888)
代谢物信息卡片
Albendazole sulfone
化学式: C12H15N3O4S (297.0783)
中文名称: 2-[(4-羟基-6-苯基嘧啶-2-基)硫代]-1-(4-硝基苯)乙基-1-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCS(=O)(=O)C1=CC2=C(C=C1)N=C(N2)NC(=O)OC
InChI: InChI=1S/C12H15N3O4S/c1-3-6-20(17,18)8-4-5-9-10(7-8)14-11(13-9)15-12(16)19-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
同义名列表
2 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:80620
- PubChem: 53174
- ChEMBL: CHEMBL1779650
- CAS: 75184-71-3
- MoNA: WA001749
- MoNA: WA001748
- MoNA: WA001747
- MoNA: WA001746
- MoNA: WA001745
- MoNA: WA001744
- KEGG: C16626
- PubChem: 51090952
- KNApSAcK: 80620
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Andi Dian Permana, Ismaiel A Tekko, Helen O McCarthy, Ryan F Donnelly. New HPLC-MS method for rapid and simultaneous quantification of doxycycline, diethylcarbamazine and albendazole metabolites in rat plasma and organs after concomitant oral administration.
Journal of pharmaceutical and biomedical analysis.
2019 Jun; 170(?):243-253. doi:
10.1016/j.jpba.2019.03.047. [PMID: 30947125] - Jessica D Schulz, Anna Neodo, Jean T Coulibaly, Jennifer Keiser. Pharmacokinetics of Albendazole, Albendazole Sulfoxide, and Albendazole Sulfone Determined from Plasma, Blood, Dried-Blood Spots, and Mitra Samples of Hookworm-Infected Adolescents.
Antimicrobial agents and chemotherapy.
2019 04; 63(4):. doi:
10.1128/aac.02489-18. [PMID: 30745388] - M Bistoletti, L Alvarez, C Lanusse, L Moreno. Effects of feeding on the plasma disposition kinetics of the anthelmintic albendazole in laying hens.
British poultry science.
2014; 55(6):824-9. doi:
10.1080/00071668.2014.958058. [PMID: 25159169] - Zaijian Li, Cuilan Chen, Diyun Ai, Chunmei Wang, Jing Li, Yuanhua Qi, Weixue Yi, Hongchun Shen, Jiyue Cao. Pharmacokinetics and tissue residues of hydrochloric acid albendazole sulfoxide and its metabolites in crucian carp (Carassius auratus) after oral administration.
Environmental toxicology and pharmacology.
2012 Mar; 33(2):197-204. doi:
10.1016/j.etap.2011.12.001. [PMID: 22227164] - Iliana González-Hernández, María Isabel Ruiz-Olmedo, Graciela Cárdenas, Helgi Jung-Cook. A simple LC-MS/MS method to determine plasma and cerebrospinal fluid levels of albendazole metabolites (albendazole sulfoxide and albendazole sulfone) in patients with neurocysticercosis.
Biomedical chromatography : BMC.
2012 Feb; 26(2):267-72. doi:
10.1002/bmc.1659. [PMID: 21721022] - Tomasz Grabowski, Jerzy Jan Jaroszewski, Anna Swierczewska, Renata Sawicka, Tomasz Maślanka, Włodzimierz Markiewicz, Hubert Ziółkowski. Application of ultra-performance columns in high-performance liquid chromatography for determination of albendazole and its metabolites in turkeys.
Biomedical chromatography : BMC.
2011 Oct; 25(10):1159-67. doi:
10.1002/bmc.1588. [PMID: 21294142] - Kátia Roberta A Belaz, Quezia B Cass, Regina V Oliveira. Determination of albendazole metabolites by direct injection of bovine plasma and multidimensional achiral-chiral high performance liquid chromatography.
Talanta.
2008 Jun; 76(1):146-53. doi:
10.1016/j.talanta.2008.02.013. [PMID: 18585256] - A K Dubey, P K Sanyal, K M Koley, P L Chaudhary, K Mukherjee, S C Mandal, S Pal. Kinetic disposition of albendazole in goats subclinically infected with gastrointestinal nematodes vis-à-vis naive animals following oral and intraruminal administration.
Journal of helminthology.
2008 Mar; 82(1):17-23. doi:
10.1017/s0022149x07870817. [PMID: 18053296] - Pierina Sueli Bonato, Anderson Rodrigo Moraes de Oliveira, Fernando José Malagueño de Santana, Bruno José Dumet Fernandes, Vera Lucia Lanchote, Armando E Gonzalez, Hector H Garcia, Osvaldo Massaiti Takayanagui. Simultaneous determination of albendazole metabolites, praziquantel and its metabolite in plasma by high-performance liquid chromatography-electrospray mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2007 Jun; 44(2):558-63. doi:
10.1016/j.jpba.2006.11.020. [PMID: 17169522] - Zimei Wu, Natalie J Medlicott, Majid Razzak, Ian G Tucker. Development and optimization of a rapid HPLC method for analysis of ricobendazole and albendazole sulfone in sheep plasma.
Journal of pharmaceutical and biomedical analysis.
2005 Sep; 39(1-2):225-32. doi:
10.1016/j.jpba.2005.03.010. [PMID: 15878252] - Dimitrios J Fletouris, Elias P Papapanagiotou, Dimitrios S Nakos, Ioannis E Psomas. Highly sensitive ion pair liquid chromatographic determination of albendazole marker residue in animal tissues.
Journal of agricultural and food chemistry.
2005 Feb; 53(4):893-8. doi:
10.1021/jf048459q. [PMID: 15712994] - G C Batzias, E Theodosiadou, G A Delis. Quantitative determination of albendazole metabolites in sheep spermatozoa and seminal plasma by liquid chromatographic analysis with fluorescence detection.
Journal of pharmaceutical and biomedical analysis.
2004 Sep; 35(5):1191-202. doi:
10.1016/j.jpba.2004.03.023. [PMID: 15336364] - Georgios C Batzias, Georgios A Delis. Reversed-phase liquid chromatographic method with fluorescence detection for the simultaneous determination of albendazole sulphoxide, albendazole sulphone and albendazole 2-aminosulphone in sheep plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Jun; 805(2):267-74. doi:
10.1016/j.jchromb.2004.03.012. [PMID: 15135100] - Jitka Caslavska, Wolfgang Thormann. Monitoring of drugs and metabolites in body fluids by capillary electrophoresis with XeHg lamp-based and laser-induced fluorescence detection.
Electrophoresis.
2004 Jun; 25(10-11):1623-31. doi:
10.1002/elps.200305821. [PMID: 15188250] - A Goudah. Aspects of the pharmacokinetics of albendazole sulphoxide in sheep.
Veterinary research communications.
2003 Oct; 27(7):555-66. doi:
10.1023/a:1026008010899. [PMID: 14609267] - G Merino, A J Molina, J L García, M M Pulido, J G Prieto, A I Alvarez. Effect of clotrimazole on microsomal metabolism and pharmacokinetics of albendazole.
The Journal of pharmacy and pharmacology.
2003 Jun; 55(6):757-64. doi:
10.1211/002235703765951357. [PMID: 12841935] - Pierina Sueli Bonato, Vera Lucia Lanchote, Osvaldo Massaiti Takayanagui. Simultaneous liquid chromatography-tandem mass spectrometric determination of albendazole sulfoxide and albendazole sulfone in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Jan; 783(1):237-45. doi:
10.1016/s1570-0232(02)00665-7. [PMID: 12450544] - A Mirfazaelian, S Dadashzadeh, M R Rouini. Effect of gender in the disposition of albendazole metabolites in humans.
European journal of clinical pharmacology.
2002 Sep; 58(6):403-8. doi:
10.1007/s00228-002-0488-8. [PMID: 12242599] - O M Takayanagui, P S Bonato, S A C Dreossi, V L Lanchote. Enantioselective distribution of albendazole metabolites in cerebrospinal fluid of patients with neurocysticercosis.
British journal of clinical pharmacology.
2002 Aug; 54(2):125-30. doi:
10.1046/j.1365-2125.2002.01634.x. [PMID: 12207631] - A Procházková, M Chouki, R Theurillat, W Thormann. Therapeutic drug monitoring of albendazole: determination of albendazole, albendazole sulfoxide, and albendazole sulfone in human plasma using nonaqueous capillary electrophoresis.
Electrophoresis.
2000 Mar; 21(4):729-36. doi:
10.1002/(sici)1522-2683(20000301)21:4<729::aid-elps729>3.0.co;2-m. [PMID: 10733213] - D Singh, P K Sanyal, C P Swarnkar, F A Khan, P S Bhagwan. Influence of diet type and pretreatment fasting on the disposition kinetics of albendazole in sheep.
Veterinary research communications.
1999 Jun; 23(4):229-40. doi:
10.1023/a:1006201226391. [PMID: 10461800] - V L Lanchote, M P Marques, O M Takayanagui, R de Carvalho, F O Paias, P S Bonato. Simultaneous determination of albendazole sulfoxide enantiomers and albendazole sulfone in plasma.
Journal of chromatography. B, Biomedical sciences and applications.
1998 May; 709(2):273-9. doi:
10.1016/s0378-4347(98)00082-6. [PMID: 9657224] - P K Sanyal. The disposition kinetics of albendazole following the administration of single and divided doses to cattle and buffalo.
Veterinary research communications.
1998 Feb; 22(2):87-96. doi:
10.1023/a:1006023328617. [PMID: 9563167] - L I Alvarez, S F Sánchez, C E Lanusse. Modified plasma and abomasal disposition of albendazole in nematode-infected sheep.
Veterinary parasitology.
1997 May; 69(3-4):241-53. doi:
10.1016/s0304-4017(96)01118-1. [PMID: 9195734] - A Lifschitz, G Virkel, M Mastromarino, C Lanusse. Enhanced plasma availability of the metabolites of albendazole in fasted adult sheep.
Veterinary research communications.
1997 Apr; 21(3):201-11. doi:
10.1023/a:1005832412415. [PMID: 9090047] - C Cristòfol, C Franquelo, M Navarro, A Carretero, J Ruberte, M Arboix. Comparative pharmacokinetics of netobimin metabolites in pregnant ewes.
Research in veterinary science.
1997 Mar; 62(2):117-20. doi:
10.1016/s0034-5288(97)90131-4. [PMID: 9243708] - L I Alvarez, C A Saumell, S F Sanchez, C E Lanusse. Plasma disposition kinetics of albendazole metabolites in pigs fed different diets.
Research in veterinary science.
1996 Mar; 60(2):152-6. doi:
10.1016/s0034-5288(96)90010-7. [PMID: 8685537] - C Cristofol, A Carretero, M Fernandez, M Navarro, J Sautet, J Ruberte, M Arboix. Transplacental transport of netobimin metabolites in ewes.
European journal of drug metabolism and pharmacokinetics.
1995 Jul; 20(3):167-71. doi:
10.1007/bf03189665. [PMID: 8751036] - M E Valois, O M Takayanagui, P S Bonato, V L Lanchote, D Carvalho. Determination of albendazole metabolites in plasma by HPLC.
Journal of analytical toxicology.
1994 Mar; 18(2):86-90. doi:
10.1093/jat/18.2.86. [PMID: 8207939] - C E Lanusse, L Gascon, R K Prichard. Methimazole-mediated modulation of netobimin biotransformation in sheep: a pharmacokinetic assessment.
Journal of veterinary pharmacology and therapeutics.
1992 Sep; 15(3):267-74. doi:
10.1111/j.1365-2885.1992.tb01016.x. [PMID: 1433490] - C E Lanusse, R K Prichard. Methimazole increases the plasma concentrations of the albendazole metabolites of netobimin in sheep.
Biopharmaceutics & drug disposition.
1992 Mar; 13(2):95-103. doi:
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Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1991 Sep; 12(5):430-4. doi:
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1991 Mar; 14(1):101-8. doi:
10.1111/j.1365-2885.1991.tb00810.x. [PMID: 2038091] - P Delatour, E Benoit, S Besse, A Boukraa. Comparative enantioselectivity in the sulphoxidation of albendazole in man, dogs and rats.
Xenobiotica; the fate of foreign compounds in biological systems.
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American journal of veterinary research.
1990 Sep; 51(9):1459-63. doi:
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Therapeutic drug monitoring.
1990 Mar; 12(2):187-90. doi:
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