Licarbazepine (BioDeep_00000408834)
Main id: BioDeep_00000001877
代谢物信息卡片
10,11-Dihydro-10-Hydroxycarbazepine
化学式: C15H14N2O2 (254.1055224)
中文名称: 10-羟基-1011-二氢-5H-二苯并[bf]氮杂卓-5-甲酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)N)O
InChI: InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)
描述信息
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
同义名列表
2 个代谢物同义名
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lihua Qu, Lixuan Pan, Li Wang, Congmin Liu, Yanhong Tian, Zhihui Hao. Development of an online solid-phase extraction-liquid chromatography-mass spectrometric analysis of oxcarbazepine and its active metabolite licarbazepine from plasma with a direct injection step.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Sep; 1125(?):121710. doi:
10.1016/j.jchromb.2019.06.037. [PMID: 31299362] - Zhichao Yang, Xueyu Xu, Lingxia Sun, Xue Zhao, Hao Wang, John Paul Fawcett, Yan Yang, Jingkai Gu. Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 May; 1020(?):36-42. doi:
10.1016/j.jchromb.2016.03.013. [PMID: 27003707] - Ana Ferreira, Márcio Rodrigues, Paula Oliveira, Joana Francisco, Ana Fortuna, Luísa Rosado, Pedro Rosado, Amílcar Falcão, Gilberto Alves. Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide and licarbazepine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Nov; 971(?):20-9. doi:
10.1016/j.jchromb.2014.09.010. [PMID: 25261836] - Teresa Nunes, José Francisco Rocha, Amílcar Falcão, Luis Almeida, Patrício Soares-da-Silva. Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers.
Epilepsia.
2013 Jan; 54(1):108-16. doi:
10.1111/j.1528-1167.2012.03595.x. [PMID: 22812691] - Ana Fortuna, Gilberto Alves, Anabela Almeida, Bruno Lopes, Amílcar Falcão, Patrício Soares-da-Silva. A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain.
Biomedical chromatography : BMC.
2012 Mar; 26(3):384-92. doi:
10.1002/bmc.1670. [PMID: 21780155] - A I Loureiro, C Fernandes-Lopes, L C Wright, P Soares-da-Silva. Development and validation of an enantioselective liquid-chromatography/tandem mass spectrometry method for the separation and quantification of eslicarbazepine acetate, eslicarbazepine, R-licarbazepine and oxcarbazepine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Sep; 879(25):2611-8. doi:
10.1016/j.jchromb.2011.07.019. [PMID: 21816689] - E Perucca, C Elger, P Halász, A Falcão, L Almeida, P Soares-da-Silva. Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures.
Epilepsy research.
2011 Sep; 96(1-2):132-9. doi:
10.1016/j.eplepsyres.2011.05.013. [PMID: 21680153] - G Flesch, C Czendlik, D Renard, P Lloyd. Pharmacokinetics of the monohydroxy derivative of oxcarbazepine and its enantiomers after a single intravenous dose given as racemate compared with a single oral dose of oxcarbazepine.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Jun; 39(6):1103-10. doi:
10.1124/dmd.109.030593. [PMID: 21389120] - Ana Fortuna, Gilberto Alves, Amílcar Falcão, Patrício Soares-da-Silva. Binding of licarbazepine enantiomers to mouse and human plasma proteins.
Biopharmaceutics & drug disposition.
2010 Jul; 31(5-6):362-6. doi:
10.1002/bdd.716. [PMID: 20578208] - Ana Fortuna, Joana Sousa, Gilberto Alves, Amílcar Falcão, Patrício Soares-da-Silva. Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.
Analytical and bioanalytical chemistry.
2010 Jun; 397(4):1605-15. doi:
10.1007/s00216-010-3673-0. [PMID: 20401721] - Gilberto Alves, Isabel Figueiredo, Amílcar Falcão, Margarida Castel-Branco, Margarida Caramona, Patrício Soares-Da-Silva. Stereoselective disposition of S- and R-licarbazepine in mice.
Chirality.
2008 Jun; 20(6):796-804. doi:
10.1002/chir.20546. [PMID: 18306292] - Gilberto Alves, Isabel Figueiredo, Margarida Castel-Branco, Ana Loureiro, Amílcar Falcão, Margarida Caramona. Simultaneous and enantioselective liquid chromatographic determination of eslicarbazepine acetate, S-licarbazepine, R-licarbazepine and oxcarbazepine in mouse tissue samples using ultraviolet detection.
Analytica chimica acta.
2007 Jul; 596(1):132-40. doi:
10.1016/j.aca.2007.05.056. [PMID: 17616250] - Iolanda Mazzucchelli, Valentina Franco, Cinzia Fattore, Roberto Marchiselli, Emilio Perucca, Giuliana Gatti. A novel enantioselective microassay for the high-performance liquid chromatography determination of oxcarbazepine and its active metabolite monohydroxycarbazepine in human plasma.
Therapeutic drug monitoring.
2007 Jun; 29(3):319-24. doi:
10.1097/ftd.0b013e318058a2c2. [PMID: 17529889] - Manuela Contin, Monica Balboni, Erica Callegati, Carmina Candela, Fiorenzo Albani, Roberto Riva, Agostino Baruzzi. Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Dec; 828(1-2):113-7. doi:
10.1016/j.jchromb.2005.09.009. [PMID: 16182617] - Nicola Marchi, Giovanna Guiso, Massimo Rizzi, Susanne Pirker, Klaus Novak, Thomas Czech, Christoph Baumgartner, Damir Janigro, Silvio Caccia, Annamaria Vezzani. A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine.
Epilepsia.
2005 Oct; 46(10):1613-9. doi:
10.1111/j.1528-1167.2005.00265.x. [PMID: 16190932] - Luis Almeida, Patrício Soares-da-Silva. Safety, tolerability, and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans.
Journal of clinical pharmacology.
2004 Aug; 44(8):906-18. doi:
10.1177/0091270004267591. [PMID: 15286095] - Gérard Flesch. Overview of the clinical pharmacokinetics of oxcarbazepine.
Clinical drug investigation.
2004; 24(4):185-203. doi:
10.2165/00044011-200424040-00001. [PMID: 17516704] - G Flesch, D Tudor, J Denouel, J Bonner, R Camisasca. Assessment of the bioequivalence of two oxcarbazepine oral suspensions versus a film-coated tablet in healthy subjects.
International journal of clinical pharmacology and therapeutics.
2003 Jul; 41(7):299-308. doi:
10.5414/cpp41299. [PMID: 12875346] - G Flesch, D Tudor, C Souppart, J D'Souza, M Hossain. Oxcarbazepine final market image tablet formulation bioequivalence study after single administration and at steady state in healthy subjects.
International journal of clinical pharmacology and therapeutics.
2002 Nov; 40(11):524-32. doi:
10.5414/cpp40524. [PMID: 12698990] - H J Hilderson, M J De Wolf, A R Lagrou, W S Dierick. Subcellular structure of bovine thyroid gland. A study on bovine thyroid membranes by buoyant-density-gradient centrifugation in a B-XIV zonal rotor.
The Biochemical journal.
1975 Dec; 152(3):601-7. doi:
10.1042/bj1520601. [PMID: 5997]