bupivacaine (BioDeep_00000408833)
Main id: BioDeep_00000001915
代谢物信息卡片
bupivacaine
化学式: C18H28N2O (288.2202)
中文名称: 丁吡卡因, 布比卡因
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN(C2)C(CCC2)C(=O)Nc(c(C)1)c(C)ccc1
InChI: InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local > N01BB - Amides
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain[1][2][3].
同义名列表
3 个代谢物同义名
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:77431
- ChEBI: CHEBI:3215
- KEGG: C07529
- KEGGdrug: D07552
- PubChem: 2474
- DrugBank: DB00297
- ChEMBL: CHEMBL1098
- MeSH: Bupivacaine
- CAS: 119427-31-5
- CAS: 38396-39-3
- CAS: 2180-92-9
- MoNA: WA000943
- MoNA: WA000942
- MoNA: WA000941
- MoNA: WA000940
- MoNA: WA000939
- PubChem: 9732
- NIKKAJI: J299.255H
- NIKKAJI: J7.351B
- medchemexpress: HY-B0405
- KNApSAcK: 3215
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tao Kang, Jiwei Tao, Xuetao Wang, Yu Liu, Dan Jin. Epidural ropivacaine versus bupivacaine for cesarean sections: a system review and meta-analysis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2024 Dec; 37(1):2313356. doi:
10.1080/14767058.2024.2313356. [PMID: 38342577] - Soo Hee Lee, Sunmin Kim, Ju-Tae Sohn. Lipid emulsion treatment for local anesthetic systemic toxicity in pediatric patients: A systematic review.
Medicine.
2024 Mar; 103(11):e37534. doi:
10.1097/md.0000000000037534. [PMID: 38489714] - Susanne K Wiedmer, Ju-Tae Sohn. Lipophilicity of drugs, including local anesthetics, and its association with lipid emulsion resuscitation.
Korean journal of anesthesiology.
2024 Feb; 77(1):170-172. doi:
10.4097/kja.23825. [PMID: 38029794] - Xia Li, Jun Zhao, Qiaoqiao Lv, Yuan Tian, Li Zhang, Tong Liu. Electroacupuncture alleviates multifidus muscle injury by modulating mitochondrial function and Ca2+ uptake.
Anatomical record (Hoboken, N.J. : 2007).
2023 12; 306(12):3060-3072. doi:
10.1002/ar.24889. [PMID: 35235712] - Danting Jia, Fang Wang, Zhixia Bai, Xuexin Chen. BDNF-TrkB/proBDNF-p75NTR pathway regulation by lipid emulsion rescues bupivacaine-induced central neurotoxicity in rats.
Scientific reports.
2023 10; 13(1):18364. doi:
10.1038/s41598-023-45572-8. [PMID: 37884604] - Philipp Gerner, Kamen Vlassakov, Alexander Stone. Lipid emulsion for reversal of acute cannabinoid toxicity?.
Regional anesthesia and pain medicine.
2023 10; 48(10):532-533. doi:
10.1136/rapm-2023-104429. [PMID: 36858481] - Vladimir Smrkolj, Domen Pregeljc, Hana Kavčič, Nejc Umek, Janez Mavri. Micro-pharmacokinetics of lidocaine and bupivacaine transfer across a myelinated nerve fiber.
Computers in biology and medicine.
2023 10; 165(?):107375. doi:
10.1016/j.compbiomed.2023.107375. [PMID: 37611421] - Soraya Babaie, Mohammad Charkhpour, Maryam Kouhsoltani, Hamed Hamishehkar, Ana Cláudia Paiva-Santos. Nano-invasomes for simultaneous topical delivery of buprenorphine and bupivacaine for dermal analgesia.
Experimental dermatology.
2023 Jun; ?(?):. doi:
10.1111/exd.14850. [PMID: 37283479] - Minzhi Yu, Wenmin Yuan, Ziyun Xia, Yayuan Liu, Yan Wang, Xiaoming Xu, Jiwen Zheng, Anna Schwendeman. Characterization of exparel bupivacaine multivesicular liposomes.
International journal of pharmaceutics.
2023 May; 639(?):122952. doi:
10.1016/j.ijpharm.2023.122952. [PMID: 37054926] - Jinxin Huang, Gengzhi Wen, Qiang Huang, Bowan Huang. Anesthesia characteristic of an algorithm of bupivacaine dose based on height in caesarean section under spinal anesthesia: a retrospective cohort study.
BMC anesthesiology.
2023 May; 23(1):146. doi:
10.1186/s12871-023-02113-0. [PMID: 37131191] - Hua Jiang, Qiong Ma, Jing Dong, Xin Ye. The effect of liposomal bupivacaine for surgical wound infiltration: A meta-analysis of randomised controlled trials.
International wound journal.
2023 May; 20(5):1591-1608. doi:
10.1111/iwj.14015. [PMID: 36345868] - Soo Hee Lee, Ju-Tae Sohn. The underlying mechanism of lipid emulsion resuscitation for drug toxicity: A narrative review.
Korean journal of anesthesiology.
2023 Jan; ?(?):. doi:
10.4097/kja.23031. [PMID: 36704816] - Soo Hee Lee, Sunmin Kim, Ju-Tae Sohn. Lipid Emulsion Treatment for Drug Toxicity Caused by Nonlocal Anesthetic Drugs in Pediatric Patients: A Narrative Review.
Pediatric emergency care.
2023 Jan; 39(1):53-59. doi:
10.1097/pec.0000000000002828. [PMID: 35981328] - Qiao-Qiao Lü, Li Zhang, Xia Li, Yuan Tian, Jing Xu, Li Chen, Ze-Jun Huo. [Effect of electroacupuncture of "Weizhong" (BL40) on iron metabolism disorder in rats with lumbar multifidus muscle injury].
Zhen ci yan jiu = Acupuncture research.
2022 Dec; 47(12):1073-9. doi:
10.13702/j.1000-0607.20211277. [PMID: 36571222] - Wentao Deng, Yu Yan, Peipei Zhuang, Xiaoxu Liu, Ke Tian, Wenfang Huang, Cai Li. Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management.
Drug delivery.
2022 Dec; 29(1):399-412. doi:
10.1080/10717544.2021.2023702. [PMID: 35098821] - Meng-Si Luo, Guan-Jiang Huang. The efficacy of peritonsillar injection of bupivacaine vs intravenous acetaminophen on post-tonsillectomy pain in children.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
2022 11; 279(11):5459-5461. doi:
10.1007/s00405-021-07146-0. [PMID: 34671857] - C Philip Larson, Kevin Youssefzadeh, Jane S Moon. The Bupivacaine Story: A Tribute to George A. Albright, MD (1931-2020).
Anesthesia and analgesia.
2022 11; 135(5):1115-1119. doi:
10.1213/ane.0000000000006161. [PMID: 35924832] - Chenran Wang, Shen Sun, Jing Jiao, Xinhua Yu, Shaoqiang Huang. Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.
Fundamental & clinical pharmacology.
2022 Oct; 36(5):811-817. doi:
10.1111/fcp.12778. [PMID: 35373856] - Susan Wojtalewicz, Jonathon Vizmeg, Sierra Erickson, Caleb Lade, Jill Shea, Himanshu Sant, Jules Magda, Bruce Gale, Jayant Agarwal, Brett Davis. Evaluating the influence of particle morphology and density on the viscosity and injectability of a novel long-acting local anesthetic suspension.
Journal of biomaterials applications.
2022 10; 37(4):724-736. doi:
10.1177/08853282221106486. [PMID: 35649287] - Yujia Li, Zhien Shen, Hongmei Wang, Tonghui Feng, Yanfei Xia. Efficacy of liposomal bupivacaine for pain control in shoulder surgery: a systematic review and meta-analysis.
Journal of shoulder and elbow surgery.
2022 Sep; 31(9):1957-1968. doi:
10.1016/j.jse.2022.02.037. [PMID: 35430368] - Ju-Tae Sohn. Lipid emulsion dosage used for resuscitation after drug toxicity.
The American journal of emergency medicine.
2022 09; 59(?):168-169. doi:
10.1016/j.ajem.2022.07.026. [PMID: 35868991] - Matilde Zaballos, Ignacio Fernández, Lucia Rodríguez, Sergio García, Olalla Varela, Oscar Quintela, María-José Anadón, Jesús Almendral. Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity.
Clinical toxicology (Philadelphia, Pa.).
2022 08; 60(8):902-911. doi:
10.1080/15563650.2022.2080075. [PMID: 35658706] - Grace Mahowald, Tahira Khaliq, Sankha Basu, David Griggs, Molly Siegel, Lisa Leffert, Sarah Bernstein, James G Flood, Sacha Uljon. Bupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC-MS/MS.
The journal of applied laboratory medicine.
2022 06; 7(4):854-862. doi:
10.1093/jalm/jfac009. [PMID: 35259249] - James D Turner, Kevin T Cortese, Seiha T Kim, Zachary L McKee, Doug Jaffe, Daryl S Henshaw, Sean W Dobson, Robert Weller, Christopher J Edwards, J Wells Reynolds, Greg Russell. Mean plasma bupivacaine concentrations following pectoral nerve blocks (PECS II).
Regional anesthesia and pain medicine.
2022 03; 47(3):194-195. doi:
10.1136/rapm-2021-102984. [PMID: 34610964] - Allison Lee, Ben Shatil, Ruth Landau, Prahlad Menon, Richard Smiley. Intrathecal 2-Chloroprocaine 3\% Versus Hyperbaric Bupivacaine 0.75\% for Cervical Cerclage: A Double-Blind Randomized Controlled Trial.
Anesthesia and analgesia.
2022 03; 134(3):624-632. doi:
10.1213/ane.0000000000005653. [PMID: 34153006] - Jessica Goldsby, Kerry Schwarz, Ike Kim, Victor Lewis, Clark Lyda. An Evaluation of the Effect of Catheter-Directed Continuous Infusion of Local Anesthetic by Elastomeric Pump on Opioid Usage Following Donor Kidney Nephrectomy.
The Annals of pharmacotherapy.
2022 02; 56(2):146-150. doi:
10.1177/10600280211017894. [PMID: 33998320] - Kaimei Lu, Liyan Zhao, Yonghai Zhang, Fan Yang, Huiwen Zhang, Jie Wang, Bin Li, Guimei Ji, Jianqiang Yu, Hanxiang Ma. Bupivacaine reduces GlyT1 expression by potentiating the p-AMPKα/BDNF signalling pathway in spinal astrocytes of rats.
Scientific reports.
2022 01; 12(1):1378. doi:
10.1038/s41598-022-05478-3. [PMID: 35082359] - Chenran Wang, Shen Sun, Jing Jiao, Xinhua Yu, Shaoqiang Huang. Effects of delta-opioid receptor agonist pretreatment on the cardiotoxicity of bupivacaine in rats.
BMC anesthesiology.
2022 01; 22(1):19. doi:
10.1186/s12871-022-01568-x. [PMID: 35021986] - Wangcheng Zhao, Yan Du, Shameen Ashfaq, Shafaqat Ali, Amer M Alanazi, Moreno Santi. Evaluation of the Efficacy, Biocompatibility, and Permeation of Bupivacaine-Loaded Poly(epsilon-caprolactone) Nano-Capsules as an Anesthetic.
Journal of biomedical nanotechnology.
2022 Jan; 18(1):268-276. doi:
10.1166/jbn.2022.3223. [PMID: 35180921] - Seong-Ho Ok, Dawon Kang, Soo Hee Lee, Hyun-Jin Kim, Seung Hyun Ahn, Ju-Tae Sohn. Lipid emulsions attenuate the inhibition of carnitine acylcarnitine translocase induced by toxic doses of local anesthetics in rat cardiomyoblasts.
Human & experimental toxicology.
2022 Jan; 41(?):9603271211065978. doi:
10.1177/09603271211065978. [PMID: 35135371] - Sanjiv Rampal, Ashish Jaiman, Mehmet Ali Tokgöz, Gayathri Arumugam, Sureshan Sivananthan, Rashdeep Singh Jagdeb Singh, Syafiqah Binti Zazali, Maziar Mohaddes. A review of the efficacy of intraarticular hip injection for patients with hip osteoarthritis: To inject or not to inject in hip osteoarthritis?.
Joint diseases and related surgery.
2022; 33(1):255-262. doi:
10.52312/jdrs.2022.402. [PMID: 35361105] - Grzegorz Kowalski, Bogumił Olczak, Wojciech Leppert, Agnieszka Bienert, Artur Teżyk, Danuta Szkutnik-Fiedler, Michał Adamski, Katarzyna Wieczorowska-Tobis. Analgesic Efficacy and Safety of Spinal Oxycodone in Total Hip Arthroplasty: A Preliminary Study.
Current medicinal chemistry.
2022; 29(21):3806-3814. doi:
10.2174/0929867329666220126125256. [PMID: 35081884] - Ryan C Dregalla, Yvette Uribe, Marko Bodor. Effect of local anesthetics on platelet physiology and function.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2021 Dec; 39(12):2744-2754. doi:
10.1002/jor.25019. [PMID: 33694196] - Victoria M Lim, Taylor Barney, Arun L Jayaraman. Multiple myeloma and malignant lesions: a potential risk factor for local anesthetic systemic toxicity.
Regional anesthesia and pain medicine.
2021 12; 46(12):1103-1106. doi:
10.1136/rapm-2021-102845. [PMID: 34535547] - Christopher F Tirotta, Alberto J de Armendi, Nicole D Horn, Gregory B Hammer, Michal Szczodry, Maria Matuszczak, Natalie Q Wang, Richard Scranton, Robert Tracy Ballock. A multicenter study to evaluate the pharmacokinetics and safety of liposomal bupivacaine for postsurgical analgesia in pediatric patients aged 6 to less than 17 years (PLAY).
Journal of clinical anesthesia.
2021 12; 75(?):110503. doi:
10.1016/j.jclinane.2021.110503. [PMID: 34534923] - D Viderman, B Ben-David, A Sarria-Santamera. Analysis of bupivacaine and ropivacaine-related cardiac arrests in regional anesthesia: A systematic review of case reports.
Revista espanola de anestesiologia y reanimacion.
2021 Oct; 68(8):472-483. doi:
10.1016/j.redare.2020.10.005. [PMID: 34538765] - Akinori Yamazaki, Keisuke Fujii, Yuichi Aratani, Toshiyuki Kuriyama, Tomoyuki Kawamata. Comparison of plasma concentrations of levobupivacaine with and without epinephrine for thoracic paravertebral block: A randomised trial.
Anaesthesia, critical care & pain medicine.
2021 10; 40(5):100952. doi:
10.1016/j.accpm.2021.100952. [PMID: 34560315] - Fernando Freitas de Lima, Bianca Brandão da Silva, Juliana Damasceno Oliveira, Ludmilla David de Moura, Gustavo Henrique Rodrigues da Silva, Priscila Cordeiro Lima Fernandes, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Eneida de Paula. Prolonged anesthesia and decreased toxicity of enantiomeric-excess bupivacaine loaded in ionic gradient liposomes.
International journal of pharmaceutics.
2021 Sep; 606(?):120944. doi:
10.1016/j.ijpharm.2021.120944. [PMID: 34324985] - Hans Albin Gritsch, Nathan Osbun, Tristan Grogan, Katherine E Fero, Parisa Partownavid, Joel Stockman, Namjeh Sadoughi, Edward Park, Eric Miller, Jeremy Blumberg, Michelle McDonald, Nicholas Cowan, Nikhil Shah, Siamak Rahman. Randomized controlled trial of a quadratus lumborum block with liposomal bupivacaine for postoperative analgesia in laparoscopic donor nephrectomy.
Clinical transplantation.
2021 09; 35(9):e14403. doi:
10.1111/ctr.14403. [PMID: 34184312] - Matthew McDaniel, Kevin B Flores, Belinda S Akpa. Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study.
Drugs in R&D.
2021 Sep; 21(3):305-320. doi:
10.1007/s40268-021-00353-4. [PMID: 34279844] - Tiina Leino, Timo Viitamaa, Jarmo S Salonen, Ullamari Pesonen, Antti Haapalinna. Effects of fadolmidine, an α2 -adrenoceptor agonist, as an adjuvant to spinal bupivacaine on antinociception and motor function in rats and dogs.
Pharmacology research & perspectives.
2021 08; 9(4):e00830. doi:
10.1002/prp2.830. [PMID: 34302721] - Shuang-Hua Dai, Ya-Wen Li, Qing-Xiong Hong, Tao Su, Shi-Yuan Xu. Exaggerated activities of TRPM7 underlie bupivacaine-induced neurotoxicity in the SH-SY5Y cells preconditioned with high glucose.
Journal of biochemical and molecular toxicology.
2021 Aug; 35(8):e22826. doi:
10.1002/jbt.22826. [PMID: 34060177] - Bernard My Cheung, Pauline Yeung Ng, Ying Liu, Manman Zhou, Vincent Yu, Julia Yang, Natalie Q Wang. Pharmacokinetics and safety of liposomal bupivacaine after local infiltration in healthy Chinese adults: a phase 1 study.
BMC anesthesiology.
2021 07; 21(1):197. doi:
10.1186/s12871-021-01407-5. [PMID: 34315419] - Samina Ismail, Aliya Ahmed, Muhammad Q Hoda, Samie Asghar, Aysha Habib, Aliya Aziz. Mid-axillary transversus abdominis plane block and stress response after abdominal hysterectomy: A randomised controlled placebo trial.
European journal of anaesthesiology.
2021 07; 38(7):768-776. doi:
10.1097/eja.0000000000001413. [PMID: 33399377] - Hirotsugu Miyoshi, Takahiro Kato, Ryuji Nakamura, Noboru Saeki, Yuko Noda, Satoshi Kamiya, Atsushi Morio, Yasuo M Tsutsumi. Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats.
Journal of anesthesia.
2021 04; 35(2):168-174. doi:
10.1007/s00540-020-02883-8. [PMID: 33386432] - Hongfei Chen, Zhousheng Jin, Fangfang Xia, Zhijian Fu. Bupivacaine inhibits a small conductance calcium-activated potassium type 2 channel in human embryonic kidney 293 cells.
BMC pharmacology & toxicology.
2021 03; 22(1):15. doi:
10.1186/s40360-021-00481-2. [PMID: 33712065] - Ivan Urits, Nathan Li, Amnon A Berger, Paul Walker, Brendan Wesp, Alec M Zamarripa, Daniel An, Elyse M Cornett, Alaa Abd-Elsayed, Alan D Kaye. Treatment and Management of Loin Pain Hematuria Syndrome.
Current pain and headache reports.
2021 Jan; 25(1):6. doi:
10.1007/s11916-020-00925-0. [PMID: 33495883] - Jinghua Xu, Yanjie Bai, Xuehui Li, Zhenping Wei, Lu Sun, Hongdan Yu, Hui Xu. Porous Core/Dense Shell PLA Microspheres Embedded with High Drug Loading of Bupivacaine Crystals for Injectable Prolonged Release.
AAPS PharmSciTech.
2021 Jan; 22(1):27. doi:
10.1208/s12249-020-01878-8. [PMID: 33404960] - David Leiman, Gwendolyn Niebler, Harold S Minkowitz. Pharmacokinetics and Safety of INL-001 (Bupivacaine HCl) Implants Compared with Bupivacaine HCl Infiltration After Open Unilateral Inguinal Hernioplasty.
Advances in therapy.
2021 01; 38(1):691-706. doi:
10.1007/s12325-020-01565-x. [PMID: 33237534] - Dennis E Feierman, Jason Kim, Aden Bronstein, Agnes Miller, Christein Dgheim, Viktoriya London, Avram Alter, Kalpana Tyagaraj. The use of bilateral transversus abdominis plane blocks with liposomal bupivacaine on postoperative cesarean delivery patients during COVID-19 pandemic is associated with reduced narcotics use and reduced length of stay.
Women's health (London, England).
2021 Jan; 17(?):17455065211058046. doi:
10.1177/17455065211058046. [PMID: 34775851] - Yi Han, Xiaoyuan Chen, Panpan Mi, Yunzhao Ji, Xiangan Meng, Pengbo Han, Jingyi Zhang. Different Concentrations of Ropivacaine under Ultrasound Guidance on Quadratus Lumbar Muscle Nerve Block in Elderly Patients with Hip Replacement.
BioMed research international.
2021; 2021(?):9911352. doi:
10.1155/2021/9911352. [PMID: 34977251] - Standiford Helm Ii, Preston C Harmon, Carl Noe, Aaron K Calodney, Alaa Abd-Elsayed, Nebojsa Nick Knezevic, Gabor B Racz. Transforaminal Epidural Steroid Injections: A Systematic Review and Meta-Analysis of Efficacy and Safety.
Pain physician.
2021 01; 24(S1):S209-S232. doi:
NULL. [PMID: 33492919] - William C Manson, Randal S Blank, Linda W Martin, Salome B Alpert, Tomasz P Dobrzanski, Eric B Schneider, Sarah J Ratcliffe, Marcel E Durieux. An Observational Study of the Pharmacokinetics of Surgeon-Performed Intercostal Nerve Blockade With Liposomal Bupivacaine for Posterior-Lateral Thoracotomy Analgesia.
Anesthesia and analgesia.
2020 12; 131(6):1843-1849. doi:
10.1213/ane.0000000000005115. [PMID: 32833710] - Hideki Hino, Tadashi Matsuura, Miyuki Kuno, Kotaro Hori, Shogo Tsujikawa, Takashi Mori, Kiyonobu Nishikawa. Left Ventricular Hypertrophy Increases Susceptibility to Bupivacaine-induced Cardiotoxicity through Overexpression of Transient Receptor Potential Canonical Channels in Rats.
Anesthesiology.
2020 11; 133(5):1077-1092. doi:
10.1097/aln.0000000000003554. [PMID: 32915958] - Brett Davis, Sierra Erickson, Susan Wojtalewicz, Andrew Simpson, Cameron Metcalf, Himanshu Sant, Jill Shea, Bruce Gale, Jayant Agarwal. Entrapping bupivacaine-loaded emulsions in a crosslinked-hydrogel increases anesthetic effect and duration in a rat sciatic nerve block model.
International journal of pharmaceutics.
2020 Oct; 588(?):119703. doi:
10.1016/j.ijpharm.2020.119703. [PMID: 32739385] - Andrew Resnick, Michael Chait, Steven Landau, Sandeep Krishnan. Erector spinae plane block with catheter for management of percutaneous nephrolithotomy: A three case report.
Medicine.
2020 Oct; 99(40):e22477. doi:
10.1097/md.0000000000022477. [PMID: 33019439] - Hyun Joo Kim, Hyun Soo Kim, Ja Rang Jung, Ha Yan Kim, Carl Lynch, Wyun Kon Park. Lipid Emulsion Restoration of Myocardial Contractions After Bupivacaine-Induced Asystole In Vitro: A Benefit of Long- and Medium-Chain Triglyceride Over Long-Chain Triglyceride.
Anesthesia and analgesia.
2020 09; 131(3):917-927. doi:
10.1213/ane.0000000000004637. [PMID: 32011393] - Eric M Yung, Faraj W Abdallah, Carla Todaro, Emily Spence, Andrew Grant, Richard Brull. Optimal local anesthetic regimen for saddle block in ambulatory anorectal surgery: an evidence-based systematic review.
Regional anesthesia and pain medicine.
2020 09; 45(9):733-739. doi:
10.1136/rapm-2020-101603. [PMID: 32699103] - Xiao-Xiao Li, Yu-Mei Li, Xue-Li Lv, Xing-He Wang, Su Liu. The efficacy and safety of intrathecal dexmedetomidine for parturients undergoing cesarean section: a double-blind randomized controlled trial.
BMC anesthesiology.
2020 08; 20(1):190. doi:
10.1186/s12871-020-01109-4. [PMID: 32746864] - Chunai Wang, Xi Liang, Yan Yu, Yulan Li, Xiaohui Wen, Min Liu. Electroacupuncture pretreatment alleviates myocardial injury through regulating mitochondrial function.
European journal of medical research.
2020 Aug; 25(1):29. doi:
10.1186/s40001-020-00431-4. [PMID: 32738910] - Liljana Markova, Nejc Umek, Simon Horvat, Admir Hadžić, Max Kuroda, Tatjana Stopar Pintarič, Vesna Mrak, Erika Cvetko. Neurotoxicity of bupivacaine and liposome bupivacaine after sciatic nerve block in healthy and streptozotocin-induced diabetic mice.
BMC veterinary research.
2020 Jul; 16(1):247. doi:
10.1186/s12917-020-02459-4. [PMID: 32680505] - Hao Nie, Zhixia Bai, Zhenzhou Li, Li Yan, Xue-Xin Chen. Intravenous lipid emulsion modifies synaptic transmission in hippocampal CA1 pyramidal neurons after bupivacaine-induced central nervous system toxicity.
Journal of neurochemistry.
2020 07; 154(2):144-157. doi:
10.1111/jnc.14924. [PMID: 31758799] - Hiba J Mustafa, Henry L Wong, Mahmoud Al-Kofahi, Malinda Schaefer, Ashwin Karanam, Michael M Todd. Bupivacaine Pharmacokinetics and Breast Milk Excretion of Liposomal Bupivacaine Administered After Cesarean Birth.
Obstetrics and gynecology.
2020 07; 136(1):70-76. doi:
10.1097/aog.0000000000003886. [PMID: 32541292] - Walaa Zarad, Heba El-Gendy, Ahmed Ali, Yasmine Aboulella, Samy Emara. Integration of Solid-Phase Extraction and Reversed-Phase Chromatography in Single Protein-Coated Columns for Direct Injection of Bupivacaine in Human Serum.
Journal of chromatographic science.
2020 Jun; 58(6):535-541. doi:
10.1093/chromsci/bmaa014. [PMID: 32303751] - Amin M Alansary, Atef Badawy, Marwa A K Elbeialy. Dexmedetomidine Added to Bupivacaine versus Bupivacaine in Transincisional Ultrasound-Guided Quadratus Lumborum Block in Open Renal Surgeries: A Randomized Trial.
Pain physician.
2020 06; 23(3):271-282. doi:
NULL. [PMID: 32517393] - Chantal A A Heppolette, Derek Brunnen, Sohail Bampoe, Peter M Odor. Clinical Pharmacokinetics and Pharmacodynamics of Levobupivacaine.
Clinical pharmacokinetics.
2020 06; 59(6):715-745. doi:
10.1007/s40262-020-00868-0. [PMID: 32034727] - Arnulfo Calixto-Flores, Monserrat Román-Sánchez, Edgar Jiménez-Sánchez, José Cruz-Santiago, Guillermo Meza-Jiménez, Germán Bernáldez-Gómez. Evaluation of Renal Function at 24, 48, and 72 Hours and 3 Months After Transplant: Comparison of 3 Anesthetic Techniques.
Transplantation proceedings.
2020 May; 52(4):1094-1101. doi:
10.1016/j.transproceed.2020.02.011. [PMID: 32178928] - Alexander M Sidlak, Joseph H Yanta, Michael J Lynch. Intrathecal bupivacaine and morphine toxicity leading to transient hypotension and delayed status epilepticus.
The American journal of emergency medicine.
2020 05; 38(5):1046.e5-1046.e7. doi:
10.1016/j.ajem.2019.12.055. [PMID: 31952869] - Gustavo H Rodrigues da Silva, Gabriela Geronimo, Lígia N M Ribeiro, Viviane A Guilherme, Ludmilla David de Moura, André L Bombeiro, Juliana Damasceno Oliveira, Márcia C Breitkreitz, Eneida de Paula. Injectable in situ forming nanogel: A hybrid Alginate-NLC formulation extends bupivacaine anesthetic effect.
Materials science & engineering. C, Materials for biological applications.
2020 Apr; 109(?):110608. doi:
10.1016/j.msec.2019.110608. [PMID: 32228992] - Marta Cuenca-Llavall, Daniel Pérez-Prieto, Francisco J Santiveri, Alfonso León Garcia, Fernando Marqués. The influence of local infiltration analgesia after total hip replacement. A randomized clinical trial.
Acta orthopaedica Belgica.
2020 Mar; 86(1):33-37. doi:
NULL. [PMID: 32490771] - Sara Marroquin, Elizabeth Tacl, Jenna Truckenbrod, Katie DeWall, Thavam Thambi-Pillai. Retrospective Cohort Study to Evaluate the Analgesic Effectiveness of Liposomal Bupivacaine for Renal Transplant Recipients.
South Dakota medicine : the journal of the South Dakota State Medical Association.
2020 Mar; 73(3):116-121. doi:
NULL. [PMID: 32142230] - L Pan, Y Zhang, Y He, Z Chen, S Wang, Y Xia, T J Papadimos, W Lin, X Xu. Dexmedetomidine elevates the lethal dose threshold of bupivacaine in rats: A dosing study.
Human & experimental toxicology.
2020 Mar; 39(3):365-373. doi:
10.1177/0960327119889658. [PMID: 31773986] - Mahmud Arif Pavel, Hae-Won Chung, E Nicholas Petersen, Scott B Hansen. Polymodal Mechanism for TWIK-Related K+ Channel Inhibition by Local Anesthetic.
Anesthesia and analgesia.
2019 10; 129(4):973-982. doi:
10.1213/ane.0000000000004216. [PMID: 31124840] - C De Diego, M Zaballos, O Quintela, R Sevilla, D Callejo, J González-Panizo, Ma J Anadón, J Almendral. Bupivacaine Toxicity Increases Transmural Dispersion of Repolarization, Developing of a Brugada-like Pattern and Ventricular Arrhythmias, Which is Reversed by Lipid Emulsion Administration. Study in an Experimental Porcine Model.
Cardiovascular toxicology.
2019 10; 19(5):432-440. doi:
10.1007/s12012-019-09515-y. [PMID: 30945064] - Petra M Meier, Luis M Pereira, David Zurakowski, Hiep T Nguyen, Carlos Munoz-San Julian, Constance S Houck. Population Pharmacokinetics of Intraperitoneal Bupivacaine Using Manual Bolus Atomization Versus Micropump Nebulization and Morphine Requirements in Young Children.
Anesthesia and analgesia.
2019 10; 129(4):963-972. doi:
10.1213/ane.0000000000004224. [PMID: 31124839] - Rama Prajapati, Susan Weng Larsen, Anan Yaghmur. Citrem-phosphatidylcholine nano-self-assemblies: solubilization of bupivacaine and its role in triggering a colloidal transition from vesicles to cubosomes and hexosomes.
Physical chemistry chemical physics : PCCP.
2019 Jul; 21(27):15142-15150. doi:
10.1039/c9cp01878f. [PMID: 31243413] - Matilde Zaballos, David Callejo, Raul Sevilla, Oscar Quintela, Ramiro López-Menchaca, Arturo Melone, Olalla Varela, Mª José Anadón Baselga, Jesús Almendral. Comparative Effects of Sodium Bicarbonate and Intravenous Lipid Emulsions on Reversing Bupivacaine-Induced Electrophysiological Toxicity in a Porcine Experimental Model.
Anesthesia and analgesia.
2019 07; 129(1):63-72. doi:
10.1213/ane.0000000000003875. [PMID: 31210652] - Guy L Weinberg, Peter Bedocs, Michael R Fettiplace. Pigs and Paradigms: Stop Using Swine to Study Lipid Resuscitation.
Anesthesia and analgesia.
2019 07; 129(1):4-7. doi:
10.1213/ane.0000000000004101. [PMID: 31206444] - Mahmoud Reza Moradkhani, Arash Karimi. Effect of Artemisia Aucheri.L and Bupivacaine Encapsulated Nanoparticles on Nociceptive Pain.
Drug research.
2019 Jul; 69(7):401-405. doi:
10.1055/a-0825-6487. [PMID: 30616248] - Jun Ho Yang, Adrian S Siregar, Eun-Jin Kim, Marie Merci Nyiramana, Eui-Jung Shin, Jaehee Han, Ju-Tae Sohn, Jong Woo Kim, Dawon Kang. Involvement of TREK-1 Channel in Cell Viability of H9c2 Rat Cardiomyoblasts Affected by Bupivacaine and Lipid Emulsion.
Cells.
2019 05; 8(5):. doi:
10.3390/cells8050454. [PMID: 31091801] - H K Knych, K R Mama, C E Moore, A E Hill, D S McKEMIE. Plasma and synovial fluid concentrations and cartilage toxicity of bupivacaine following intra-articular administration of a liposomal formulation to horses.
Equine veterinary journal.
2019 May; 51(3):408-414. doi:
10.1111/evj.13015. [PMID: 30182426] - D H Lim, J-T Sohn. Bupivacaine-induced cardiotoxicity and lipid emulsion.
Human & experimental toxicology.
2019 04; 38(4):494-495. doi:
10.1177/0960327118819042. [PMID: 30556419] - Bryant W Tran, Spencer T Liebman, Trevor W Reichman, Michael J Scott. Hemodynamic Instability and Lipid Emulsion Resuscitation After Subcutaneous Injection of a Liposomal Bupivacaine Admixture: A Case Report.
A&A practice.
2019 Apr; 12(7):223-225. doi:
10.1213/xaa.0000000000000889. [PMID: 30199400] - Joseph Marino, Giles Scuderi, Oonagh Dowling, Rena Farquhar, Bridget Freycinet, Frank Overdyk. Periarticular Knee Injection With Liposomal Bupivacaine and Continuous Femoral Nerve Block for Postoperative Pain Management After Total Knee Arthroplasty: A Randomized Controlled Trial.
The Journal of arthroplasty.
2019 03; 34(3):495-500. doi:
10.1016/j.arth.2018.11.025. [PMID: 30583813] - Marília Cristina Oliveira Souza, Maria Paula Marques, Geraldo Duarte, Vera Lucia Lanchote. Analysis of bupivacaine enantiomers in plasma as total and unbound concentrations using LC-MS/MS: Application in a pharmacokinetic study of a parturient with placental transfer.
Journal of pharmaceutical and biomedical analysis.
2019 Feb; 164(?):268-275. doi:
10.1016/j.jpba.2018.10.040. [PMID: 30399533] - Le Liu, Zhousheng Jin, Xixi Cai, Yun Xia, Meiling Zhang, Thomas J Papadimos, Xuzhong Xu, Kejian Shi. Comparative Regimens of Lipid Rescue From Bupivacaine-Induced Asystole in a Rat Model.
Anesthesia and analgesia.
2019 02; 128(2):256-263. doi:
10.1213/ane.0000000000003711. [PMID: 30113398] - José Luis Zeballos, Gary R Strichartz. Tuning Up the Life Saver: An Experimental Approach to Optimizing the Delivery of Intravenous Lipid Emulsions.
Anesthesia and analgesia.
2019 02; 128(2):199-201. doi:
10.1213/ane.0000000000003863. [PMID: 30649040] - Soumyarwit Manna, Yong Wu, Yan Wang, Bonhye Koo, Lynn Chen, Peter Petrochenko, Yixuan Dong, Stephanie Choi, Darby Kozak, Berk Oktem, Xiaoming Xu, Jiwen Zheng. Probing the mechanism of bupivacaine drug release from multivesicular liposomes.
Journal of controlled release : official journal of the Controlled Release Society.
2019 01; 294(?):279-287. doi:
10.1016/j.jconrel.2018.12.029. [PMID: 30576748] - A G Del Arroyo, J Sanchez, S Patel, S Phillips, A Reyes, C Cubillos, R Fernando, A L David, P Sultan, G L Ackland. Role of leucocyte caspase-1 activity in epidural-related maternal fever: a single-centre, observational, mechanistic cohort study.
British journal of anaesthesia.
2019 Jan; 122(1):92-102. doi:
10.1016/j.bja.2018.09.024. [PMID: 30579413] - Hans W Sollinger, Talal Al-Qaoud, Natalie Bath, Robert R Redfield. The 'UW-LPHS Test': A New Test to Predict the Outcome of Renal Autotransplant for Loin Pain Hematuria Syndrome.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2018 12; 16(6):651-655. doi:
10.6002/ect.2018.0236. [PMID: 30251941] - Hongfei Chen, Fangfang Xia, Zhousheng Jin, Kejian Shi, Yun Xia, Le Liu, Thomas J Papadimos, Xuzhong Xu, Limei Chen. Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart.
BMC anesthesiology.
2018 11; 18(1):174. doi:
10.1186/s12871-018-0627-0. [PMID: 30458723] - N Parikh, N Parikh. Management of anesthesia for cesarean delivery in a patient with an unruptured intracranial aneurysm.
International journal of obstetric anesthesia.
2018 Nov; 36(?):118-121. doi:
10.1016/j.ijoa.2018.06.007. [PMID: 30057147] - Shariq Anis Khan, Salman El Khalid, Fouzia Naeem Effendi, Mohammad Hammad Mithani, Adnan Siddique Awan, Tooba Mugal. Postoperative Pain Score of Bupivacaine versus Placebo in Patients Undergoing Percutaneous Nephrolithotomy.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2018 Nov; 28(11):858-861. doi:
10.29271/jcpsp.2018.11.858. [PMID: 30369379] - Thomas M Kelley, Daniel W Bailey, Preston Sparks, Robert Rice, Erin Caddell, Heather Currier, Dominic Gallo. Intercostal Nerve Blockade with Exparel® Results in Lower Opioid Usage during the First 24 Hours after Video-Assisted Thorascopic Surgery.
The American surgeon.
2018 Sep; 84(9):1433-1438. doi:
10.1177/000313481808400945. [PMID: 30268171] - Meriç Uğurlar, Mesut Mehmet Sönmez, Özge Yapıcı Uğurlar, Levent Adıyeke, Hakkı Yıldırım, Osman Tuğrul Eren. Effectiveness of Four Different Treatment Modalities in the Treatment of Chronic Plantar Fasciitis During a 36-Month Follow-Up Period: A Randomized Controlled Trial.
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons.
2018 Sep; 57(5):913-918. doi:
10.1053/j.jfas.2018.03.017. [PMID: 30149850] - Jeong Eun Lee, Kyung-Hwa Kwak. A liver transplant recipient with possible bupivacaine-induced liver injury caused by intra-articular injection after total knee arthroplasty: A case report.
Medicine.
2018 Sep; 97(38):e12481. doi:
10.1097/md.0000000000012481. [PMID: 30235748] - Xianyi Cai, Yunlu Liu, Yiqiang Hu, Xianzhe Liu, Hongyan Jiang, Shuhua Yang, Zengwu Shao, Yun Xia, Liming Xiong. ROS-mediated lysosomal membrane permeabilization is involved in bupivacaine-induced death of rabbit intervertebral disc cells.
Redox biology.
2018 09; 18(?):65-76. doi:
10.1016/j.redox.2018.06.010. [PMID: 29986210] - Abbas Basiri, Amir Hossein Kashi, Mahdi Zeinali, Mahmoud Reza Nasiri, Reza Valipour, Reza Sarhangnejad. Limitations of Spinal Anesthesia for Patient and Surgeon During Percutaneous Nephrolithotomy.
Urology journal.
2018 07; 15(4):164-167. doi:
10.22037/uj.v0i0.3993. [PMID: 29308578] - Siavash Beiranvand, Mahmoud Reza Moradkhani. Bupivacaine Versus Liposomal Bupivacaine For Pain Control.
Drug research.
2018 Jul; 68(7):365-369. doi:
10.1055/s-0043-121142. [PMID: 29108087]
