propafenone (BioDeep_00000408817)
Main id: BioDeep_00000002059
代谢物信息卡片
propafenone
化学式: C21H27NO3 (341.1990832)
中文名称: 普罗帕酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
InChI: InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BC - Antiarrhythmics, class ic
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM)[1]. Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9?μm and 8.6?μm, respectively[2]. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis[3].
同义名列表
4 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:63619
- KEGG: C07381
- KEGGdrug: D08435
- PubChem: 4932
- DrugBank: DB01182
- ChEMBL: CHEMBL631
- MeSH: Propafenone
- CAS: 54063-53-5
- MoNA: WA000689
- MoNA: WA000688
- MoNA: WA000687
- MoNA: WA000686
- PubChem: 9585
- NIKKAJI: J12.333A
- RefMet: Propafenone
- medchemexpress: HY-B0432
- KNApSAcK: 63619
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Jinlian Wei, Yongyun Li, Ruoxi Li, Xin Chen, Tiannuo Yang, Liang Liao, Yuqing Xie, Jin Zhu, Fei Mao, Renbing Jia, Xiaofang Xu, Jian Li. Drug repurposing of propafenone to discover novel anti-tumor agents by impairing homologous recombination to delay DNA damage recovery of rare disease conjunctival melanoma.
European journal of medicinal chemistry.
2023 Feb; 250(?):115238. doi:
10.1016/j.ejmech.2023.115238. [PMID: 36868105] - Jiaru Li, Junzu Shi, Chenyang Jia, Wei Li, Ying Peng, Jiang Zheng. Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6.
Chemical research in toxicology.
2022 05; 35(5):829-839. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jun; 36(6):1126-34. doi:
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International journal of pharmaceutics.
2008 Apr; 353(1-2):124-30. doi:
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The Annals of pharmacotherapy.
2008 Mar; 42(3):434-8. doi:
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Nature protocols.
2008; 3(8):1341-9. doi:
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Vascular health and risk management.
2008; 4(1):23-30. doi:
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International journal of chronic obstructive pulmonary disease.
2008; 3(1):45-53. doi:
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The Journal of pharmacology and experimental therapeutics.
2008 Jan; 324(1):322-30. doi:
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Journal of medical case reports.
2007 Dec; 1(?):187. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 857(1):130-5. doi:
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World journal of gastroenterology.
2007 Feb; 13(6):975-7. doi:
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Analytical chemistry.
2007 Jan; 79(2):434-44. doi:
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Clinical drug investigation.
2007; 27(7):505-8. doi:
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Therapeutic drug monitoring.
2006 Dec; 28(6):779-83. doi:
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Chemical & pharmaceutical bulletin.
2006 Jul; 54(7):1026-9. doi:
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Electrophoresis.
2006 Apr; 27(8):1517-25. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2006 Apr; 26(4):311-5. doi:
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The Journal of pharmacology and experimental therapeutics.
2006 Mar; 316(3):1098-106. doi:
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Biomedical chromatography : BMC.
2005 Dec; 19(10):771-6. doi:
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Therapeutics and clinical risk management.
2005 Dec; 1(4):299-306. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2005 Jun; 33(6):726-32. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2005 Mar; 371(3):195-201. doi:
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Molecular pharmacology.
2005 Feb; 67(2):365-74. doi:
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2004 Sep; 20(9):1307-11. doi:
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Journal of medicinal chemistry.
2004 Mar; 47(7):1783-8. doi:
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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2004 Mar; 2(2):97-9. doi:
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Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
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Journal of Zhejiang University. Science.
2004 Feb; 5(2):226-9. doi:
10.1007/bf02840928. [PMID: 14674037] - Min Zhu, Tong-wei Yao, Su Zeng. [Glucuronidation and in vitro interaction of Ginkgo flavonoids with other drugs].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
2004 01; 33(1):15-20. doi:
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Receptors & channels.
2004; 10(3-4):131-8. doi:
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Bratislavske lekarske listy.
2004; 105(1):14-7. doi:
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Acta pharmacologica Sinica.
2003 Dec; 24(12):1277-80. doi:
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British journal of cancer.
2003 Nov; 89(10):1855-9. doi:
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Journal of analytical toxicology.
2003 Nov; 27(8):595-9. doi:
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Digestive diseases and sciences.
2003 Feb; 48(2):354-7. doi:
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Drugs.
2003; 63(8):769-802. doi:
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Current drug targets.
2003 Jan; 4(1):31-43. doi:
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Acta pharmacologica Sinica.
2002 Nov; 23(11):1040-4. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2002 Nov; 40(11):1633-56. doi:
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Journal of medicinal chemistry.
2002 Jun; 45(13):2867-76. doi:
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Drugs.
2002; 62(3):415-23. doi:
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Clinical pharmacokinetics.
2002; 41(8):533-58. doi:
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Expert opinion on pharmacotherapy.
2001 Nov; 2(11):1877-90. doi:
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